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Patent # Description
2018/0066068 ANTI-PSYK ANTIBODY MOLECULES AND USE OF SAME FOR SYK-TARGETED THERAPY
The invention relates to antibody molecules which bind pSYK, and methods for using the same for diagnosis, prognosis, to select patients for treatment with a...
2018/0066066 HER3 SPECIFIC MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis...
2018/0066065 COMBINATION THERAPIES COMPRISING ANTI-ERBB3 AGENTS
Disclosed are methods and compositions for inhibiting the growth of a tumor (e.g., a malignant 5 tumor) in a subject. In particular, combination therapies for...
2018/0066064 BIOTHERAPEUTICS TARGETING GPR158 FOR CANCER
Prostate cancer (PCa) is typically associated with genetic alterations involving androgen sensitivity and the androgen receptor (AR). Described herein is the...
2018/0066063 ANTIBODIES AND VACCINES FOR USE IN TREATING ROR1 CANCERS AND INHIBITING METASTASIS
The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments,...
2018/0066062 OSTEOARTHRITIS TREATMENT
The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an...
2018/0066061 Methods of treating Sporadic Inclusion Body Myositis
The disclosure relates to the treatment of sporadic inclusion body myositis and other muscle wasting disorders with novel regimens, which employ a...
2018/0066060 Cell Line Overexpressing Human CD303 Antigen
The invention relates to a cell line expressing the gamma chain of the Fc.epsilon.RI receptor and human CD303 antigen, characterised in that said cell line is...
2018/0066059 ANTI-B7-H6 ANTIBODY, FUSION PROTEINS, AND METHODS OF USING THE SAME
Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and...
2018/0066058 ANTI-ICOS ANTIBODIES
Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and...
2018/0066057 TARGETED/IMMUNOMODULATORY FUSION PROTEINS AND METHODS FOR MAKING SAME
The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences...
2018/0066056 ANTI-H7CR ANTIBODIES
Antibodies and humanized variants thereof and their antigen-binding fragments and other molecules that are capable of immunospecifically binding to the B7-H7...
2018/0066055 ANTI-TIGIT ANTIBODIES
The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
2018/0066054 HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3), AND USES THEREOF
The present disclosure provides isolated monoclonal antibodies that specifically bind to LAG-3 with high affinity, particularly human monoclonal antibodies....
2018/0066053 AGONISTIC ANTIBODIES THAT BIND HUMAN CD40 AND USES THEREOF
Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are...
2018/0066052 COMPOSITIONS AND METHODS FOR REGULATING SAS1R
The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an...
2018/0066051 ANTAGONISTS OF IL-17 ISOFORMS AND THEIR USES
The invention relates generally to antagonists of IL-17 isoforms and their uses in diagnosis and therapy, especially for the treatment or prevention of cancers...
2018/0066050 USE OF IL-31 MONOCLONAL ANTIBODIES FOR ANTAGONIZING SIGNAL TRANSDUCTION IN DORSAL ROOT GANGLION CELLS
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in...
2018/0066049 Increasing the half-life of a full-length or a functional fragment of variant anti-human TNF-alpha antibody
Tumor Necrosis Factor-.alpha. (TNF.alpha.) promotes an inflammatory response resulting in many clinical problems associated with autoimmune disorders such as...
2018/0066048 INDUCTION DOSING REGIMEN
The invention relates to a multiple-variable dose method for treating a disorder in which TNF.alpha. activity is detrimental, comprising administering to a...
2018/0066047 Method for producing human monoclonal antibodies that binds to at least one part of HMGB1
The present invention relates to methods of making human anti-HMGB1 antibodies, compositions comprising these antibodies and methods of using the antibodies...
2018/0066046 ANTI-IL-6 ANTIBODIES FOR THE TREATMENT OF ARTHRITIS
The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity...
2018/0066045 ASSAYS FOR IGFBP7 HAVING IMPROVED PERFORMANCE IN BIOLOGICAL SAMPLES
The invention provides IGFBP7 immunoassays with improved clinical performance, particularly when used in the evaluation of renal injuries. The immunoassays...
2018/0066044 MONOCLONAL ANTIBODIES AGAINST AMYLOID BETA PROTEIN AND USES THEREOF
The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of...
2018/0066043 MYCOBACTERIAL ANTIGEN COMPOSITION
The present invention provides an antigenic composition for use as a mycobacterial vaccine, said composition comprising (i) a first mycobacterial antigenic...
2018/0066042 ANTIBODY AND ANTIBODY-CONTAINING COMPOSITION
For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance...
