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Patent # Description
2018/0119133 PROXIMITY BASED METHODS FOR SELECTION OF BINDING PARTNERS
The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods...
2018/0119131 METHOD OF RNA ISOLATION FROM CLINICAL SAMPLES
The disclosure provides methods for isolating nucleic acids from a biological fluid. In one aspect, the disclosure provides a method for isolating RNA. In...
2018/0119127 PROLINE-SPECIFIC ENDOPROTEASE AND USE THEREOF
The present invention relates to a polypeptide having proline-specific endoprotease activity, wherein the polypeptide has less than 70% residual activity when...
2018/0119125 CELLULASE COMPOSITIONS AND METHODS OF USING THE SAME FOR IMPROVED CONVERSIONOF LIGNOCELLULOSIC BIOMASS INTO...
The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having .beta.-glucosidase...
2018/0119123 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION AND AIDS
CRISPR/CAS-related systems, compositions and methods for editing CCR5 and/or CXCR4 genes in human cells are described, as are cells and compositions including...
2018/0119121 MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex...
2018/0119119 DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS BY BACTERIAL INJECTION OF TALEN PROTEINS
In some aspects, the disclosure relates to methods and compositions for delivery of proteins into mammalian cells. In some embodiments, the disclosure provides...
2018/0119118 DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)
Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are...
2018/0119116 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2018/0119115 RECOMBINANT DNA POLYMERASE FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
A composition comprising a recombinant DNA polymerase and 3'-esterified nucleotide analogues is provided. The recombinant DNA polymerase includes an amino acid...
2018/0119114 METHOD FOR OBTAINING A BIOMASS OF A MICROALGA OF THE SPECIES Tetraselmis chuii ENRICHED IN SUPEROXIDE DISMUTASE...
The invention relates to a method for enriching a biomass of a microalga of the species Tetraselmis chuii in superoxide dismutase (SOD) by placing said...
2018/0119113 SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon...
2018/0119111 ICP0-MEDIATED ENHANCED EXPRESSION SYSTEM
Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are...
2018/0119109 NOVEL LACTOBACILLUS PLANTARUM BACTERIOPHAGE LAC-PLP-1 AND USE THEREOF FOR INHIBITING LACTOBACILLUS PLANTARUM...
The present invention relates to a Siphoviridae bacteriophage Lac-PLP-1 that is isolated from the nature and can kill Lactobacillus plantarum cells...
2018/0119108 METHODS AND MATERIALS FOR OBTAINING INDUCED PLURIPOTENT STEM CELLS
This document provides methods and materials involved obtaining induced pluripotent stem (iPS) cells. For example, methods and materials for increasing the...
2018/0119107 METHODS TO PRESERVE TUMOR-STROMAL INTERACTIONS IN CULTURE AND THERAPEUTIC PREDICTIVE APPLICATIONS THEREOF
Functional in vitro assays are provided for determining patient specific responsiveness to immunotherapy agents within a clinically actionable time frame.
2018/0119106 3D-PRINTED SCAFFOLD DEVICE FOR CELL TRANSPLANTATION
Disclosed herein is a 3D-printed, biocompatible macroporous device that houses stem cell derived .beta.-cell (SC-.beta. cell) clusters within a degradable...
2018/0119104 GENERATING VASCULOGENIC CELL POPULATIONS
The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention...
2018/0119102 MODIFIED CELLS FOR PRODUCTION OF BLOOD CELLS
A genetically modified cell (e.g., stem cell) containing a complete or partial gene deletion of one or more genes of a blood group antigen (BGA) biosynthesis...
2018/0119101 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or...
2018/0119100 T-REG Cell Expansion
This invention relates to methods of expanding T regulatory cells through OX40L and Jagged-1 induced signaling. The methods can be used for treating autoimmune...
2018/0119099 COMPOSITIONS AND METHODS FOR DIMINISHING AN IMMUNE RESPONSE
The invention is based upon the discovery that T regulatory type 1 (Tr1) cells express particular cell surface markers that allow for their selection,...
2018/0119098 METHODS OF MAINTAINING, EXPANDING, AND DIFFERENTIATING NEURONAL SUBTYPE SPECIFIC PROGENITORS
Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are...
2018/0119096 CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF
The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or...
2018/0119094 Passive Replacement of Media
Embodiments described herein generally relate to passively replacing media in a closed cell expansion system to reduce or prevent the dilution of chemical...
2018/0119093 Method of Progenitor Cell Isolation From Different Organs by Natural Destruction of Extracellular Matrix
The present invention is directed to novel methods comprising the isolation of viable fetal progenitor cells from organs of aborted fetus. The invention...
2018/0119092 HYDROGEL PRECURSOR FORMULATION AND PRODUCTION PROCESS THEREOF
A hydrogel precursor formulation, its process of production as well as a kit comprising the formulation and a method of production of a hydrogel using the...
