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Patent # Description
2018/0100176 CELL EXPRESSION SYSTEM
An expression system for expressing a protein comprising: a eukaryotic host cell carrying a dihydrofolate reductase (DHFR) deficiency; and an expression...
2018/0100175 HIGH-PURITY STEVIOL GLYCOSIDES
Methods of preparing highly purified steviol glycosides, particularly rebaudiosides A, D and M are described. The methods include utilizing recombinant...
2018/0100174 CONVERTING BIOMASS TO FERMENTATIVE PRODUCTS
The present application relates to reaction mixtures comprising biomass, a solid acid catalyst and celluloytic enzymes or organisms expressing such enzymes for...
2018/0100173 GLUCONATE REPRESSOR VARIANT, MICROORGANISM CONTAINING THE SAME PRODUCING L-LYSINE, AND METHOD FOR PRODUCING...
The present invention relates to a novel gluconate repressor variant, a microorganism containing the same, and a method for producing L-lysine using the same.
2018/0100172 PREPARATION OF 6-AMINOCAPROIC ACID FROM 5-FORMYL VALERIC ACID
The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as `6-ACA`) using a biocatalyst. The invention further...
2018/0100171 ACIDOPHILIC FUSARIUM OXYSPORUM STRAINS, METHODS OF THEIR PRODUCTION AND METHODS OF THEIR USE
The present invention provides isolated acidophilic Fusarium oxysporum strains, such as MK7, and their progeny, compositions comprising such strains and their...
2018/0100170 Yeast Cells Having Reductive TCA Pathway From Pyruvate To Succinate And Overexpressing An Exogenous NAD(P)+...
Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an...
2018/0100169 MODIFIED MICROORGANISM FOR THE OPTIMIZED PRODUCTION OF 2,4-DIHYDROXYBUTYRATE
The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via...
2018/0100168 MUTANT MICROORGANISMS AND METHODS OF MAKING AND USING
This disclosure describes methods that allow for the uncoupling of microbial growth from product formation, which allows for maximal use of raw material and...
2018/0100167 Methods For Enriching Gene-Targeted Cells
A gene of interest and the gene encoding hypoxanthine-aminopterin-thymidine (HPRT) can be co-targeted for Casp9 nuclease-mediated editing or alteration in a...
2018/0100166 Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells
Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives...
2018/0100165 RAAV-GUANYLATE CYCLASE COMPOSITIONS AND METHODS FOR TREATING LEBER'S CONGENITAL AMAUROSIS-1 (LCA1)
Disclosed are viral vector compositions comprising polynucleotide sequences that express one or more biologically-active mammalian guanylate cyclase proteins....
2018/0100164 MODIFIED SEROTYPE 28 ADENOVIRAL VECTORS
The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein...
2018/0100163 NUCLEIC ACID CONSTRUCT
The present invention provides a nucleic acid construct comprising the following structure: A-X-B in which A and B are nucleic acid sequences encoding a first...
2018/0100162 Modulation of Transgene Expression in Plants
This disclosure concerns the use of endogenous plant RNAi machinery to preferentially or specifically reduce transgene expression. In some embodiments, the...
2018/0100161 MULTI-PULSE TRANSFECTION METHODS AND CELLS
Systems and methods are provided for transfecting immune competent cells with RNA at high efficiency and viability.
2018/0100160 ENHANCED PROCESSES AND REAGENTS FOR HOST ENGINEERING
Nonnaturally occurring host cells altered to increase their ability to transfer genetic molecules into the host cells as compared to an unaltered host cell are...
2018/0100159 BACTERIAL MINICELLS FOR DELIVERING NUCLEIC ACID ADJUVANTS AND METHODS OF USING THE SAME
This disclosure provides intact bacterially derived minicells containing nucleic acids adjuvants or plasmids encoding nucleic acids adjuvants that can produce...
2018/0100158 RATIONALLY-DESIGNED SYNTHETIC PEPTIDE SHUTTLE AGENTS FOR DELIVERING POLYPEPTIDE CARGOS FROM AN EXTRACELLULAR...
The present description relates to methods for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic...
2018/0100157 REDUCTION OF TGF BETA SIGNALING IN MYELOID CELLS IN THE TREATMENT OF CANCER
Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing TGF.beta. signaling, for example, by reducing TGF.beta....
2018/0100156 MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE
The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting...
2018/0100155 DIAGNOSTIC AND SCREENING METHODS FOR ATOPIC DERMATITIS
The present disclosure provides methods for identifying agents that are candidate agents for treating atopic dermatitis. The present disclosure provides...
2018/0100154 RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT...
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond...
2018/0100153 Method and kit for use in inhiiting tumor progression, predicting or determining tumor progression state in VGF...
The present invention provides a method of inhibiting tumor progression in a subject suffering from VGF expressing cancers. The present invention also provides...
2018/0100152 FUNCTIONAL LIGANDS TO CHIKUNGUNYA ENVELOPE PROTEINS
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2018/0100151 ORGANIC COMPOSITIONS TO TREAT EPAS1 - RELATED DISEASES
The present disclosure relates to methods of treating EPAS1-related diseases such as cancer, metastases, astrocytoma, bladder cancer, breast cancer,...
