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Patent # Description
2018/0078581 Exosomes Sourced from Granulocytic Myeloid-derived Suppressor Cells and Application thereof
Provided are exosomes sourced from a granulocyte myeloid-derived suppressor cell and an application thereof. The exosomes are named as G-MDSC exo. Also...
2018/0078580 NANOPARTICLE COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING TISSUE INFECTIONS AND DISEASES
Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently...
2018/0078579 MICRONUTRIENT FORMULATIONS FOR ENVIRONMENTAL EXPOSURE APPLICATIONS
A radioactive protection micronutrient formulation system is provided and the system comprises: a formulation consisting essentially of antioxidants, the...
2018/0078578 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY AND IMMUNOLOGICAL DISORDERS
The present invention provides a method for treating, preventing, or managing local inflammatory symptoms, including symptoms associated with acute or chronic...
2018/0078577 NONSURGICAL TECHNIQUES FOR RESTORING TOOTH ENAMEL
In some examples, the disclosure relates to a method including applying biomimetic mineralization process to an enamel defect of a tooth, wherein the applied...
2018/0078576 SULPHATED XYLANS FOR TREATMENT OR PROPHYLAXIS OF RESPIRATORY DISEASES
The present invention relates generally to agents and medicinal protocols useful in the prophylaxis and/or treatment of respiratory diseases or conditions such...
2018/0078575 METHODS AND MATERIALS FOR REDUCING AMYLOID BETA LEVELS WITHIN A MAMMAL
This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this...
2018/0078574 MIXTURES OF HUMAN MILK OLIGOSACCHARIDES COMPRISING 3 '-O-SIALYLLACTOSE
A mixture of human milk oligosaccharides that consists essentially of 3'-O-sialyllactose, a component A which is either 3-O-fucosyllactose or lacto-N-tetraose,...
2018/0078573 COMPOSITIONS FOR USE IN IMPROVING STOOL CONSISTENCY OR FREQUENCY IN INFANTS OR YOUNG CHILDREN
The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide for use in preventing and/or treating...
2018/0078572 COMPOSITIONS FOR USE IN IMPROVING STOOL CONSISTENCY OR FREQUENCY IN INFANTS OR YOUNG CHILDREN
The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide,...
2018/0078571 METHOD FOR LOWERING THYROTROPIN LEVELS IN ADULTS
The inventor has discovered that a particular dosage of Alpha Glycerylphosphoryl Choline administered to adult males results in a reduction of thyrotropin...
2018/0078570 TETRACYCLINE COMPOSITIONS
The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved...
2018/0078569 KITS FOR INDENTIFYING AND TREATING SUBJECTS RESISTANT TO ACETYL SALICYLIC ACID
In alternative embodiments, the invention provides compositions and methods for overcoming or diminishing or preventing Growth Factor Inhibitor resistance in a...
2018/0078568 PHARMACEUTICAL COMPOSITION AND METHODS
Disclosed herein are compositions having a lipophilic active agent and methods of their use.
2018/0078567 THERAPEUTIC AGENT FOR INTRACTABLE LEUKEMIA
The present invention provides a therapeutic composition for intractable leukemia comprising a drug (a) and a drug (b), wherein the drug (a) is a compound...
2018/0078566 PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME
A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one...
2018/0078565 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS IN COMBINATION WITH GLUCOCORTICOIDS TO TREAT ADRENAL INSUFFICIENCY
This invention provides for a method of treating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and...
2018/0078564 lanthanide toolbox for multi-modal, non-invasive tumor specific theranostic prodrugs
The present disclosure relates to theranostic prodrugs with responsive signals in-vitro or in-vivo and uses thereof. It also relates to synthesized europium...
2018/0078563 NOVEL THERAPIES FOR CANCER
The invention relates to 6-{4-[1-(Propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl}-N-(pyridin-4-yl)p- yridine-2-carboxamide, or a pharmaceutically acceptable salt...
2018/0078561 ACTIVE METABOLITES OF APILIMOD AND USES THEREOF
The present invention relates to compositions comprising one or more active metabolites of apilimod and methods for their use in treating cancer.
2018/0078560 USE OF 4-(4-FLUORO-2-METHOXYPHENYL)-N-{3-[(S-METHYLSULFONIMIDOYL)METHYL]PH- ENYL}-1,3,5-TRIAZIN-2-AMINE FOR...
The present invention relates to the use of 4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-- 1,3,5-triazin-2-amine (compound A), more...
2018/0078559 TARGETING cGMP-RELATED PHOSPHODIESTERASES TO REDUCE CYST FORMATION IN CYSTIC KIDNEY DISEASE, AND RELATED...
Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific...
2018/0078558 METHODS OF TREATING AND PREVENTING ALLOANTIBODY DRIVEN CHRONIC GRAFT VERSUS HOST DISEASE
Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an...
