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Patent # Description
2018/0118843 SILENT Fc VARIANTS OF ANTI-CD40 ANTIBODIES
The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological...
2018/0118842 ANTIBODIES TARGETING B-CELL MATURATION ANTIGEN AND METHODS OF USE
The presently disclosed subject matter provides antibodies that bind to B-cell maturation antigen (BCMA) and methods of using the same.
2018/0118841 NOVEL POLYPEPTIDES
The present invention provides bispecific polypeptides, such as bispecific antibodies, comprising a first binding domain capable of specifically binding to a...
2018/0118839 ANTI-IFNAR1 ANTIBODIES WITH REDUCED FC LIGAND AFFINITY
The invention provides anti-IFNAR1 antibodies with reduced affinity for Fc receptors and/or ligands and methods of making and using such antibodies.
2018/0118838 FLT3 DIRECTED CAR CELLS FOR IMMUNOTHERAPY
CAR cells targeting FLT3 relevant antigens are described as a new method of cancer treatment. It is proposed that FLT3 CAR cells are safe and effective in...
2018/0118835 ANTI-ALK2 ANTIBODY
This application provides: an antibody which specifically binds to an ALK2 protein and has an activity of inhibiting BMP signal transduction mediated by ALK2;...
2018/0118832 COMBINATION THERAPY FOR CANCER
This invention relates generally to a combination therapy for the treatment of cancer, particularly to a combination of (i) a bifunctional molecule comprising...
2018/0118831 CAR T-CELLS FOR THE TREATMENT OF B7-H4 EXPRESSING SOLID TUMORS
CAR cells and antibodies targeting human B7-H4 expressed on many human cancers including but not limited to breast ovarian, and renal cancers are described as...
2018/0118828 BISPECIFIC HETERODIMERIC FUSION PROTEINS CONTAINING IL-15 - IL-15Ralpha Fc-FUSION PROTEINS AND IMMUNE...
The present invention is directed to novel bispecific heterodimeric Fc fusion proteins comprising an IL-15/IL-15R.alpha. Fc-fusion protein and a PD-1 antibody...
2018/0118827 HETERODIMERIC ANTIBODIES THAT BIND SOMATOSTATIN RECEPTOR 2
The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2)
2018/0118823 SINGLE-CHAIN MULTIVALENT BINDING PROTEINS WITH EFFECTOR FUNCTION
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids,...
2018/0118821 ANTI-IL-33 ANTIBODIES AND USES THEREOF
Antibodies which bind and neutralize human IL-33, and methods of using same, are provided, said antibodies are useful as agents for treating conditions...
2018/0118820 IL-17A BINDING PROTEINS
Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
2018/0118819 TREATMENT OF AGE-RELATED AND MITOCHONDRIAL DISEASES BY INHIBITION OF HIF-1 ALPHA FUNCTION
Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance,...
2018/0118817 BISPECIFIC PERTUSSIS ANTIBODIES
The present invention relates, in part, to bispecific antibodies that bind the pertussis toxin protein. The present invention further relates to the use of the...
2018/0118813 METHOD FOR IMPROVING ANTIBODY
The present invention provides for a method for improving properties of an antibody such as an expression level and stability. A method for obtaining an...
2018/0118812 METHOD FOR INACTIVATION/REMOVAL OF COAGULATION FACTORS BY PRECIPITATION
A method for inactivation or removal of coagulation factors VII, FVII, FVIIa, FIX, FIXa, FX, FXI and FXIa inor from protein containing solutions obtained from...
2018/0118810 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARBOXYHEMOGLOBINEMIA
Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed...
2018/0118805 IL15/IL15Ralpha HETERODIMERIC Fc-FUSION PROTEINS
The present invention is directed to novel IL15/IL15R.alpha. heterodimeric Fc fusion proteins.
2018/0118803 CHIMERIC ANTIGEN RECEPTORS TARGETING G-PROTEIN COUPLED RECEPTOR AND USES THEREOF
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs)...
2018/0118801 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AUTOIMMUNE DISEASES
Disclosed are compositions and methods for detecting, isolating, and/or characterizing a T cell or autoantibody associated with type I diabetes. The...
2018/0118791 MODIFIED LANTIBIOTICS AND METHODS OF MAKING AND USING THE MODIFIED LANTIBIOTICS
The subject invention pertains to a modified lantibiotic containing an intact cysteine at the C-terminus, particularly, a cysteine that is not decarboxylated...
2018/0118785 COMPSTATIN ANALOGS WITH IMPROVED ACTIVITY
Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. These compounds display...
2018/0118784 MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the...
2018/0118783 PEPTIDE WITH ANTI-OBESITY AND ANTI-DIABETES ACTIVITY AND USE THEREOF
A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat,...
