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Patent # Description
2018/0073040 Processes Of Producing Ethanol Using A Fermenting Organism
The invention relates to improved processes of producing ethanol from starch-containing material wherein saccharification and/or fermentation is done at a...
2018/0073039 HOMOLOGOUS RECOMBINATION FACTORS
The invention relates to factors that influence or regulate homologous recombination, methods to monitor these factors, the use of these factors to screen for...
2018/0073038 FURIN-KNOCKDOWN AND GM-CSF-AUGMENTED (FANG) CANCER VACCINE
Compositions and methods for cancer treatment are disclosed herein. More specifically, the present invention describes an autologous cancer vaccine genetically...
2018/0073037 COMPOSITIONS AND METHODS FOR CONTROL OF INSECT INFESTATIONS IN PLANTS
The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention...
2018/0073036 PRODUCTION OF DHA AND OTHER LC PUFAS IN PLANTS
The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more...
2018/0073035 A METHOD FOR PRECISE MODIFICATION OF PLANT VIA TRANSIENT GENE EXPRESSION
Provided is a method for conducting site-specific modification in a plant through gene transient expression, comprising the following steps: transiently...
2018/0073034 D-AMINO ACID-INDUCIBLE GENE EXPRESSION SYSTEM FOR RHODOSPORIDIUM AND RHODOTORULA
The present invention relates to the field of fungal biotechnology, more particularly to a strong inducible gene expression system in fungal species, such as a...
2018/0073033 GENES THAT IMPROVE TOLERANCE TO LIGNOCELLULOSIC TOXINS WHEN OVEREXPRESSED IN YEAST AND METHODS OF USE IN...
The present invention provides isolated gene sequences useful in increasing lignocellulosic toxin tolerance in yeast. Such engineered yeast are useful in...
2018/0073032 REGULATORY ELEMENT FOR HETEROLOGOUS PROTEIN PRODUCTION IN THE FRUITING BODY OF FILAMENTOUS FUNGI
The present invention provides compositions and methods for regulating expression of nucleotide sequences in fungi. Compositions are novel nucleotide sequences...
2018/0073031 TRANSCRIPTIONAL SENSOR FOR BILE ACIDS IN BACTEROIDES THETAIOTAOMICRON
The present disclosure relates, in some aspects, to bile acid sensors.
2018/0073030 E. coli Separatome-Based Protein Expression And Purification Platform
Provided is a separatome-based peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of...
2018/0073029 HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION
A method is provided for achieving transfection of host cells using sonoporation. An acoustic radiation generator is positioned in acoustic coupling...
2018/0073028 SYNTHETIC GENE CLUSTERS
Methods for making synthetic gene clusters are described.
2018/0073027 CD117 Ligand-Drug Conjugates For Targeted Cancer Therapy
Disclosed are compositions and methods relating to nucleic acid aptamers that specifically target CD117 protein and also selective binding to CD117-expressing...
2018/0073026 NOVEL EXPRESSION REGULATING RNA-MOLECULES AND USES THEREOF
The present application relates to a RNA molecule comprising a RNA-polymerase binding aptamer, wherein said RNA-polymerase binding aptamer has a length of 15...
2018/0073025 Micro-RNA Inhibitors and Their Uses in Disease
The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor...
2018/0073024 CHIMERIC DOUBLE-STRANDED NUCLEIC ACID
A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid...
2018/0073023 CIRCULAR SINGLE-STRANDED NUCLEIC ACID, METHOD FOR PREPARING THE SAME, AND METHOD FOR USING THE SAME
An object of the present invention is to provide a circular single-stranded nucleic acid, and a method for preparing the same and a method for using the same....
2018/0073022 MODULATION OF ALPHA SYNUCLEIN EXPRESSION
Disclosed herein are antisense compounds and methods for decreasing alpha-synuclein mRNA and protein expression. Also disclosed herein are methods for...
2018/0073021 RECOMBINANT PROTEIN-BASED METHOD FOR THE DELIVERY OF SILENCER RNA TO TARGET THE BRAIN
The present invention relates to the design and development of recombinant protein for the delivery of silencer RNA complex to mediate RNA interference since...
2018/0073020 SINGLE-CHAIN CIRCULAR RNA AND METHOD OF PRODUCING THE SAME
The present invention relates to a single-chain circular RNA having a sustained or slow-releasing RNA interference effect, characterized in that the...
2018/0073019 TAT-INDUCED CRISPR/ENDONUCLEASE-BASED GENE EDITING
Compositions and methods are provided for Tat-inducible expression of a CRISPR-associated endonuclease by a truncated HIV LTR promoter containing at least a...
2018/0073018 COMPOSITIONS AND METHODS FOR SPECIFIC REACTIVATION OF HIV LATENT RESERVOIR
The present invention relates to compositions and methods for reactivation of HIV in vivo or in vitro. latently infected cell. In one embodiment, the present...
