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Patent # Description
2018/0066017 CLASS I MHC PHOSPHOPEPTIDES FOR CANCER IMMUNOTHERAPY AND DIAGNOSIS
A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have...
2018/0066016 Pharmaceutical Compositions and Therapeutic Methods of Use Comprising Selective Agonists of Melanocortin 1 Receptor
Short tri- and tetrapeptides according to the following Formula I Ar(CH2).sub.mX.sup.1--X.sup.2--CO--X.sup.3--X.sup.4--X.sup.5-(Trp).sub.n-- NX.sup.6R are...
2018/0066015 INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES
The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin,...
2018/0066014 MOLECULAR GELATORS FOR CONTAINING OIL SPILLAGE
In accordance with the present subject matter there is provided peptide-based compounds. methods of making such compounds, gels comprising such compounds,...
2018/0066013 Use of Excess Carbodiimide for Peptide Synthesis at Elevated Temperatures
An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same...
2018/0066012 SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino...
2018/0066011 METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION
A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps...
2018/0066010 ISOXAZOLIDINE DERIVATIVES
Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for...
2018/0066009 Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as...
The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on...
2018/0066008 MACROLIDES WITH MODIFIED DESOSAMINE SUGARS AND USES THEREOF
Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered...
2018/0066007 Macrocyclic Compounds And Methods Of Making And Using The Same
The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: ##STR00001## or a pharmaceutically acceptable salt, ester,...
2018/0066006 E-SELECTIN ANTAGONIST COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding...
2018/0066005 TRANS-RESVERATROL POLYSACCHARIDE, METHOD OF PRODUCING THE SAME, AND COMPOSITION COMPRISING THE SAME
An object of the present invention is to provide a trans-resveratrol derivative that resists isomerization to the cis-form. Another object of the present...
2018/0066004 MITOCHONDRIA-TARGETING PLATINUM(IV) PRODRUG
Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based...
2018/0066003 ORGANIC COMPOUNDS
A process for the hydrogenation of a substrate comprising a carbon heteroatom double bond in the presence of a transition metal complex comprising a tridentate...
2018/0066002 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME
Organometallic compounds and organic electroluminescence devices employing the same are provided. The organometallic compound has a chemical structure...
2018/0066001 HETEROLEPTIC IRIDIUM COMPLEX, AND LIGHT-EMITTING MATERIAL AND ORGANIC LIGHT-EMITTING ELEMENT USING COMPOUND
A novel iridium complex which can be applied in an organic electroluminescent light emitting device, an organic electrochemical light emitting device, or the...
2018/0066000 Metal Complexes and Electroluminescent Devices Comprising These Metal Complexes
The present invention relates to metal complexes having a metal atom of groups 13 to 15 and at least one ligand, where the ligand comprises at least one...
2018/0065999 ANTIVIRAL BETA-AMINO ACID ESTER PHOSPHODIAMIDE COMPOUNDS
Compounds of Formula I: ##STR00001## and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may...
2018/0065998 WATER SOLUBLE FLUORESCENT OR COLORED DYES COMPRISING CONJUGATING GROUPS
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof,...
2018/0065997 ELECTROLYTE FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY INCLUDING THE ELECTROLYTE
An electrolyte for a lithium secondary battery, the electrolyte including: a compound represented by Formula 1; a lithium salt; and an organic solvent, wherein...
2018/0065996 [BIS(TRIHYDROCARBYLSILYL)AMINOSILYL]-FUNCTIONALIZED STYRENE AND A METHOD FOR ITS PREPARATION
The invention relates to [bis(trihydrocarbylsilyl)aminosilyl]-functionalized styrene and a method for its preparation. The invention further relates to the use...
2018/0065995 NANOCOMPOSITE SILICON OXYGEN CARBON MATERIALS AND USES
Nanocomposite silicon and carbon compositions. These compositions can be made from polymer derived ceramics, and in particular, polysilocarb precursors. The...
2018/0065994 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds,...
2018/0065993 RAPID AND EFFICIENT BIOORTHOGONAL LIGATION REACTION AND BORON-CONTAINING HETEROCYCLES USEFUL IN CONJUNCTION...
A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an .alpha.-effect amine in aqueous solution at a temperature...
2018/0065992 MONOMERIC BIMETAL HYDROXYCITRIC ACID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
Monomeric bimetal hydroxycitric acid (HCA) compounds are provided. The subject compounds include a divalent metal (X) bonded to the carboxylic acids of C2 and...
2018/0065991 NOVEL OXATHIOLANE CARBOXYLIC ACIDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
2018/0065990 PROCESS FOR THE PREPARATION OF A SUBSTITUTED IMIDAZOTHIAZOLONE COMPOUND
The present invention provides a new process for the preparation of a substituted imidazothiazolone compound. The process of the present invention uses a...
2018/0065989 Broad Spectrum Beta-Lactamase Inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
2018/0065988 PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMORPHIC FORMS ALPHA, BETA, AND GAMMA OF RIFAXIMIN
Crystalline polymorphous forms of rifaximin (INN), referred to as rifaximin .alpha. and rifaximin .beta., and a poorly crystalline form referred to as...
2018/0065987 POLYMORPHIC FORMS ALPHA, BETA AND GAMMA OF RIFAXIMIN
Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin cc and rifaximin .beta., and a poorly crystalline form named rifaximin .gamma.,...
2018/0065986 SODIUM (2R,5S,13AR)-7,9-DIOXO-10-((2,4,6-TRIFLUOROBENZYL)CARBAMOYL)-2,3,4,- ...
The present invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,- ...
2018/0065985 PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS
The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts...
2018/0065984 Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol
The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol,...
2018/0065983 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: ##STR00001## or...
2018/0065982 SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH
The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such...
2018/0065981 HETEROCYCLYLMETHYL-THIENOURACILE AS ANTAGONISTS OF THE ADENOSINE-A2B-RECEPTOR
The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione ("thienouracil") derivatives bearing a particular type of (azaheterocyclyl)methyl...
2018/0065980 CYANATED BENZOXANTHENE AND BENZOTHIOXANTHENE COMPOUNDS
Disclosed herein are cyanated compounds of the formula (I) wherein at least one of the radicals R.sup.2, R.sup.3, R.sup.4 and R.sup.5 is CN, and the remaining...
2018/0065979 CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease...
2018/0065978 CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease...
2018/0065977 CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease...
2018/0065976 DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining...
2018/0065975 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE, PRODRUGS,...
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone...
2018/0065974 BRUTON'S TYROSINE KINASE INHIBITORS
The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
2018/0065973 PROCESS FOR MAKING BETA 3 AGONISTS AND INTERMEDIATES
The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are...
2018/0065972 NOVEL N-ACYL-(3-SUBSTITUTED)-(8-METHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]- PYRAZINES AS SELECTIVE NK-3 RECEPTOR...
Novel compounds of Formula I ##STR00001## methods of manufacturing the compounds and their use in therapeutic treatments are presented.
2018/0065970 UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS
The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and...
2018/0065969 THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED...
The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one...
2018/0065968 NEW SUBSTITUTED TRIAZOLOPYRIMIDINES AS ANTI-MALARIAL AGENTS
The present invention is related to a use of triazolopyrimidine derivatives in the manufacture of a medicament for preventing or treating malaria....
2018/0065967 GABAERGIC LIGANDS AND THEIR USES
Described herein are .alpha.3 or .alpha.2 or .alpha.2/.alpha.3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of...
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