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Patent # Description
2018/0087067 MUTATION OF THE EAR MOTIF OF CLASS II HD-ZIP POLYPEPTIDES
The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant...
2018/0087066 Soybean Seed and Oil Compositions and Methods of Making Same
Methods for obtaining soybean plants that produce seed with low linolenic acid levels and moderately increased oleic levels are disclosed. Also disclosed are...
2018/0087065 Soybean Seed and Oil Compositions and Methods of Making Same
Soybean oil compositions with unique fatty acid profiles are disclosed. These oils can be derived by the suppression of endogenous soybean FAD2 and FAD3 genes...
2018/0087064 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2018/0087063 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2018/0087062 PLANT TOLERANCE TO LOW WATER, LOW NITROGEN AND COLD II
Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the...
2018/0087061 PROMOTER EXHIBITING HIGH EXPRESSION ACTIVITY IN MORTIERELLA MICROORGANISMS
The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus Mortierella. The present invention...
2018/0087060 BACTERIAL MEDIATED THF ALPHA GENE SILENCING
Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for...
2018/0087059 ENGINEERING OF MULTI-CARBON SUBSTRATE UTILIZATION PATHWAYS IN METHANOTROPHIC BACTERIA
The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glycerol) as...
2018/0087058 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the TMPRSS6 gene, and methods of using such RNAi agents to inhibit...
2018/0087057 METHODS OF TREATING CANCER
A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition...
2018/0087056 OLIGONUCLEOTIDE COMPOSITIONS WITH ENHANCED EFFICIENCY
The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an...
2018/0087055 MODIFIED TGF-BETA2 OLIGONUCLEOTIDES
The invention refers to an oligonucleotide consisting of 10 to 18 nucleotides of selected regions of the TGF-beta2 nucleic acid sequence, which comprises...
2018/0087054 ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of...
2018/0087053 ANTI-CANCER RNA APTAMERS
Provided herein, inter alia, are compounds capable of binding HSP70 (e.g. mHSP70) on a cell and internalizing into said cell. The compositions provided herein...
2018/0087052 MODULATION OF HUNTINGTIN EXPRESSION
Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and...
2018/0087051 METHOD AND SYSTEM FOR CRISPR-BASED LIBRARY PREPARATION AND SEQUENCING
Embodiments of a method and system for improved microbiome sequencing can include: generating guide RNA complexes for a set of targets corresponding to a set...
2018/0087050 METHODS OF INSERTING MOLECULAR BARCODES
The present invention provides compositions, methods, and kits for inserting a plurality of synthetic transposons each comprising a different nucleic acid...
2018/0087049 MAXIMIZING DNA YIELD OF BLOOD SPECIMENS COLLECTED IN RAPID CLOT TUBES
The invention provides methods for isolating DNA from a blood sample collected into tubes containing a rapid clot activator, which involves the use of a lysis...
2018/0087048 ALKYLENE GLYCOLS AND POLYMERS AND COPOLYMERS THEREOF FOR DIRECT ISOLATION OF NUCLEIC ACID FROM EMBEDDED SAMPLES
Methods of directly isolating nucleic acid from an embedded biological sample are provided. An emulsified digest is generated in the presence of a thermostable...
2018/0087047 METHOD OF EXTRACTION OF GENOMIC DNA FOR MOLECULAR DIAGNOSTICS AND APPLICATION
Methods and systems for extracting DNA from a sample are provided. A method includes: lysing red blood cells of the sample using a first solution; dissolving...
2018/0087046 VECTOR-BASED MUTAGENESIS SYSTEM
Strategies, reagents, methods, and systems for modulating the mutation rate in cells are provided herein. The strategies, reagents, methods, and systems are...
2018/0087045 CELL-FREE PRODUCTION OF RIBONUCLEIC ACID
Provided herein, in some aspects, are methods and compositions for cell-free production of ribonucleic acid.
2018/0087044 ACOUSTOPHORETIC SEPARATION TECHNOLOGY USING MULTI-DIMENSIONAL STANDING WAVES
A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the...
2018/0087043 HIERARCHICAL MAGNETIC NANOPARTICLE-ENZYME MESOPOROUS ASSEMBLIES EMBEDDED IN MACROPOROUS SCAFFOLDS
A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic...
2018/0087042 LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of...
2018/0087041 TAGGED FORM OF MUT ENZYME, GENETIC CONSTRUCTS INCORPORATING IT, AND ITS USE IN GENE THEREAPY
Disclosed are polynucleotides, polypeptides, and gene therapy vectors relating to biologically active methylmalonyl-CoA mutase enzymes, internally tagged with...
