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Patent # Description
2018/0110774 COMPOSITIONS AND METHODS FOR TREATMENT OF PULMONARY HYPERTENSION
Methods and composition for treating or preventing pulmonary hypertension are provided. In certain aspects, compounds that inhibit T.sub.H17 cell maturation or...
2018/0110773 Polymorphic Forms of Naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
2018/0110772 THERAPY FOR METASTATIC UROTHELIAL CANCER WITH THE ANTIBODY-DRUG CONJUGATE, SACITUZUMAB GOVITECAN (IMMU-132)
The present invention relates to therapeutic ADCs comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. The ADC may be...
2018/0110771 Liposomal Irinotecan Preparations
Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can...
2018/0110770 FERROPTOSIS AND GLUTAMINOLYSIS INHIBITORS AND METHODS OF TREATMENT
The present invention is directed to ferroptosis and glutaminolysis inhibitors and to methods of treatment or prevention of an organ injury caused by...
2018/0110769 Cabozantinib Salts And Their Use As Anti-Cancer Agents
The present invention relates to crystalline forms of cabozantinib succinate (Form A) and cabozantinib acetate (Form A-1) and to pharmaceutical compositions...
2018/0110768 METHODS AND COMPOSITIONS FOR REDUCTION OF SIDE EFFECTS OF THERAPEUTIC TREATMENTS
The invention provides compositions and methods utilizing a nicotinic receptor modulator, e.g., to reduce or eliminate a side effect associated with...
2018/0110767 NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ATTENTION DEFICIT DISORDER AND 22Q...
This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities...
2018/0110766 SELECTIVE NR2B ANTAGONISTS
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
2018/0110765 METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment...
2018/0110764 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
2018/0110763 PHARMACEUTICAL FORMULATIONS
This invention relates to pharmaceutical formulations comprising 1-(2-thien-2'-yl-2-oxo-ethyl)-3-(methanesulfonyl hydrazine carbonyl) pyridinium, its...
2018/0110762 Compositions Methods for Treating Chronic Kidney Disease
This invention relates to the treatment of chronic kidney disease, including diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), nephrotic...
2018/0110761 METHOD OF TREATMENT WITH TRADIPITANT
This application relates to a method of treatment with tradipitant, and more particularly, to a method of treatment pruritus with tradipitant.
2018/0110760 COMPOSITIONS AND METHODS FOR THE TREATMENTOF NEURODEGENERATIVE AND OTHER DISEASES
In one embodiment, the present application discloses methods of treating diseases and disorders with sulfasalazine, an ABCG2 inhibitor and pharmaceutical...
2018/0110759 EXTERNAL MEDICINE FOR DIFFUSE PLEXIFORM NEUROFIBROMA
An external medicine for diffuse plexiform neurofibromas is provided. The external medicine for diffuse plexiform neurofibromas in accordance with an...
2018/0110758 COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE
Pharmaceutical compositions of (R)-pramipexole and one or more secondary therapeutic agents such as, for example, dopamine agonists, dopaminergic agonists,...
2018/0110757 METHODS OF TREATING PRURITIS AND PAIN
The present disclosure provides compositions and methods for treating pruritis and for treating certain types of pain.
2018/0110755 BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY
A compound of formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compound. The compound is useful in...
2018/0110754 CENICRIVIROC FOR THE TREATMENT OF FIBROSIS
The disclosure includes the use of cenicriviroc or a salt or solvate thereof and pharmaceutical compositions containing the same in the treatment of...
2018/0110753 SUPPOSITORIES COMPRISING CANNABINOIDS
This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal...
2018/0110752 HIGHLY WATER-SOLUBLE SALTS OF A SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKER AND USES THEREOF
The present invention includes surprisingly water-soluble salts of a phenylalkylamine compound that are potent antagonists of L-type calcium channels. Aqueous...
2018/0110751 COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS
The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and...
2018/0110750 HYDROXYCITRIC ACID COMPOUNDS AND CAPSULE LIQUID DELIVERY
A capsule oral delivery system is disclosed. The system includes an outer capsule completely enclosing an inner content, or a hard shell comprised of...
2018/0110749 USE OF A COMPOSITION COMPRISING FISH OIL AND JUICE FOR THE TREATMENT AND/OR POST TREATMENT OF CANCER
Disclosed is a composition including a fish oil and a juice in an oil-in-water emulsion for use in treatment and post-treatment of cancer.
2018/0110748 COMPOSITION FOR REDUCING OR SUPPRESSING INCREASE IN NEUTRAL FAT LEVEL CONTAINING N-3 UNSATURATED FATTY ACID,...
A composition which can efficiently obtain an effect of decreasing or suppressing an increase in the neutral fat level is provided. Docosahexaenoic acid (DHA)...
2018/0110747 USE OF THIA OXO COMPOUNDS FOR LOWERING APO C3
Methods are disclosed to reduce apolipoprotein C-III (apoC-III) mRNA or protein in a subject in need thereof, comprising administering a pharmaceutically...
2018/0110746 SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING
The present invention is drawn to therapeutics and methods of inhibiting signaling by TLR2. The invention provides a method of treating an inflammatory disease...
