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Patent # Description
2018/0064751 COMPOSITIONS AND METHODS FOR TREATING HYPERKALEMIA
The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of...
2018/0064750 Methods of Treating Osteoarthritis
In one aspect, the present invention relates to a new method of treating or osteoarthritis in a mammal in need thereof. In certain embodiments, the method...
2018/0064749 CONJUGATION OF LIPOPHILIC ALBUMIN-BINDING MOIETY TO RNA FOR IMPROVED CARRIER-FREE IN VIVO PHARMACOKINETICS AND...
Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes...
2018/0064748 METHODS OF TREATING MOTOR NEURON DISEASES
A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent...
2018/0064747 DNA-FUNCTIONALIZED SCAFFOLDS FOR DRUG CAPTURE APPLICATIONS
This disclosure is directed to structured compositions, including DNA-functionalized scaffolds, for drug capture, and methods and devices for sequestering...
2018/0064745 COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE" - DEPENDENT SIGNALLING
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor...
2018/0064744 NUCLEOSIDE AGENTS FOR THE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED NUCLEOTIDE REPEAT CONTAINING GENES
Aspects of the invention include methods of reducing the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by...
2018/0064743 NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards...
2018/0064742 PET IMAGING TRACER FOR IMAGING PROSTATE CANCER
In various embodiments, the invention provides a radiotracer comprising a positron emitting atom bound to a deoxy sugar moiety. The radiotracer is reversible...
2018/0064741 USE OF GINSENOSIDE M1 FOR PREVENTING OR TREATING SILICOSIS
The present invention discloses a new use of ginsenoside M1 for treating or preventing silicosis.
2018/0064740 USE OF GINSENOSIDE M1 FOR PREVENTING OR TREATING GOUT
The present invention discloses a new use of ginsenoside M1 for treating or preventing gout.
2018/0064739 NUTRITIONAL COMPOSITION WITH HUMAN MILK OLIGOSACCHARIDES AND USES THEREOF
The present disclosure generally relates to pediatric nutritional compositions including a human milk oligosaccharide or a precursor thereof. Further, the...
2018/0064738 METHOD OF TREATING INFECTIONS USING SILOXANE DERIVATIVES
Pharmaceutical compositions are disclosed that comprise at least one compound of formula I: ##STR00001## wherein the substituent groups are as defined in the...
2018/0064737 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and...
2018/0064736 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING COMPLEX REGIONAL PAIN...
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2018/0064735 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING COMPLEX REGIONAL PAIN...
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2018/0064734 NERIDRONIC ACID FOR TREATING COMPLEX REGIONAL PAIN SYNDROME
Osteoclast inhibitors, such as neridronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as complex...
2018/0064733 USE OF BISPHOSPHONATES AS HIV/AIDS ADJUNCTIVE TREATMENT
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises...
2018/0064732 COMPOSITIONS AND METHODS FOR SUPPRESSING OR REDUCING SYSTEMIC IMMUNE RESPONSE IN A SUBJECT
The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically...
2018/0064731 SMALL MOLECULE THERAPEUTIC COMPOUNDS THAT REDUCE THE INCIDENCE OF INTRACEREBRAL HEMORRHAGE AND BRAIN...
The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain ...
2018/0064730 Cardiac glycosides to reduce pulmonary exacerbations and other adverse events in cystic fibrosis and other...
A small molecule inhibitor for treating a disorder in mammals, wherein the disorder is characterized by high levels of inflammatory components. In a preferred...
2018/0064729 Treatment of Pulmonary Disease
The present invention relates to methods of treating, reducing the risk of, preventing, or alleviating a symptom of a pulmonary disease or condition, reducing...
2018/0064728 TREATMENT OF SYMPTOMS RELATED TO NEURODEGENERATIVE DISORDERS THROUGH PHARMACOLOGICAL DERMAL ACTIVATION OF...
A method for treating a symptom of a neurodegenerative condition. The method includes topically administering a composition that contains a sex steroid or a...
2018/0064727 V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS
This invention relates to a new medical use for certain chemical compounds and pharmaceutical compositions containing them. The invention relates to compounds...
2018/0064726 Deuterium-Substituted Oxazepin Compounds
Described are deuterium-substituted oxazepin compounds of structural Formula I, which are inhibitors/blockers of the late sodium current. Also described are...
