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Patent # Description
2018/0080098 MULTI-PROCESS HARDENING METHOD
Embodiments of multi-process hardened golf club heads and methods of multi-process hardening of golf club heads are generally described herein. Other...
2018/0080097 HIGH FREQUENCY HEAT TREATMENT METHOD OF ULTRA-HIGH STRENGTH PARTS
Disclosed is a high frequency heat treatment method of hot-stamping-treated ultra-high strength parts, which comprises: a first step of heating the parts until...
2018/0080096 DECARBURIZED SELF-PIERCING RIVET
A decarburized self-piercing rivet is provided that can join dissimilar sheets of material while reducing the likelihood of forming cracks during the riveting...
2018/0080095 POWDER METALLURGICALLY MANUFACTURED HIGH SPEED STEEL
The present invention relates to a high speed steel with a chemical composition that comprises, in % by weight: 0.6-2.1 C 3-5 Cr 4-14 Mo max 5 W max 15 Co...
2018/0080094 MOUNTING ENCLOSURE WITH EXTERNALLY REMOVABLE INSERT PANEL
The disclosed technology includes a mounting enclosure having a replaceable insert panel used to mount an apparatus used in a melting furnace. The replaceable...
2018/0080093 COMPOSITIONS COMPRISING C5 AND C6 MONOSACCHARIDES
Compositions comprising C5 and C6 monosaccharides and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are...
2018/0080092 ONE-STOP TREATMENT METHOD FOR BREAKING NUCLEIC ACID BY MEANS OF TRANSPOSASE, AND REAGENT
Disclosed are a one-stop treatment method for breaking a nucleic acid by means of a transposase, and a reagent. The method of the present invention comprises...
2018/0080091 DETECTION OF INFLUENZA B VIRUSES
Primers, probes and kits for detection and lineage differentiation of influenza B virus strains are provided. Also provided are the corresponding assays and...
2018/0080090 MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILES
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer,...
2018/0080089 METHODS FOR BREAST CANCER RISK ASSESSMENT
The present invention relates to methods and systems for assessing the overall risk of a human female subject for developing a breast cancer phenotype. In...
2018/0080088 MARKER GENES FOR PROSTATE CANCER CLASSIFICATION
The present invention relates to a method for classifying a prostate cancer in a subject, the method comprising the steps of a) determining a gene expression...
2018/0080087 METHODS OF DETERMINING AN IMMUNE RESPONSE SCORE
The present disclosure provides method for determining an immune response score (irScore), the method comprising: determining a number of differentially...
2018/0080086 FISH PANEL FOR CTCL
Described herein are probes useful to detect gene copy number alterations of genes characteristic/indicative of cutaneous T cell lymphoma (CTCL), such as CTCL...
2018/0080085 METHODS AND MATERIALS FOR ASSESSING AND TREATING CANCER
This document provides methods and materials involved in assessing cancer (e.g., breast cancer). For example, methods and materials for determining whether or...
2018/0080084 COMPOSITIONS AND METHODS FOR THE DETECTION AND TREATMENT OF CERVICAL CANCER AND CERVICAL INTRAEPITHELIAL NEOPLASIA
Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding...
2018/0080083 Methods for Detecting an increased risk for coronary heart disease
The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such...
2018/0080082 COMPOSITIONS AND METHODS FOR SJOGREN'S SYNDROME
The present invention provides methods and compositions involving epigenetic and gene expression signatures and their association with Sjogren's syndrome.
2018/0080081 DNA CONFORMATION (LOOP STRUCTURES) IN NORMAL AND ABNORMAL GENE EXPRESSION
Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of...
2018/0080080 GENE EXPRESSION MARKERS AND TREATMENT OF MULTIPLE SCLEROSIS
The present invention concerns markers of multiple sclerosis, their use, and treatment with IL-17 antagonists, including IL-17 antibodies, of subjects with...
2018/0080079 DIAGNOSIS, PROGNOSIS AND IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS OF MULTIPLE MYELOMA BASED ON GENE...
Gene expression profiling is a powerful tool that has varied utility. It enables classification of multiple myeloma into subtypes and identifying genes...
2018/0080078 METHOD OF IDENTIFYING HUMAN COMPATIBLE T CELL RECEPTORS SPECIFIC FOR AN ANTIGENIC TARGET
Methods are provided for identifying T cell receptors that specifically bind a particular antigenic target and can be used as therapeutics against disease.
2018/0080077 MARKERS FOR DIFFERENTIATION OF STEM CELLS INTO DIFFERENTIATED CELL POPULATIONS
Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for...
2018/0080076 NUCLEIC ACID DETECTION METHOD, DETECTION PROBE, DETECTION PROBE SET, AND NUCLEIC ACID QUANTIFICATION METHOD
A method for detecting a target nucleic acid, comprising: (a) contacting a nucleic acid sample comprising a target nucleic acid, comprising a first portion and...
2018/0080075 METHODS FOR ANALYZING NUCLEIC ACIDS FROM SINGLE CELLS
Aspects of the present invention include analyzing nucleic acids from single cells using methods that include using tagged polynucleotides containing multiplex...
2018/0080074 SINGLE NUCLEOTIDE DETECTION METHOD
A method of sequencing a nucleic acid such as DNA or RNA is provided. It is characterised by the steps of (1) generating a stream of single nucleoside...
2018/0080073 METHOD AND SYSTEM FOR SEQUENCING NUCLEIC ACIDS
Provided are compositions, methods and systems for determining the sequence of a template nucleic acid using a polymerase-based, sequencing-by-binding...
