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Patent # Description
2018/0079846 CATALYST MODIFICATION TO CONTROL POLYMER ARCHITECTURE
By controlling the ratio of catalyst components or the type of activator the homogeneity of a polymer produced using a single site catalyst may be improved.
2018/0079845 Multimodal and Broad Molecular Weight High Density Polyethylene
This invention relates to new multimodal and/or broad molecular weight high density polyethylene polymers. The polymers may be made in a single reactor,...
2018/0079844 "Conjugated Diene Polymer and Modified Conjugated Diene Polymer Produced Using the Same, Rubber Composition for...
A conjugated diene polymer having a high content of cis-1,4-structures with a high activity, a conjugated diene polymer and a modified conjugated diene polymer...
2018/0079843 METALLOCENE COMPLEX WITH A HETEROATOM-CONTAINING PI-LIGAND AND PREPARATION METHOD THEREFOR, CATALYST SYSTEM...
The present invention relates to a metallocene complex with a heteroatom-containing .pi.-ligand, having a chemical structure represented by formula (I) as...
2018/0079842 CONTINUOUS GAS-PHASE POLYMERIZATION PROCESSES
The present disclosure relates to a continuous process for the preparation of ethylene homopolymers or ethylene copolymers comprising polymerizing ethylene or...
2018/0079841 METALLOCENE SUPPORTED CATALYST AND METHOD FOR PREPARING POLYOLEFIN USING THE SAME
The present disclosure relates to a novel metallocene supported catalyst, and a method for preparing a polyolefin using the same. The metallocene supported...
2018/0079840 HALOGENATED POLYISOOLEFINS WITH REDUCED HALOGENATED OLIGOMERS
A halogenated polyisoolefin copolymer is composed of at least one isoolefin monomer, at least one multiolefin monomer, a halogen content of 0.05-2.5 mol %, and...
2018/0079839 HIGH ALCOHOL TOLERANT COPOLYMERS AND TERPOLYMERS BASED ON POLYVINYL ALCOHOLS
The present application describes barrier coatings and barrier films comprising copolymers and terpolymers that are soluble in aqueous solutions containing...
2018/0079838 CATALYSTS FOR CONTROL OF LONG CHAIN BRANCHING
Catalyst systems and methods for making and using the same are disclosed. A catalyst composition is provided that includes a catalyst compound supported to...
2018/0079837 MAGNESIUM DICHLORIDE-ETHANOL ADDUCTS AND CATALYST COMPONENTS OBTAINED THEREFROM
Solid adducts comprising MgCl.sub.2 and an alcohol ROH in which R is a C1-C20 hydrocarbon group, in which the amount of alcohol ranges from higher than 42% to...
2018/0079836 CLOSED REACTOR TRANSITIONS BETWEEN METALLOCENE CATALYSTS
A method for transitioning a gas phase polymerization reactor between metallocene catalysts is provided. The method comprises first reducing the superficial...
2018/0079835 SITU PREPARATION OF A REDOX INITIATED BIMORPHOLOGICAL LATEX
The present invention relates to an in situ preparation of a redox initiated bimorphological aqueous dispersion of first polymer particles with protuberating...
2018/0079834 RUBBER COMPOSITION FOR TIRE TREADS, AND PNEUMATIC TIRE
The present invention provides a rubber composition for tire treads, the rubber composition achieving high rubber hardness and 300% modulus at high...
2018/0079833 BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS
Naphthalimide compounds as used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500...
2018/0079832 OXIDIZED SOY POLYSACCHARIDE
Compositions comprising oxidized soy polysaccharide compounds are disclosed herein. Oxidized soy polysaccharide compounds are produced by contacting soy...
2018/0079831 Novel Process
The present invention relates to the use of extrusion technology in a process for the low-moisture continuous gelatinisation and the enzymatic hydrolysis of...
2018/0079830 Enclosed Weather Protection Element With Integrated Adapter Panel For Camping Hammocks
An adapter panel for use with an undercover and canopy for weather protection of a hammock is disclosed. An example includes an undercover having side edges. A...
2018/0079829 APOLIPOPROTEIN NANODISCS WITH TELODENDRIMER
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The...
2018/0079828 CONJUGATION METHODS
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group...
2018/0079827 ANTI-CEA ANTIBODIES
The present invention provides antigen binding molecules (ABMs) which bind membrane-bound CEA, including ABMs with improved therapeutic properties, and methods...
2018/0079826 PREVENTION AND TREATMENT OF COMPLEMENT-ASSOCIATED EYE CONDITIONS
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular...
2018/0079825 METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES
The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject...
2018/0079824 HER2/ErbB2 Chimeric Antigen Receptor
Embodiments of the disclosure include immune cells expressing HER2-specific chimeric antigen receptors (CAR) and treatment of cancer therewith. In specific...
