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Patent # Description
2018/0086814 MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM
The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects,...
2018/0086813 Peptides that Inhibit Syndecan-1 Activation of VLA-4 and IGF-1R
A fusion peptides with sequences derived from the extracellular domain of syndecan-1 that inhibits VLA-4 and IGF-1R signaling are disclosed. The fusion...
2018/0086812 STABILIZED SINGLE HUMAN CD4 DOMAINS AND FUSION PROTEINS
The invention provides a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the single domain CD4 and one or more fusion...
2018/0086811 HEPCIDIN ANALOGUES AND USES THEREOF
The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and...
2018/0086810 T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THEREOF
Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been...
2018/0086809 A SOLUBLE CHIMERIC INTERLEUKIN-10 RECEPTOR AND THERAPEUTIC USE THEREOF
Chimeric soluble receptor of interleukin 10 and relative use in treating tumors and in treating diseases which are characterized by high production of...
2018/0086808 A PROCESS FOR PREPARING G-CSF (GRANULOCYTE COLONY STIMULATING FACTOR)
The present invention is related to a novel process of isolating and purifying granulocyte colony stimulating factor (G-CSF) from a G-CSF-producing...
2018/0086807 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA...
2018/0086806 BMPRII POLYPEPTIDES AND USES THEREOF
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of bone...
2018/0086805 proNGF mutants and uses thereof for the preparation of NGF mutants
Pro-NGF--Nerve Growth Factor--mutants and their uses for the production of NGF mutants are disclosed. Also disclosed are useful new process to optimize and...
2018/0086804 Immunogenic Peptides of the Cyclin B1 Tumor Antigen
The present invention relates to peptides comprising at least one CD4.sup.+ T epitope, which is immunodominant in vitro, of the cyclin B1 tumor antigen, said...
2018/0086803 ENGINEERED CALMODULIN FOR TREATMENT OF RYANOPATHIES
Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic...
2018/0086802 PEPTIDE
There is provided a peptide which is capable of binding to an MHC molecule in vitro and being presented to a T cell without antigen processing (i.e. an...
2018/0086801 BIPARTITE MOLECULES AND USES THEREOF IN TREATING DISEASES ASSOCIATED WITH ABNORMAL PROTEIN AGGREGATES
Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate...
2018/0086800 NUCLEOTIDE SEQUENCE AND PHARMACEUTICAL COMPOSITION BASED THEREON WITH PROLONGED VEGF TRANSGENE EXPRESSION
A nucleic acid or transgene comprising a modified VEGF 3'-untranslated region (3'-UTR) polynucleotide sequence and a polynucleotide sequence encoding a...
2018/0086799 NOVEL PROTEINS SPECIFIC FOR PYOVERDINE AND PYOCHELIN
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
2018/0086798 NOVEL PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF RESPIRATORY SYSTEM DISEASES
Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and...
2018/0086797 IMMUNOMODULATORY PROTEINS
A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an...
2018/0086796 USE OF Cyt1Aa AS BROAD SPECTRUM TARGETING DOMAIN FOR INSECTICIDAL PROTEINS WITH BASIC RESEARCH AND...
A chimeric protein comprising a cytolytic .delta.-endotoxin portion and a heterologous polypeptide portion is provided. Nucleic acids encoding the chimeric...
2018/0086795 VEGETATIVE INSECTICIDAL PROTEINS USEFUL FOR CONTROL OF INSECT PESTS
DIG-657 vegetative insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such...
2018/0086794 MUTATED SALMONELLA ENTERICA
A novel, mutated Salmonella enterica serovar Typhimurium vaccine is generated and imparts protective immunity in vaccinated animals for a range of S. enterica...
2018/0086793 IMMUNOMODULATORS
The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and...
2018/0086792 ANTIMICROBIAL PEPTIDES AND THEIR USE FOR THE TREATMENT OF TOPICAL INFECTIONS
Synthetic analogs of general formula (I-A), TABLE-US-00001 (I-A) a-Ile-b-c-d-e-f-Lys-Lys-g-h-i-j-Ile-k-Lys-NH.sub.2 where a is Gly, Lys or .beta.-Ala; b...
2018/0086791 INHIBITION OF PULMONARY FIBROSIS WITH NUTLIN-3A AND PEPTIDES
In fibrotic lung fibroblasts, basal levels of p53 protein (and miR-34a) are markedly suppressed, leading to reduced p53-mediated inhibition of uPA and uPAR, or...