2018/0078557 MEDICINAL AGENT AND BEVERAGE/FOOD FOR PREVENTING CEREBRAL DYSFUNCTION AND IMPROVIDNG SAME
Provided is method for improving depression of a patient by administering to a patient suffering from depression an effective dose of sepiapterin or a...
2018/0078556 Methods for Treating Metastatic Pancreatic Cancer Using Combination Therapies Comprising Liposomal Irinotecan...
Combination therapy regimens including liposomal irinotecan, oxaliplatin and 5-fluorouracil are useful in the treatment of pancreatic cancer, including...
2018/0078555 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE
Described herein are methods for treating and preventing graft versus host disease using ACK inhibitors. The methods include administering to an individual in...
2018/0078554 ORGANIC LIGHT EMITTING DEVICE
An OLED comprising a hole-transporting layer and light-emitting layer wherein the hole-transporting layer comprises a hole-transporting polymer wherein no more...
2018/0078553 INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological...
2018/0078552 METHODS FOR TREATING HEMOLYTIC DISEASES AND SICKLE CELL DISEASE
The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds...
2018/0078551 COMBINATION THERAPY WITH AN ANTITUMOR ALKALOID
The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor...
2018/0078550 COMBINATION THERAPY WITH AN ANTITUMOR ALKALOID
The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor...
2018/0078549 SOLID ORAL FILM DOSAGE FORMS AND METHODS FOR MAKING SAME
Improved pharmaceutical solid oral dosage forms for the buccal and/or sublingual delivery of Tadalafil. The improved delivery systems for solubilizing and...
2018/0078548 Methods for Treating Central Nervous System Disorders Using VDAC Inhibitors
The present invention relates to use of small organic compounds interacting with the Voltage-Dependent Anion Channel (VDAC) for the treatment of diseases...
2018/0078547 NOVEL COMPOUND USEFUL FOR THE TREATEMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates...
2018/0078546 PROCESS OF MAKING AND USING PHARMACEUTICAL FORMULATIONS OF ANTINEOPLASTIC AGENTS
In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable...
2018/0078545 METHODS FOR TREATING CANCER WITH TRKA RECEPTOR TYROSINE KINASE ANTAGONISTS
The present disclosure relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same, said compounds being...
2018/0078544 TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and...
2018/0078543 Compositions of Buprenorphine and .mu. Antagonists
The invention relates to a composition comprising buprenorphine and a .mu. opioid receptor antagonist, wherein the composition is characterized by an Agonist...
2018/0078542 COMPOSITIONS OF BUPRENORPHINE AND .mu. ANTAGONISTS
The invention relates to a composition comprising buprenorphine and a .mu. opioid receptor antagonist, wherein the composition is characterized by an Agonist...
2018/0078541 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL
The present invention relates to a compound according to general formula (I) ##STR00001## which acts as a modulator of FPR2 and can be used in the treatment...
2018/0078540 DOSAGE REGIMEN FOR AN ALPHA-ISOFORM SELECTIVE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR
The present invention relates to methods of treating or preventing a proliferative disease in a patient in need thereof by orally administering a...
2018/0078539 T-CELL REGULATION IN T-CELL MEDIATED DISEASES BY REDUCING PATHOGENIC FUNCTION OF TH17 IN A HUMAN SUBJECT...
A method of reducing pathogenic T-helper cell activity in a human subject in need thereof is disclosed. The method comprises administering to the human...
2018/0078538 METHOD OF TREATING A HUMAN SUBJECT HAVING A DESMOSOME ASSOCIATED DISORDER BY ADMINISTERING A NITROXIDE
A method of treating an individual having a desmosome-associated disorder is disclosed. The method comprises administering to the individual an effective...
2018/0078537 SYSTEMIC TREATMENT OF BLOOD-SUCKING AND BLOOD-CONSUMING PARASITES BY ORAL ADMINISTRATION OF A PARASITICIDAL AGENT
Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking...
2018/0078536 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, ##STR00001## wherein X is CH.sub.2 or a single bond; Y is a group of formula ...
2018/0078535 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF
Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all...
2018/0078534 COMPOSITIONS AND METHODS FOR TREATING MIDDLE-OF-THE-NIGHT INSOMNIA
The present invention provides liquid dosage forms for treating narcolepsy. The liquid dosage form includes zolpidem or a pharmaceutically acceptable salt...
2018/0078533 COMPOUNDS AND METHODS FOR TREATING INFLUENZA
This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds...
2018/0078532 IMMEDIATE RELEASE FORMULATIONS FOR OPROZOMIB
This disclosure features immediate release pharmaceutical formulations (e.g., solid dosage forms, e.g., tablets) that are useful for the oral administration of...
2018/0078531 OCULAR FORMULATIONS FOR DRUG-DELIVERY AND PROTECTION OF THE ANTERIOR SEGMENT OF THE EYE
The present application relates to topical formulations comprising Compound-I ##STR00001## or its free base, and a second active agent selected from nicotinic...
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