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Patent # Description
2018/0080048 POXVIRUS-DERIVED PROMOTER, AND VECTOR COMPRISING SAME
The present invention provides a poxvirus-derived promoter, a vector comprising the same, a method for expressing a transgene using the promoter, and use of...
2018/0080047 PROMOTERS
The present invention relates to the field of (vector) vaccines, and especially to novel promoter sequences, expression cassettes and vectors, which are...
2018/0080046 VIRAL VECTORS FOR THE TREATMENT OF RETINAL DYSTROPHY
The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and...
2018/0080045 CANINE ADENOVIRUS VECTORS
The present invention relates to the field of CAdV vector vaccines, and especially to promoters suitable to express target antigens from such vector vaccines....
2018/0080044 NEW SWINE INFLUENZA VACCINE
The present invention relates to Equine Herpes Virus (EHV) vectors comprising at least one exogenous antigen encoding sequence relating to a pathogen infecting...
2018/0080043 EHV INSERTION SITE ORF70
The present invention relates to the field of (vector) vaccines, and especially to the novel EHV insertion site ORF70. The present invention further concerns...
2018/0080042 WHOLE EXPRESSED CELL AS ANTIGEN CARRIER, AND USE THEREOF IN PREPARING VACCINE OR DIAGNOSTIC AGENT, AND...
A mammalian cell co-transfect with an expression plasmid comprising T7 promoter and an open reading frame (ORF) of target antigen, and a vT7 recombinant...
2018/0080041 INTRACELLULAR TRANSLATION OF CIRCULAR RNA
A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely...
2018/0080040 Methods and Compositions for Gray Leaf Spot Resistance in Corn
The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic...
2018/0080039 AXMI205 VARIANT PROTEINS AND METHODS FOR THEIR USE
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding...
2018/0080038 METHODS AND COMPOSITIONS FOR ENHANCED FORAGE QUALITY
The invention provides a method to select an alfalfa plant with enhanced feed value and increased flexibility in management either to increase quality of...
2018/0080037 TONOPLAST PROTON/SUGAR ANTIPORTER PROTEINS AND THE USE THEREOF TO INCREASE THE SACCHAROSE CONCENTRATION IN A...
The invention relates to tonoplast proton/sugar antiporter proteins, more particularly tonoplast proton/saccharose antiporter proteins, the nucleotide...
2018/0080036 MARKER ASSOCIATED WITH EVERBEARING PROPERTIES IN PLANT OF GENUS FRAGARIA AND USE THEREOF
This invention intends to develop many DNA markers for a plant of the genus Fragaria and identify everbearing lines with high precision by using the many DNA...
2018/0080035 MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the...
2018/0080034 Biosynthesis Of Human Milk Oligosaccharides In Engineered Bacteria
The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or...
2018/0080033 DELIVERY OF STRUCTURALLY DIVERSE POLYPEPTIDE CARGO INTO MAMMALIAN CELLS BY A BACTERIAL TOXIN
There is a need for delivery platforms with robust capacity that offer the possibility to deliver diverse protein-based therapeutics into specific cells....
2018/0080032 BIOSYNTHETIC PATHWAYS AND METHODS
This disclosure describes a recombinant microbial cells and methods of making and using such recombinant microbial cells. Generally, the recombinant cells may...
2018/0080031 COMPOSITIONS AND METHODS OF BIOSYNTHESIZING CAROTENOIDS AND THEIR DERIVATIVES
The present invention relates to compositions and methods of producing carotenoids and carotenoid derivatives.
2018/0080030 COMPOSITIONS AND METHODS FOR CORRECTING LIMB GIRDLE MUSCULAR DYSTROPHY TYPE 2C USING EXON SKIPPING
The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the...
2018/0080029 COMPOSITION FOR PREVENTING OR TREATING ATOPIC DERMATITIS COMPRISING X-SHAPE DNA STRUCTURE AS ACTIVE INGREDIENT
The present invention relates to a pharmaceutical composition for preventing or treating atopic dermatitis, the pharmaceutical composition including, as an...
2018/0080028 MULTI-CONJUGATE OF SIRNA AND PREPARING METHOD THEREOF
The present invention relates to a multi-conjugate of small interfering RNA (siRNA) and a preparing method of the same, more precisely a multi-conjugate of...
2018/0080027 METHODS OF USING PVT1 EXON 9 TO DIAGNOSE AND TREAT PROSTATE CANCER
PVT1 exon 9 is overexpressed in aggressively tumorigenic prostate cancer cell lines and prostate tumor tissues. This exon provides a diagnostic tool for the...
2018/0080026 CELL-SPECIFIC INTERNALIZING RNA APTAMERS AGAINST HUMAN CCR5 AND USES THEREFORE
Provided herein are fluoropyrimidine-modified RNA aptamers capable of binding CCR5. The compositions and methods provided herein are, inter alia, useful for...
2018/0080025 DNA-BASED TESTING FOR ENVIRONMENTAL CONTAMINATION
The present invention provides synthetic DNA aptamers that bind a target explosive to allow detection of that explosive. In various embodiments, the synthetic...
