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Patent # Description
2018/0105515 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS
This invention is directed to compounds, which are useful as protein kinase (PK) inhibitors and can be used to treat such diseases as cancer, blood vessel...
2018/0105514 HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS
Disclosed are compounds having the formula: ##STR00001## wherein q, r, s, A, B, C, R.sup.A1, R.sup.A2, R.sup.B1, R.sup.B2, R.sup.C1, R.sup.C2, R.sup.3,...
2018/0105513 PYRAZOLE COMPOUNDS OR SALTS THEREOF, PREPARATION METHODS THEREFOR, HERBICIDAL COMPOSITIONS AND USE THEREOF
The present invention relates to the technical field of pesticides, particularly relates to a pyrazole compound or a salt thereof, a preparation method...
2018/0105512 SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES
The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, characterized by a...
2018/0105511 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES
The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its...
2018/0105510 SALT AND CRYSTALLINE FORMS THEREOF OF A DRUG
A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events...
2018/0105509 AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS
The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by...
2018/0105508 INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF
The present invention provides compounds pounds of Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
2018/0105507 ANTIIFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES ABD 2-OXOTHIOPHENES COMPOUNDS
A compound of formula (I) ##STR00001## wherein X is O, C.dbd.O or S; Y is N or CH; R.sub.2 and R.sub.4 are each independently H, --(CH.sub.2).sub.pCOOH, ...
2018/0105506 TOCOPHEROL AND TOCOPHERYL QUINONE DERIVATIVES AS CORRECTORS OF LYSOSOMAL STORAGE DISORDERS
The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some...
2018/0105505 GLUTATHIONE-CLEAVABLE PRODRUG AND METHODS OF USE THEREOF
A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can...
2018/0105504 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
The invention provides a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the variables X, Y.sup.1-Y.sup.5, R.sup.1,...
2018/0105503 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, X, R.sup.4, R.sup.5, and R.sup.6 are as ...
2018/0105502 PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY
The present application provides a one-pot catalytic process which involves the formation of 1,4-dibenzodiazepines from o-haloaldimines (either pre-formed or...
2018/0105501 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein A, Z, R.sup.1 R.sup.2, R.sup.3 and m are...
2018/0105500 NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF
The present invention provides novel inhibitors of TAK1 and methods of using such compounds to treat various diseases.
2018/0105499 PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL)AMINO-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ...
An alkyl ester of 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butyric acid, such as ethyl ...
2018/0105498 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
Methods and compounds useful for reducing, treating, preventing, or sustaining the reduction of a metabolic disease or disorder are provided herein. Also...
2018/0105497 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2018/0105496 PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS
The invention relates to compounds of formula (I) ##STR00001## wherein X, Y, R.sup.1, R.sup.2, (R.sup.4).sub.n, and (R.sup.5).sub.m are as defined in the...
2018/0105495 AZO-QUATERNARY PYRIDINIUM SALTS WITH ACID-ENHANCED ANTIBACTERIAL EFFICACY, METHODS OF USE, METHODS OF...
A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH=5); in neutral or basic conditions, this new Azo-QPS...
2018/0105494 N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL...
The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a...
2018/0105493 CATIONIC LIPID
The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of...
2018/0105492 COMPOUNDS DERIVED FROM 3-ALKYLAMINE-1H-INDOLYL ACRYLATE AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE...
The invention relates to the methods for producing derivatives of 3-alkylamino-1H-indole acrylate (I) with transcription factor Nrf2-inducing activity, free...
2018/0105491 PHARMACEUTICAL COMPOUNDS
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor or M.sub.1 and M.sub.4 receptors and which are useful in the treatment...
2018/0105490 PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES
Disclosed is a process for preparing unsaturated malonates and/or their isomers. The process includes the step of reacting an aldehyde and a dialkyl malonate...
2018/0105489 Separation Method and Method for Producing Isocyanate
Disclosed is a method for separating, with a multi-stage distillation column, a mixture containing an active hydrogen-containing compound (A) and a compound...
2018/0105488 CYANATE ESTER COMPOUND, CURABLE RESIN COMPOSITION CONTAINING THE COMPOUND, AND HARDENED PRODUCT THEREOF
The present invention provides a novel cyanate ester compound which has excellent solvent solubility and from which a hardened product having a low...
2018/0105487 PROCESS FOR THE PREPARATION OF LOMITAPIDE
The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels...
