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Patent # Description
2018/0066270 REGULATORY NUCLEIC ACID MOLECULES FOR ENHANCING CONSTITUTIVE GENE EXPRESSION IN PLANTS
The present invention is in the field of plant molecular biology and provides methods for production of high expressing constitutive promoters and the...
2018/0066269 NOVEL PROMOTER AND USES THEREOF
Provided are a novel promoter and a method of producing a target product using the same.
2018/0066268 USE OF VITAMINS AND VITAMIN METABOLIC GENES AND PROTEINS FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS
Disclosed are eukaryotic expression systems and methods for the selection of mammalian cell lines that produce proteins of interest, such as therapeutic...
2018/0066267 FUSION PROTEIN COMPRISING GAUSSIA LUCIFERASE, TRANSLATION INTERRUPTER SEQUENCE, AND INTERFERON AMINO ACID SEQUENCES
Polynucleotides encoding fusion proteins comprising interferons and luciferases which have biotherapeutic, diagnostic, and quality control applications in...
2018/0066266 EML4-ALK FUSION GENE
The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion...
2018/0066265 MCP-1 Binding Nucleic Acids
The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group comprising type 1A nucleic acids, type 1B nucleic...
2018/0066264 FUNCTIONAL LIGANDS TO THC
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2018/0066263 NUCLEIC ACID APTAMERS BINDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
[Problem] To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis...
2018/0066262 OLIGONUCLEOTIDE PROBES AND USES THEREOF
Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include...
2018/0066261 REPLICATION FACTOR C-40 (RFC40/RFC2) AS A PROGNOSTIC MARKER AND TARGET IN ESTROGEN POSITIVE AND NEGATIVE AND...
The present disclosure relates generally to cancer and particularly to breast cancer including estrogen sensitive, estrogen resistant and triple negative...
2018/0066260 TREATMENT OF INTERFERON REGULATORY FACTOR 8 (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in...
2018/0066259 MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
Provided are antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping, and methods of use thereof...
2018/0066258 SPECIFIC SYNTHETIC CHIMERIC XENONUCLEIC ACID GUIDE RNA; s(XNA-gRNA) FOR ENHANCING CRISPR MEDIATED GENOME...
The invention provides specific synthetic chimeric xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing crispr mediated genome editing efficiency. The...
2018/0066257 PHARMACEUTICAL COMPOSITION FOR TREATING CHARCOT MARIE TOOTH DISEASE
An siRNA for specifically targeting a PMP22 mutant gene and a pharmaceutical composition for preventing or treating Charcot Marie Tooth disease, which includes...
2018/0066256 RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Neuromuscular Disorders
The current invention provides an improved oligonucleotide and its use for treating, ameliorating, preventing, delaying and/or treating a human cis-element...
2018/0066255 Compositions and Methods for Inhibition of Expression of Protein C (PROC) Genes
The invention relates to double-stranded ribonucleic acid (dsRNA) targeting a PROC gene, and methods of using the dsRNA to inhibit expression of PROC.
2018/0066254 RNA INTERFERENCE MEDIATED THERAPY FOR NEURODEGENERATIVE DISEASES
Therapeutic agent for use in the treatment of neurodegenerative diseases associated with abnormalities of MAPT gene encoded protein tau, wherein said...
2018/0066253 METHODS AND COMPOSITIONS FOR MODIFYING ENDOTHELIAL CELLS
The present invention includes methods and compositions for modifying endothelial cells for improved vascular self-assembly. In some embodiments, the invention...
2018/0066252 p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE
Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to...
2018/0066251 RNA PRODUCTS AND USES THEREOF
The present invention relates to small RNAs, inhibitors thereof, inhibitors of enzymes producing thereof, and their use to modulate the response of a cell to a...
2018/0066250 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ENDOCRINE DISRUPTING CHEMICALS-INDUCED DISEASES AND...
A pharmaceutical composition for preventing and treating endocrine disrupting chemicals-induced diseases and a treating method using the same. Since the...
2018/0066249 METHODS FOR LABELING AND MANIPULATING A CELLULAR CIRCUIT
The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the...
2018/0066248 MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS
A system, configured to facilitate processing and detection of nucleic acids, the system comprising a process fluid container and a cartridge comprising: a top...
2018/0066247 BIOLOGICAL TISSUE GRINDING CONTAINER
According to one embodiment, a biological tissue grinding container includes a container portion and a vibrated portion, and vibration is transmitted to...
2018/0066246 ISOLATION OF NUCLEIC ACIDS
Methods of isolating nucleic acids comprising DNA from biological material are disclosed. The methods comprise a lysis step using an aqueous composition which...
2018/0066245 COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or...
2018/0066244 USE AND PRODUCTION OF STORAGE-STABLE NEUTRAL METALLOPROTEASE
The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some...