2018/0080024 SINGLE-STRANDED RNAI AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER
The instant disclosure features single-stranded RNA molecules comprising one or more internal, non-nucleotide spacers. A non-nucleotide spacer covalently links...
2018/0080023 MIRNA MIMETICS AND THEIR USE IN TREATING SENSORY CONDITIONS
The present invention provides microRNA mimetic compounds that mimic the function or activity of miR-96, miR-182, and/or miR-183. The microRNA mimetic...
2018/0080022 Catalytic Strands of Minimal Hammerhead Ribozymes and Methods of Using the Same
Provided are minimal hammerhead ribozymes and catalytic strands thereof. Aspects of the present disclosure include a catalytic strand of a minimal hammerhead...
2018/0080021 SIMULTANEOUS SEQUENCING OF RNA AND DNA FROM THE SAME SAMPLE
Methods, compositions, and kits for simultaneously generating RNA and DNA sequencing libraries are disclosed. In particular, the disclosed methods allow...
2018/0080020 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial...
2018/0080019 ENCODING OF DNA VECTOR IDENTITY VIA ITERATIVE HYBRIDIZATION DETECTION OF A BARCODE TRANSCRIPT
Embodiments disclosed herein are directed to a new genetic perturbation and screening method that combines advantages of pooled perturbation with imaging...
2018/0080018 Methods and Compositions for Synthetic RNA Endonucleases
The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
2018/0080017 NOVEL METALLOPROTEASES
Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods...
2018/0080016 ENGINEERED BOTULINUM NEUROTOXIN
Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify...
2018/0080015 MODIFIED XYLANASE
Provided is a modified xylanase. The polypeptide has xylanase activity and has an amino acid sequence with deletion of at least 12 consecutive amino acid...
2018/0080013 RNA-GUIDED GENE EDITING SYSTEM AND USES THEREOF
The present invention provides RNA-guided gene editing systems and methods of use thereof.
2018/0080012 METHOD FOR DECREASING THE BODY FAT CONTENT IN A SUBJECT BY ADMINISTERING AN ACTRIIB PROTEIN
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone,...
2018/0080011 TRICHOTHECENE-TRANSFORMING ALCOHOL DEHYDROGENASE, METHOD FOR TRANSFORMING TRICHOTHECENES AND...
A alcohol dehydrogenase of sequence ID no. 1 containing metal ions and a quinone cofactor, or in addition, a functional variant exhibiting a sequence identity...
2018/0080010 METHOD FOR THE PRODUCTION OF AD26 ADENOVIRAL VECTORS
Described are methods for large-scale production of recombinant adenovirus 26, utilizing perfusion systems and infection at very high cell densities.
2018/0080009 METHOD FOR PRODUCING NA VE PLURIPOTENT STEM CELLS
To produce and/or maintain naive pluripotent stem cells capable of highly expressing genes important for maintaining an undifferentiated state, which could not...
2018/0080008 CAR-T LYMPHOCYTES ENGINEERED TO HOME TO LYMPH NODE B CELL ZONE, SKIN, OR GASTROINTESTINAL TRACT
In one embodiment, provided herein are cells, e.g., T cells expressing receptors that that cause a cell expressing the receptors to home to specific anatomical...
2018/0080007 HUMAN STEM CELL-DERIVED NEURAL PRECURSORS FOR TREATMENT OF AUTOIMMUNE DISEASES OF THE CENTRAL NERVOUS SYSTEM
The present invention concerns the use of a population of cells comprising: (a) neural precursor cells committed to an oligodendroglial fate; (b) uncommitted...
2018/0080006 CELL CULTURE MEDIUM
The present invention relates to a cell culture medium for culturing human cells comprising an anti-coagulated total blood material wherein the hemoglobin...
2018/0080005 CULTURE MEDIUM FOR THE ISOLATION OF CLINICAL SAMPLES OF SPECIES SUCH AS MYCOPLASMA INCLUDING THOSE WHICH ARE...
The present invention relates to a culture medium specific for microorganisms of Mycoplasma genus and, in particular, for species of hardly cultivable...
2018/0080004 IN VITRO PROPAGATION OF BABESIA MICROTI
A method for continuous in vitro propagation of Babesia microti and microti-like species is disclosed. The method comprises incubating B. microti in culture...
2018/0080003 INTERCELLULAR SEPARATION METHOD FOR CULTURED CELLS
The present invention relates to a method of separating cultured cells, which is used in a configuration including: a first accommodation space; a cell...
2018/0080002 CELL DISPERSION DEVICE, AND AUTOMATIC SUBCULTURE SYSTEM USING SAME
The purpose of the present invention is to provide a means for dispersing cell aggregates without damaging the cells, such that a sufficient multiplication...
2018/0080001 MODULAR SYSTEM AND METHOD FOR DETECTING MICROORGANISMS
A modular automated system for sample processing and/or detection of microorganisms is provided. The modular system includes modules that perform at least one...
2018/0080000 Optics Cup With Curved Bottom
The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More...
2018/0079999 CELL MAINTAINER FOR AUTOLOGOUS CELL THERAPY PRODUCTION
In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture...
2018/0079998 FLOW ASSEMBLY FOR CELLS
In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a...
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