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Patent # Description
2018/0085398 COMPOSITIONS AND METHODS OF TREATING CANCER
The present invention provides compositions and methods for treating cancer.
2018/0085397 One day burns treatment discovery for an industrial material
The grease (Machines lubricant), as burns medicine (treatment for burns), which is consisting of: 70-95% Base oil, 3-30% Thickner, F0-10% Additives, which is...
2018/0085396 INHERENTLY RADIOPAQUE POLYMERIC PRODUCTS FOR EMBOLOTHERAPY
Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for...
2018/0085395 POLYION COMPLEX OF POLY(L-ARGININE) SEGMENT-CONTAINING BLOCK COPOLYMER AND POLYANIONIC POLYMER
An object of the present invention is to provide a composition that serves as an efficient arginine substrate for inducible NO synthase (iNOS) in tumor. The...
2018/0085394 LOCAL APPLICATION OF D-LACTIC ACID DIMER IS SELECTIVELY CYTOTOXIC WHEN APPLIED TO CANCER CELLS
At equimolar concentrations, D-lactic acid dimer is more cytotoxic than L-lactic acid when directly applied to human HeLa cells in culture. The cytotoxicity of...
2018/0085393 COMPOSITIONS FOR SENSITIVE SKIN
Disclosed are compositions and methods for their use that include a combination of hydrolyzed algin, escin, Ruscus aculeatus root extract, ammonium...
2018/0085392 CYCLODEXTRIN COMPOUNDS FOR THE PREVENTION AND TREATMENT OF AGING
Cyclodextrin compound therapeutics to reduce age-related non-bisretinoid lipofuscin in a patient having a buildup of same, said method comprising administering...
2018/0085391 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASES AND CONDITIONS
The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention...
2018/0085390 Polyvalent RNA-Nanoparticle Compositions
The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More...
2018/0085389 AGENTS AND METHODS FOR TREATING PANCREATIC DUCTAL ADENOCARCINOMAS
It has been discovered that NAD+-dependent histone deacetylase SIRT6 is critical for suppression of PDAC by con trolling the expression of Lin28b, which is a...
2018/0085388 DELIVERY OF RNA TO TRIGGER MULTIPLE IMMUNE PATHWAYS
RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The...
2018/0085387 THERAPEUTIC COMPOSITIONS FOR TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS
Pharmaceutical formulations suitable for treating viral infections such as HIV are provided, in particular solid oral dosage forms including the compounds of...
2018/0085386 URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE
This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and...
2018/0085385 GLUCOSE-SENSITIVE CELL PROTECTING AGENT
The invention provides an agent containing N-acetyl-D-mannosamine for protecting a glucose-sensitive cell from glucose toxicity due to high glucose...
2018/0085384 NUTRITIONAL COMPOSITIONS AND INFANT FORMULAS CONTAINING OLIGOFRUCTOSE FOR REDUCING THE LOAD OF PATHOGENIC...
The invention relates to a nutrition composition with oligofructose and optionally high sn-2 palmitate for down regulating, decreasing or inhibiting the growth...
2018/0085383 SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME
The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38...
2018/0085382 COMPOSITIONS AND METHODS FOR COGNITIVE HEALTH AND MEMORY
The present disclosure is a compound, a method of making the compound and method of using such compound preferably in the form of a dietary supplement that,...
2018/0085381 Adjunctive Therapy With 25-Hydroxyvitamin D
Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin D are disclosed. The 25-hydroxyvitamin D may be administered with an agent that...
2018/0085380 Composition for Curing Migraine Headaches
The invention is directed to methods and compositions for curing migraine headaches. In particular, compositions are described involving the combination of...
2018/0085379 METHODS OF MONITORING ESTRIOL THERAPY
Provided are methods for treating a neurodegenerative disease, such as multiple sclerosis, in a subject receiving a first estriol treatment regimen, comprising...
2018/0085378 Antimicrobial Compound
The invention relates to compounds of formula (I), and pharmaceutical uses thereof. Particular aspects of the invention relate to methods of synthesising the...
2018/0085377 CO-CRYSTAL COMPOSITION AND ITS PHARMACEUTICAL USE
This invention discloses pharmaceutical use of a dicycloplatin (DCP) for the prophylaxis or treatment of proliferative diseases, degenerative diseases,...
2018/0085376 USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and...
2018/0085375 POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF
The present disclosure provides a conjugate of formula (I) ##STR00001## wherein each wherein each X, Nt, R, n, m and j are as defined herein. There is also...
2018/0085374 Use of Morpholino Compounds for the Treatment of Halitosis
Use of a morpholino compound having the general formula (I) wherein R.sub.1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or...