2018/0119088 METHOD FOR PREPARING MICROENCAPSULATED HEAT-SENSITIVE BIOACTIVE MATERIAL
Microparticles include a matrix of an encapsulating material, in which are dispersed particles of a low melting point fat and a bioactive material, such as one...
2018/0119086 METHOD AND APPARATUS FOR ATTACHING, DETECTING AND RETRIEVING A SINGLE CELL ON A SURFACE
The present disclosure relates to a method for attaching, detecting and retrieving a single cell on a manipulation medium comprising the steps of: attaching...
2018/0119083 Airlift Reactor Assembly with Helical Sieve Plate
The present invention discloses an airlift reactor assembly with a helical sieve plate, comprising a reaction tank, wherein a draft tube and a gas sparger are...
2018/0119081 Microfluidic Device Having Offset, High-Shear Seeding Channels
A microfluidic device for determining a response of cells comprises a microchannel and a seeding channel. The microchannel is at least partially defined by a...
2018/0119079 SYMBIOTIC ALGAE SYSTEM
According to present disclosure, there is disclosed an algae growth and cultivation system that provides a cost-efficient means of producing algae biomass as...
2018/0119076 METHOD FOR AGING OR MATURING ETHYL OR ETHANOL ALCOHOL BASED BEVERAGES
A method and apparatus for aging spirits using a novel wooden medallion, where the method requires selecting a type of wood, washing the wood, roasting the...
2018/0119075 COMPOSITIONS COMPRISING YEAST CELLS AND POLYPHENOLS AND THEIR USE
Disclosed is a composition including yeast cells and at least one polyphenols having a molecular weight above 620 Da, the polyphenols are adsorbed and retained...
2018/0119073 Use of M4 Metalloprotease in Wort Production
A method of preparing a wort with an increased level of free amino nitrogen (FAN) comprising: a) preparing a mash from a grist comprising malt and/or adjunct;...
2018/0119070 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS, PACKAGING, KITS AND METHODS THEREOF
A laundry care composition including: (a) at least one laundry care ingredient; (b) a leuco composition and (c) an oxidizing agent. The leuco composition and...
2018/0119069 REACTIVE LEUCO COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
A leuco composition comprises at least one reactive leuco compound, which reactive leuco compound comprises a leuco moiety and at least one reactive moiety...
2018/0119068 METHODS OF USING LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A method for treating textile articles includes the steps of: (a) providing a laundry care composition comprising a leuco composition; (b) adding the laundry...
2018/0119067 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including: (a) at least one laundry care ingredient and (b) a leuco composition. The laundry care composition after 30 days of...
2018/0119066 LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including (i) from 2 to 70 wt % of a surfactant; and, (ii) from 0.01 to 20.0 wt % of a leuco polymer of the formula: ##STR00001## ...
2018/0119065 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including: (a) at least one laundry care ingredient and (b) a leuco composition. The laundry care composition has a .DELTA.HA of at...
2018/0119064 LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including (i) from 2 to 70 wt % of a surfactant; and (ii) from 0.0001 to 20.0 wt % of a leuco polymer that includes a...
2018/0119063 LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including (i) from 2 to 70 wt % of a surfactant; and (ii) from 0.0001 to 20.0 wt % of a leuco polymer including an alkoxylated...
2018/0119060 LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A method of obtaining a laundry care composition, the method comprising the steps of (a) reacting a reactive leuco compound with a polymer to form a leuco...
2018/0119059 LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition comprising: (a) at least one laundry care ingredient and (b) at least one leuco polymer includes a leuco monomer and an alkene. The...
2018/0119058 LEUCO TRIPHENYLMETHANE COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including: (a) at least one laundry care ingredient and (b) a least one compound represented by Formula (I): ##STR00001## The ratio of...
2018/0119049 LUBRICANT COMPOSITION
The present invention relates to a lubricating oil composition prepared by blending (A) a tertiary amine having a specific structure, (B) a metal-based...
2018/0119047 ADDITIVE FOR LUBRICATING OIL, AND LUBIRICATING OIL COMPOSITION
Object There found a demand for ashless type novel lubricant which does not contain phosphorus, sulfur or metals and has high friction reducing effect, and...
2018/0119046 LUBRICANT COMPOSITIONS COMPRISING THIOPHOSPHATES AND THIOPHOSPHATE DERIVATIVES
The invention relates to lubricant additive compositions and lubricant compositions each comprising thiophosphates and thiophosphate derivatives, methods for...
2018/0119042 Device for Starting and Maintaining a Campfire
A device for starting and maintaining a campfire includes an inner combustible structure formed from a plurality of inner combustible members having bottom end...
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