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Patent # Description
2018/0072686 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR ...
Provided herein are 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl-3,4-dihyropyrimidin-2(1H)-one and processes for their preparation which may...
2018/0072685 METHOD FOR PRODUCING (4S)-4-[4-CYANO-2-(METHYLSULFONYL)PHENYL]-3,6-DIMETHYL-2-OXO-1-[3-(TRIFLU- ...
The present invention concerns a new and improved method for preparation of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(tri- ...
2018/0072684 META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS
The present disclosure provides pharmaceutical agents of the formula: ##STR00001## wherein the variables are defined herein. Also provided are pharmaceutical...
2018/0072683 PYRIDAZINE DERIVATIVES AS RORc MODULATORS
Compounds of formula I: ##STR00001## or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5are as defined...
2018/0072682 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.
2018/0072681 BACKFUNCTIONALIZED IMIDAZOLINIUM SALTS AND NHC CARBENE-METAL COMPLEXES
Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium...
2018/0072680 PROCESSES USEFUL FOR THE PREPARATION OF ...
The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-N ...
2018/0072679 NOVEL 1,4-BIS(3-AMINOPROPYL)PIPERAZINE DERIVATIVE AND ITS USE
The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or...
2018/0072678 CONDENSED RING DERIVATIVE, AND PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring...
2018/0072677 Peptidomimetics and Methods of Using the Same
Disclosed herein are compounds useful for modulating the mu-opioid receptor ("MOR") and/or delta-opioid receptor ("DOR"), and methods of using these compounds...
2018/0072676 CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION
A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin...
2018/0072675 ANTIMICROBIAL PYRIDINOHYDRAZIDE AND HYDRAZOMETHYLPYRIDINE-BASED AGENTS
A class of modified salicylaldehyde derivatives has also been synthesized and a series of modified pyridine-based hydrazones identified that have potent...
2018/0072674 NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2
Described are negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu.sub.2), pharmaceutical compositions including the compounds, and...
2018/0072673 N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease
The invention relates to heterocyclic compounds of the formula (I) ##STR00001## in which all of the variables are as defined in the specification; capable of...
2018/0072672 BIPYRIDYL COMPOUND
There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a...
2018/0072671 INHIBITORS OF HISTONE DEACETYLASE
The present invention relates to compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein...
2018/0072670 FLAVOR MODULATOR HAVING PYRIDINE DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT
2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active...
2018/0072669 MATERIALS FOR USE IN AN AQUEOUS ORGANIC REDOX FLOW BATTERY
Described herein are aqueous organic redox flow batteries that include a first redox active material that can include a metallocene or a salt thereof, and a...
2018/0072668 PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS
Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
2018/0072667 SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS
The present invention relates to compounds having a selective FKBP51 ligand scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical...
2018/0072666 ENOYL REDUCTASE INHIBITORS WITH ANTIBACTERIAL ACTIVITY
The present disclosure provides FabI inhibitors and methods of treating or preventing a disease or disorder in a subject by administering same.
2018/0072665 ORGANIC SULFUR MATERIAL AND METHOD FOR PRODUCING SAME
The present invention provides an organic sulfur material comprising carbon, hydrogen, and sulfur as constituent elements, and having peaks in the vicinity of...
2018/0072664 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
What is described is a compound having the formula ##STR00001## wherein R.sub.1 is branched alkyl of the structure (CH.sub.3(CH.sub.2).sub.m).sub.2CH--,...
2018/0072663 Methods for Producing Thiol Compounds and Sulfide Compounds Using Diphenylamine or a Phenol Compound
The present invention discloses processes for producing a thiol compound or a sulfide compound from an olefin compound. Diphenylamine or a phenol compound can...
2018/0072662 PROCESS FOR THE MANUFACTURE OF DIHALODIPHENYLSULFONES
A process for the preparation of dihalodiphenylsulfones such as 4,4'-dichlorodiphenyl sulfone or 4,4'-bis-(4-chlorophenylsulfonyl)biphenyl with high...
2018/0072661 PHARMACEUTICAL FORMULATIONS OF HDAC INHIBITORS
This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity)...
2018/0072660 INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions...
2018/0072659 PROCESS FOR THE PRODUCTION OF FORMALDEHYDE
A process is described for the production of formaldehyde, comprising (a) subjecting methanol to oxidation with air in a formaldehyde production unit thereby...
2018/0072658 INTEGRATED PROCESS FOR THE PRODUCTION OF FORMALDEHYDE-STABILIZED UREA
A process for the production of formaldehyde-stabilised urea is described comprising the steps of: (a) generating a synthesis gas comprising hydrogen,...
