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Patent # Description
2018/0071421 BIOLOGICAL INDICATOR WITH VARIABLE RESISTANCE
A biological indicator with variable resistance may be controlled by moving a cap or housing of the biological indicator to cause the size of vents that allow...
2018/0071420 Mouth guard cleaning and storage device and related methods
Disclosed generally is a mouth guard cleaning and storage device. In use, the device may be used to clean and store mouth guards and other dental appliances....
2018/0071419 HIGH EFFICIENCY POLYMERIC STERILANT CONTAINER ASSEMBLY
The present invention relates to a method for sterilizing an article inside a sealed container by placing a polyoxymethylene melt formable co-polymer fiber...
2018/0071418 PROCESS CHALLENGE DEVICE FOR AUTOMATED ENDOSCOPE REPROCESSOR
The present disclosure describes a novel monitoring system which enables a user to verify the effectiveness of the disinfection cycle provided by an automated...
2018/0071417 Method and Apparatus for Rapid Sterilization
Methods and systems for sterilizing a tools and equipment are disclosed, including using a UV source to generate a pulsed UV light within or exterior to an...
2018/0071415 REPEATED STERILE USE OF A GAUGE IN A STEAM STERILIZABLE FREEZE-DRYING SYSTEM
An assembly is described, including a filter disposed downstream from a freeze dryer chamber, a first valve and a second valve disposed downstream from the...
2018/0071414 UV-C Based Skin Sterilization Device
Disclosed is a UV-C based skin sterilizer that includes a main console connected to a delivery system and a display screen, the delivery system including a...
2018/0071413 NON-INVASIVE IMAGING OF TUMOR PD-L1 EXPRESSION
The present invention relates to a method for detecting a PD-L1-positive tumor in a patient by imaging using a radiolabelled anti-PD-L1 antibody.
2018/0071412 PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES
The present invention is directed to pyrrolopyridine compounds of formula (I) ##STR00001## or their pharmaceutically acceptable salts, which may be suitable for ...
2018/0071411 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID
Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more...
2018/0071410 Contrast Agents for Magnetic Resonance Imaging
Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out...
2018/0071409 PHOTOLUMINESCENT HYDROGEL
Shown and described is a composition and a method to prepare a dopant-free photoluminescent hydrogel with synthetic polymers are disclosed. The hydrogel can be...
2018/0071408 CHOLECYSTOKININ 2 RECEPTOR TARGETED NIR IMAGING AND USE THEREOF
Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection,...
2018/0071407 SYSTEMS AND METHODS FOR INTRA-TARGET MICRODOSING (ITM)
Systems and methods for intra-target microdosing are disclosed. According to an aspect, a method for intra-target microdosing includes administering a...
2018/0071406 Optimized Liver-Specific Expression Systems for FVIII and FIX
The present invention relates to nucleic acid expression cassettes and vectors containing liver-specific regulatory elements and codon-optimized factor IX or...
2018/0071405 ENDONUCLEASE TARGETING BLOOD COAGULATION FACTOR VIII GENE AND COMPOSITION FOR TREATING HEMOPHILIA COMPRISING SAME
The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of...
2018/0071404 TREATMENT OF CANCER
Provided are methods relating to compositions that include a CDP-topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g.,...
2018/0071403 ANTIBODY-DRUG CONJUGATE PRODUCED BY BINDING THROUGH LINKER HAVING HYDROPHILIC STRUCTURE
As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound...
2018/0071402 ENZYMATIC CONJUGATION OF POLYPEPTIDES
The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents,...
2018/0071401 Intranasal Administration of Guanidinylated Aminoglycosides
This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides ("guanidinoglycosides") and a polypeptide (e.g.,...
2018/0071400 IMMUNOGENIC POLYPEPTIDES
The present invention relates to isolated immunogenic polypeptides and their use. In one aspect, the isolated immunogenic polypeptide includes a scaffold...
2018/0071399 Use of Single Dendritic Wedge Cell Penetrating Peptides to Facilitate Cellular Delivery of Nanoparticles and...
Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic...
2018/0071398 POLYPEPTIDE THAT BINDS ABERRANT CELLS AND INDUCES APOPTOSIS
Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on...
2018/0071397 NOVEL LIPID FORMULATIONS FOR DELIVERY OF THERAPEUTIC AGENTS TO SOLID TUMORS
The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid...
2018/0071396 AQUEOUS SOLUTION OF AN ESTERIFIED CELLULOSE ETHER
An aqueous composition comprising an esterified cellulose ether being at least partially dissolved in an aqueous liquid, wherein the esterified cellulose ether...
2018/0071395 PHARMACEUTICAL PREPARATIONS CONTAINING HIGHLY VOLATILE SILICONES
The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient...
