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Patent # Description
2018/0065966 Antimicrobial Compounds And Methods Of Making And Using The Same
The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for...
2018/0065965 SULFAMIDE AND SULFAMATE INHIBITORS OF hHint1
Embodiments provide, among things, compounds of the formula I and methods for using such compounds to reduce pain (e.g., neuronal pain), treat a mammal's...
2018/0065964 SOLID FORMS OF A SELECTIVE CDK4/6 INHIBITOR
This invention relates to the crystalline free base of acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-p- yrido[2,3-d]pyrimidin-7-one,...
2018/0065963 INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: ...
2018/0065962 METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
A method of preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## comprises: (a) reacting Compound (1): ##STR00002## ...
2018/0065961 SALTS AND CRYSTALLINE FORMS OF AN APOPTOSIS-INDUCING AGENT
Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin- ...
2018/0065960 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS
Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are...
2018/0065959 BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the...
2018/0065958 PREPARATION METHOD OF PCI-32765 CRYSTAL FORM A
A preparation method of PCI-32765 crystalline form A, which comprises the following steps: 1) dissolving free base of PCI-32765 in a good solvent; 2) the...
2018/0065957 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases,...
2018/0065956 INSECTICIDAL COMPOUNDS
The invention relates to compounds of formula (I): ##STR00001## where A.sup.1, A.sup.2, A.sup.3, A.sup.4, G, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined...
2018/0065955 INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS
The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of...
2018/0065954 SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
The present invention relates to substituted bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these...
2018/0065953 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), ##STR00001## or pharmaceutically acceptable salts thereof, in...
2018/0065952 COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
The present invention provides modulators of protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, and...
2018/0065951 Formylated N-heterocyclic derivatives as FGFR4 inhibitors
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## a method for manufacturing said compound,...
2018/0065950 CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
A compound exerts an analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. A cyclic amine derivative represented by the...
2018/0065949 1-(TRIAZIN-3-YL/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREFOR FOR INHIBITING THE...
The present invention relates to compounds of formula I: ##STR00001## in which Y.sub.1, Y.sub.2, Y.sub.3, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
2018/0065948 Method for Synthesizing Cyclic Carbonates
The present invention relates to a method for synthesizing cyclocarbonates by reacting an epoxy compound and carbon dioxide at atmospheric pressure and...
2018/0065947 T-TYPE CALCIUM CHANNEL INHIBITOR
The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this...
2018/0065946 Miliusanes As Antiviral Agents
The present disclosure relates to miliusane and analogs thereof that are useful as anti-virals, such as anti-HIV and anti-influenza virus agents. The present...
2018/0065945 SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS...
Disclosed are unnatural analogs of Diptoindonesin G, methods to make the analogs, pharmaceutical compositions containing the analogs, and methods of using the...
2018/0065944 METHODS OF PRODUCING ALKYLFURANS
Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example,...
2018/0065943 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE...
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
2018/0065942 CRYSTALLINE SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND PROCESS FOR PREPARING
The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) ...
2018/0065941 PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS
The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these...
2018/0065940 METAL-BINDING COMPOUNDS, HETEROLOGOUS PRODUCTION AND USES THEREOF
Provided are Ybt analogs and derivatives thereof and compositions comprising Ybt and Ybt analogs and derivatives thereof. Methods of making Ybt and Ybt analogs...
2018/0065939 AN IMPROVED PROCESS FOR THE PREPARATION OF CLOBAZAM AND ITS INTERMEDIATE
The present invention provides an improved process for the preparation of 8-chloro-1-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (hereafter referred to...
2018/0065938 TOLL LIKE RECEPTOR MODULATOR COMPOUNDS
This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like...
2018/0065937 METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE
The present application relates to methods of preparing Compound A: ##STR00001## or a salt thereof, and a polymorph of Compound A dihydrochloride salt: ##STR00002##
2018/0065936 THERAPEUTIC COMPOUNDS
The invention provides compounds formula (I) and salts thereof: wherein R1-R4 have any of the values defined in the specification. The compounds are useful for...
2018/0065935 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS
A method for preparing a functionalized polymer, the method comprising the steps of (i) polymerizing monomer to form a reactive polymer; and (ii) reacting the...
2018/0065934 INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS
The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of...
2018/0065933 DEUTERIUM-ENRICHED HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE ENZYME INHIBITORS
Provided herein are deuterium-enriched compounds of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V), and Formula (VI). Pharmaceutical...
2018/0065932 ANTIVIRAL COMPOUNDS
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of...
2018/0065931 METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF
The present invention provides a method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof, the method including the...
2018/0065930 COMPOUND, RESIN, MATERIAL FOR FORMING UNDERLAYER FILM FOR LITHOGRAPHY, COMPOSITION FOR FORMING UNDERLAYER FILM...
A compound represented by the following formula (1). ##STR00001## (in formula (1), each X independently represents an oxygen atom, a sulfur atom, or...
2018/0065929 CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
Inhibitors of HBV replication of formula (I) ##STR00001## including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein, X, R.sup.1...
2018/0065928 MONOMER FOR COPOLYMERIZATION WITH ALKENES, DIENES, VINYL COMPOUNDS AND/OR VINYLIDENE COMPOUNDS, METHOD FOR THE...
Disclosed are monomers for copolymerization with alkenes, dienes, vinyl compounds, and/or vinylidene compounds, a process for preparing a copolymer, a...
2018/0065927 ORGANIC SULFUR MATERIAL AND METHOD FOR PRODUCING SAME
An organic sulfur material comprising carbon, hydrogen, oxygen, and sulfur as constituent elements, and having peaks in the vicinity of 482 cm-1, 846 cm-1,...
2018/0065926 PULVERULENT COMPOSITIONS OF A COMPLEX BETWEEN AN ACID AND A METAL HAVING A HIGH ORGANOSULFUR COMPOUND CONTENT...
Disclosed are pulverulent compositions of a complex between an acid and a metal, having a high organosulfur compound content, and method for preparing same.
2018/0065925 SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
A salt represented by formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 independently each represent a C6-C18 unsubstituted or substituted aromatic...
2018/0065924 SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
A salt represented by formula (I): ##STR00001## wherein Q.sup.1 and Q.sup.2 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, R.sup.1...
2018/0065923 Modularized System and Method for Urea Production Using A Bio-Mass Feedstock
A modular system and method for producing urea from bio-mass includes means and steps for "homogenizing" a biomass feedstock stream having components with...
2018/0065922 NOVEL BENZOIC ACID AMIDE COMPOUND
Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate...
2018/0065921 METHODS OF TREATING FIBROSIS
The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a...
2018/0065920 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a...
2018/0065919 MIXTURES OF CHELATING AGENTS, AND PROCESS FOR MAKING SUCH MIXTURES
The present invention is directed towards mixtures comprising (A) 90 to 99.9% by weight of a mixture of L- and D-enantiomers of methyl glycine diacetic acid...
2018/0065918 LIPID CONTAINING FORMULATIONS
Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
2018/0065917 IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a...
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