2018/0105486 PROCESS FOR MAKING MIXTURES OF CHELATING AGENTS
Process for making a chelating agent according to the general formula (I), R.sup.1--CH(COOX.sup.1)--N(CH2COOX.sup.1).sub.2 wherein R.sup.1 is selected from...
2018/0105485 CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
Cyclic vinylogous amides of Formula I are disclosed ##STR00001## The compounds are useful for treating diseases that arise from inappropriate activity of...
2018/0105484 Polyol Esters of Metathesized Fatty Acids and Uses Thereof
Polyol esters of metathesized fatty acids are generally disclosed herein. Methods of using such compounds, for example, as cleaning agents, solvents, and...
2018/0105483 METHOD FOR PRODUCING (METH)ACRYLATE
A method for producing a (meth) acrylate comprises transesterification reaction of an alcohol and a monofunctional (meth) acrylate with catalysts in...
2018/0105482 SMALL MOLECULE INHIBITORS OF TRPA1
The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can...
2018/0105481 BIO-BASED METHACRYLIC ACID AND OTHER ALKENOIC-DERIVED MONOMERS VIA CATALYTIC DECARBOXYLATION
A novel method for the catalytic selective decarboxylation of a starting material to produce an organic acid is disclosed. According to at least one...
2018/0105480 METHODS FOR PRODUCTION OF AROMATIC DICARBOXYLIC ACIDS AND DERIVATIVES THEREOF
Provided are methods for the production of isophthalic acid (IP A) and derivatives thereof. The methods are based on the addition of beta propiolactone to...
2018/0105479 PROCESS FOR PREPARING 1,3-BUTADIENE FROM N-BUTENES BY OXIDATIVE DEHYDROGENATION
The invention relates to a process for producing butadiene from n-butenes which comprises the steps of: A) providing a vaporous n-butenes-comprising input gas...
2018/0105478 Process for Reducing the Light Oligomer Content of Polypropylene Oils
Disclosed herein are catalyst systems containing an alpha-diimine nickel halide complex, a chemically-treated solid oxide, and an optional co-catalyst. These...
2018/0105477 A METHOD FOR PREPARING OPTICALLY ACTIVE CARBONYL COMPOUND
The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine...
2018/0105476 COMPOST BIN
A compost bin module for aerobic decomposition of organic matter. The module is in the form of a container comprising a free-standing portable structural frame...
2018/0105475 NUTRIENT SYSTEM
An alternative salt nutrient mixture for plant growth, wherein one or more of the following nutrients is present as a carbonate: nitrogen (eg ammonium),...
2018/0105474 High Value Organic Containing Fertilizers and Methods of Manufacture
The invention is directed to manufacturing fertilizers having commercial levels of nitrogen reacted with organic substances. The process comprises treatment of...
2018/0105473 High temperature and bright red ink-jet ink for ceramic decoration, its preparation method and application thereof
The present invention provides a high temperature and bright red ink-jet ink for ceramic decoration, its preparation method and application thereof. On the...
2018/0105472 AEROGEL COMPOSITE AND PREPARATION METHOD THEREOF
The present invention relates to an aerogel composite and a preparation method thereof. The preparation method of the aerogel composite of the present...
2018/0105471 CERAMIC MATRIX COMPOSITE REINFORCED MATERIAL
A CMC article may include a CMC substrate defining a major surface and a plurality of CMC reinforcing pins at least partially embedded in the CMC substrate....
2018/0105470 BONDED ZIRCONIA REFRACTORIES AND METHODS FOR MAKING THE SAME
Disclosed herein are methods for making a bonded refractory material, the methods comprising preparing a slurry comprising glass precursor particles having an...
2018/0105469 CERMET BODY
A cermet body, including a ceramic portion and a plurality of high magnetic permeability magnetic metallic particles distributed throughout the ceramic...
2018/0105468 CERMET MATERIAL
A cermet material, including a plurality of ceramic particles defining a ceramic portion; and a plurality of high magnetic permeability metallic particles...
2018/0105467 REFRACTORY ARTICLES AND METHODS FOR FORMING SAME
A refractory article can include a body including a content of alumina of at least 60 wt %, a content of silica of not greater than 20 wt %, a content of...
2018/0105466 CONSTRUCTION CHEMICAL FORMULATION
The present invention relates to a quick and low-stress setting chemical formulation for construction, containing at least one binding agent on the basis of...
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