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Patent # Description
2018/0087118 METHOD FOR IDENTIFYING COMPOUND FOR INHIBITING AN ACTIVITY OF A HISTONE LYSINE DEMETHYLASE
A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of...
2018/0087117 ANTI-MICROBIAL AGENT FROM PAENIBACILLUS SP. AND METHODS AND USES THEREOF
The present invention provides, in part, a Paenibacillus sp. isolate, designated Paenibacillus polymyxa JB05-01-1, as well as an anti-microbial agent obtained...
2018/0087116 METHODS AND BIOSENSORS FOR TUMOR DETECTION
A method for tumor marker detection is disclosed. The method includes preparing a biosensor, forming a reference solution by adding the biosensor to a buffer...
2018/0087115 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS
The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from...
2018/0087114 EARLY ASSESSMENT OF MECHANISM OF ACTION AND EFFICACY OF ANTI-CANCER THERAPIES USING MOLECULAR MARKERS IN BODILY...
Provided is a method of determining responsiveness of a subject to a treatment for a cancer. Also provided is a method of determining treatment recommendations...
2018/0087113 METHODS FOR PREDICTING DRUG RESPONSIVENESS IN CANCER PATIENTS
The present invention features methods, devices, and kits for detecting gene expression in a patient having cancer or determining responsive of a patient...
2018/0087112 METHOD FOR DETERMINING GENETIC CONDITION OF FETUS
Provided is a method for determining a genetic condition of a fetus, the method including: an objective region selection step of selecting an objective region...
2018/0087111 MIRNA FINGERPRINT IN THE DIAGNOSIS OF LUNG CANCER
The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in...
2018/0087110 COMPOSITIONS AND METHODS FOR XI CHROMOSOME REACTIVATION
In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and...
2018/0087109 DETERMINING ANTIGEN-SPECIFIC T-CELLS
The invention is directed to methods for determining antigen-specific T cells. In some embodiments, methods of the invention may be implemented by the steps of...
2018/0087108 IMMUNO-PETE
Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
2018/0087107 COMPETITIVE MODULATION OF MICRORNAS
The present invention provides compounds and methods for competitive modulation of microRNAs. Such copounds and methods have profound effects on cells.
2018/0087106 METHOD FOR DETECTING AND QUANTIFYING TARGET NUCLEIC ACID IN TEST SAMPLE USING NOVEL POSITIVE CONTROL NUCLEIC ACID
An object of the present invention is to provide a set capable of conveniently and rapidly confirming the presence or absence of contamination of a container...
2018/0087105 METHODS OF PREPARING AND ANALYZING CELL-FREE NUCLEIC ACID SEQUENCING LIBRARIES
Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample...
2018/0087103 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION AND RELATED METHODS
Nucleic acid sequencing methods and related products and methods for detection and presentation of the same are disclosed. Methods for sequencing a target...
2018/0087102 QUANTUM MOLECULAR SEQUENCING (QM-SEQ): IDENTIFICATION OF UNIQUE NANOELECTRONIC TUNNELING SPECTROSCOPY...
Techniques, methods, devices, and compositions are disclosed that are useful in identifying and sequencing natural and synthetic, and modified and unmodified...
2018/0087101 METHOD OF TARGET MOLECULE CHARACTERISATION USING A MOLECULAR PORE
The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling...
2018/0087100 ANALYSIS CHIP
An analysis chip includes a substrate main body having a plurality of reaction portions in which a selective binding substance selectively binding to a...
2018/0087099 METHOD FOR HYBRIDIZING A NUCLEIC ACID MOLECULE
The present invention is directed to a method for hybridizing a nucleic acid molecule to another nucleic acid molecule and to a use of a nucleic acid molecule...
2018/0087098 Methods for detecting rapidly processed introns to evaulate allelic expression
The invention is directed to methods for identifying one or more introns of a gene that are rapidly processed from a nascent RNA molecule transcribed from the...
2018/0087097 METHOD AND APPARATUS FOR ANALYSING A BIOLOGICAL SAMPLE
A system for preparing and analysing a sample of biological material, including a test cartridge having a first housing defining a flow-through chamber, a...
2018/0087096 GENE MUTATION DETECTION METHOD AND FLUORESCENCE-LABELED OLIGONUCLEOTIDE USED IN SAME
Provided are techniques by which a mutant gene in a gene group comprising a large number of wild-type genes can be detected with high sensitivity and in a...
2018/0087095 On-Slide Staining by Primer Extension
A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to...
2018/0087094 ALTERED MICROBIOME OF CHRONIC PELVIC PAIN
Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome...
2018/0087093 PROBE FOR DETECTING DRUG RESISTANT GRAM-POSITIVE PATHOGENS, PROBE SET AND METHOD FOR DETECTING DRUG RESISTENT...
The present invention relates to a probe for detecting drug-resistant gram-positive pathogens, a probe set, and a method of detecting drug-resistant...
