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Patent # Description
2018/0094076 Methods and Compositions for the Treatment of Autoimmune and Inflammatory Diseases
Compositions and methods for the treatment of autoimmune and inflammatory diseases are disclosed.
2018/0094075 ANTI-PTK7 ANTIBODY-DRUG CONJUGATES
The present invention provides anti-PTK7 antibody-drug conjugates and methods for preparing and using the same.
2018/0094074 IGE ANTI-HMW-MAA Antibody
In one aspect, there is provided an antibody or a functional fragment thereof, wherein the antibody or functional fragment thereof is capable of binding...
2018/0094073 ANTI-TROP2 ANTIBODY-DRUG CONJUGATE
It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is...
2018/0094072 Bi-Specific Monovalent Diabodies That are Capable of Binding CD123 and CD3, and Uses Thereof
The present invention is directed to sequence-optimized CD123.times.CD3 bi-specific monovalent diabodies that are capable of simultaneous binding to CD123 and...
2018/0094071 ANTIGEN PRESENTING CELL TARGETED VACCINES
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen...
2018/0094070 Methods for Treating Allergy and Enhancing Allergen-Specific Immunotherapy by Administering an IL-4R Inhibitor
The present invention provides methods for treating, preventing or reducing the severity of allergic reactions. The present invention also provides methods for...
2018/0094069 Methods for Treating Allergy and Enhancing Allergen-Specific Immunotherapy by Administering an IL-4R Inhibitor
The present invention provides methods for treating, preventing or reducing the severity of allergic reactions. The present invention also provides methods for...
2018/0094068 METHODS OF TREATING SKIN DISORDERS USING ANTI-IL-31RA ANTIBODIES
The present invention relates to methods of treating patients suffering from Contact dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic...
2018/0094067 ANTI-CSF1R ANTIBODY AND ANTI PD-1 ANTIBODY COMBINATION THERAPY FOR CANCER
Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
2018/0094066 ANTI-PRLR ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to prolactin receptor (PRLR) and methods of using the same. According to certain embodiments, the...
2018/0094065 ANTIBODIES DIRECTED AGAINST INTERLEUKIN 36 RECEPTOR (IL-36R)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein...
2018/0094064 AFFINITY MATURED ANTI-CCR4 HUMANIZED MONOCLONAL ANTIBODIES AND METHODS OF USE
The present invention provides affinity matured humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to...
2018/0094063 MONOCLONAL ANTIBODIES TO FIBROBLAST GROWTH FACTOR RECEPTOR 2
The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and...
2018/0094062 HER3 ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3
The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these...
2018/0094061 MOLECULES WITH ANTIGEN BINDING AND POLYVALENT FC GAMMA RECEPTOR BINDING ACTIVITY
The current invention involves biologically active proteins termed stradobodies. The stradobodies have two or more domains that create stradobody multimers....
2018/0094060 IGF-1R ANTIBODY AND ITS USE FOR THE DIAGNOSIS OF CANCER
The present disclosure relates to a novel antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid...
2018/0094059 SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF
The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family...
2018/0094058 COMPOSITIONS AND METHODS FOR PREVENTING TUMOR GROWTH AND TREATING CANCER BY TARGETING LECTIN...
The present invention discloses a method of treating, preventing or ameliorating tumor growth by immune response modulation via targeting LGALS3BP-CD33 related...
2018/0094057 METHODS OF TREATING VITILIGO USING PD-1 BINDING PROTEINS
Provided herein are methods for managing, treating, or preventing vitiligo using proteins that specifically bind to Programmed Death-1 (PD-1) and modulate the...
2018/0094056 ANTI-HER2 ANTIBODIES AND METHODS OF USE
The invention provides anti-HER2 antibodies, including anti-HER2 antibodies of improved stability or affinity, and methods of using the same.
2018/0094055 HUMAN PAC1 ANTIBODIES
Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments...
2018/0094054 ANTIBODIES THAT BIND CELL SURFACE GRP78 AND THEIR USE FOR DETECTION OF CANCER
This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor...
2018/0094053 Antibodies That Bind Interleukin-2 and Uses Thereof
The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2...
2018/0094052 Safe and Effective Method of Treating Psoriasis with Anti-IL23 Specific Antibody
A method of treating psoriasis in a patient by administering an IL-23 specific antibody, e.g., guselkumab, in a safe and effective amount and the patient...
2018/0094051 METHOD FOR INHIBITING LYMPHANGIOGENESIS BY ADMINISTRATION OF AN INHIBITOR OF THE CXCL12 PATHWAY
The present invention provides a method for inhibiting lymphangiogenesis in a subject, comprising administering a therapeutically effective amount of a CXCR4...
