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Patent # Description
2018/0110875 ANTI-C-MET ANTIBODY AND ANTI-C-MET ANTIBODY-CYTOTOXIC DRUG CONJUGATE AND PHARMACEUTICAL USE THEREOF
Provided are an anti-c-Met antibody or an antigen binding fragment thereof, and an anti-c-Met antibody-cytotoxic drug conjugate, wherein the antibody or...
2018/0110874 Compounds and Compositions for Immunotherapy
The present invention relates to compounds for targeted immunotherapy, as well as compositions comprising the same. Further, the present invention relates to...
2018/0110873 ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
A compound capable of inhibiting cell proliferation, having a structure according to formula (I) ##STR00001## wherein the variables in formula (I) are as defined...
2018/0110872 MULTI-ARM LINKERS FOR CONSTRUCTING PHARMACEUTICAL MOLECULES
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using...
2018/0110871 DUAL DISULFIDE DRUG CONJUGATES
The invention described herein pertains to dual disulfide drug conjugates. In particular, the invention described herein pertains to dual disulfide drug...
2018/0110870 ExPEC glycoconjugate vaccine formulations
Compositions and methods for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) are described. In particular, multivalent...
2018/0110869 BIOCONJUGATE MOLECULES WITH BIOLOGICAL AND TECHNO-FUNCTIONAL ACTIVITY, METHOD FOR THE PRODUCTION THEREOF AND...
The present invention regards the synthesis of bioconjugated molecules, formed between two or more of the following functional groups: sugars, prebiotics,...
2018/0110868 REACTIVE AND SORBENT MATERIALS
Reactive and sorbent materials including a non-encapsulated crosslinked biological material immobilized on a support matrix that includes a polyamine and at...
2018/0110867 CONJUGATE OF POLYETHYLENE GLYCOL AND ANESTHETIC, AND PREPARATION METHOD THEREOF
A conjugate represented by general formula (I), wherein R.sub.0 is a C.sub.1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium...
2018/0110866 POLYMERIC ANTIBIOTICS
The disclosure provides, inter alia, polymeric antibiotic compounds such as modified chitosans and methods of use thereof.
2018/0110865 POLYMER SYSTEMS AND THEIR APPLICATIONS IN DIAGNOSTICS AND DRUG DELIVERY
The present invention provides a biodegradable "precision polymer system" (poly system) and methods for preparing pharmaceutically effective "precision polymer...
2018/0110864 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF OCULAR DISORDERS
The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and...
2018/0110863 GLUCOSE-RESPONSIVE INSULIN CONJUGATES
Insulin conjugates comprising an insulin analog molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached...
2018/0110862 ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF
Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target...
2018/0110861 Curcumin Conjugates and Methods of Use Thereof
Curcumin-based conjugates and methods of use thereof are provided. Pharmaceutical compositions including an effective amount of one or more curcumin conjugates...
2018/0110860 IMMUNE CONJUGATE HAVING DENDRON CONJUGATED TO ANTIBODY AND USE THEREOF
An immune conjugate according to the present invention provides a pharmaceutical composition, which can be used in the target-oriented drug treatment by...
2018/0110859 METHOD FOR BOWEL PREPARATION
The present invention provides methods for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic, surgical or therapeutic...
2018/0110858 Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment
Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl...
2018/0110857 FLAVOR MODIFYING COMPOSITION, USES THEREOF AND PRODUCTS COMPRISING THE SAME
Provided is a flavor modifying composition including a blend of a water soluble filler including plant fibers; and at least one sucrose substitute of natural...
2018/0110856 Pharmaceutical Formulations and Methods of Making the Same
The invention relates to the formulation of pharmaceutical compositions of etanercept. The invention also relates to methods of removing buffer and of...
2018/0110855 NEUTRALIZING ANTI-TL1A MONOCLONAL ANTIBODIES
Described herein are methods and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), Crohn's Disease (CD), ulcerative colitis...
2018/0110854 METHODS FOR TREATING JUVENILE IDIOPATHIC ARTHRITIS
The invention provides methods and compositions for the treatment of juvenile idiopathic arthritis (JIA) where a TNF.alpha. inhibitor, such as a human...
2018/0110853 Vaccine Adjuvant
A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also...
2018/0110852 RECOMBINANT VECTORS EXPRESSING ANTIGENS OF AVIAN INFLUENZA VIRUS AND USES THEREOF
The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral...
2018/0110851 FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPs)
The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus...
2018/0110850 IMMUNOGENIC RSV POLYPEPTIDES
This invention provides immunogenic compositions comprising an immune stimulant and an respiratory syncytial virus (RSV) oligopeptide or an unglycosylated RSV...
