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Patent # Description
2018/0079795 INTEGRIN HETERODIMER AND A SUBUNIT THEREOF
A recombinant or isolated integrin heterodimer comprising a novel subunit .alpha.10 in association with a subunit .beta. is described. The .alpha.10 integrin...
2018/0079794 PHARMACEUTICAL PREPARATION
Preparations including recombinant FSH (rFSH).
2018/0079793 IL2 and TNF Immunoconjugates
The present application relates to conjugates comprising interleukin 2 (IL2), and a tumour necrosis factor, such as tumour necrosis factor alpha (TNF.alpha.),...
2018/0079792 PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO...
The present invention relates to a peptide having eight amino acid sequences derived from CAGE and retaining anticancer activity and activity to promote...
2018/0079791 CDCA1-DERIVED PEPTIDE AND VACCINE CONTAINING SAME
The present invention provides CDCA1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides...
2018/0079790 GROWTH DIFFERENTIATION FACTOR 15 (GDF-15) CONSTRUCTS
Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in...
2018/0079789 TRANSGENIC PLANTS HAVING INCREASED BIOMASS
Methods and materials for modulating biomass levels in plants are disclosed. For example, nucleic acids encoding biomass-modulating polypeptides are disclosed...
2018/0079788 Constitutive Yeast LLP Promotor-Based Expression Systems
The present invention belongs to the field of biotechnology, recombinant protein production, molecular biology, microbiology and microbial genetics. It...
2018/0079787 METHOD FOR INCREASING ETEC CS6 ANTIGEN PRESENTATION ON CELL SURFACE AND PRODUCTS OBTAINABLE THEREOF
A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous...
2018/0079786 CONSTRUCTS FOR CONTINUOUS MONITORING OF LIVE CELLS
Embodiments disclosed herein provide nucleic acid constructs and methods of use thereof that induce a live cell to give off sub-samples of the cell's cytosolic...
2018/0079785 AZA-AMINO ACID COLLAGEN COMPOUNDS
The invention relates to aza-amino acid backbone-modified biomimetic collagens and general methods for designing and making biomimetic materials and molecular...
2018/0079784 Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with...
2018/0079783 ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors...
2018/0079782 ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors...
2018/0079781 BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
Benzodiazepine dimers having a structure represented by ##STR00001## wherein R.sup.1 is ##STR00002## wherein the variables in formulae (I), (Ia), and (Ib) are as...
2018/0079780 NOVEL PEPTIDE COMPOUND, PRODUCTION METHOD THEREFOR, AND USE THEREOF
Provided are a novel peptide compound, a method of producing the same, and use of the peptide compound. Since the peptide compound has anticancer activity, the...
2018/0079779 METHOD FOR THE PURIFICATION OF A THERAPEUTIC RECOMBINANT PROTEIN FROM TRANSGENIC MILK
The invention relates to a method for the purification of a therapeutic protein from transgenic milk, comprising a clarification step using a salt of...
2018/0079778 METHOD OF REMOVING PROTEIN AGGREGATE
Provided is a method of removing a protein aggregate which can obtain a useful protein monomer in a high yield and a high purity as a raw material of a...
2018/0079777 SOLUTION PHASE METHOD FOR PREPARING ETELCALCETIDE
The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
2018/0079776 PROCESS FOR PREPARING BILE ACID DERIVATIVES
The present invention relates to processes for preparing compounds of formula I: ##STR00001## or a pharmaceutically acceptable salt or solvate thereof.
2018/0079775 METHOD FOR PREPARING SUBSTITUTED 3,7-DIHYDROXY STEROIDS
The invention relates to processes for preparing 17-alkynyl-7-hydroxy-steroids, such as 17-Ethynyl-10R,13S-dimethyl 2,3,4,7,8R,9S, ...
2018/0079774 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
2018/0079773 PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS
The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
2018/0079772 SALTS OF HIV INHIBITOR COMPOUNDS
The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such...
