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Patent # Description
2018/0112242 RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS
The present invention relates to a recombinant microorganism, to a method for producing alanine and to the use of the recombinant microorganism for the...
2018/0112241 EXTRACELLULAR PRODUCTION OF DESIGNER HYDROXYALKANOYLOXY ALKANOIC ACIDS WITH RECOMBINANT BACTERIA
The present invention relates to a host cell comprising an rhlA gene or an ortholog thereof that is capable of producing hydroxyalkanoyloxy alkanoic acid (HAA)...
2018/0112240 FUNGAL CELLS AND METHODS FOR PRODUCTION OF VERY LONG CHAIN FATTY ACID DERIVED PRODUCTS
The present invention generally relates to a genetically modified fungal cell capable of producing a very long, chain fatty acid (VLCFA) and/or a VLCFA...
2018/0112239 INDUCIBLE TRICHODERMA REESEI PROMOTERS
The invention relates to strains of Trichoderma reesei wherein the inducibility of the promoters of the cellulase genes is modified. The expression of...
2018/0112238 METHOD AND SYSTEM FOR TREATMENT OF MICROORGANISMS DURING PROPAGATION, CONDITIONING, FERMENTATION, AND...
What is disclosed is a method of reducing undesirable concentrations of microorganisms without the use of man-made antibiotics, comprising the steps of:...
2018/0112237 METHOD FOR PRODUCING ETHANOL AND ETHANOL PRODUCING SYSTEM
The invention relates to a method for producing ethanol comprising providing biomass, supplying yeast to the biomass, reducing the size of the biomass,...
2018/0112236 Microvesicles
A method of producing a population of differentiated cells comprising: a) inducing differentiation in a first population of cells by applying an inducer to...
2018/0112235 METHODS AND COMPOSITIONS FOR MODIFYING GENOMIC DNA
Compositions and methods concern the sequence modification of an endogenous genomic DNA region. Certain aspects relate to a method for site-specific sequence...
2018/0112234 METHODS AND COMPOSITIONS FOR GENE EDITING
Compositions and methods are provided for enhancing the efficiency of gene editing by timing the expression and activity of a nuclease to correspond with...
2018/0112233 BIO-PRODUCTION OF LENTIVIRAL VECTORS
The present disclosure provides a method of generating a stable producer cell line. The generation of stable producer cell lines, such as those provided in...
2018/0112232 SMAD7 GENE DELIVERY AS A THERAPEUTIC
Described herein are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing Smad7. The disclosed AAV vectors and rAAV can be...
2018/0112231 METHODS AND COMPOSITIONS FOR RESTORATION OF CONE FUNCTION IN BCM
Provided are nucleic acid sequences, recombinant adeno-associated viral particles, compositions, and methods related to treating cone monochromacies, such as...
2018/0112230 RHG1 MEDIATED RESISTANCE TO SOYBEAN CYST NEMATODE
Methods of increasing the resistance of plants, in particular soybeans, to nematodes, in particular soybean cyst nematodes, are provided herein. The methods...
2018/0112229 NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES CONFERRING IMPROVED NITROGEN USE EFFICIENCY CHARACTERISTICS...
Methods and materials for modulating low-nitrogen tolerance levels in plants are disclosed. For example, nucleic acids encoding low nitrogen ...
2018/0112228 ENVIRONMENTAL STRESS RESPONSE TRANSCRIPTIONAL REGULATORY NETWORK
This disclosure provides methods of downregulating or eliminating gene expression of one or more Dynamic Influencer of Gene expression (DIG) and/or one or more...
2018/0112227 OFF-AXIS COLLIMATION OPTICS
A light funnel collimator has a central lens surface and a back reflecting surface, shaped to provide a wider background beam and a narrower hotspot beam...
2018/0112226 METHODS OF MODULATING NUCLEIC ACID STABILITY AND PROTEIN EXPRESSION
A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been...
2018/0112225 CYANOBACTERIAL STRAINS CAPABLE OF UTILIZING PHOSPHITE
The invention provides genetically modified cyanobacterial cells that are capable of utilizing phosphite as a primary phosphorus source, and can out-compete...
2018/0112224 ENGINEERING OF MULTI-CARBON SUBSTRATE UTILIZATION PATHWAYS IN METHANOTROPHIC BACTERIA
The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glucose) as...
2018/0112223 RNA Interference-Based Therapeutic Against Anthrax
The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of...
2018/0112222 METHODS OF INDUCING INSULIN PRODUCTION
The present invention provides a method of inducing insulin production in a cell by up-regulating a target gene involved in insulin production in said cell...
2018/0112221 Engineered Nucleic Acids and Methods of Use Thereof
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such...
2018/0112220 GENE THERAPEUTIC FOR THE TREATMENT OF HIV AND USES THEREOF
The present disclosure provides for an expression vector comprising (i) at least one nucleic acid sequence encoding a transcriptional gene silencing element;...
2018/0112219 COMPOSITIONS COMPRISING TALENS AND METHODS OF TREATING HIV
Disclosed herein, are compositions and methods for the treatment of human immunodeficiency virus infection. The compositions comprise engineered transcription...