2018/0100150 Factor XII (Hageman Factor) (F12), KALLIKREIN B, PLASMA (FLETCHER FACTOR) 1 (KLKB1), and Kininogen 1 (KNG1)...
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) gene, the...
2018/0100149 EXOSOMES AND MICRO-RIBONUCLEIC ACIDS FOR TISSUE REGENERATION
Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues...
2018/0100148 S. PYOGENES CAS9 MUTANT GENES AND POLYPEPTIDES ENCODED BY SAME
This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the...
2018/0100147 METHODS AND COMPOSITIONS FOR GENERATING CRISPR GUIDE RNA LIBRARIES
The disclosure generally relates to compositions, polynucleotides, kits, methods, and systems for generating clustered regularly interspaced short palindromic...
2018/0100146 HIGH-SPEED PHOTO-CROSS-LINKING LINKER FOR MOLECULAR INTERACTION ANALYSIS AND IN VITRO SELECTION, AND IN VITRO...
Provided is a linker for both screening assessment of the candidate clones without using enzymes, and to provide an in vitro selection method using thereof....
2018/0100145 Robust Quantification of Single Molecules in Next-Generation Sequencing Using Non-Random Combinatorial...
A population of nucleic acid adaptors is provided. In some embodiments, the population contains at least 50,000 different molecular barcode sequences, where...
2018/0100144 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS
The present invention relates to compositions and methods for the treatment of nucleotide repeat expansion disorders such as myotonic dystrophy.
2018/0100143 REMOVAL OF CONTAMINATING VIRUSES FROM AAV PREPARATIONS
The present invention relates to a separation of viruses of an essentially spherical shape from viruses with a rod-like shape that are comprised in a sample,...
2018/0100142 Methods and Kits for Production of Tissue Equivalents from Cryopreserved Cells
Methods are provided for production of differentiated tissue equivalent model systems from cryopreserved undifferentiated cells. The methods include seeding...
2018/0100141 MULTIPOTENT PROGENITOR CELL DERIVED FROM ADIPOSE TISSUE
Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived...
2018/0100140 CD133+ CELLS AND METHOD FOR EXPANDING
Provided herein are isolated CD133+ cells, such as human CD133+ cells, that have been expanded in culture and populations of isolated CD133+ cells that have...
2018/0100139 DECELLULARIZED HUMAN AMNIOTIC MEMBRANE FOR CELL DELIVERY, CELL CULTURE AND INFLAMMATION PREVENTION
Provided herein is an isolated decelluarized amniotic membrane (DCM) and methods for using same therapeutically in vivo and in vitro. In one aspect, the...
2018/0100137 AUTOMATED CULTURE MEDIA PREPARATION SYSTEM AND METHOD FOR MICROBIOLOGY TESTING
A process and system for automated culture media preparation for microbiology testing includes providing a non-pressurized water tank having an air filter...
2018/0100136 Mutant Yarrowia Strain Capable of Degrading Galactose
The invention relates to a method for obtaining a mutant Yarrowia yeast strain capable of growing on D-galactose as sole carbon source, comprising over...
2018/0100135 Novel Cryopreservation Bags and method of use thereof for Closed System, High Capacity Cell-Banking
The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train...
2018/0100134 CANCER CELL ENRICHMENT SYSTEM
The present invention describes a method for the propagation of a subpopulation of cells. The subpopulation of cells can be grown in specific culture...
2018/0100133 SYSTEMS AND METHODS FOR AUTOLOGOUS BIOLOGICAL THERAPEUTICS
An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve,...
2018/0100132 Large Container
A large container having a rigid wall constructed of plates and an inner, fluid-impermeable film that covers the inner surface of the plates, so as to provide...
2018/0100131 SELF-CONTAINED ANAEROBIC ENVIRONMENT-GENERATING CULTURE DEVICE
A device for culturing anaerobic microorganisms is provided. The device comprises a body comprising a waterproof base, a waterproof coversheet attached to the...
2018/0100130 METHOD AND DEVICE FOR STABILIZING POLYPHENOL-CONTAINING LIQUIDS
A process for stabilizing a liquid that contains a first type of polyphenol includes measuring the liquid's spectrum, comparing it to a reference spectrum,...
2018/0100129 CHEMICAL COMPOSITIONS AND METHOD FOR DEGASSING OF PROCESSING EQUIPMENT
The use of a chemical composition in degassing of vessels is taught, said chemical composition comprising 1-10% by weight of an oxyalkylated dodecyl thiol; and...
2018/0100128 CLEANING FORMULATIONS FOR REMOVING RESIDUES ON SEMICONDUCTOR SUBSTRATES
This disclosure relates to a cleaning composition that contains 1) at least one redox agent; 2) at least one organic solvent selected from the group consisting...
2018/0100127 LAUNDRY DETERGENT COMPOSITION
The present invention provides a domestic laundry cleaning composition, said composition comprising an anionic charged surfactant, an alkyl ether carboxylic...
2018/0100126 ENZYME-CONTAINING DETERGENT AND PRESOAK COMPOSITION AND METHODS OF USING
A cleaning composition is provided including an alkalinity source, builder, surfactant, water, a reducing agent and amylase in the ratio of from about 1:1 to...
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