2018/0066041 ANTIBODIES TARGETING A GALACTAN-BASED O-ANTIGEN OF K. PNEUMONIAE
The invention provides for an isolated antibody that specifically recognizes a galactan-III epitope of the lipopolysaccharide (LPS) O-antigen structure of...
2018/0066040 COMPOUNDS FOR TREATING THE REMYELINATION BLOCKADE IN DISEASES ASSOCIATED WITH THE EXPRESSION OF HERV-W ENVELOPE...
The present invention deals with innovative compounds and compositions for preventing and/or treating a newly discovered detrimental mechanism, which blocks...
2018/0066039 MAST CELL STABILIZERS FOR TREATMENT OF HYPERCYTOKINEMIA AND VIRAL INFECTION
The present invention relates to methods for treating hypercytokinemia and viral infections associated with hypercytokinemia using a mast cell stabilizing...
2018/0066038 Transgenic Chicken Comprising an Inactivated Immunoglobulin Gene
A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and...
2018/0066037 TRANSDUCED T CELLS EXPRESSING HUMAN SSTR2 AND APPLICATION THEREOF
The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT...
2018/0066036 SINGLE-CHAIN CD40-RECEPTOR AGONIST PROTEINS
Provided herein are specific CD40 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a CD40L-associated...
2018/0066035 I DOMAIN CHIMERIC ANTIGEN RECEPTOR SPECIFIC TO ICAM-1
The present invention relates to chimeric antigen receptors (CARs) specific to ICAM-1 comprising I domain of the .alpha..sub.L subunit of human lymphocyte...
2018/0066034 CHIMERIC ANTIGEN RECEPTORS (CARs), TARGETING HEMATOLOGIC MALIGNANCIES, COMPOSITIONS AND METHODS OF USE THEREOF
The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens,...
2018/0066033 TARGETING TRASTUZUMAB-RESISTANT HER2+ BREAST CANCER WITH A HER3-TARGETING NANOPARTICLE
Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with an anti-HER2...
2018/0066032 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST OVARIAN CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0066031 ENZYMATICALLY-CLEAVABLE PEPTIDE AMPHIPHILES
Provided herein are enzymatically-cleavable peptide amphiphiles and methods of use thereof.
2018/0066030 MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE
Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising DNA encoding a variant inducible heat shock protein 70 (HSP70i)...
2018/0066029 ISOLATION OF NUCLEOSOMES HAVING MULTIPLE-MODIFIED HISTONE PROTEIN OCTAMERS
The invention discloses the use of an artificial protein for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer,...
2018/0066028 MUTEINS OF A1M LIPOCALIN AND METHOD OF PRODUCTION THEREFOR
The present disclosure relates to a collection of novel muteins derived from human .alpha.1m (or a1m) polypeptide or a functional homologue thereof. The...
2018/0066027 PROTAMINE IN TREATMENT OF NEURONAL INJURIES
The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite...
2018/0066026 MODULATION OF YEP6 GENE EXPRESSION TO INCREASE YIELD AND OTHER RELATED TRAITS IN PLANTS
Nucleotide sequences encoding YEP6 polypeptides are provided herein, along with plants and cells having reduced levels of YEP6 gene expression, reduced levels...
2018/0066025 Pesticidal Genes and Methods of Use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
2018/0066024 MUTATED STRUCTURAL PROTEIN OF A PARVOVIRUS
The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the...
2018/0066023 APPROACH TO PRODUCE HIV-1 GP140 ENVELOPE PROTEIN TRIMERS
An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers...
2018/0066022 COMPOSITIONS AND METHODS FOR INTRAVITREAL DELIVERY OF POLYNUCLEOTIDES TO RETINAL CONES
Methods and compositions are provided for intravitreally delivering a polynucleotide to cone photoreceptors. Aspects of the methods include injecting a...
2018/0066021 CXCR4 ANTAGONISTS AND METHODS OF USE
The present invention provides compounds that are antagonists of CXCR4 and methods for using the same for treatment of a clinical condition associated with...
2018/0066020 A CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE
The present invention is aimed for providing a novel peptide with a high drug efficacy and strong effect, a medicament or external preparation comprising it,...
2018/0066019 SCORPION VENOM HEAT-RESISTANT SYNTHETIC PEPTIDE AND APPLICATIONS THEREOF
A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can...
2018/0066018 CONFORMATIONALLY STABLE ANALOGS OF THE RESPONSE SELECTIVE C5A AGONIST EP67
Conformationally-stable peptide analogs of the response selective C5a agonist EP67 having the formula Tyr-Ser-Phe-Lys-Asp-Met-Xaa-(Xaa2)-(D-Ala)-Arg (SEQ ID...
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