2018/0079823 NOVEL BENZODIAZEPINE DERIVATIVES
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and...
2018/0079822 Single Domain Antibodies that Bind to Human CD20
Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful...
2018/0079821 Fusion Proteins for Modulating Regulatory and Effector T Cells
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. The proteins...
2018/0079820 Methods For Treating Obesity And Nonalcoholic Fatty Liver Disease Or Nonalcoholic Steatohepatitis Using...
The present disclosure relates to methods for treating or preventing obesity and/or nonalcoholic fatty liver diseases (NAFLDs) and/or nonalcoholic...
2018/0079819 ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF
The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the...
2018/0079818 METHOD OF INHIBITION OF LEUKEMIC STEM CELLS
A method for inhibition of leukemic stem cells expressing IL-3R.alpha. (CD123), comprises contacting the cells with an antigen binding molecule comprising a Fc...
2018/0079817 PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF ATOPIC DERMATITIS COMPRISING IL-31 ANTAGONIST AS...
In a non-limiting embodiment, there is provided a pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising an IL-31...
2018/0079815 CONSTRUCTS TARGETING AFP PEPTIDE/MHC COMPLEXES AND USES THEREOF
The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I...
2018/0079814 COMBINED ANTI-PLD-1 AND ANTI-CTLA-4 ANTIBODIES FOR TREATING NON-SMALL LUNG CANCER
A method for treating lung cancer (e.g., non-small cell lung cancer) with an anti-PD-L1 antibody (MEDI4736), alone or in combination with an anti-CTLA4...
2018/0079813 ANTI-H7CR ANTIBODIES
Antibodies and humanized variants thereof and their antigen-binding fragments and other molecules that are capable of immunospecifically binding to the B7-H7...
2018/0079812 BINDING-TRIGGERED TRANSCRIPTIONAL SWITCHES AND METHODS OF USE THEREOF
The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the ...
2018/0079811 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides antagonistic and agonistic anti-human VISTA antibodies and antibody fragments. These antagonist antibodies and antibody fragments may be...
2018/0079810 Humanized Antibodies To LIV-1 And Use Of Same To Treat Cancer
The invention provides humanized antibodies that specifically bind to LIV-1. The antibodies are useful for treatment and diagnoses of various cancers as well...
2018/0079809 Anti-IL-12 Antibodies, Epitopes, Compositions, Methods and Uses
An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the...
2018/0079808 METHODS AND COMPOSITIONS FOR TREATING ASTHMA USING ANTI-IL-13 ANTIBODIES
The invention provides methods and compositions for treating asthma, e.g., mild or moderate asthma, in a subject using an anti-IL-13 antibody, or...
2018/0079807 ANTI-IL-17A AND IL-17F CROSS REACTIVE ANTIBODY VARIANTS AND COMPOSITIONS COMPRISING AND METHODS OF MAKING AND...
The present application relates to variants of an anti-IL-17A/F antibody, in particular, an glycosylation variant, a charge variant, an acidic variant, a HMWS...
2018/0079806 CHIMERIC FIBROBLAST GROWTH FACTORS WITH ALTERED RECEPTOR SPECIFICITY
The present invention is directed to novel chimeric fibroblast growth factor (FGF) polypeptides, novel DNA encoding chimeric FGF polypeptides, and to the...
2018/0079805 BISPECIFIC ANTIGEN BINDING PROTEINS
The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and...
2018/0079804 HUMANIZED ANTI-TAU(PS422) ANTIBODIES AND METHODS OF USE
The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
2018/0079803 VACCINES AND DIAGNOSTICS FOR THE EHRLICHIOSES
The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies,...
2018/0079802 ANTIBODY-MEDIATED NEUTRALIZATION OF CHIKUNGUNYA VIRUS
The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
2018/0079801 HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (CD4bs ANTIBODIES)
The invention relates to the identification of monoclonal HIV-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the CD4 binding...
2018/0079800 Human Immunodeficiency Virus Neutralizing Antibodies and Methods of Use Thereof
The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides...
2018/0079799 POLYOMAVIRUS NEUTRALIZING ANTIBODIES
The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and...
2018/0079798 TRISPECIFIC BINDING MOLECULES FOR TREATING HBV INFECTION AND ASSOCIATED CONDITIONS
The present invention relates to a binding molecule comprising at least three binding specificities, wherein (a) the first specificity is for a Hepatitis B...
2018/0079797 METHODS FOR PURIFYING HETERODIMERIC MULTISPECIFIC ANTIBODIES FROM PARENTAL HOMODIMERIC ANTIBODY SPECIES
Methods for purifying multispecific antibodies on interest (MAIs) that co-engage at least two different antigens or epitopes (also referred to targets, used...
2018/0079796 ANTI-TNF-ALPHA POLYPEPTIDE COMPOSITION AND USE THEREOF
The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of...
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