2018/0110745 COMPOSITIONS AND METHODS OF USE OF BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB) AND PROBIOTICS
The present invention provides a composition comprising HMB and at least one probiotic. Methods of administering HMB and at least one probiotic to an animal...
2018/0110744 DISULFIRAM AND METAL SALT STAGGERED ORAL DOSING REGIMEN AND STAGGERED-RELEASE ORAL UNIT DOSAGE FORMS
This application relates to methods and compositions for the administration of disulfiram (DSF) and heavy metals zinc and copper for the treatment and...
2018/0110743 COMPOSITIONS AND METHODS FOR TREATING HEPATOCELLULAR CARCINOMA
Provided herein are compositions and methods for treating, ameliorating, or preventing hepatocellular carcinoma in patients. In particular, the invention...
2018/0110742 NMDA ANTAGONISTS FOR THE TREATMENT OF MENTAL DISORDERS WITH OCCURRENCE OF AGGRESSIVE AND/OR IMPULSIVE BEHAVIOR
Disclosed is the use of N-Methyl-D-aspartate (NMDA) antagonists at sub-anesthetic doses for the treatment of motor dysfunction in mental or psychiatric...
2018/0110741 ASTAXANTHIN COMPOSITIONS (I)
The present invention relates to astaxanthin compositions for use in foodstuffs, food supplements or feedstuffs or as a medicament. ##STR00001## Astaxanthin...
2018/0110740 METHODS AND MATERIALS FOR TREATING ENDOMETRIOSIS
This document provides methods and materials for treating endometriosis. For example, methods and materials for using histone acetyl transferase inhibitors...
2018/0110739 Transdermal Delivery Systems
Disclosed are bupivacaine transdermal delivery systems, and related methods.
2018/0110738 DEVICE AND METHOD OF TREATING CONDITIONS ASSOCIATED WITH NEUROINFLAMMATION
Disclosed is a device and method for treating a neurodegenerative disease or condition associated with neuroinflammation induced by a leukotriene. The device...
2018/0110737 EXTENDED-RELEASE ORAL PHARMACEUTICAL COMPOSITION OF AMPHETAMINE
Extended-release oral pharmaceutical compositions of amphetamine, a pharmaceutically acceptable salt, enantiomer, or combination thereof are provided. The...
2018/0110736 Nozzle, Apparatus, and Method for Producing Microparticles
A nozzle includes a nozzle body having a fluid passageway to which extension tubes are communicated. Each extension tube includes an end having an outlet port....
2018/0110735 ANTIMICROBIAL ALGINATE-BASED MICROPARTICLES AND RELATED MATERIALS AND METHODS
Microparticles that include a charged polysaccharide (e.g., alginate) and an antimicrobial agent (e.g., chlorhexidine), along with related compositions and...
2018/0110734 PHARMACEUTICAL COMPOSITIONS COMPRISING LONAFARNIB AND RITONAVIR
Lonafarnib and ritonavir, or a pharmaceutically acceptable salt thereof, are used in combination to treat HDV infection. In one aspect, amorphous ...
2018/0110733 METHODS AND COMPOSITIONS FOR LOCALIZED AGENT DELIVERY
The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded ...
2018/0110732 ONE-STEP METHOD FOR PRODUCTION OF ULTRA-SMALL LIPID STRUCTURES
Ultra-small Lipid Structures (USLS) with an average mean particle diameter of less than 100 nm are made using a single step process by diluting a hydro-organic...
2018/0110731 HYDROGEL COMPOSITIONS AND DRUG DELIVERY SYSTEMS COMPRISING THE SAME
A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG)...
2018/0110730 CHEWING GUM COMPOSITION COMPRISING CANNABINOIDS AND OPIOID AGONISTS AND/OR ANTAGONISTS
A chewing gum composition comprising cannabinoids or derivatives thereof and at least one opioid and optionally an opioid antagonist is provided. The chewing...
2018/0110729 DIETARY SUPPLEMENT NON-FLUORIDE TOOTHPASTE AND METHODS OF MAKING AND USING THE SAME
Provided herein is a storage stable non-fluoride toothpaste composition enriched with a dietary supplement containing both oil soluble and water soluble...
2018/0110728 TOPICAL OPHTHALMIC FORMULATIONS OF ENDOTHELIN RECEPTOR ANTAGONISTS
The present invention relates to a topical ophthalmic formulation comprising at least one antagonist of the endothelin receptor, preferably selected from...
2018/0110727 CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase ("ATPase") modulator...
2018/0110726 COMPOSITIONS AND METHODS TO PROMOTE WOUND HEALING
The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1B) receptor...
2018/0110725 COMPOSITIONS, METHODS AND KITS FOR THE SAFE INHALED DELIVERY OF TARGETED OPIOIDS FOR THE TREATMENT OF PAIN AND...
A composition having one or more targeted opioids for administration by inhalation is provided. Targeted opioids include morphine, morphine sulfate, 6 mono...
2018/0110724 FILM DOSAGE FORM WITH MULTIMODAL AND PARTICLE SIZE DISTRIBUTIONS
Oral film dosage forms that provide improved solubilization and stabilization of an active ingredient in particle form include at least one primary...
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