2018/0079771 SOFOSBUVIR IN CRYSTALLINE FORM AND PROCESS FOR ITS PREPARATION
Sofosbuvir in crystalline Form .alpha., process for its production and use in pharmaceutical compositions.
2018/0079770 NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF...
The present invention relates to a novel compound of 4'-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an...
2018/0079769 NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or...
2018/0079768 METHOD FOR PRODUCING GLYCOSIDE COMPOUNDS
The invention provides a production method of a glycoside compound or a salt thereof, which includes subjecting a thioether compound and an alcohol compound to...
2018/0079767 METHODS OF PREPARING STEVIOL GLYCOSIDES AND USES OF THE SAME
Methods of preparing steviol glycosides, including Rebaudioside D, Rebaudioside E, Rebaudioside M, Rebaudioside N and Rebaudioside O are provided herein....
2018/0079766 METHODS FOR PREPARING THERMALLY STABLE LIGNIN FRACTIONS
The present invention relates to fractions of high purity lignin which are thermally stable, and to methods of producing said fractions from lignocellulosic...
2018/0079765 Double Metal Cyanide Catalyst and Epoxide/Carbon Dioxide Copolymer Prepared Using the Same
Provided are a double metal cyanide (DMC) catalyst used in copolymerization of an epoxide/carbon dioxide useful for preparing polyurethane, a foaming agent, an...
2018/0079764 CHEMICAL DEPOSITION RAW MATERIAL INCLUDING HETEROGENEOUS POLYNUCLEAR COMPLEX AND CHEMICAL DEPOSITION METHOD...
The present invention relates to a chemical deposition raw material including a heterogeneous polynuclear complex in which as ligands, at least a diimine and a...
2018/0079763 TRIPHENYLPHOSPHINE OXIDE DERIVATIVE AND ELECTROPHOSPHORESCENT LUMINESCENT DEVICE
A triphenylphosphine oxide derivative is described, which is applied to a phosphorescence host and an electron transport material. R in a structural formula of...
2018/0079762 Carbidopa and L-Dopa Prodrugs and Methods of use
The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa...
2018/0079761 High-RI siloxane monomers, their polymerization and use
Phenoxyphenylsilane monomers were synthesized and polymerized. The polymers have high refractive indices and excellent UV and thermal stability. Their water...
2018/0079760 BETA-LACTAMASE INHIBITORS
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
2018/0079759 Boron-Containing Diacylhydrazines
The present disclosure provides boron-containing diacylhydrazines having Formula I: ##STR00001## and the pharmaceutically acceptable salts and solvates thereof,...
2018/0079758 SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS
Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1...
2018/0079757 BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY
The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical...
2018/0079756 HETEROCYCLIC COMPOUND
The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of...
2018/0079755 PROCESS FOR THE SYNTHESIS OF E1 ACTIVATING ENZYME INHIBITORS
The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((4S, 2S, ...
2018/0079754 TEMOZOLOMIDE COMPOUNDS, POLYMERS PREPARED THEREFROM, AND METHOD OF TREATING A DISEASE
A temozolomide compound according to formula (I) ##STR00001## is described, wherein R.sup.1, L.sup.1, and X are defined herein. The temozolomide compound can be...
2018/0079753 INHIBITORS OF CELLULAR METABOLIC PROCESSES
The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to...
2018/0079752 BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to...
2018/0079751 PROCESS FOR PRODUCING PURINONE DERIVATIVE
According to the present invention, differently from well-known production methods, with the use of a different starting material, Ullmann condensation which...
2018/0079750 NOVEL COMPOSITIONS, USES AND METHODS FOR MAKING THEM
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce...
2018/0079749 PROCESS OF SYNTHESIZING SUBSTITUTED PYRIDINE AND PYRIMIDINE COMPOUND
Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method for preparing a compound of formula...
2018/0079748 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers...
2018/0079747 COMPOUNDS WITH ANTI-TUMORAL ACTIVITY
The present invention relates to compounds of general formula (I). ##STR00001## wherein A represents an optionally substituted heterocycle group, B represents an...
2018/0079746 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid...
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