2018/0072657 MARINE SESSILE ORGANISM-REPELLING COMPOSITION
A compound represented by the formula below: ##STR00001## wherein R is selected from the group consisting of benzyl, C.sub.3-11 alkyl, C.sub.3-11 alkenyl,...
2018/0072656 Sodium Channel Modulators
The present disclosure relates generally to compounds having activity as voltage-gated sodium channel blockers and their use in the field of therapeutic...
2018/0072655 AROMATIC DIAMINE, AN INTERMEDIATE THEREFOR, A METHOD FOR PRODUCING THE AROMATIC DIAMINE, AND A METHOD FOR...
An asymmetric diamine suitable for preparing a soluble polyimide and a method for preparing the same, including a compound represented by the following formula...
2018/0072654 Diphenethylamine Derivatives Which Are Inter Alia Useful As Analgesics And Method For Their Production
Diphenethylamine derivatives for use as highly active analgesics, diuretics, anxiolytics, for the treatment of neurode-generative, psychiatric and...
2018/0072653 PROCESS TO PREPARE 3-METHYL-2-NITROBENZOIC ACID BY AIR OXIDATION
A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1,3-dimethyl-2-nitrobenzene is combined with an oxidation catalayst in the presence of...
2018/0072652 NOVEL ASPIRIN DERIVATIVES AND USES THEREOF
The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be...
2018/0072651 RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN
A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, and which includes a...
2018/0072650 PROCESS FOR THE PRODUCTION OF HIGH VOLTAGE ELECTROLYTE SOLVENTS FOR LI-ION BATTERIES
A method for producing halogenated carbonates is provided, the method having the steps of reacting a halogenated hydroxyl moiety with an alkyl formate in the...
2018/0072649 SOLID FORMS OF TREPROSTINIL
There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same.
2018/0072648 OPTIMIZED LIQUID-PHASE OXIDATION
Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such...
2018/0072647 DEHYDROGENATION OF LPG OR NGL AND FLEXIBLE UTILIZATION OF THE OLEFINS THUS OBTAINED
The object of the invention is to specify a process with which both C.sub.5 and C.sub.9 aldehydes can be produced economically. Here, the process should be...
2018/0072646 METHOD FOR PREPARING CYCLOHEXANONE BY HYDROGENATING PHENOL
A method of preparing cyclohexanone by hydrogenating phenol is provided. The method includes a step of introducing an additional flammable gas to dilute...
2018/0072645 1,3-FATTY DIOL COMPOUNDS AND DERIVATIVES THEREOF
The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which...
2018/0072644 Method for the Conversion of Abienol to Sclarediol
A method of selective conversion of Abienol, represented by formula 1, to Sclareodiol, represented by formula 2 ##STR00001## by ozonolysis and subsequent...
2018/0072643 PROCESS OF REMOVING HEAT
The present invention provides an improved process for removing heat from an exothermic reaction. In particular, the present invention provides a process...
2018/0072642 Process for Making 2,3,3,3-Tetrafluoropropene and/or Vinylidene Fluoride
Disclosed is a process for the formation of a mixture of the compounds 2,3,3,3-tetrafluoropropene (HFO-1234yf) and vinylidene fluoride, comprising pyrolyzing...
2018/0072641 CATALYST AND PROCESS USING THE CATALYST
A new chromium-containing fluorination catalyst is described. The catalyst comprises an amount of zinc that promotes activity and from 0.1 to 8.0% by weight of...
2018/0072639 Side Rectifier Column for Olefin and Diluent Recovery
Processes and systems for olefin and diluent recovery utilizing one or more side columns, including a side rectifier column and/or a side degassing column, in...
2018/0072638 PROCESS FOR PREPARING 1,3-BUTADIENE FROM N-BUTENES BY OXIDATIVE DEHYDROGENATION
The invention relates to a process for producing butadiene from n-butenes, comprising the steps of: A) providing an n-butenes-comprising input gas stream a1, ...
2018/0072637 BUTADIENE TELOMERIZATION CATALYST AND PREPARATION THEREOF
Catalyst compositions are prepared by contacting a palladium source and 1,3,5,7-tetramethyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamant- ane and a...
2018/0072636 CATALYST FOR ISOBUTYLENE PRODUCTION AND METHOD FOR PRODUCING ISOBUTYLENE
Provided are: a catalyst for dehydration, with which isobutylene is able to be produced with high conversion and high selectivity through a dehydration...
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