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Patent # Description
2018/0094026 METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES
The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
2018/0094025 CRYSTAL OF REDUCED GLUTATHIONE
The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to...
2018/0094024 SEPARATION METHOD
The invention relates to a method of isolating an immunoglobulin, comprising the steps of: a) providing a separation matrix comprising multimers of ...
2018/0094023 METHOD FOR SEPARATION OF MONOMERIC POLYPEPTIDES FROM AGGREGATED POLYPEPTIDES
Herein is reported a method for obtaining a polypeptide in monomeric form comprising the steps of a) providing a solution comprising the polypeptide in...
2018/0094022 CHROMATOGRAPHY MEDIUM
The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a...
2018/0094021 COMPOUND FOR TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTION AND PREPARATION METHOD AND USE THEREOF
The present invention declares a kind of compound to treat respiratory syncytial virus infection and its preparation method and application. The compound...
2018/0094020 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF
The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethy- ...
2018/0094019 CRYSTALLINE FORMS OF MODIFIED TRITERPENOID HYDROCHLORIDE SALTS WITH HIV MATURATION INHIBITOR ACTIVITY
The present invention relates to crystalline forms of modified triterpenoid hydrochloride salts with HIV maturation inhibitor activity. More specifically, the...
2018/0094018 Progesterone Phosphate Analogs and Uses Related Thereto
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed...
2018/0094017 OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE CONSTRUCT USING THE SAME, AND METHODS FOR PRODUCING THEM
The oligonucleotide derivative of the present invention is represented by Formula (1). This derivative is considered to be introduced into cells by binding of...
2018/0094015 ENZYME-DIRECTED IMMUNOSTIMULANT AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATION(S)
The disclosed invention relates to the novel composition of matter that allows for the controlled release of highly active compounds to be delivered to a...
2018/0094014 METHOD OF PRODUCING EPIRUBICIN AND NOVEL PRODUCTION INTERMEDIATE THEREOF
According to the present invention, it is possible to efficiently remove 13-dihydroepi-daunorubicin and 4'-epi-feudomycin, which are typical impurities...
2018/0094013 ADVANCED GLYCATION END PRODUCT ANALOGUES
Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing...
2018/0094012 NICKEL-BASED CATALYSTS FOR C=O REDUCTION AND OXYGEN EVOLUTION
A compound having formula I that is useful for C.dbd.O reduction is provided: ##STR00001## wherein: M is a transition metal; X.sub.1, X.sub.2 are each...
2018/0094011 BIOFILM INHIBITING COMPOSITIONS ENHANCING WEIGHT GAIN IN LIVESTOCK
A method of enhancing the growth of an animal, as well as treating or preventing antimicrobial infections is provided. The method includes causing the animal...
2018/0094010 TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds are...
2018/0094009 COMPOUNDS WITH PHOSPHINE OXIDE AND AMINE FUNCTIONS, USEFUL AS URANIUM (VI) LIGANDS, AND USES THEREOF, IN...
The invention relates to compounds which correspond to the general formula (I) below: ##STR00001## in which: R.sup.1 and R.sup.2 represent, independently of one...
2018/0094008 Method for Purification of Lecithin
The present invention relates to a method for the purification of lecithin, comprising the steps of (a) mixing lecithin with active carbon to form a...
2018/0094007 EPOXY PHOSPHONATE ESTER AS A COUPLING AGENT FOR TRANSITION METAL AND METAL OXIDE SURFACES
A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a compound comprising an ester group and an epoxy ring,...
2018/0094006 FUNCTIONALIZED F-POSS MONOMER COMPOSITIONS AND USES THEREOF
Functionalized F-POSS compounds comprising synthetic blends of at least two feedstocks that produce a distribution of fluorinated polyhedral oligomeric...
2018/0094005 METHOD OF FORMING CYCLIC SILOXANE COMPOUNDS FROM ORGANODIHALOSILANES
A method is useful for forming a product including a cyclic siloxane compound. The method includes combining an organodihalosilane and a transition metal on...
2018/0094004 FLAME RETARDANT FILLER
A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards...
2018/0094003 FLAME RETARDANT FILLER
A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards...
