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Patent # Description
2018/0111938 Synthesis of Intermediates Used in the Manufacture of Anti-HIV Agents
The present invention relates to a process of preparing intermediates of Formula (I). The process comprises of reacting compound of Formula (III) with compound...
2018/0111937 TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF
Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: --(CR3R3)2-5-, --(CR3R3)x-Y--(CR3R3)y-, --Y--(CR3R3)2-3-Y--, ...
2018/0111936 SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS
Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) --(CR.sub.3R.sub.3).sub.1-4--; (ii) ...
2018/0111935 SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to spiro-isoquinoline-1,4'-piperidine compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor...
2018/0111934 HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0111933 FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
2018/0111932 NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## Wherein R.sup.1, R.sup.3-R.sup.6, X.sup.2...
2018/0111931 CHEMICAL COMPOUNDS
The specification relates to compounds of Formula (I): ##STR00001## and to pharmaceutically acceptable salts thereof, to processes and intermediates used for...
2018/0111930 COMPOSITIONS AND USES THEREOF
Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid ...
2018/0111929 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant...
2018/0111928 PHARMACEUTICAL SALT FORMS OF AN INHIBITOR OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO)
The mesylate and sulphate salts of (3S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylat- e mesylate, and hydrates...
2018/0111927 HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
The present invention relates to heterocyclic-imidazole derivatives, a preparation method therefor, and a medical use thereof, and particularly to new...
2018/0111926 NEW PYRIDOPYRIMIDINES DERIVATIVES COMPOUNDS
The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): ##STR00001## or pharmaceutically...
2018/0111925 3-ARYL-2H-PYRAZOLO[4,3-b]PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
2018/0111924 MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO
This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce...
2018/0111923 IRAK INHIBITORS AND METHOD FOR MAKING AND USING
Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such...
2018/0111922 DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE...
The invention provides dihydro-2H-benzo[b] [1,4]oxazine sulfonamide and related compounds, pharmaceutical compositions, methods of promoting ROR.gamma....
2018/0111921 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS
This invention is directed to compounds, which are useful as protein kinase (PK) inhibitors and can be used to treat such diseases as cancer, blood vessel...
2018/0111920 DEUTERATED VX-661
This invention relates to novel, deuterated forms of VX-661 and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising...
2018/0111919 NEW FYN KINASE INHIBITORS
The invention relates to new selective FYN kinase inhibitors of Formula (I), pharmaceutical compositions containing them, and their use for the pharmacological...
2018/0111918 DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical...
2018/0111917 AMIDE COMPOUNDS AND METHOD FOR MAKING AND USING
Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are...
2018/0111916 STK4 INHIBITORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES
The application relates to compounds of Formula (I'): ##STR00001## which modulate the activity of a kinase (e.g., STK4), a pharmaceutical composition comprising...
2018/0111915 Novel Polymorphic Form X of Nilotinib Dihydrochloride Hydrate
The present invention relates to a novel polymorph of nilotinib hydrochloride (Form X), to processes for its preparation, to pharmaceutical compositions...
2018/0111914 WATER-SOLUBLE PRODRUGS
The present invention provides compounds represented by formula (1A), or pharmaceutically acceptable salts. Compounds represented by formula (1A), or...
2018/0111913 SUBSTITUTED BENZOFURAN DERIVATIVES AS NOVEL ANTIMYCOBACTERIAL AGENTS
Novel bacterial inhibitors comprising benzofuran derivatives, and methods of bacterial inhibition using the inhibitors are disclosed. The inhibitors may...
2018/0111912 Maleinated Derivatives
This invention relates to malienated derivatives made from maleic anhydride, functionalized monomers, and one or more additional reagents, e.g., an...
2018/0111911 PREPARATION OF PANTOLACTONE
The present invention relates to a novel process for the preparation of pantolactone by reaction of hydroxypivalaldehyde cyanohydrin in a phase separation...
2018/0111910 PAIN-RELIEVING COMPOSITIONS AND USES THEREFOR
Compositions and methods are for inducing, promoting or otherwise facilitating pain relief. More particularly, sub-doses of nitric oxide donors are used in the...