2018/0118781 ANTIBODY PURIFICATION BY CATION EXCHANGE CHROMATOGRAPHY
A method for purifying an antibody by cation exchange chromatography is described in which a high pH wash step is used to remove of contaminants prior to...
2018/0118779 USE OF PARTICULAR COMBINATIONS OF CARBOHYDRATES FOR STABILIZING PROTEINS, AND PROTEIN COMPOSITIONS CONTAINING...
One subject of the present invention is the use of a combination of a polyol (i) consisting of 12 carbon atoms and of a polyol (ii) consisting of 4 to 6 carbon...
2018/0118778 CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF
Compounds of Formula (A'), (B'), (C'), (D'), (E'), (A''), (B''), (C''), (D''), (E''), (G1), and (G2) are useful as therapeutics for treating a wide variety of...
2018/0118776 NUCLEOSIDE PHOSPHORAMIDATES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS AND PREPARATION THEREOF
Two processes are described for preparing, in different diastereomeric purity degrees, the compound ...
2018/0118774 METHOD OF PERFORMING A PLURALITY OF SYNTHESIS PROCESSES OF PREPARING A RADIOPHARMACEUTICAL IN SERIES, A DEVICE...
A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series includes carrying out a first synthesis run including...
2018/0118773 CRYSTALLINE FORM OF BENZYLBENZENE SGLT2 INHIBITOR
Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides...
2018/0118772 CATALYST FOR SYNTHESIZING METHANOL OR ITS PRECURSOR, METHOD FOR PREPARING THE CATALYST AND METHOD FOR PRODUCING...
Disclosed is a novel catalyst having amine ligands for synthesizing methanol or its precursor. When the catalyst is allowed to react with an alkane in the...
2018/0118771 METHOD FOR PRODUCING AQUEOUS PREPARATIONS OF COMPLEXES OF PLATINUM GROUP METALS
The invention relates to a method for producing aqueous preparations of complexes of platinum group metals (PGM) Pt, Pd, Rh and Ir having the general formula ...
2018/0118770 N-Heterocyclic Phosphines
Provided herein are N-heterocyclic phosphines (NHPs) useful in metal-free phosphorus-carbon bond forming reactions. Methods for preparing vinylphosphonates...
2018/0118769 PHOSPHORUS-CONTAINING HETEROCYCLES AND A METHOD FOR MAKING AND USING
Disclosed embodiments concern a phosphorus-containing heterocyclic compound. Certain embodiments, fluoresce with excitation by light. The compounds are useful...
2018/0118768 A Fluorination Method for Phosphonitrilic Chloride Trimer and Its Derivatives
The present invention relates to a fluorination method for phosphonitrilic chloride trimer and its derivatives including using phosphonitrilic chloride or...
2018/0118766 BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to...
2018/0118763 Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1 to R.sup.4 are as described herein, and their prodrugs or ...
2018/0118762 HETEROARYLS AND USES THEREOF
The present invention provides a compound of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2, R.sup.3,...
2018/0118758 DEUTERIUM-ENRICHED ISOINDOLINONYL-PIPERIDINONYL CONJUGATES AND OXOQUINAZOLIN-3(4H)-YL-PIPERIDINONYL CONJUGATES...
The invention provides deuterium-enriched isoindolinonyl-piperidinonyl conjugates, deuterium-enriched oxoquinazolin-3(4H)-yl-piperidinonyl conjugates,...
2018/0118757 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): ##STR00001## or a...
2018/0118754 COMPOUNDS
The present invention relates to compounds of formula (I) ##STR00001## and to compositions comprising the same and to the use of the compounds and their...
2018/0118752 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE
Described herein are fused bicyclic compounds, compositions, and methods for their use for the treatment of disease.
2018/0118751 IMIDAZOPYRAZINES AND PYRAZOLOPYRIMIDINES AND THEIR USE AS AMPA RECEPTOR MODULATORS
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
2018/0118749 P2X7 MODULATORS
The present invention is directed to compounds of Formula (I), which includes enantiomer and diasteromers thereof: These compounds are suitable for use in the...
2018/0118747 METHOD OF ISOLATING THEACRINE AND COMPOSITION COMPRISING THEACRINE
Disclosed are improved methods for producing solid powdered theacrine compositions that are virtually flavorless and improved theacrine compositions.
2018/0118745 NOVEL INHIBITORS OF PROTEIN KINASES
Protein kinases are regulators of cellular signaling and their functional dysregulation is common in carcinogenesis and many other disease states or disorders....
2018/0118742 ORGANIC COMPOUND, AND ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DISPLAY DEVICE INCLUDING THE SAME
An embodiment of the present invention provides an organic compound represented by: ##STR00001## and an organic light emitting diode and an organic light...
2018/0118740 AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
2018/0118739 COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROARYLOXY, PREPARATION METHOD THEREOF...
A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided....
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