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Patent # Description
2018/0094278 NOVEL INSECTICIDAL PROTEINS AND METHODS OF USE
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2018/0094277 BINARY INSECTICIDAL CRY TOXINS
The subject invention concerns new classes of insecticidally-active proteins and the polynucleotide sequences which encode these proteins. More specifically,...
2018/0094276 MELON PLANTS WITH IMPROVED TRAITS
The present disclosure provides melon plants exhibiting resistance to powdery mildew, aphids, and cucumber vein yellowing virus (CVYV). In certain embodiments,...
2018/0094275 Methods for Plant Improvement
The invention provides methods and materials for increasing root biomass in a plant, by increasing the expression of at least one PEAPOD protein, or fragment...
2018/0094274 14-3-3 Proteins Enhance WRINKLED1 Transcription Factor-Regulated Oil Production
The application describes plants, plant cells, and seeds that express WRINKLED1 transcription factors and/or 14-3-3 proteins that are useful for increasing...
2018/0094273 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2018/0094272 DRO1 RELATED GENES INFLUENCE LATERAL ROOT ORIENTATION AND GROWTH IN ARABIDOPSIS AND PRUNUS SPECIES
Root orientation, or angle, is an important component of root architecture and depth of the root system. We have determined that DRO1 and DRO1-related genes...
2018/0094271 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2018/0094270 COMPOSITION, CONTAINING BASS2 PROTEIN OR GENE ENCODING SAID PROTEIN, FOR INCREASING SIZE OF PLANT SEEDS AND...
The present invention relates to a technique of increasing the size of plant seeds and the content of storage fat in seeds by using a pyruvic acid transporter...
2018/0094269 GLUCOAMYLASE-MODIFIED YEAST STRAINS AND METHODS FOR BIOPRODUCT PRODUCTION
Genetically engineered yeast with a heterologous glucoamylase and fermentation methods are described. The engineered yeast can have multiple exogenous nucleic...
2018/0094268 NOVEL PROMOTER AND USE THEREOF
The present disclosure relates to a novel promoter, a vector comprising the promoter, a microorganism comprising the vector, and a method for producing a...
2018/0094267 NON-HUMAN ANIMALS HAVING A HEXANUCLEOTIDE REPEAT EXPANSION IN A C9ORF72 LOCUS
A non-human animal (e.g., a rodent) model for diseases associated with a C9ORF72 heterologous hexanucleotide repeat expansion sequence is provided, which...
2018/0094266 Antisense Compounds Targeting Leucine-Rich Repeat Kinase 2 (LRRK2) For The Treatment Of Parkinsons Disease
The present disclosure relates generally to compounds comprising oligonucleotides complementary to a Leucine-Rich-Repeat-Kinase (LRRK2) RNA transcript. Certain...
2018/0094265 DOWN-REGULATING GENE EXPRESSION IN INSECT PESTS
The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants,...
2018/0094264 AAV TREATMENT OF HUNTINGTON'S DISEASE
Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering...
2018/0094263 OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
2018/0094262 INHIBITORS OF MYH7B AND USES THEREOF
The present invention provides nucleic acid inhibitors of MYH7B and compositions thereof. The present invention also provides methods of treating or preventing...
2018/0094261 COMPOSITIONS FOR MODULATING TAU EXPRESSION
Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to...
2018/0094260 EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds,...
2018/0094259 METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs
The present invention relates to compositions and methods for detecting motor neuron-specific miRNAs in a population of cells or subject. More particularly,...
2018/0094258 METHOD FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS
Some embodiments relate to methods for the recombinant expression of a protein of interest in a mammalian host cell, use of an shRNA or an siRNA directed...
2018/0094257 THREE-COMPONENT CRISPR/CAS COMPLEX SYSTEM AND USES THEREOF
The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention...
2018/0094256 PROTEIN SCREENING METHODS
The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
2018/0094255 Droplet-Based Selection By Injection
A method for the identification of a polynucleotide encoding an enzyme of interest in a microfluidic device by providing an emulsion of microfluidic droplets...
2018/0094254 ENRICHMENT OF SMALL NUCLEIC ACIDS
Provided herein is technology related to processing samples of nucleic acids and particularly, but not exclusively, to methods for enriching samples for small...
2018/0094253 XYLANASES FOR SOLUBILISING ARABINOXYLAN-CONTAINING MATERIAL
The present invention relates to a method for solubilising arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material),...
