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Patent # Description
2018/0111989 INHIBITORS OF NEUROLIGIN 4 - NEUREXIN 1-BETA PROTEIN-PROTEIN INTERACTION FOR TREATMENT OF LIVER DISORDERS
Provided is a method for treating, attenuating and/or preventing progression of a liver disorder in a subject, the method including administering a...
2018/0111988 PHARMACEUTICAL COMPOSITION FOR TREATING RHEUMATOID ARTHRITIS
An object of the present invention is to provide a pharmaceutical composition comprising an anti-fractalkine antibody, and a method for treating rheumatoid...
2018/0111987 MONOCLONAL ANTIBODY AND ANTIGENS FOR DIAGNOSING AND TREATING LUNG DISEASE AND INJURY
The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in...
2018/0111986 ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN
The invention relates to the treatment of bone disorders. In particular, the invention provides an approach involving administration of a high initial dose or...
2018/0111985 DKK1 ANTIBODIES AND METHODS OF USE
The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such...
2018/0111984 TREATING CLUSTER HEADACHE
Disclosed herein are methods of treating or reducing incidence of a cluster headache, e.g., chronic cluster headache and episodic cluster headache, and/or at...
2018/0111983 Treatment of Fibrodysplasia Ossificans Progressiva
Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided. Such methods involve administering to a subject having FOP an effective regime...
2018/0111982 METHODS, COMPOSITIONS AND APPARATUSES FOR FACILITATING REGENERATION
Apparatuses, compositions and methods for removing cells which interfere with regenerative processes. The apparatuses, compositions and methods selectively...
2018/0111981 Monoclonal Antibodies that Neutralize Anthrax Toxins
The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA)....
2018/0111980 Polypeptides Targeting HIV Fusion
The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations...
2018/0111979 COLLAGEN MIMETIC PEPTIDE
This disclosure relates to a novel Collagen Mimetic Peptide; a multi-arm conjugate comprising said peptide that mimics the higher order triple helical...
2018/0111978 POLYPEPTIDE COMPOSITIONS AND METHODS OF USING THE SAME
Disclosed herein are polypeptides comprising an amino acid sequence of {[VPGVG].sub.4IPGVG}.sub.n, wherein n is an integer greater than 1. The polypeptides can...
2018/0111977 RECOMBINANT SOLUBLE HUMAN TISSUE FACTOR, METHOD OF ITS PRODUCTION AND USES THEREOF
The present invention relates to a novel recombinant soluble human Tissue Factor(RshTF), which is an extrinsic hemostasis factor, produced in human HEK-cells....
2018/0111976 IDENTIFICATION OF IMMUNOGENIC MHC CLASS II PEPTIDES FOR IMMUNE-BASED THERAPY
The invention provides compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with...
2018/0111975 NUCLEASE-MEDIATED REGULATION OF GENE EXPRESSION
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
2018/0111974 METHODS OF PRODUCING LONG ACTING CTP-MODIFIED GROWTH HORMONE POLYPEPTIDES
Disclosed herein is a method for manufacturing a recombinant human growth hormone (h GH) modified by a CTP extension in a mammalian cells culture system.
2018/0111973 PURIFICATION OF BONE MORPHOGENETIC PROTEINS (BMPS)
The present invention relates to a method for purifying a protein belonging to the transforming growth factor-.beta. (TGF-.beta.) superfamily, said method...
2018/0111972 HYBRID CHIMERA POLYPEPTIDES AS DUAL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND...
Polypeptides comprising hybrid VEGF and PDGF sequences are provided. The polypeptides are useful in inhibition of angiogenesis and treatment of diseases...
2018/0111971 CYCLIC, AMYLOID BETA-BINDING PEPTIDES AND THE USE THEREOF.
A peptide comprising at least one peptide binding to an amyloid beta species, wherein the peptide includes an amino acid sequence that is present in cyclized...
2018/0111970 LONG UNIFORM RECOMBINANT PROTEIN FIBERS
The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides...
2018/0111969 A NUCLEIC ACID MOLECULE FOR CONFERRING INSECTICIDAL PROPERTIES IN PLANTS
The present invention is drawn to a nucleic acid sequence which confers expression of the insecticidal proteins mCry3A and eCry3.1Ab when introduced into a cell.
2018/0111968 CELL-DIRECTED SYNTHESIS OF MULTIFUNCTIONAL NANOPATTERNS AND NANOMATERIALS
Aspects of the invention relate to the engineering of biological nanostructures and materials.