2018/0094002 FLAME RETARDANT FILLER
A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards...
2018/0094001 PROCESS FOR THE FUNCTIONALIZATION OF SP2-H CARBONS USING FRUSTRATED LEWIS PAIR CATALYSTS
A catalytic process for the metal-free functionalization of sp.sup.2-carbons is described herein. The catalytic process is suitable for forming borylated...
2018/0094000 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION
The objective of the invention is to provide a polycyclic aromatic compound in which solubility to a solvent, film formability, wet coatability, thermal...
2018/0093999 NOVEL SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONE FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1 to R.sup.5 are as described herein, and their prodrugs or ...
2018/0093998 CHEMICAL COMPOUNDS
Provided are a series of novel pyridine or pyrimidine derivatives which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In...
2018/0093997 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS
The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
2018/0093996 THIENOTHIOPHENE/DITHIENOTHIOPHENE - TRIPHENYLAMINE/TETRAPHENYLETHYLENE DERIVATIVES FOR ORGANIC LIGHT EMITTING...
The present invention discloses new molecules having defined structures of a series of thienothiophene (TT), dithienothiophene (DTT) and their substituted...
2018/0093995 HYPOXIA-INDUCIBLE FACTOR 1 (HIF-1) INHIBITORS
Embodiments of small molecule inhibitors of hypoxia inducible factor 1 (HIF-1) and pharmaceutical compositions thereof are disclosed. The disclosed compounds...
2018/0093994 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as...
2018/0093993 JOINT PRODUCTION METHOD AND DEVICE FOR AZIRIDINE, PIPERAZINE AND TRIETHYLENEDIAMINE
Disclosed are a joint production method and device for aziridine, piperazine and triethylenediamine. The method comprises: reaction 1, preparing piperazine and...
2018/0093992 PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS
A process for preparing a compound of structural Formula Ia: ##STR00001## comprising Boc deprotection with TFA of: ##STR00002## and reductive amination of: ...
2018/0093991 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of...
2018/0093990 HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION
Provided are bifunctional small molecules of Formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein M represents a small organic...
2018/0093989 INDOLE DERIVATIVES
The present invention relates to compounds of the general form (I). The present invention relates to new substituted diazepino-indole derivatives of the...
2018/0093988 WNT PATHWAY MODULATORS
The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making...
2018/0093987 IMPROVED PROCESS FOR PREPARING IDELALISIB
The present invention relates to an improved process for preparing Idelalisib (1). In this process, acid addition salts of idelalisamine (2) are useful...
2018/0093986 METHODS AND COMPOSITIONS FOR TREATING PAIN
The present application relates to compounds and methods for treating pain, incontinence and other conditions.
2018/0093985 Heterocyclic Compounds and Their Use in Preventing or Treating Bacterial Infections
The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof,...
2018/0093984 N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
The invention relates to compounds of formula (I): ##STR00001## or a salt thereof, wherein R.sup.1, A, L, and R.sup.2 and n are as described herein. Compounds of...
2018/0093983 5H-PYRIDO[3,2-B]INDOLE COMPOUNDS AS ANTICANCER AGENTS
The present invention is directed to tricyclic compounds of formula (I), pharmaceutically acceptable compositions comprising compounds of the invention and...
2018/0093982 METHODS AND USES OF COMPOUNDS FOR TREATING DISEASE
The present invention provides methods for treating polycystic kidney disease by administering a compound or pharmaceutical composition thereof having the...
2018/0093981 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors
A compound is represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a...
2018/0093980 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical...
2018/0093979 HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION
The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods...
2018/0093978 INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE...
The invention provides indazolyl thiadiazolamines and related compounds, pharmaceutical compositions, methods of inhibiting Rho-associated protein kinase, and...
2018/0093977 Glycosidase Inhibitors
Compounds of formula (I) ##STR00001## wherein X.sup.1, X.sup.2, W, R.sup.1 to R.sup.5, L and m have the meaning according to the claims, are glucosidase...
2018/0093976 PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
The invention relates to a compound of having the following formulae and methods of treating cystic fibrosis: ##STR00001##
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