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Patent # Description
2018/0086713 CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
The present invention provides therapeutic strategies for treatment of severe debilitating diseases associated with IFN-I due to cGAS activation. In one...
2018/0086712 ASYMMETRIC BIS-ACRIDINES WITH ANTITUMOUR ACTIVITY AND THEIR USES
We disclose novel asymmetric bis-acridines with antitumour activity. These compounds are useful for use in pharmaceuticals, particularly in the treatment or...
2018/0086711 DEUTERATED CFTR POTENTIATORS
This invention relates to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof. This invention also provides compositions...
2018/0086710 Determining Degradation of 3,4-Diaminopyridine
The present invention relates to methods of determining the purity of a sample of 3,4-diaminopyridine comprising determining the presence, absence, or amount...
2018/0086709 TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS
The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,...
2018/0086708 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS
The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention...
2018/0086707 DISUBSTITUTED PIPERIDINE DERIVATIVES AS BUTYRYLCHOLINESTERASE INHIBITORS FOR USE IN THE TREATMENT OF ALZHEIMER
This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description....
2018/0086706 HYDRATE OF 2-ISOPROPOXY-5-METHYL-4-(PIPERIDIN-4-YL) ANILINE DIHYDROCHLORIDE, PREPARATION METHOD AND USE OF THE SAME
The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The...
2018/0086705 METHODS OF PREPARING TECOVIRIMAT
Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly...
2018/0086704 METHOD FOR PRODUCING BISIMIDE DICARBOXYLIC ACID
An object of the present invention is to provide an industrially advantageous method for producing a bisimide dicarboxylic acid, which uses substantially no...
2018/0086703 ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse...
2018/0086702 INDOLE ANALOGS AS 5-OXO-ETE RECEPTOR ANTAGONISTS AND METHOD OF USE THEREOF
This invention relates to novel pharmaceutically-useful compounds, to methods for their preparation, and to pharmaceutical compositions and therapeutic methods...
2018/0086701 ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS
Compounds according to formula (I) or (II), wherein R.sup.1, R.sup.2, and R.sup.3 are as defined in the specification, are versatile intermediates for the...
2018/0086700 INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME
Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer....
2018/0086699 EBNA1 INHIBITORS AND THEIR METHOD OF USE
Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious...
2018/0086698 SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS OF SSAO AND USES THEREOF
The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the...
2018/0086697 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV)...
2018/0086696 RUNX2 Transcription Factor Inhibitors and Uses Thereof
Provide herein are compounds with a general chemical structure of: ##STR00001## Substituents R.sub.1 and R.sub.2 independently are H, Cl, F, Br, CH.sub.3,...
2018/0086695 CRYSTALLINE FORM OF AHU377, PREPARATION METHOD AND USE THEREOF
The present disclosure relates to a novel crystalline form of a compound of formula (I), preparation method and use thereof. The novel crystalline form in the...
2018/0086694 DISINFECTING COMPOSITIONS HAVING IMPROVED ANTIMICROBIAL EFFICACY
Disinfecting compositions effective against multiple bacterial, fungal or viral organisms are described herein. Personal or consumer care products as well as...
2018/0086693 NITROBENZYL DERIVATIVES OF ANTI-CANCER AGENTS
Provided herein are compounds of formula I, wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising...
2018/0086692 SOLID FORMS
The instant invention relates to novel solid forms of the compound of formula (I) or salts thereof ##STR00001## as well as processes for their manufacture,...
2018/0086691 SYNTHESIS OF A SUBSTITUTED INDENE DERIVATIVE
This invention is directed to methods of preparing AQX-1125 having the formula: ##STR00001## This invention is also directed to intermediates utilized in the...
2018/0086690 Direct Amination of Hydrocarbons
Process for preparing aminated aromatic hydrocarbons that may be substituted comprising the steps of reacting an aromatic hydrocarbon with ammonia in the...
2018/0086689 ESTERIFICATION PROCESS
The present disclosure relates to a process of esterification in presence of a catalyst. The catalyst of the present disclosure is an aryloxy based phosphoric...
2018/0086688 PREPARATION AND SEPARATION OF A DI-CARBOXYLIC ACID-CONTAINING MIXTURE
Processes for separating a di-carboxylic acid or salt thereof from a mixture containing the di-carboxylic acid or salt thereof and one or more other components...
2018/0086687 METHOD FOR PRODUCING 2-HALOGENATED BENZOIC ACIDS
The purpose of the present invention is to provide a method for producing 2-halogenated benzoic acids, the method imparting high regioselectivity (high...
2018/0086686 PROCESS FOR THE PRODUCTION OF GLYCOLIC ACID
A process for the production of glycolic acid or derivatives thereof from formaldehyde comprising reacting formaldehyde with carbon monoxide and water in the...