2018/0094050 VACCINES AGAINST HER3 ANTIGENS AND METHODS OF USING THE SAME
The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to antigenic...
2018/0094049 AMYLOID-BETA BINDING PROTEINS
The present invention relates to amyloid-beta (A.beta.) binding proteins. Antibodies of the invention have high affinity to A.beta.(20-42) globulomer or any...
2018/0094048 High Affinity Antibodies That Neutralize Staphylococcus Enterotoxin B
Provided herein are antibodies that specifically bind and neutralize Staphylococcus enterotoxin B. In addition, nucleic acids encoding such antibodies, and...
2018/0094047 ANTI-PRE-S1 HBV ANTIBODIES
Provided are human antibodies that specifically bind to HBV Pre-S1 domain ligand and inhibit HBV or HDV infection, antibodies binding to a set of amino acid...
2018/0094046 Mosaic chimeric viral vaccine{[s]] particle
The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some...
2018/0094045 FUSION PROTEIN SLIT2D2-HSA AND ITS USE IN TREATMENT OF SEPSIS
Disclosed is a fusion protein Slit2D2-HSA formed by fusion of a Slit2D2 polypeptide and a human serum albumin HSA, and use thereof for the manufacture of a...
2018/0094044 Chimeric Antigen Receptors
In a first aspect, provided herein are chimeric antigen receptors (CAR) composed of at least an extracellular domain, a transmembrane domain and an...
2018/0094043 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0094042 LUNG CANCER DIAGNOSIS MARKER, ANTIBODY AND APPLICATION THEREOF
A human lung cancer marker N3G4, and use of the same as human lung cancer marker is disclosed. Hybridoma cells which produce anti-N3G4 monoclonal antibodies,...
2018/0094041 ANTI-HUMAN PAPILLOMAVIRUS 16 E6 T CELL RECEPTORS
Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E6.sub.29-38. Related...
2018/0094040 Compositions and Methods for Diagnosing and Treating Cancer
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means...
2018/0094039 PHARMACEUTICAL COMPOUND
The present invention relates to compounds comprising a quaternary ammonium group, their use in skin diseases, and their preparation.
2018/0094038 ACYLATED GLUCAGON ANALOGUE
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular,...
2018/0094037 FUSION PROTEIN COMPRISING AN INTERLEUKIN 4 AND INTERLEUKIN 10
The invention is concerned with a fusion protein comprising interleukin 10 and interleukin 4, a nucleic acid molecule encoding such fusion protein, a vector...
2018/0094036 Method for the Purification of G-CSF
The present invention relates to a method for obtaining recombinant granulocyte-colony stimulating factor (G-CSF), comprising at least one cation exchange...
2018/0094035 ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT
The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen...
2018/0094034 INHIBITION OF AXL/GAS6 SIGNALING IN THE TREATMENT OF LIVER FIBROSIS
Compositions and methods are provided for alleviating endometriosis, kidney disease, inflammatory disease and/or transplant rejection in a mammal by...
2018/0094033 NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A AND B
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid...
2018/0094032 NOVEL HPV16 NON HLA-RESTRICTED T-CELL VACCINES, COMPOSITIONS AND METHODS OF USE THEREOF
Novel human papillomovirus immunogenic compositions and methods of use thereof are provided. The compositions comprise unique combinations of multi-epitope...
2018/0094031 CYCLOSPORIN DERIVATIVES WHEREIN THE MEBMT SIDECHAIN HAS BEEN CYCLIZED
The present invention relates to cyclosporin analogs that are potent inhibitors of cyclophilin D and have low immunosuppressive activity; processes for...
2018/0094030 CELL PENETRATING PEPTIDES & METHODS OF IDENTIFYING CELL PENETRATING PEPTIDES
The present invention relates to cell penetrating peptides and methods of identifying cell penetrating peptides based upon hydrophobicity and polarity.
2018/0094029 METHODS OF TREATING OPHTHALMIC DISEASES USING NPR-B AGONISTS
Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or...
2018/0094028 ACTIVE PEPTIDE FOR INHIBITING AMPA RECEPTOR AND PREPARATION METHOD AND USE THEREOF
Provided is an active peptide for inhibiting an AMPA receptor and a preparation method and use thereof. The method for preparing the active peptide comprises...
2018/0094027 DIPEPTIDYL PEPTIDASE-IV (DPPIV), INHIBITORY PEPTIDE COMPOUND, COMPOSITION CONTAINING THE SAME, AND PRODUCTION...
A peptide compound having a dipeptidyl peptidase-IV (DPPIV) inhibitory activity or a composition containing the peptide compound that can make a contribution...
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