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Patent # Description
2018/0100024 HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF
The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their...
2018/0100023 Composition Enriched in Anti-A and /or Anti B Polyclonal Immunoglobulins
The present invention relates to a composition highly enriched in anti-A and/or anti-B polyclonal immunoglobulins, comprising human polyclonal immunoglobulins,...
2018/0100022 HER1 ANTIGEN BINDING PROTEINS BINDING TO THE BETA-HAIRPIN OF HER1
The invention relates to anti-HER1 antigen binding proteins, e.g. anti-HER1 antibodies, that bind to the beta-hairpin of HER1, methods for selecting these...
2018/0100021 PROSTATE-SPECIFIC MEMBRANE ANTIGEN BINDING PROTEINS AND RELATED COMPOSITIONS AND METHODS
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane...
2018/0100020 CHIMERIC RABBIT/HUMAN ROR1 ANTIBODIES
The invention relates to antibodies having specificity for human ROR1, compositions thereof, and methods for using such antibodies, including in the diagnosis...
2018/0100019 Humanized Anti-CXCR5 Antibodies, Derivatives Thereof and Their Use
The present invention relates to humanized antibodies that specifically bind to CXCR5 and can, for example, inhibit CXCR5 function. The invention also includes...
2018/0100018 FGFR1 AGONISTS AND METHODS OF USE
The invention provides nucleic acid molecules encoding anti-fibroblast growth factor receptor-1 (FGFR1) antibodies and vectors and host cells comprising the...
2018/0100017 ANTI-FLT-1 ANTIBODIES IN TREATING BRONCHOPULMONARY DYSPLASIA
The present invention provides, among other things, methods and compositions for treating chronic lung disorders, in particular, bronchopulmonary dysplasia...
2018/0100016 USE OF CAR-MODIFIED HUMAN NATURAL KILLER CELLS TO TREAT CANCER
The invention provides a Natural Killer Cell, which may be a NK92 cell that is modified to express one or more types of Chimeric Antigen Receptor (CAR) on its...
2018/0100015 COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL...
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of...
2018/0100014 BINDING PROTEINS AND METHODS OF USE THEREOF
The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
2018/0100013 ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the...
2018/0100012 RGMa BINDING PROTEIN AND USE THEREOF
The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity arid few side effects which can be...
2018/0100011 ERYTHROCYTE-BINDING THERAPEUTICS
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or...
2018/0100010 FC CONTAINING POLYPEPTIDES WITH ALTERED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION
Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced...
2018/0100009 POLYPEPTIDE COMPRISING AN IMMUNOGLOBULIN CHAIN VARIABLE DOMAIN WHICH BINDS TO CLOSTRIDIUM DIFFICILE TOXIN A
There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to Clostridium difficile toxin A.
2018/0100008 POLYPEPTIDE COMPRISING AN IMMUNOGLOBULIN CHAIN VARIABLE DOMAIN WHICH BINDS TO CLOSTRIDIUM DIFFICILE TOXIN B
There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to Clostridium difficile toxin B.
2018/0100007 METHOD FOR PROTEIN PURIFICATION
The present invention provides a method for recovering a human VH3 domain-containing antibody in monomeric form. In particular the present invention provides a...
2018/0100006 METHOD FOR THE EXPRESSION OF POLYPEPTIDES USING MODIFIED NUCLEIC ACIDS
Herein is reported a method for recombinantly producing a polypeptide in a cell comprising the step of cultivating a cell which comprises a nucleic acid...
2018/0100005 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0100004 HEPCIDIN ANALOGUES AND USES THEREOF
The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and...
2018/0100003 Compositions and Methods of Use For Treating Metabolic Disorders
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
2018/0100002 COMPOSITION AND METHOD FOR DELIVERY OF BMP-2 AMPLIFIER/CO-ACTIVATOR FOR ENHANCEMENT OF OSTEOGENESIS
A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds...
2018/0100001 BIFUNCTIONAL STAPLED POLYPEPTIDES AND USES THEREOF
The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to...
2018/0100000 NOVEL INSECT INHIBITORY PROTEINS
Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4472, TIC4472PL,...
