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Patent # Description
2018/0099973 PDE1 INHIBITOR
The present invention provides a compound of Formula I: ##STR00001## useful for treating chronic kidney disease and diabetic kidney disease.
2018/0099972 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also...
2018/0099971 POLYMORPH OF SYK INHIBITORS
Polymorphs of a bis-mesylate salt of a compound of Formula I: ##STR00001## or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a...
2018/0099970 PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR SUBSTITUTED FIVE-MEMBERED RING HETEROCYLES
Polycyclic derivatives of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers,...
2018/0099969 POLYMORPHS
The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
2018/0099968 COMPOUND, PREPARATION METHOD THEREOF AND ORGANIC LIGHT EMITTING DISPLAY DEVICE
The present disclosure relates to the field of technology of an OLED material and a device having the same, and particularly to a compound, a preparation...
2018/0099967 FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS
The present invention relates to Fused Tricyclic Heterocyclic Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein...
2018/0099966 TRICYCLIC COMPOUND AND JAK INHIBITOR
Novel tricyclic compounds which have JAK inhibitory activities are useful for prevention, treatment or improvement of autoimmune diseases, inflammatory...
2018/0099965 Diazabicyclooctane Compounds
The present invention relates to compounds according to Formula (II): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt or ester ...
2018/0099964 PYRAZOLE DERIVATIVE MANUFACTURING METHOD
The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided are a method for manufacturing a ...
2018/0099963 PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF
The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of...
2018/0099962 NAPHTHYRIDINE COMPOUNDS, MEDICAL COMBINATIONS AND USE THEREOF
This invention involves the field of biomedicine, and reveals naphthyridine compounds, medical combinations and use thereof. The naphthyridine compounds has...
2018/0099961 PROTEIN KINASE INHIBITORS
The present invention concerns novel deuterated and non-deuterated cyclic chemical compounds and their corresponding salts thereof active on protein kinases in...
2018/0099960 PROTEIN KINASE INHIBITORS
The present invention concerns novel deuterated and non-deuterated cyclic chemical compounds and their corresponding salts thereof active on protein kinases in...
2018/0099959 PROTEIN KINASE INHIBITORS
The present invention concerns novel deuterated and non-deuterated cyclic chemical compounds and their corresponding salts thereof active on protein kinases in...
2018/0099958 PESTICIDAL COMPOSITIONS AND METHODS
This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce...
2018/0099957 ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds of Formula I, ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
2018/0099956 Cognition Enhancing Compounds and Compositions, Methods of Making, and Methods of Treating
The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among...
2018/0099955 PRODRUG OF 1,1'-(1,6-DIOXO-1,6-HEXANEDIYL)BIS-D-PROLINE
The present invention relates to the compound (2R,2'R)-bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate),...
2018/0099954 NOVEL KAPPA OPIOID LIGANDS
The invention provides novel ligands of Kappa (.kappa.) opioid receptors, such as can be used to modulate a Kappa opioid receptor. Methods of synthesis and...
2018/0099953 BENZOFURANS SUBSTITUTED WITH SECONDARY BENZAMIDE AS HCV INHIBITORS
Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
2018/0099952 HEPATITIS B VIRAL ASSEMBLY EFFECTORS
Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described...
2018/0099951 METHODS OF TREATING INFLAMMATION OR NEUROPATHIC PAIN
Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
2018/0099950 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITOR
The present invention relates to a compound of formula (I): ##STR00001## The compound has apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and is...
2018/0099949 PYRROLIDINE GPR40 MODULATORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a...
2018/0099948 CRYSTALLINE SALTS OF (S)-6-((1-ACETYLPIPERIDIN-4-YL)AMINO)-N-(3-(3,4-DIHYDROISOQUINOLIN-2(1H)-- ...
Disclosed are novel crystalline salts of (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-- yl)-2-hydroxypropyl)pyrimidine-4-carboxamide...
2018/0099947 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES
Compounds of the formula I ##STR00001## in which W, R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5,...
2018/0099946 Quinazoline Derivatives as VEGF Inhibitors
The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R.sup.1 represents halogeno or C.sub.1-3alkyl; X.sup.1...