2018/0094252 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF
The present invention relates to variants of a parent glucoamylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
2018/0094251 MATERIALS AND METHODS FOR USING AN ACYL-ACYL CARRIER PROTEIN THIOESTERASE AND MUTANTS AND CHIMERAS THEREOF IN...
A method of increasing production of fatty acids comprising introducing into a host and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE)...
2018/0094250 Methods And Compositions For PCR
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a...
2018/0094249 Polymerase Variants
The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant...
2018/0094248 Necroptosis Signaling as a Therapeutic Target for Alzheimer's Disease
Therapeutic methods for conditions associated with neuronal loss and necroptosis are provided. More particularly, provided herein are methods of treating...
2018/0094247 ADSORPTIVE MEMBRANES FOR TRAPPING VIRUSES
A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable,...
2018/0094246 Primed Cardiac Progenitors and Methods for Making and Using Same
An improvement to the GiWi protocol for differentiating human pluripotent cells to developmentally mature cardiomyocytes includes a step of activating innate...
2018/0094245 METHODS FOR CARDIAC FIBROBLAST DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
Methods for generating high-yield, high-purity cardiac fibroblasts are described. Differentiation methods comprising chemically defined culture conditions and...
2018/0094244 COMBINATION IMMUNE THERAPY AND CYTOKINE CONTROL THERAPY FOR CANCER TREATMENT
Compositions disclosed herein, and methods of use thereof included those for inhibiting or reducing the incidence of cytokine release syndrome or cytokine...
2018/0094243 COMPOSITION AND METHODS OF GENOME EDITING OF B-CELLS
The present invention provides methods compositions and methods of preparing autologous B-cells that secrete a monoclonal of interest useful in immunotherapy.
2018/0094242 METHODS OF IN VITRO DIFFERENTIATION OF MIDBRAIN DOPAMINE (MDA) NEURONS
The presently disclosed subject matter provides for in vitro methods of inducing differentiation of human stem cells into midbrain dopamine neurons, and...
2018/0094241 METHOD FOR INDUCING CEREBRAL CORTEX NEURONS
Provided is a method for producing cerebral cortex neurons from pluripotent stem cells. Provided is a method for producing cerebral cortex neurons from ...
2018/0094240 ARTIFICIAL OOCYTE ACTIVATION
The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the...
2018/0094239 Method for Producing Pluripotent Stem Cells
The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the...
2018/0094238 COMPOSITIONS AND METHODS FOR THE INDUCTION AND TUNING OF GENE EXPRESSION
Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene...
2018/0094237 REPLICATION OF UNDIFFERENTIATED CELLS IN A WEIGHTLESS ENVIRONMENT, USES THEREOF AND FACILITY FOR SUCH...
Manufacturing processes are described for biological replication of undifferentiated plant and animal cells and tissue in a weightless condition, including...
2018/0094236 CELL LINES THAT ARE FREE OF VIRAL INFECTION AND METHODS FOR THEIR PRODUCTION
The present invention relates to cells and cell lines that are free of viral contamination and methods for eliminating viral contamination from a cell or cell...
2018/0094235 COMPOSITIONS AND METHODS FOR MAINTAINING CELL VIABILITY
The present disclosure provides for a cell stabilizing medium which comprises gelatin. The cell stabilizing medium help maintain cell viability, e.g., after...
2018/0094234 Media Compositions for Promoting Bacterial and Fungal Growth
Methods and compositions for enhancing or promoting germination of bacterial spores, and yeasts are disclosed herein. The composition of the present invention...
2018/0094233 METHOD OF CULTURING AKKERMANSIA
A method for cost-effectively and efficiently culturing Akkermansia muciniphilais is disclosed. High biomass yields can be obtained on chemically defined...
2018/0094232 Methods For The Cryopreservation Of Mammalian Cells
Manufactured capillary tubes can include: a tubular member; and a coating applied partially covering the tubular member, the coating defining a window where...
2018/0094231 Reactor Surface Finish Remediation
Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein....
2018/0094230 DEVICE AND METHOD OF HEATING/BENDING/FORMING AND HEATING/TOASTING BARRELS, CASKS, VATS AND THE LIKE FOR...
A heating/bending/forming and heating/toasting device of barrels, casks, vats or the like comprising: heating/toasting means (brazier) suitable to generate...
2018/0094229 SYSTEM AND METHOD FOR WORT GENERATION
A system and method for generating wort utilizing steam injection heating and stratified flow. The system mixes a fine ground grain with water to form a...
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