2018/0086790 BIOACTIVE PEPTIDES HAVING INSECTICIDE ACTIVITY
Disclosed are novel bioactive peptides derived as antagonists to a fire ant receptor for a pheromone biosynthesis-activating neuropeptide/pyrokinin...
2018/0086789 PHARMACEUTICAL COMPOUND
The present invention relates to an alpha-MSH analogue compound, the use in skin diseases, and the preparation.
2018/0086788 PEPTIDE HAVING ANTICANCER ACTIVITY, AND PHARMACEUTICAL COMPOSITION AND DIETARY SUPPLEMENT COMPOSITION FOR...
The present invention relates to a peptide having an anticancer activity, and a pharmaceutical composition and a dietary supplement composition for preventing...
2018/0086787 ESTROGEN RECEPTOR MODULATORS
Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
2018/0086786 PREPARATION OF DEOXYCHOLIC ACID
The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as...
2018/0086785 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the...
2018/0086784 Phosphonate analogs of HIV inhibitor compounds
The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that...
2018/0086783 Crystalline Form Of Nicotinamide Riboside
Provided are crystalline forms of nicotinamide riboside, including a Form I of nicotinamide riboside chloride according to formula (I). Also disclosed are...
2018/0086782 Guanidinoglycoside-mediated liposome-based delivery of therapeutics
This disclosure relates to the incorporation of amphiphilic guanidinylated aminoglycosides (e.g., neomycin) into liposomal assemblies, which contain entrapped...
2018/0086781 STEGANOGRAPHIC EMBEDDING OF INFORMATION IN CODING GENES
The present invention relates to the storage of information in nucleic acid sequences. The invention also relates to nucleic acid sequences containing desired...
2018/0086780 METHOD OF PRODUCTION OF N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE-2-AMINE 2-OXIDE
The invention relates to a method of production of N,N-bis(2-chloroethyl)amino)-2-oxo-1,3,2-oxazaphosphorinane in a reaction of phosphorous oxychloride...
2018/0086779 TOCOPHEROL PHOSPHORIC ACID ESTER SALT, METHOD FOR MANUFACTURING THE SAME, AND SKIN EXTERNAL PREPARATION
A tocopherol phosphoric acid ester salt in which the tocopherol phosphoric acid ester salt is represented by Formula (1), and in the Formula (1), "R1", "R2",...
2018/0086778 CARBONATE PRODRUGS AND METHODS OF USING THE SAME
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a...
2018/0086777 COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS
The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of...
2018/0086776 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Disclosed herein are substituted 8-aminothieno[3,2-e][1,2,4]triazolo[4,3-b]pyridazine-7-carboxamide compounds, which may be useful as positive allosteric...
2018/0086775 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME
The present specification provides a heterocyclic compound and an organic light emitting device including the same.
2018/0086774 COMPOUNDS AS TYROSINE KINASE MODULATORS
The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are...
2018/0086773 METHOD FOR ISOLATING FLAVONOIDS FROM RICE PLANT INOCULATED WITH WHITEBACKED PLANTHOPPER
The present invention relates to a method for isolating flavonoids such as cochlioquinone or chrysoeriol from a rice plant inoculated with a whitebacked...
2018/0086772 MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF
A compound and a method thereof are provided. The compound of the invention has formula I shown below. Each variable in formula I and manufacturing method are...
2018/0086771 FULLERENE DERIVATIVE AND LUBRICANT
A fullerene derivative, used as a lubricant, includes, in a molecule: a fullerene backbone; and n pyrrolidine rings each being condensed to the fullerene...
2018/0086770 METHOD FOR PRODUCNG TRICYCLIC COMPOUND, AND TRICYCLIC COMPOUND CAPABLE OF BEING PRODUCED BY SAID PRODUCTION METHOD
An object of the present invention is to provide a method for reproducibly producing a pyrrolopyrimidine ring-containing tricyclic compound in high yield with...
2018/0086769 IMIDAZOPYRAZINE SYK INHIBITORS
Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and...
2018/0086768 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
The present application provides the compounds of formula I ##STR00001## or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein...
2018/0086767 WDR5 INHIBITORS AND MODULATORS
Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the...
2018/0086766 CXCR7 ANTAGONISTS
Compounds having formula I, ##STR00001## or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and...
2018/0086765 NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV...
Disclosed are novel intermediates for use in preparing DPP-IV inhibitors, methods for preparing the same, and methods for preparing DPP-IV inhibitors using the...
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