2018/0112218 Targeting Hepatitis B Virus (HBV) Host Factors
Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors...
2018/0112217 Stereospecific Phosphorothioate LNA
The present invention provides stereodefined phosphorothioate LNA oligonucleotide, comprising at least one stereodefined phosphorothioate linkage between a LNA...
2018/0112216 SEGMENTED MICRO RNA MIMETICS
This invention relates generally to segmented oligonucleotides capable of modulating gene expression. Specifically, the instant invention relates to segmented...
2018/0112215 NOVEL THERAPY
IRF-7 inhibitors have been found to be useful in the treatment of infections, such as bacterial infections. Suitable inhibitors include siRNA molecules as well...
2018/0112214 Treatment Of Genetic Disorders Associated With DNA Repeat Instability
The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene...
2018/0112213 CRISPR/CAS-RELATED METHODS, COMPOSITIONS AND COMPONENTS
CRISPR/Cas-related compositions and methods which provide for efficient gene editing of eukaryotic cells using modified gRNAs.
2018/0112212 PROTEOMIC ANALYSIS WITH NUCLEIC ACID IDENTIFIERS
The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes),...
2018/0112211 RNA Array Compositions and Methods
Described herein are RNA arrays, and compositions and methods for generating RNA arrays, particularly high density RNA arrays. The disclosed methods for...
2018/0112210 BROAD-SPECTRUM SEROLOGICAL DIAGNOSTICS AND USES THEREOF
In some embodiments, the present disclosure pertains to method of screening a biological sample for a plurality of diseases. In some embodiments, such a method...
2018/0112209 SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS
The present disclosure relates to systems and methods for nucleic acid isolation. In particular, the present disclosure provides systems and methods for...
2018/0112208 A METHOD FOR ISOLATING A NUCLEIC ACID FROM AN FFPE TISSUE
The present invention relates to a method for isolating a nucleic acid from a sample comprising a formalin-fixed, paraffin-embedded (FFPE) tissue fragment, a...
2018/0112207 DEVICE FOR MANIPULATING MAGNETIC PARTICLES AND METHOD FOR MANIPULATING MAGNETIC PARTICLES
A device for manipulating magnetic particles includes a gelled medium layer and liquid layers alternately stacked in a tubular container along a longitudinal...
2018/0112206 Methods and Compositions for Segregating Target Nucleic Acid From Mixed Nucleic Acid Samples
The invention provides methods, compositions and kits for segregating a target nucleic acid from a mixed nucleic acid sample. The methods, compositions and...
2018/0112205 IN VITRO METHOD FOR STEM CELL PROLIFERATION AND USE OF A DEVICE FOR INCREASING THE PROLIFERATION OF STEM CELLS...
In vitro method for stem cell proliferation and use of a device for increasing the proliferation of stem cells in vitro The invention relates to an in vitro method...
2018/0112204 AprL-CLADE PROTEASE VARIANTS AND USES THEREOF
The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and...
2018/0112203 AMYLASE WITH MALTOGENIC PROPERTIES
The present teachings provide an amylase with maltogenic properties. Nucleic acids encoding the maltogenic amylase and variants thereof, expression vectors,...
2018/0112202 PURIFICATION OF RECOMBINANT HUMAN GALACTOCEREBROSIDE B-GALACTOSIDASE (rhGALC)
The present invention relates to a process for purifying recombinant human Galactocerebroside .beta.-Galactosidase (rhGALC) from a cell culture, wherein a...
2018/0112201 MODIFIED DNASE AND USES THEREOF
Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits...
2018/0112200 COMPOSITIONS AND METHODS FOR GENERATING ANTIGENS, ANTIBODIES, AND IMMUNOTHERAPEUTIC COMPOSITIONS AND METHODS
In some aspects, the invention relates to compositions and methods of generating antigens, wherein the antigen is a biomolecule that is modified by a reactive...
2018/0112199 COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF
A composition comprising recombinant iduronate-2-sulfatase (IDS) and a method for producing a purified recombinant IDS are provided. The glycosylation pattern...
2018/0112198 TUMOR SUPPRESSION BY MCPIP1
The present disclosure relates to the identification of MCPIP1 as tumor suppressor. Methods of employing MCPIP1 to treat cancer are described.
2018/0112197 RECOMBINANT MICROORGANISM INCLUDING GENETIC MODIFICATION THAT INCREASES PYRUVATE, PHOSPHATE DIKINASE ACTIVITY...
Provided are a recombinant microorganism including a genetic modification that increases a pyruvate, phosphate dikinase activity, a method of producing...
2018/0112196 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2018/0112195 MUTANT POLYMERASES AND USES THEREOF
Provided are mutant polymerases having DNA polymerase activity and reverse transcriptase activity or strand displacement activity, along with target nucleic...
2018/0112194 MUTANT HUMAN DEOXYCYTIDINE KINASE
An isolated nucleic acid includes a sequence encoding a mutant human deoxycytidine kinase (hdCK) capable of converting prodrugs, such as a nucleoside analogue,...
2018/0112193 CSF1 THERAPEUTICS
The present invention relates to compositions of matter and methods of using the same in enhancing regeneration or restoring function of an injured liver. The...
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