2018/0073017 METHODS FOR SELECTING ENZYMES HAVING ENHANCED ACTIVITY
Provided herein are methods and means for enhancing enzymatic activity. The system makes use of an emulsion for in vitro compartmentalization of a library of...
2018/0073016 COMPOSITIONS AND METHODS FOR REPRESENTATIONAL SELECTION OF NUCLEIC ACIDS FROM COMPLEX MIXTURE
The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a...
2018/0073015 METHOD OF MEASURING ADAPTIVE IMMUNITY
A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the...
2018/0073014 Immune Repertoire Sequence Amplification Methods and Applications
The present invention relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources....
2018/0073013 METHOD OF DETECTING NEW IMMUNOGENIC T CELL EPITOPES AND ISOLATING NEW ANTIGEN-SPECIFIC T CELL RECEPTORS BY...
The present invention relates to the field of immunotherapy, in particular, to adoptive T cell therapy, T cell receptor (TCR) gene therapy and vaccination. The...
2018/0073012 ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF
The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA. The disclosure also provides fusion proteins comprising a Cas9...
2018/0073011 METHODS AND COMPOSITIONS FOR PURIFYING DOUBLE STRANDED NUCLEIC ACIDS
Provided herein are methods and compositions to effectively isolate short, double-stranded nucleic acids on magnetic glass particles.
2018/0073010 NUCLEIC ACID PREPARATION COMPOSITIONS AND METHODS
Provided herein are methods and compositions to extract and enrich by, physical separation or amplification, relatively short nucleic acids from a nucleic acid...
2018/0073009 COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
The invention provides methods of preparing nucleic acids, such as RNA molecules, of a defined size or range of sizes. The invention provides compositions,...
2018/0073008 REACTION MIXTURES
The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried...
2018/0073006 NOVEL METALLOPROTEASES
Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods...
2018/0073005 Expression Vectors for an Improved Protein Secretion
The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process....
2018/0073004 Fungus-Sourced High-Temperature Acid B-Glucosidase as well as Coding Gene and Application Thereof
Provided are a fungus-sourced high-temperature acid .beta.-glucosidase as well as a coding gene, and an application thereof. The provide .beta.-glucosidase has...
2018/0073003 Method of Treating Glycogen Storage Disease
The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease and to compounds and...
2018/0073002 ACTIVATABLE CRISPR/CAS9 FOR SPATIAL AND TEMPORAL CONTROL OF GENOME EDITING
Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino...
2018/0073001 USE OF ENZYMES WITH A WIDE PH ACTIVITY RANGE AS MEDICAMENTS FOR PROMOTING DIGESTION
Disclosed is a combination of two or more lipase enzymes, and its use for treating a lipid digestion deficiency and/or a digestive disorder. At least one...
2018/0073000 REDUCED IMMUNOGENIC PROTEINS FOR LYSOSOMAL STORAGE DISORDERS
Disclosed are methods and compositions for reduced immunogenic proteins used in enzyme replacement therapy for lysosomal storage disorders. More specifically...
2018/0072999 TRICHOPLUSIA NI PIGGYBAC TRANSPOSASES WITH REDUCED INTEGRATION ACTIVITY
The present invention is directed to nucleic acid and amino acid sequences of a novel piggyBac transposase enzymes created by modifying the transposase of...
2018/0072998 ENGINEERED GLUCOSYLTRANSFERASES
Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower...
2018/0072997 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Compounds of Formulas I-VI, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV)...
2018/0072996 Vascularized Skin Models
A synthetic skin tissue is served by at least one synthetic blood vessel and includes a physiologically representative population of cells including...
2018/0072995 CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS COMPRISING THE STEM CELLS
The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and...
2018/0072994 MULTIPOTENT PROGENITOR CELL DERIVED FROM ADIPOSE TISSUE
Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived...
2018/0072993 METHODS FOR ENHANCING MATURATION OF CARDIOMYOCYTES
Methods for promoting maturation of cardiomyocytes, involving introducing a microRNA combination containing miR-125b, miR-199a, miR-221, and/or miR222, or...
2018/0072992 METHODS AND COMPOSITIONS FOR INDUCING HEMATOPOIETIC CELL DIFFERENTIATION
The invention provides culture platforms, cell media, and methods of differentiating pluriptent cells into hematopoietic cells. The invention further provides...
2018/0072991 METHODS AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and...
2018/0072990 GENERATING VIRUS OR OTHER ANTIGEN-SPECIFIC T CELLS FROM A NA VE T CELL POPULATION
Safe, rapid and efficient methods for producing virus-specific or other antigen-specific T-cells from cord blood and other samples containing naive immune cells.
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