2018/0080072 DETECTION OF NUCLEIC ACID MOLECULES USING NANOPORES AND TAGS
The present disclosure provides methods and systems for assaying the presence of a target nucleic acid molecule in a sample having or suspected of having the...
2018/0080071 DETECTION OF NUCLEIC ACID MOLECULES USING NANOPORES AND COMPLEXING MOIETIES
The present disclosure provides methods and systems for assaying the presence of a target nucleic acid molecule in a sample having or suspected of having the...
2018/0080070 METHOD FOR TEMPLATE-DEPENDENT MULTIPLE DISPLACEMENT AMPLIFICATION
Provided herein are methods for template-dependent multiple displacement amplification (tdMDA) that preferably use 5' blocked pentamer primers.
2018/0080069 GENE SYNTHESIS PROCESS, GENE CHIP AND KIT
Provided is a chip process of gene synthesis, and the process comprises incorporating the whole procedure, which comprises amplifying oligonucleotides and...
2018/0080068 Methods and Systems for Ultra-Sensitive Detection of Genomic Alterations
The invention discloses methods and apparatuses for the detection and diagnostics of genetic alterations/mutations in a target sample, which may be a solid...
2018/0080067 RAPID PERTUSSIS DIAGNOSIS ON A POINT-OF-CARE HYBRID MICROFLUIDIC BIOCHIP
Certain embodiments are directed to a point-of-care (POC) microfluidic biochip for rapid, highly sensitive and specific pertussis diagnosis. The POC biochip...
2018/0080066 PRIMER PAIR, KIT AND METHOD FOR DETECTING EHRLICHIA CANIS
Primer pair, kit and method for detecting Ehrlichia Canis are disclosed. The primer pair includes a forward primer and a reverse primer, and the kit includes...
2018/0080065 UNIVERSAL METHOD FOR EXTRACTING NUCLEIC ACID MOLECULES FROM A DIVERSE POPULATION OF ONE OR MORE TYPES OF...
Disclosed herein are methods of extracting genetic material from a diverse population of one or more types of microbes in a sample. Microbes can be prokaryotes...
2018/0080064 LED DRIVEN PLASMONIC HEATING APPARATUS FOR NUCLEIC ACIDS AMPLIFICATION
Systems and methods for plasmonic heating by combined use of thin plasmonic film-based 2D and 3D structures and a light-emitting diode (LED) for nucleic acids...
2018/0080063 APPARATUS AND METHODS FOR CONDUCTING CHEMICAL REACTIONS
Provided herein are devices, systems, and methods for conducting nucleic acid amplification. The devices, systems, and methods are suited for portability,...
2018/0080062 Enrichment of Nucleic Acids by Complimentary Capture
Assays can be used to detect mutations found in neoplasms of the pancreas, as well as for other neoplasms and other uses. Nucleic acids can be captured from...
2018/0080061 BIOSYNTHETIC LABELING AND SEPARATION OF RNA
Methods are provided for differential biosynthetic labeling of RNA, including identification of cell type-specific programs of gene expression. The methods and...
2018/0080060 SEPARATION OF MOLECULES USING NANOPILLAR ARRAYS
A technique relates to separation of a mixture. A nano-deterministic lateral displacement (nanoDLD) array is configured to separate the mixture in a fluid. A...
2018/0080059 DETECTION OF OLIGOSACCHARIDES
Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an...
2018/0080058 NANOPATTERNED EXTRACELLULAR MATRICES ENABLE CELL-BASED ASSAYS WITH A MASS SPECTROMETRIC READOUT
The present disclosure provides methods in which adherent cells are treated with small molecules, cultured, lysed, and then analyzed by mass spectrometry to...
2018/0080057 DIAGNOSIS OF BACTERIAL VAGINOSIS
A method of diagnosing bacterial vaginosis (BV) in a female subject including: (a) obtaining an appropriate sample from the subject; and (b) detecting the...
2018/0080056 METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in...
2018/0080055 PRODUCTION OF NON-CALORIC SWEETENERS USING ENGINEERED WHOLE-CELL CATALYSTS
Disclosed are whole-cell catalysts, methods of making the whole-cell catalysts, and methods of using the whole-cell catalysts to produce steviol glycosides.
2018/0080054 Increased Production of Terpenes and Terpenoids
This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid...
2018/0080053 METHODS AND COMPOSITIONS FOR PRODUCING FATTY ALCOHOLS AND FATTY ALDEHYDES
Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.
2018/0080052 Novel Host Cells and Methods for Producing Isopentenol from Mevalonate
The present invention provides for a genetically modified host cell capable of producing isopentenol and/or 3-methyl-3-butenol, comprising (a) an increased...
2018/0080051 CAS 9 RETROVIRAL INTEGRASE AND CAS 9 RECOMBINASE SYSTEMS FOR TARGETED INCORPORATION OF A DNA SEQUENCE INTO A...
The instant disclosure relates to the use of engineered proteins such as Cas9, Cpf1, TALE and Zinc finger proteins attached with a viral integrases,...
2018/0080050 HIGHLY SPECIFIC DELIVERY OF POLYNUCLEOTIDES TO THE CELL NUCLEUS VIA COMPRESSION
The subject invention pertains to delivering a polynucleotide into a target cell, particularly, into the nucleus of the target cell. The method comprises the...
2018/0080049 SYSTEMS AND METHODS FOR POINT/CENTER-OF-CARE IMMUNOTHERAPY
A cell modification device, comprising a centrifugation chamber with at least one cell modifying surface with a normal vector having an angle of 135-45.degree....
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