2018/0110849 METHODS FOR IMMUNIZING AGAINST CLOSTRIDIUM DIFFICILE
The disclosure relates to generally to the field of therapeutic and/or protective vaccination against Clostridium dificile (C. difficile). More specifically,...
2018/0110848 MEASLES VIRUS ENCODING A TUMOR ANTIGEN
The present invention relates to a recombinant virus of the family Paramyxoviridae comprising an expressible polynucleotide encoding at least one of (i) a...
2018/0110847 Immunotherapy of Cancer by Induction of Immunologically-Mediated Selective Killing of Tumor Vasculature Using...
Disclosed are methods, protocols, and compositions of matter useful for treatment of cancer by elicitation of immunity towards tumor blood vessels. In one...
2018/0110846 IL-23-P19 VACCINES
Disclosed is a vaccine, preferably for use in the prevention or treatment of an interleukin 23 (IL-23) related disease, comprising a peptide bound to a...
2018/0110845 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS
A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response...
2018/0110844 C1-INH COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF DISORDERS ASSOCIATED WITH C1 ESTERASE...
Compositions and methods for the treatment and/or prevention of disorders associated with C1 esterase inhibitor deficiency are disclosed.
2018/0110842 COMPOSITIONS COMPRISING ADAMTS13 FOR USE IN METHODS FOR THE RECANALIZATION OF OCCLUDED BLOOD VESSELS IN AN...
Provided herein are methods for recanalization of occluded blood vessels in a subject having an infarction. The method includes a step of administering to the...
2018/0110841 GLUCOSE-RESPONSIVE INSULIN DELIVERY SYSTEM USING HYPOXIA-SENSITIVE NANOCOMPOSITES
A closed-loop insulin delivery system is described. More particularly, the presently disclosed insulin delivery system can comprise glucose-responsive vesicles...
2018/0110840 USE OF OVOTRANSFERRIN TO PROMOTE BONE HEALTH
Described herein is the use of ovotransferrin to promote bone health. It has been discovered that we found that ovotransferrin can promote cell proliferation...
2018/0110839 Blood Plasma Fractions as a Treatment for Aging-Associated Cognitive Disorders
Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include fractions derived...
2018/0110838 NOVEL USE OF VON WILLEBRAND FACTOR
The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with...
2018/0110837 METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION
The technology described herein is directed to methods and assay related to macrophage differentiation and the role of such in pathogenesis.
2018/0110836 COMPOSITIONS COMPRISING ANAKINRA
The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the...
2018/0110835 COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING OR PREVENTING CANCER METASTASIS, AND METHODS USING SAME
The invention includes a method of preventing or treating metastasis in a subject diagnosed with prostate cancer. In certain embodiments, the metastasis...
2018/0110834 METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS AND PREDICTION OF CLINICAL SENSITIVITY TO TREATMENT OF...
Provided herein are methods of using 7a-hydroxy-4-cholsten-3-one (C4) in predicting the clinical sensitivity to treatment of bile acid-related and associated...
2018/0110833 NERVE GROWTH FACTOR COMPOSITION AND POWDER INJECTION
The present invention discloses a nerve growth factor composition and an injection powder comprising a nerve growth factor, a stabilizer, a supporting agent, a...
2018/0110832 CLEC11A IS A BONE GROWTH AGENT
The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while...
2018/0110831 CD 47 CONTAINING POROUS NANOPARTICLE SUPPORTED LIPID BILAYERS (PROTOCELLS) FIELD OF THE INVENTION
The present invention is directed to protocells, which have a core and a lipid bilayer surrounding the core, with at least one CD47 molecule or an active...
2018/0110830 THERAPEUTIC MODULATION OF SKIN IMMUNE SYSTEM WITH GAL-7
This invention provides methods of modulating immune responses in the skin. The invention further provides methods of treatment for psoriasis, epidermal and...
2018/0110829 TAFA4 COMPOUNDS AND USES THEREOF FOR TREATING PAIN
The present invention relates to a method of using a TAFA4 protein or an agonist thereof for preventing, alleviating or treating pain in a subject. In one...
2018/0110828 USE OF CD24 FOR LOWERING LOW-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS
The present invention relates to the use of a CD24 protein for lowering low-density lipoprotein cholesterol levels, treating and preventing atherosclerosis,...
2018/0110827 METHOD AND KIT FOR BOWEL PREPARATION
The present invention provides methods and taste-modifying kits for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic,...
2018/0110826 THERAPEUTIC COMPOSITIONS FOR NEUTRALIZING TYPE I INTERFERONS, AND METHODS OF USE
The inventions describe here cover therapeutic compositions, and methods of use, for neutralizing Type I interferons in a mammal. The compositions contain a...
2018/0110825 NOVEL ENTERIC COMBINATION THERAPY
There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel...
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