2018/0111909 Purification of Flow Sodium 5- Nitrotetrazolate Solutions with Copper Modified Cation Exchange Resin
Described are methods for purifying a 5-nitrotetrazolate solution with a copper(II) modified cation exchange resin. The method can be performed as a...
2018/0111908 5-HT2B Antagonists
The invention provides novel compounds and compositions comprising a 5-HT.sub.2B antagonist of formula I: ##STR00001## and related methods for treating a person...
2018/0111907 DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER...
Sodium channel blockers represented by the formula: ##STR00001## are provided where the structural variables are defined herein. The invention also includes a...
2018/0111906 IMPROVED PROCESS FOR PREPARING A STATIN PRECURSOR
The present invention relates to a process comprising reacting p-fluorobenzaldehyde, 4-methyl-3-oxopentanenitrile and urea in a first reaction mixture...
2018/0111905 N2-(2-METHOXYPHENYL)PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR CANCER...
The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention...
2018/0111904 DIMERIC QUINACRINE DERIVATIVES AS AUTOPHAGY INHIBITORS FOR CANCER THERAPY
The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit...
2018/0111903 Crystalline Forms of Cabozantinib Phosphate And Cabozantinib Hydrochloride
The present invention relates to crystalline forms of cabozantinib phosphoric acid salt and cabozantinib hydrochloric acid salt and to a method for their...
2018/0111902 N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B
The present invention relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment...
2018/0111901 Novel Intermediates, their Process And Use In Preparation of Selective a1-Adrenoceptor Antagonists, Silodosin
The present invention provides novel process for the preparation of the .alpha.1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts...
2018/0111900 WATER SOLUBLE CHAIN TRANSFER AGENTS
The disclosed technology relates to water soluble, or partially water soluble, chain transfer agents for preparing water soluble polymers by Reversible...
2018/0111899 METHOD FOR MAKING METHIONINE
The invention concerns a continuous process for manufacturing methionine by alkaline hydrolysis of methionine hydantoin in aqueous phase, removing NH.sub.3 and...
2018/0111898 COMPOSITION, FLUORINATING REAGENT, AND METHOD FOR PRODUCING FLUORINATED ORGANIC COMPOUND
An object of the present invention is to provide a method for producing a fluorinated organic compound with a high yield without using carbon tetrachloride in...
2018/0111897 PROCESS FOR THE PREPARATION OF A SULFUR-AMINE
The present invention relates to a process for the synthesis of cysteamine or a salt thereof.
2018/0111896 INHIBITORS AND THEIR USES
The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by...
2018/0111895 Heterodimers of Glutamic Acid
Compounds of Formula (Ia) ##STR00001## wherein R is a C.sub.6-C.sub.12 substituted or unsubstituted aryl, a C.sub.6-C.sub.12 substituted or unsubstituted...
2018/0111894 Benzimidazole Inhibitors of the Sodium Channel
The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with...
2018/0111893 POLYCATIONIC AMPHIPHILES AND POLYMERS THEREOF AS ANTIMICROBIAL AGENTS AND METHODS USING SAME
The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes novel polymers...
2018/0111892 MATERIALS AND METHODS FOR THE SELECTIVE RECOVERY OF MULTIVALENT PRODUCTS
Described herein are processes and apparatus for the high purity and high concentration recovery of multivalent products via continuous ion exchange from...
2018/0111891 POLYMORPHIC FORMS OF SODIUM BENZOATE AND USES THEREOF
The present disclosure provides polymorphic forms of sodium benzoate with a X-ray diffraction pattern comprising characteristic peaks at a reflection angle...
2018/0111890 Process for the Preparation of Ethacrynic Acid
The invention provides an improved process for preparing Ethacrynic acid of formula I, including the steps of: (a) reacting 4-butyryl-2,3-dichloro-phenoxy...
2018/0111889 METHODS OF MAKING MULTICYCLIC COMPOUNDS USING MULTICOMPONENT/TANDEM REACTION SEQUENCES
Disclosed herein are embodiments of multicyclic compounds and methods of making such compounds. The disclosed methods reduce step-counts in the synthesis of...
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