2018/0087040 ENZYME FOR BIOSYNTHESIS OF ISOPRENE AND ISOPENTENYL, AND MUTANT THEREOF
The invention provides a polypeptide capable of using 4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) as a substrate to produce isoprene, a nucleic acid...
2018/0087039 TISSUE FACTOR (TF)-TARGETED NANOTHERAPY
Provided herein are tissue factor (TF)-targeted nanofibers and methods of treating hemorrhage in a subject therewith. In particular, peptide amphiphiles (PAs)...
2018/0087038 NOVEL METALLOPROTEASES
Aspects of the present compositions and methods relate to novel metalloproteases, polynucleotides encoding the novel metalloproteases, and compositions and...
2018/0087037 BGL7 Beta-Glucosidase and Nucleic Acids Encoding the Same
The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention...
2018/0087036 Mutant Reverse Transcriptase
A mutant MMLV reverse transcriptase that may have an improvement in one or more properties is provided. For example, the present reverse transcriptase is...
2018/0087035 RECOMBINANT VECTORS
This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and...
2018/0087034 Controlled Induction of Human Pancreatic Progenitors Produces Functional Beta-Like Cells
Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting...
2018/0087033 COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g.,...
2018/0087032 MESENCHYMAL STEM CELLS EXPRESSING TNF-ALPHA RECEPTORS
Mesenchymal stem cells which express TNF-.alpha. receptor Type I in an amount of at least 13 pg/10.sup.6 cells. Such mesenchymal stem cells inhibit the...
2018/0087031 CELL THERAPY WITH POLARIZED MACROPHAGES FOR TISSUE REGENERATION
The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype useful for tissue repair. The method described in the present...
2018/0087030 ARTIFICIAL SKIN CULTURE CONTAINER AND METHOD FOR PRODUCING ARTIFICIAL SKIN USING SAME
An artificial skin culture container according to the present invention can solve the problems of the contraction of the dermal layer of artificial skin and...
2018/0087029 Methods of Culturing Retinal Pigmented Epithelium Cells, Including Xeno-Free Production, RPE Enrichment, and...
The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are...
2018/0087028 DIRECT CONVERSION METHOD OF SOMATIC CELL INTO HEPATIC STEM CELL, HEPATIC CELL, OR CHOLANGIOCYTE
The present invention relates to a composition for inducing direct conversion from a somatic cell into one or more kinds selected from the group consisting of...
2018/0087027 METHOD FOR INCREASING STEMNESS OF HUMAN MESENCHYMAL STEM CELLS
The present invention relates to a method for increasing the stemness of human mesenchymal stem cells and, more particularly, to: a method for increasing the...
2018/0087026 METHOD FOR PRODUCING OTIC PROGENITORS
This invention relates to an improved method for generating otic progenitor cells. The invention also relates to uses of such otic progenitor cells, for...
2018/0087025 RELEASE-MATRICES FOR CONTROLLED RELEASE OF MATERIALS INTO A SURROUNDING MEDIUM
The present invention refers to release matrices which include a material that can be released in a controlled way or with predefined kinetics into a...
2018/0087024 GENETICALLY ENGINEERED C1-UTILIZING MICROORGANISMS AND PROCESSES FOR THEIR PRODUCTION AND USE
Described are genetically engineered C1-utilizing bacteria for the preparation of dicarboxylic acids, e.g. succinic acid. For instance, the bacteria comprise a...
2018/0087023 METHOD OF PRODUCING BIOPRODUCTS
Methods for production of a bioproduct with a microorganism and selective extraction of bioproducts from a fermentation broth. The methods may include mixing a...
2018/0087022 METHOD FOR CUTTING CELL SHEET
The present invention relates to a method for cutting a cell sheet S, which includes cutting the cell sheet S that is cultured in the inside of a container 4...
2018/0087021 CELL CULTURE INCUBATORS WITH INTEGRATED CELL MANIPULATION SYSTEMS
Aspects of the invention relate to automated cell culture incubators. In some embodiments, automated cell culture incubators comprise an integrated...
2018/0087020 AUTOMATED CELL CULTURE INCUBATOR
Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an...
2018/0087019 MICROORGANISM GROWTH AND PRODUCTS RECOVERY
Herein disclosed is a method of generating products from microorganisms, comprising super-saturating a liquid medium with a gas consumable by the ...
2018/0087018 Materials and Methods for Extended Continuous Flow Fermentation of Reduced Genome Bacteria
A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations....
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