2018/0066243 HOST CELL CAPABLE OF PRODUCING ENZYMES USEFUL FOR DEGRADATION OF LIGNOCELLULOSIC MATERIAL
The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding...
2018/0066242 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS, STRUCTURAL INFORMATION AND INDUCIBLE...
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are...
2018/0066241 PRO-APOPTOTIC SET AND PP2A PEPTIDES
The invention provide chimeric peptides comprising a chimeric peptide comprising a cell-penetrating peptide linked to a pro-apoptotic peptide, wherein the...
2018/0066239 KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE
The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.
2018/0066238 LIVE ATTENUATED VACCINES FOR PNEUMOVIRUSES AND RELATED METHODS AND MATERIALS
Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the pneumovirus,...
2018/0066237 METHODS OF PURIFYING ADENO-ASSOCIATED VIRUS (AAV) AND/OR RECOMBINANT ADENO-ASSOCIATED VIRUS (rAAV) AND...
A method of purifying a viral vector is provided. The method includes loading a nonionic density gradient into a continuous flow centrifuge rotor; loading a...
2018/0066236 IBV STRAINS AND USES THEREOF
The present invention relates to novel infectious bronchitis virus strains and the uses thereof. The invention particularly relates to an inactivated or...
2018/0066235 Modified Foot-And-Mouth Disease Virus 3C Proteases, Compositions And Methods Thereof
This application is directed generally to foot-and-mouth disease virus (FMDV) 3C proteases that have been modified by mutating a polynucleotide sequence coding...
2018/0066234 OPTICAL-QUALITY SURFACE THAT IMPARTS SPATIAL CONTROL OF MACROPHAGE FUSION
Methods to form a surface coating and surface pattern, which are based on adsorption of hydrocarbon chains that can be used with imaging optics to visualize...
2018/0066233 LIVER ORGANOID, USES THEREOF AND CULTURE METHOD FOR OBTAINING THEM
The invention relates to a liver organoid, uses thereof and method for obtaining them.
2018/0066232 Method and device for preparing non-embryonic stem cells
The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, comprising a...
2018/0066231 MESENCHYMAL STEM CELL CULTURE MEDIUM, METHODS FOR CULTURING MESENCHYMAL STEM CELLS, AND MESENCHYMAL STEM CELLS
The present invention aims to provide a mesenchymal stem cell culture medium suitable for culturing umbilical cord mesenchymal stem cells in particular, among...
2018/0066230 Culture scaffold for enhancing differentiation of osteoblast using pattern
The present disclosure relates to a culture scaffold for promoting differentiation from stem cells or precursor cells into osteoblasts, in which the culture...
2018/0066229 METHOD FOR PREPARING DENDRITIC CELLS VIA NON-ADHESIVE CULTURE USING IFN
This invention provides a method for preparing dendritic cells from monocytes with the use of interferon .alpha. via non-adhesive culture. The method for...
2018/0066228 Detection of T Cell Exhaustion or Lack of T Cell Costimulation and Uses Thereof
The application relates to methods of assessing whether an individual has an exhausted CD8.sup.+ T cell or lack of CD4.sup.+ T cell costimulation phenotype,...
2018/0066227 METHODS OF EXPANDING EMBRYONIC STEM CELLS IN A SUSPENSION CULTURE
A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under...
2018/0066226 CULTURE SUPPORT HAVING IMPROVED CELL ADHESIVENESS AND MOBILITY
Provided is a cell culture support having improved cell adhesion and mobility, which includes: a fibrous web which is made by accumulating fibers containing a...
2018/0066225 METHOD OF PREPARING BACTERIAL GHOSTS FROM GRAM-POSITIVE BACTERIA BY HYDROCHLORIC ACID TREATMENT
The present invention relates to bacterial ghosts, and more particularly, to a method of preparing bacterial ghosts from gram-positive bacteria by hydrochloric...
2018/0066224 ACOUSTIC PERFUSION DEVICES
Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the...
2018/0066223 CANCER CELL ENRICHMENT SYSTEM
Embodiments of the invention relate to a cell culture incubator having a gas flow regulation system that exerts control over atmospheric parameters within the...
2018/0066222 DEVICE FOR MASSIVELY PARALLEL HIGH THROUGHPUT SINGLE CELL ELECTROPORATION AND USES THEREOF
In various embodiments a Massively parallel Single-cell Electroporation Platform (MSEP) for low voltage, high efficiency delivery of extracellular materials...
2018/0066221 BUFFER TANK AND CULTURE SYSTEM
A buffer tank for storing a culture medium for cell culture, includes: a tank main body including a cylindrical inner surface extending in a vertical...
2018/0066220 DEVICES FOR CELL CULTURE AND METHODS OF MAKING AND USING THE SAME
Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels...
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