2018/0071394 POLYESTER POLYMER MATRICES FOR THE DELIVERY OF ALLERGENS
Provided herein are polyester polymer synthetic nanocarriers that encapsulate allergens as well as methods of their use and production.
2018/0071393 STABLE INTRAVENOUS FORMULATION
A stable lyophilized formulation for intravenous administration of the compound 4-{[(2R, 3S, ...
2018/0071392 LIPOSOME COMPOSITION USING SUGAR ALCOHOL WITH MODIFIED SURFACE AREA AND/OR POROSITY AS CARRIER AND METHOD FOR...
The present disclosure relates to a method for preparing a novel sugar alcohol with a modified, that is, increased or decreased surface area and/or porosity...
2018/0071391 Topical Pharmaceutical Cosmetic and Disinfectant Compositions Comprising Phosphatidylcholine
A topical carrier consists of 99% by weight or more of phosphatidylcholine and volatile solvent selected from the group consisting of: ethanol and its...
2018/0071390 COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES
The present invention relates to pharmaceutical compositions of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing...
2018/0071389 Monoclonal Antibodies for Ebola and Marburg Viruses
Described herein are a number of Ebola and Marburg monoclonal antibodies.
2018/0071388 USE OF VAP-1 INHIBITORS FOR TREATING FIBROTIC CONDITIONS
The present invention relates to inhibitors of VAP-1 and their use as medicaments in treating fibrotic conditions. Furthermore, the present invention relates...
2018/0071387 IMMUNOMODULATORY COMPOSITIONS COMPRISING A POLYMER MATRIX AND AN OIL PHASE
A pharmaceutical composition comprising a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising at least one...
2018/0071386 SILICON DIOXIDE NANOPARTICLES AND THE USE THEREOF FOR VACCINATION
The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The...
2018/0071385 PD-1 Peptide Inhibitors
This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of...
2018/0071384 VACCINES BASED ON HEPATITIS B CORE ANTIGENS
The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sequence of the formula X.sub.pZ.sub.qX.sub.r in an e1 loop, wherein X is a...
2018/0071383 Immunogenic Influenza Composition
Methods for providing novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not...
2018/0071382 COMPOSITIONS AND METHODS FOR DETECTING, TREATING, AND PROTECTING AGAINST FUSOBACTERIUM INFECTION
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and...
2018/0071381 TRANSCUTANEOUS HAEMOPHILIUS INFLUENZAE VACCINE FORMULATIONS AND METHODS
Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a...
2018/0071380 IMMUNOGENIC COMPOSITIONS FOR USE IN VACCINATION AGAINST BORDETELLA
The present application relates to immunogenic compositions comprising a mixture of Bordetella (e.g., B. pertussis) antigens and an oil in water nanoemulsion....
2018/0071379 COMBINED THERAPY AND PROPHYLAXIS FOR GENITAL TRACT INFECTIONS
Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application...
2018/0071378 MYCOBACTERIUM ANTIGENIC COMPOSITION
Immunogenic compositions comprising an M72 related antigen, wherein the conductivity of the composition is 13 mS/cm or lower, or the concentration of salts of...
2018/0071377 SUBUNIT VACCINE DELIVERY PLATFORM FOR ROBUST HUMORAL AND CELLULAR IMMUNE RESPONSES
The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a...
2018/0071376 TOLEROGENIC NANOPARTICLES FOR TREATING DIABETES MELLITUS
Methods and compositions for increasing the number and/or activity of regulatory T cells (Tregs) in vivo and in vitro, to induce tolerance to diabetogenic...
2018/0071375 Methods and Compositions for the Treatment of Symptoms of Complex Regional Pain Syndrome
A therapeutic composition for the treatment of the symptoms of complex regional pain syndrome and the method for preparing the therapeutic agents is disclosed....
2018/0071374 Pharmaceutical Preparation for the Treatment of the Symptoms of Addiction and Method of Diagnosing Same
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a...
2018/0071373 ADENO-ASSOCIATED VIRUS FOR THERAPEUTIC DELIVERY TO CENTRAL NERVOUS SYSTEM
A method to prevent, inhibit or treat one or more symptoms associated with disease of the central nervous system by intranasally, intrathecally,...
2018/0071372 INJECTION COMPOSITION COMPRISING HYALURONIDASE FOR REMOVAL OF TOPICAL FAT
The present invention relates to an injection composition comprising hyaluronidase for topical fat reduction. More particularly, the present invention relates...
2018/0071371 TREATMENT OF COGNITIVE IMPAIRMENT OF HUNTER SYNDROME BY INTRATHECAL DELIVERY OF IDURONATE-2-SULFATASE
The present invention, provides a method of treating cognitive impairment of Hunter syndrome. Among other things, the present invention provides a method...
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