2018/0087092 SIMULTANEOUS DETECTION OF TARGET PROTEIN AND TARGET NUCLEIC ACIDS IN A SINGLE CELL
Methods, reagents, and kits for detection and analysis of nucleic acids are provided. The methods can be used in conjunction with a proximity extension assay...
2018/0087091 METHODS AND COMPOSITIONS FOR LABELING NUCLEIC ACIDS
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] ...
2018/0087090 Method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction
The present disclosure relates to a method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction (dPCR)...
2018/0087089 Method for Analysing Nuclease Hypersensitive Sites
The present invention provides a method for analysing nuclease hypersensitive sites which method comprises: i) cleaving a nucleic acid sample comprising...
2018/0087088 RESTORING FUNCTION OF TUMOUR ACIDIFIED T CELLS
Methods and compositions to restore function to acidified T cells are provided. The methods comprise administering urease to the T cells. Compositions comprise...
2018/0087087 A METHOD FOR MEASURING THE PROTEASE ACTIVITY OF C3 AND C5 CONVERTASE OF THE ALTERNATIVE COMPLEMENT PATHWAY
A method for measuring the protease activity of a convertase of the alternative complement pathway is provided. The method typically comprises immobilizing a...
2018/0087086 CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS
The present invention provides cell egress and invasion inhibitors and their use as antiparasitical agents.
2018/0087085 METHODS FOR IMPROVED IN VITRO - IN VIVO EFFICACY DETERMINATION
The invention provides methods for determining and evaluating the in vitro-in vivo activity relationship of the efficacy of families of compounds for...
2018/0087084 COMPOSITIONS FOR THE DETECTION OF INTRACELLULAR BACTERIAL TARGETS AND OTHER INTRACELLULAR MICROORGANISM TARGETS
Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g.,...
2018/0087083 Sensors, Methods and Kits for Detecting Nicotinamide Adenine Dinucleotides
The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide...
2018/0087082 HYDROXYACYL-COENZYME A DEHYDROGENASE GENE, AN ACYL-COENZYME A THIOLASE GENE, GENETICALLY ENGINEERED STRAINS AND...
The present invention provides a hydroxyacyl-coenzyme A dehydrogenase gene, an acyl-coenzyme A thiolase gene, genetically engineered strains and a use thereof....
2018/0087081 PROTEIN EXPRESSION ENHANCING POLYPEPTIDES
Fusion proteins comprising a protein expression enhancing polypeptide linked to a target protein binding domain and nucleic acid molecules encoding such fusion...
2018/0087080 METHODS FOR CONTROLLING FUCOSYLATION LEVELS IN PROTEINS
The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein...
2018/0087079 METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE
Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition...
2018/0087078 BARCODING SYSTEMS AND METHODS FOR GENE SEQUENCING AND OTHER APPLICATIONS
The present invention generally relates to microfluidics and labeled nucleic acids. In one aspect, the present invention is generally directed to a method,...
2018/0087077 A MICROORGANISM OF THE GENUS ESCHERICHIA PRODUCING L-TRYPTOPHAN AND METHOD FOR PRODUCING L-TRYPTOPHAN USING THE...
The present invention relates to a microorganism of the genus Escherichia in which L-tryptophan productivity is improved by inactivating phosphatase activity....
2018/0087076 METHOD OF MANUFACTURING MICROBIALLY PRODUCED PLASTIC AND MICROBIALLY PRODUCED PLASTIC
Provided is a method of manufacturing a microbially produced plastic having low coloration, good tone, and low odor, based on a simple, low-cost method that is...
2018/0087075 METHOD OF PRODUCING BIOPRODUCTS
Methods for production of a bioproduct with a microorganism and selective extraction of bioproducts from a fermentation broth. The methods may include mixing a...
2018/0087074 MICROORGANISMS AND METHODS FOR PRODUCING PYRUVATE, ETHANOL, AND OTHER COMPOUNDS
Microorganisms comprising modifications for producing pyruvate, ethanol, and other compounds. The microorganisms comprise modifications that reduce or ablate...
2018/0087073 Use of Bacteriocin-Producing Ethanologens In Biofuel Production
An ethanologen for producing biofuel from one or more carbohydrates and reducing lactate and acetate production in a biofuel manufacturing process. The...
2018/0087072 ENGINEERED TARGET SPECIFIC NUCLEASES
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger...
2018/0087071 Method for Producing Chimeric Microbial Hybrids
Described is a method to transfer chromosomal DNA between two microbial species without genetic engineering or vectors. The strains resulting from this method...
2018/0087070 ENHANCED BACULOVIRUS YIELD
A method for increasing or enhancing baculovirus yield and/or recombinant protein expression from a baculovirus is provided, wherein said method includes the...
2018/0087069 CYTOMEGALOVIRUS VECTORS ENABLING CONTROL OF T CELL TARGETING
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof)...
2018/0087068 Lepidopteran-Active Cry1Da1 Amino Acid Sequence Variant Proteins
Engineered Cry1Da amino acid sequences are provided that exhibit improved Lepidopteran insecticidal activity and an enhanced Lepidopteran spectrum compared to...
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