2018/0099999 FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA
Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of...
2018/0099998 STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS, AND USES THEREOF
Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB,...
2018/0099997 VIBRO-BASED DELIVERY SYSTEM AND IMMUNE SUPPRESSION
Embodiments described are immunosuppressant therapeutics and compositions comprising a Vop protein derived from Vibro parahaemolyticus; and drug delivery...
2018/0099996 FUNCTIONAL LIGANDS TO PHTHATATES
This invention relates to functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, more particularly to...
2018/0099995 NOVEL a4B7 THIOETHER PEPTIDE DIMER ANTAGONISTS
The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of .alpha.4.beta.7 to the mucosal addressing cell adhesion...
2018/0099994 NUCLEIC ACID CONSTRUCT
The present invention provides a nucleic acid construct comprising the following structure: A-X--B in which A is nucleic acid sequence encoding a first...
2018/0099993 SHORT SYNTHETIC PEPTIDE FOR TREATING DISEASES AND/OR CONDITIONS RELATED TO ANGIOGENESIS
Disclosed herein are synthetic peptides and compositions comprising the same, for the treatment and/or prophylaxis of a disease or a condition related to...
2018/0099992 METHOD CAPABLE OF BEING USED FOR PROTEIN RENATURATION INDEPENDENTLY OR BEING USED AS PRECEDING OPERATIONS OF...
Provided is a method of treating a protein to be renatured, including: (1) mixing the protein to be renatured with a denaturing solution containing a...
2018/0099991 SALTS OF OBETICHOLIC ACID
The invention relates to salts of Obeticholic Acid, their amorphous and crystalline polymorphic form and processes for preparation thereof.
2018/0099990 URACYL SPIROOXETANE NUCLEOSIDES
The present invention relates to compounds of the formula I: ##STR00001## including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as...
2018/0099989 Macroheterocyclic nucleoside derivatives and their analogues, production and use thereof
Nucleosides and nucleotides (nucleos(t)ides) have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with viral...
2018/0099988 DITHIOLENE METAL COMPLEX COLORLESS IR ABSORBERS
The invention relates to the use of compounds of formulae (I) and/or (II) as colorless 1R absorbers wherein M is Ni, Pd, Pt, Au, Ir, Fe, Zn, W, Cu, Mo, In, Mn,...
2018/0099987 FUNCTIONALIZED MAGNETIC NANOPARTICLE, A CATALYST, A METHOD FOR FORMING C-C BONDS
A functionalized magnetic nanoparticle including an organometallic sandwich compound and a magnetic metal oxide. The functionalized magnetic nanoparticle may...
2018/0099986 Controlled Synthesis of Polymeric Perylene Diimide and Applications Thereof
Perylene diimide phosphoramidite derivatives and methods for polymerization of perylene diimide phosphoramidite derivatives and applications thereof are...
2018/0099985 Novel AminoBisPhosphonate Antiwear Additives
The present invention relates to novel aminobisphosphonate compounds useful as antiwear and/or friction modifier additive components, lubricant additive...
2018/0099984 PROTEASOME INHIBITORS
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the...
2018/0099983 Heterocyclic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device
Provided are a heterocyclic compound which emits blue light and is represented by General Formula (G1) below, and a light-emitting element, a light-emitting...
2018/0099982 PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES
Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII),...
2018/0099981 COMPOUNDS, COMPOSITIONS AND METHODS
The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
2018/0099980 METHODS FOR THE ACYLATION OF MAYTANSINOL
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence...
2018/0099978 PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO
This invention relates to processes for preparing a JAK1 inhibitor having Formula Ia: ##STR00001## as well as new forms of the inhibitor.
2018/0099977 INHIBITORS OF HISTONE DEACETYLASE
The present invention relates to compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U,...
2018/0099976 NOVEL COMPOUNDS AS REARRANGED DURING TRANSFECTION (RET) INHIBITORS
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing...
2018/0099975 COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat...
2018/0099974 METHODS OF TREATING OR PREVENTING A PROTEOPATHY
Methods for the treatment or prevention of a proteopathy are described herein.
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