2018/0099945 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2018/0099944 CRYSTAL FORMS OF IMMUNOMODULATORY DRUG POMALIDOMIDE AND CO-CRYSTAL WITH GENTISIC ACID
The present invention relates to novel solid crystal forms of Pomalidomide named Form B, Form M, Pomalidomide:Gentisic acid co-crystal and their preparation....
2018/0099943 Catalytic Enantioselective Synthesis of 2-Aryl Chromenes and Related Phosphoramidite Ligands and Catalyst Compounds
Methods to access 2-aryl chromene compounds via an asymmetric catalytic process.
2018/0099942 METHOD FOR MANUFACTURING FURAN-2,5-DICARBOXYLIC ACID (FDCA) FROM A SOLID SALT
A method for manufacturing furan-2,5-dicarboxylic acid (FDCA) by converting a furan-2,5-dicarboxylate salt (MFDC) into furan-2,5-dicarboxylic acid (FDCA),...
2018/0099941 HIGH-PRESSURE REACTOR FOR THE SYNTHESIS OF MELAMINE
Reactor for the synthesis of melamine from urea, in accordance with the high-pressure non-catalytic process, comprising: a vertical reactor body (1), at least...
2018/0099940 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure...
2018/0099939 COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION AND INDICATIONS THEREFOR
Disclosed are compounds of Formula I(a): ##STR00001## or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof,...
2018/0099938 PROCESS FOR THE PREPARATION OF ANDROGEN RECEPTOR ANTAGONISTS AND INTERMEDIATES THEREOF
The present invention relates to an improved process for the preparation of carboxamide structured androgen receptor (AR) antagonists such as ...
2018/0099937 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS
The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory...
2018/0099936 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which...
2018/0099935 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES
Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0099934 PSMA-TARGETED NIR DYES AND THEIR USES
The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method...
2018/0099933 Compound and analogues for tracing histone acetylation inhibitors PET imaging for diagnosis and treatment of tumors
The present invention relates to a group of compounds for nuclear medicine imaging through F-18 labeled histone acetylation inhibitors (HDACi) of indole or...
2018/0099932 Substituted Pyrrolidines and Methods of Use
The invention discloses compounds of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.2A, R.sup.3, R.sup.3A, R.sup.4, and R.sup.5 are as defined herein....
2018/0099931 Substituted Pyrrolidines and Methods of Use
The invention discloses compounds of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.2A, R.sup.3, R.sup.3A, R.sup.4, R.sup.4A, and R.sup.5 are as...
2018/0099930 METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETIDINONE COMPOUND
Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the...
2018/0099929 PRODUCTION OF TERT-BUTYL HYDROPEROXIDE SOLUTION AND PROCESS TO FORM PRODUCTS THEREFROM
A process for forming a concentrated solution, including distilling in a distillation zone comprised of 10 or more theoretical distillation stages, at a...
2018/0099928 SULFONIUM COMPOUND, RESIST COMPOSITION, AND PATTERN FORMING PROCESS
A sulfonium compound having formula (1) is provided wherein R.sup.1, R.sup.2 and R.sup.3 are a C.sub.1-C.sub.20 monovalent hydrocarbon group which may contain...
2018/0099927 UV-ABSORBING COMPOUNDS WITH AT LEAST ONE REACTIVE HYDROGEN
UV-absorbing compounds are provided that have at least one reactive hydrogen. These compounds have structures: ##STR00001## wherein the generic notations have...
2018/0099926 METHOD AND SYSTEM FOR THE INTEGRATED PRODUCTION OF UREA AND MELAMINE
Disclosed is an integrated process for the production of urea and melamine, as well as a system for carrying out the process. The invention thereby pertains to...
2018/0099925 AMMOXIDATION CATALYST WITH SELECTIVE CO-PRODUCT HCN PRODUCTION
A catalytic composition and process useful for the conversion of an olefin selected from the group consisting of propylene, isobutylene or mixtures thereof, to...
2018/0099924 METABOLITES OF (1R-TRANS)-N-[[2-(2,3-DIHYDRO-4-BENZOFURANYL)CYCLOPROPYL]METHYL]PROPANAMI- DE
Isolated metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]-methyl]propanam- ide, methods for their use, and compositions containing the...
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