2018/0064725 IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The...
2018/0064724 METHODS FOR TREATING INTRAPULMONARY INFECTIONS
This disclosure relates to the treatment of intrapulmonary bacterial infections, including treatment of nosocomial pneumonia lung infections with...
2018/0064723 Antibacterial compositions and methods
A method for treating bacterial infection using: (a) cefepime or a pharmaceutically acceptable salt thereof, (b) arginine or a pharmaceutically acceptable salt...
2018/0064722 ANTIBACTERIAL COMPOSITIONS
Pharmaceutical compositions comprising cefepime or a pharmaceutically acceptable salt thereof, tazobactam or a pharmaceutically acceptable salt thereof, and...
2018/0064721 COMBINATION OF BRIMONIDINE AND TIMOLOL FOR TOPICAL OPHTHALMIC USE
Disclosed are pharmaceutical compositions comprising brimonidine and timolol for topical ophthalmic delivery and a method of treatment comprising administering...
2018/0064720 COMBINATION OF BRIMONIDINE AND TIMOLOL FOR TOPICAL OPHTHALMIC USE
Disclosed are pharmaceutical compositions comprising brimonidine and timolol for topical ophthalmic delivery and a method of treatment comprising administering...
2018/0064719 Method of maintaining oral health in animals
Use of a compound having the formula (I) in the manufacture of a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal...
2018/0064718 COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION
The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and...
2018/0064717 DEUTERATED ANALONGS OF ETIFOXINE, THEIR DERIVATIVES AND USES THEREOF
This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to...
2018/0064716 COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND THERAPY FOR MENIERE'S DISEASE
Provided are articles of manufacture, compositions and methods for prophylaxis and/or therapy for disorders involving dizziness and/or vertigo. The articles of...
2018/0064715 TABLET COMPOSITIONS
Provided herein is a tablet comprising 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)p- ...
2018/0064714 Process for the Preparation of Amorphous Idelalisib and its Premix
Processes for the preparation of amorphous idelalisib are provided. Processes for the preparation of a premix of amorphous idelalisib are also provided.
2018/0064713 Modulators of Androgen Synthesis
The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses...
2018/0064712 METHODS OF REDUCING IMMUNE CELL ACTIVATION AND USES THEREOF
The present invention encompasses methods of reducing inflammatory immune cell activation and inflammation via inhibiting mitochondrial fission.
2018/0064711 METHODS FOR TREATING CRYPTOSPORIDIOSIS USING TRIAZOLOPYRIDAZINES
Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical...
2018/0064710 ANTIFUNGAL TREATMENT OF PSORIASIS
Methods of treating disorders with a combination of antifungals is provided. The methods include topically administering a combination of antifungal agents to...
2018/0064709 PHARMACEUTICAL COMBINATIONS
A pharmaceutical combination comprising N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2- ...
2018/0064708 Nutlin-3a for Treatment of Proliferative Vitreoretinopathy
The invention provides compositions and methods for treatment of proliferative vitreoretinopathy.
2018/0064707 PHARMACEUTICAL COMPOSITION FOR TREATING POSTTRAUMATIC STRESS DISORDER
Provided are a posttraumatic stress disorder (PTSD) animal model in which dopamine receptor subtype 4 (D4R) is damaged or deficient, a method for preparing the...
2018/0064706 ABUSE-RESISTANT MUCOADHESIVE DEVICES FOR DELIVERY OF BUPRENORPHINE
The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing...
2018/0064705 HYDROMORPHONE AND NALOXONE FOR TREATMENT OF PAIN AND OPIOID BOWEL DYSFUNCTION SYNDROME
The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and...
2018/0064704 IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING OXYCODONE AND NALOXONE
The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone...
2018/0064703 STABLE INFUSION DOSAGE FORM OF MORPHINE
The present invention relates to an infusion dosage form comprising (i) an aqueous solution of morphine or its pharmaceutically acceptable salt as a sole...
2018/0064702 TREATMENT OF PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS WITH LAQUINIMOD
This invention provides a method for treating a human subject afflicted with a progressive form of multiple sclerosis, comprising periodically administering to...
2018/0064701 METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS
Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity,...
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