2018/0085373 THERAPEUTIC AND/OR PROPHYLACTIC AGENT FOR LEWY BODY DISEASE
The present invention provides a therapeutic and/or prophylactic agent and the like, comprising istradefylline as an active ingredient, for Lewy body disease...
2018/0085372 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the...
2018/0085371 COMBINATION OF PANOBINOSTAT AND RUXOLITINIB IN THE TREATMENT OF CANCER SUCH AS A MYELOPROLIFERATIVE NEOPLASM
The invention relates to a combination which comprises: (a) Compound A ((R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopenty- ...
2018/0085370 MODULATORS OF TOLL-LIKE RECEPTORS
Provided are modulators of TLRs of Formula II: ##STR00001## pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic...
2018/0085369 SALTS OF QUINAZOLINE DERIVATIVE AND METHOD FOR PREPARING THE SAME
The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in...
2018/0085368 MNK INHIBITORS AND METHODS RELATED THERETO
The present invention relates to compounds according to Formula (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, ...
2018/0085367 COMBINATIONS COMPRISING 3-PHENYLSULFONYL-8-PIPERAZINYL-1YL-QUINOLINE
The combination of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or a pharmaceutically acceptable salt thereof with a second therapeutic agent, and its use for...
2018/0085366 OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE
The invention provides pharmaceutical compositions comprising macromolecular gastrointestinal enzyme-labile opioid prodrugs, co-formulated with small-molecule...
2018/0085365 AMINO-QUINOLINES AS KINASE INHIBITORS
Disclosed are compounds having the formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and Z are as defined herein, and methods of making and using the same.
2018/0085364 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTIPSYCHOTIC DRUG AND A VMAT2 INHIBITOR AND USES THEREOF
New methods of treating schizophrenia and schizoaffective disorder by administration of pharmaceutical compositions comprising an antipsychotic compound and a...
2018/0085363 COMBINED COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING A BENZOPHENONE THIAZOLE DERIVATIVES AS A VDA...
The present invention relates to a pharmaceutical combined composition for preventing or treating cancer comprising a compound of formula 1 or a ...
2018/0085362 COMBINATION OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) INHIBITOR AND A MTOR INHIBITOR
The present invention relates to a pharmaceutical combination comprising a phosphatidylinositol-3-kinase (PI3K) inhibitor compound which is a 2-carboxamide...
2018/0085360 CENTRALLY ACTING ACETYLCHOLINESTERASE INHIBITORS FOR THE PREVENTION AND/OR TREATMENT OF CHEMICALLY INDUCED...
The invention relates to a composition for using in the treatment and/or prevention of chemically induced neuropathies, said composition comprising at least...
2018/0085359 USE OF CHELATORS OF DIVALENT CATIONS TO PROMOTE NERVE REGENERATION
Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to...
2018/0085358 CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS,...
The present invention provides certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I): ##STR00001## or a pharmaceutically...
2018/0085357 CRYSTALLINE COMPOUND AS SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) ENZYME INHIBITOR
A specific crystalline mesylate salt form of (3S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxyla- te, and the...
2018/0085356 METHOD OF TREATING DISEASE CHARACTERISED BY PROTEIN AGGREGATE DEPOSITION IN NEURONAL CELLS
This invention relates to the use of a very low dose of tacrolimus to treat amyotrophic lateral sclerosis or Parkinson's disease.
2018/0085355 Compositions and Methods for Inhibiting Bacterial Growth
The present disclosure provides, among other a things, compositions and methods useful for inhibiting bacteria such as Mycobacterium tuberculosis. These...
2018/0085354 METHODS OF TREATMENT FOR CHOLESTATIC AND FIBROTIC DISEASES
The present invention relates to the compound [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate (Nitazoxanide) or...
2018/0085353 CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS OF NITOZOXANIDE
Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion....
2018/0085352 Topical Localized Isoxazoline Formulation
This invention provides topical localized formulations comprising an isoxazoline compound and a pharmaceutically or veterinary acceptable liquid carrier...
2018/0085351 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
The present invention relates to certain compositions of a 5-HT.sub.2A serotonin receptor modulator and methods for their preparation. The compositions...
2018/0085350 COMPOSITIONS AND METHODS OF TREATING CANCER
The present invention provides compositions and methods for treating cancer.
2018/0085349 STABLE PRESERVATIVE-FREE MYDRIATIC AND ANTI-INFLAMMATORY SOLUTIONS FOR INJECTION
The present invention relates to stable, preservative- and antioxidant-free liquid formulations of phenylephrine and ketorolac for injection.
2018/0085348 METHODS FOR TREATING CANCER WITH RORGAMMA INHIBITORS
The present invention provides compositions, methods, and kits comprising one or more ROR.gamma. inhibitors, alone or in combination with one or more...
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