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Patent # Description
2018/0072787 DESIGNER OSTEOGENIC PROTEINS
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use...
2018/0072786 SPECIFIC AMYLOID BETA BINDING PEPTIDES AND THE USE OF SAME FOR TREATING AND DIAGNOSING ALZHEIMER'S DEMENTIA
Peptides specifically binding amyloid beta and to methods of treating and diagnosing Alzheimer's dementia using such peptides are provided.
2018/0072785 PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF
(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR.alpha.-positive cells such as...
2018/0072784 TFPI INHIBITORS AND METHODS OF USE
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides...
2018/0072783 Ang-2 Binding Modular Recognition Domain Complexes and Pharmaceutical Compositions Thereof
Complexes containing one or more modular recognition domains (MRDs) and MRDs attached to scaffolds including antibodies are described. The manufacture of these...
2018/0072782 DISRUPTION OF THE WAVE3 PROTEIN COMPLEX FOR SUPPRESSION OF INVASION AND METASTASIS
As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein...
2018/0072781 DUAL PROTECTED PRO-COELENTERAZINE SUBSTRATES
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection...
2018/0072780 COMPOSITIONS AND METHODS FOR STABILITY TESTING OF BOTULINUM TOXIN
Compositions for characterization of Botulinum toxin (BoNT) are described that include a genetically modified cell that is transfected with an artificial...
2018/0072779 Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2018/0072778 POLYPEPTIDE AND IMMUNE MODULATION
The present invention relates to Roseburia flagellin, and/or a polynucleotide sequence encoding said Roseburia flagellin, and/or a vector comprising said...
2018/0072777 TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS
Human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope...
2018/0072776 BETA-HAIRPIN PEPTIDOMIMETICS
Beta-hairpin peptidomimetics of the general formula (I), cyclo[P.sup.1--P.sup.2--P.sup.3--P.sup.4--P.sup.5--P.sup.6--P.sup.7--P.su- ...
2018/0072775 Beta-Hairpin Peptidomimetics
Beta-hairpin peptidomimetics of the general formula (I), and pharmaceutically acceptable salts thereof, with P, T, Q, and optionally L being elements as...
2018/0072774 BACKBONE-CYCLIZED PEPTIDOMIMETICS WITH GLP-1R MODULATING ACTIVITY
Novel backbone-cyclized peptidomimetics of the general formula cyclo[-P.sup.1-P.sup.2-P.sup.3-P.sup.4-P.sup.5-P.sup.6-P.sup.7-P.sup.8-T- .sup.1-T.sup.2-] (I) ...
2018/0072773 CANCER STEM CELL TARGETING PEPTIDE AND USE THEREOF
A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15....
2018/0072772 MUTANT AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases...
2018/0072771 PEPTIDES AND COMPOSITIONS COMPRISING SAME AND USES THEREOF IN THE TREATMENT OF DISEASES
Isolated peptides are disclosed. The peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-5 and 11-15, with the proviso...
2018/0072770 Influenza Virus Binding Peptides
Influenza virus binding peptides and methods for using these peptides are disclosed. In an embodiment a peptide having from 8 to 40 amino acids includes a...
2018/0072769 VIRUS FILTRATION
Provided herein are methods of performing viral filtration on a fluid including a recombinant antibody, and the use of these methods in methods of...
2018/0072768 SYNTHETIC ROUTE TO 2'-DEOXY-2',2'-DIFLUOROTETRAHYDROURIDINES
The present invention relates to methods and intermediates for synthesizing 2'-deoxy-2',2'-difluorotetrahydrouridine compounds.
2018/0072767 TREHALOSE ANALOGUES
Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the...
2018/0072766 Group 3 Metal Catalyst System and Process to Produce Ethylene Polymers Therewith
This invention relates to a process to using dimers of a group 3 metal (typically scandium) catalyst compound to produce ethylene polymers, such as...
2018/0072765 RAW MATERIAL FOR CHEMICAL DEPOSITION COMPOSED OF ORGANOPLATINUM COMPOUND, AND CHEMICAL DEPOSITION METHOD USING...
The present invention relates to a raw material for chemical deposition shown in a formulae below and including an organoplatinum compound in which diimine...
2018/0072764 SYNTHESIS AND USE OF PRECURSORS FOR ALD OF TELLURIUM AND SELENIUM THIN FILMS
Atomic layer deposition (ALD) processes for forming Te-containing thin films, such as Sb--Te, Ge--Te, Ge--Sb--Te, Bi--Te, and Zn--Te thin films are provided....
2018/0072763 TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also...
2018/0072762 ALKYNE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2018/0072761 TRANS-CYCLOHEPTENES AND HETERO-TRANS-CYCLOHEPTENES FOR BIOORTHOGONAL COUPLING
A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR.sup.1.sub.R.sup.2, CH.sub.2,...
2018/0072760 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOALl AGENTS
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds,...
2018/0072759 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one...
2018/0072758 5HT3 RECEPTOR ANTAGONISTS
The present invention provides compounds of the formula: ##STR00001## that are 5-HT3 receptor antagonists and are therefore useful for the treatment of diseases...
2018/0072757 Novel Heterocyclic Derivatives as Modulators of Kinase Activity
The invention provides novel imidazol-piperidinyl derivatives of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, W, X.sup.1, X.sup.2, X.sup.3, X.sup.4...
2018/0072756 Methods of Treating or Preventing Autoimmune Diseases with 2,4-Pyrimidinediamine Compounds
The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating,...
2018/0072755 THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY...
Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I)...
2018/0072754 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA
Piperidino-dihydrothienopyrimidine sulfoxides of formula I ##STR00001## wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen...
2018/0072753 NOVEL ORGANIC HETEROCYCLIC COMPOUND AND LIGHT-EMITTING DEVICE COMPRISING SAME
The present invention relates to an organic light-emitting compound represented by [Chemical Formula A] and an organic light-emitting device. In Chemical...
2018/0072752 COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE
The present invention discloses the novel coumarin derivative of formula (1): ##STR00001## its synthesis, pharmaceutical composition, preparation and use...
2018/0072751 SHMT Inhibitors
The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have...
2018/0072750 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
2018/0072749 PROCESS FOR THE MANUFACTURE OF IXABEPILONE
The invention relates to the process of manufacturing Epothilone compounds of Formulas I-IV. The process of the present invention is totally synthetic,...
2018/0072748 CRYSTAL OF 6,7-UNSATURATED-7-CARBAMOYL MORPHINAN DERIVATIVE AND METHOD FOR PRODUCING THE SAME
Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the present...
2018/0072747 METHODS FOR THE CHEMICAL SYNTHESIS OF PYRROLE-LINKED BIVALENT COMPOUNDS, AND COMPOSITIONS THEREOF
The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as...
2018/0072746 DE NOVO SYNTHESIS OF BACTERIOCHLORINS
A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II ##STR00001## to produce the bacteriochlorin, wherein R is an...
2018/0072745 IRE-1alpha INHIBITORS
The invention provides compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds...
2018/0072744 HETEROARYL SYK INHIBITORS
The invention relates to new substituted heteroaryls of formula 1 ##STR00001## wherein A is selected from the group consisting of N and CH D is selected from...
2018/0072743 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.
2018/0072742 ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or...
2018/0072741 PYRAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds....
2018/0072740 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.
2018/0072739 CO-CRYSTALS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Disclosed are co-crystals of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2018/0072738 SOLVATED FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimid- ...
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