2018/0111967 STRUCTURE BASED METHODS FOR MODIFICATION OF PIP-72 POLYPEPTIDES AND PIP-72 POLYPEPTIDES DERIVED THEREFROM
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2018/0111966 PR13.5 PROMOTER FOR ROBUST T-CELL AND ANTIBODY RESPONSES
The invention encompasses recombinant poxviruses, preferably modified Vaccinia Ankara (MVA) viruses, comprising a Pr13.5 promoter operably linked to a...
2018/0111965 CAPSID
There is described an AAV capsid protein having an amino acid sequence which has at least 98% identity to the sequence of SEQ ID NO: 3 or at least 94% identity...
2018/0111964 Fusion polypeptide for immuno-enhancement and method for enhancing stimulation of immune response using the same
A fusion polypeptide is disclosed, which includes: (a) a mucosa targeting polypeptide; (b) a translocating peptide for translocation; and (c) a antigenic...
2018/0111963 ANTI-MICROBIAL SUPRAMOLECULAR STRUCTURES
Supramolecular structures comprising noncovalently associated peptide amphiphiles and lipids are provided. In particular, provided herein are supramolecular...
2018/0111962 CALCIUM BINDING COMPOUNDS BASED ON GAMMA-CARBOXY GLUTAMATE
Compounds capable of binding calcium ions comprising a certain number of gamma-carboxy glutamate units have been found useful in treating and/or preventing...
2018/0111961 Purification method for divalent cation binding proteins by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange...
2018/0111960 METHODS FOR PREPARING DEOXYCHOLIC ACID
The present invention discloses method for preparing deoxycholic acid (DCA) or an ester thereof or a pharmaceutically acceptable salt thereof. Said compounds...
2018/0111959 COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS
Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme...
2018/0111958 METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS
Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein...
2018/0111957 POLYMETHINE COMPOUNDS WITH LONG STOKES SHIFTS AND THEIR USE AS FLUORESCENT LABELS
The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic...
2018/0111956 SYNTHESIS OF DESOSAMINES
The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of...
2018/0111955 THIOSACCHARIDE MUCOLYTIC AGENTS
There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including...
2018/0111953 METHOD FOR SYNTHESIS OF MONOCYCLOPENTADIENYL COMPLEXES OF ZIRCONIUM AND HAFNIUM
Catalyst systems and methods for making and using the same are disclosed. In an example, a method of synthesizing a monocyclopentadienyl compound is provided....
2018/0111952 COMPOUND AND ORGANIC PHOTOELECTRONIC DEVICE AND IMAGE SENSOR
A compound may be represented by Chemical Formula 1, an organic photoelectronic device may include a first electrode and a second electrode facing each other...
2018/0111951 ANTICANCER ACTIVITY OF GOLD(III) COMPLEXES OF MESO-1,2-DI(1-NAPHTHYL)-1,2-DIAMINOETHANE
A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl.sub.2]Cl.2H.sub.2O (1)...
2018/0111950 SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS
The present application relates to a substituted amino six-membered saturated heteroalicycle represented by formula I as a long-acting DPP-IV inhibitor, a...
2018/0111949 NOVEL INDUSTRIAL CRYSTALLIZATION METHOD OF CEFUROXIME SODIUM AND PREPARATION THEREOF
It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline...
2018/0111948 HERBICIDAL COMPOUNDS
The present invention relates to herbicidal benzyloxy-substituted phenyl diones and benzyloxy-substituted phenyl-di-oxo-thiazinone derivatives of formula (I),...
2018/0111947 Method for Producing Levoglucosenone
There is described a method of producing (-)-levoglucosenone, said method comprising, heating lignin to a temperature in excess of 150.degree. C. for a time...
2018/0111946 PROCESS FOR IMPROVED OPIOID SYNTHESIS
Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an...
2018/0111945 Chlorin e6 Derivative and Pharmaceutically Acceptable Salt Thereof and Process for Preparing and Use of the Same
Chlorin e6 derivatives and pharmaceutically acceptable salt thereof, as well as preparation and use thereof, which belongs to the medicine field. The chlorin...
2018/0111944 (R)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
(R)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and...
2018/0111943 NOVEL N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4- ,3-a]PYRAZINES AS SELECTIVE NK-3...
A method for treating and/or preventing polycystic ovary syndrome (PCOS) including the administration, to a patient in need thereof, of a pharmaceutically...
2018/0111942 FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
2018/0111941 BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
Compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of...
2018/0111940 IMIDAZOPYRAZINE DERIVED COMPOUNDS FOR ELECTRONIC DEVICES
The invention provides a composition comprising at least one compound of Formula 1 through Formula 8, each as described herein. These compounds, containing an...
2018/0111939 7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR...
A compound of the general formula (I) wherein Y represents --CH.sub.2-- or >C=0; R.sup.1 is selected from the group consisting of A1, A2 and A3; R.sup.2...
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