2018/0086685 BRIDGED BI-AROMATIC LIGANDS AND TRANSITION METAL COMPOUNDS PREPARED THEREFROM
Disclosed are novel bridged bi-aromatic phenol ligands and transition metal compounds derived therefrom. Also disclosed are methods of making the ligands and...
2018/0086684 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN
A method for producing at least one compound selected from the group consisting of a compound represented by the following formula (10), a compound represented...
2018/0086683 SMALL SCALE PRODUCTION OF METHOXY COMPOUNDS
A method includes receiving a base raw material at a system. The base raw material is converted to synthesis gas. The synthesis gas is conditioned to remove...
2018/0086682 PROCESSES FOR PREPARING VINYLIDENE DIMER DERIVATIVES
This disclosure provides a process for producing vinylidene dimer derivatives by subjecting one or more vinylidene dimers and one or more carbonyl-containing...
2018/0086681 CONTINUOUS PROCESSES FOR THE HIGHLY SELECTIVE CONVERSION OF SUGARS TO PROPYLENE GLYCOL OR MIXTURES OF PROPYLENE...
Continuous processes for making propylene glycol from ketose-yielding carbohydrates are disclosed which enhance the selectivity to propylene glycol.
2018/0086680 ETHYNYL DERIVATIVES
The present invention relates to ethynyl derivatives of formula I ##STR00001## with variables as defined herein, or to a pharmaceutically acceptable acid...
2018/0086679 PROCESS FOR PRODUCING BUTADIENE BY OXIDATIVE DEHYDROGENATION OF BUTYLENE
The present invention provides a process for producing butadiene by oxidative dehydrogenation of butylene, comprising: a reaction stage, wherein a multi-stage...
2018/0086678 Phosphorous Modified Molecular Sieves, Their Use in Conversion of Organics to Olefins
The present invention is a phosphorous modified zeolite (A) made by a process comprising in that order: selecting a zeolite with low Si/Al ratio...
2018/0086677 UPGRADING 5-NONANONE
Provided are fuel components, a method for producing fuel components, use of the fuel components and fuel containing the fuel components based on 5-nonanone.
2018/0086676 IGNITION SYSTEM
An ignition system includes a multi-metallic ignition body that has at least two metallic elements in contact with each other. The metallic elements define an...
2018/0086675 Biotic Phosphate Fertilizers and Methods for Production
Bioactive fertilizers with improved extended phosphorous availability comprise fractured animal manure waste blended with at least potassium, phosphorus and...
2018/0086674 METHOD FOR PRODUCING A THERMALLY INSULATING MORTAR
A method for producing a thermally insulating mortar includes introducing water, cement and a liquid surfactant containing a foam concentrate that forms a foam...
2018/0086673 TEMPERATURE COMPENSATED DIELECTRIC MATERIAL
Disclosed are embodiments of tungsten bronze crystal structures that can have both a high dielectric constant and low temperature coefficient, making them...
2018/0086672 ENHANCED FRACTURE TOUGHNESS THERMAL BARRIER COATING MATERIAL
Disclosed are embodiments of a multi-phase ceramic material which can have advantageous properties as a thermal barrier coating. In particular, embodiments of...
2018/0086671 ARTIFICIAL STONE COMPRISED OF WASTE PLASTIC MATERIALS
Disclosed herein is an artificial stone comprised of a first waste plastic material and a second waste plastic material, wherein the first and/or second waste...
2018/0086670 METHOD OF PROVIDING CHEMICALLY INERT CONCRETE
A method of providing a chemically inert concrete includes the steps of providing and mixing an aqueous colloidal silica dispersion with a quantity of glass...
2018/0086669 DISPERSANT COMPOSITION FOR HYDRAULIC COMPOSITION
The present invention is a dispersant composition for a hydraulic composition, which includes (A) a high-molecular compound having a naphthalene...
2018/0086668 SETTING ACCELERATOR FOR A TILE ADHESIVE BLEND
The application relates to the use of a powder comprising calcium nitrate as a setting accelerator for a tile adhesive blend, wherein nitrate powder comprising...
2018/0086667 Cement Containing Forms with Insulating Properties
Various cement-containing forms and related compositions and methods are disclosed herein. Some cement-containing forms disclosed in this application include...
2018/0086666 GLASS REINFORCEMENT
A glass reinforcement for a cementitious board is provided. The glass reinforcement includes at least one glass fiber and a coating on the at least one glass...
2018/0086665 GLAZING UNIT
Disclosed is a glazing unit including an insulating glazing unit that is assembled with at least three panes for use in a window or as a part of a wall in a...
2018/0086664 GLASS-SENSOR STRUCTURES
The present invention generally relates to glass-sensor structures and methods of making the same.
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