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Patent # Description
2018/0118737 DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM
Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a...
2018/0118735 INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and...
2018/0118734 THERAPEUTIC COMPOUNDS
Compounds disclosed herein including compounds of Formula I: ##STR00001## and salts thereof are provided. Pharmaceutical compositions comprising compounds...
2018/0118732 QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
2018/0118731 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical...
2018/0118728 NOVEL PYRIDINIUM COMPOUNDS
The present invention relates to novel pyridinium compounds, their isomers, steroisomers, atropisomers, conformers, tautomers, polymorphs, hydrates and...
2018/0118727 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The...
2018/0118726 LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF
Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed....
2018/0118724 Receptor-Type Kinase Modulators and Methods of Use
The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by...
2018/0118723 FLUORESCENT COMPOUNDS
Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for...
2018/0118722 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS
The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory...
2018/0118719 PYRAZOLYL UREAS AS KINASE INHIBITORS
There are provided compounds of formula (I) as defined in the specification which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter...
2018/0118717 Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors
The present invention relates to compounds of the following formula (I) and pharmaceutically acceptable salts and solvates thereof, their methods of...
2018/0118716 Chemical Process
The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The...
2018/0118714 PROCESS FOR THE PREPARATION OF EFINACONAZOLE
The present invention provides an improved process for the preparation of Efinaconazole in higher yield by the ring-opening addition reaction of epoxytriazole...
2018/0118712 2',6'-DIOXO-3'-DEUTERO-PIPERDIN-3-YL-ISOINDOLINE COMPOUNDS
The present application describes 2-(2',6'-dioxo-3'-deutero-piperidin-3'-yl)isoindoles, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically...
2018/0118711 PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety,...
2018/0118707 BETA-NAPHTHOISOFLAVONES, COMPOSITIONS CONTAINING, AND USES OF, SAME
The present invention provides compounds of the following structure, ##STR00001## methods of using such compounds, and pharmaceutical compositions containing...
2018/0118705 PROCESS FOR PREPARING 4-AMINO-5-BIPHENYL-4-YL-2-HYDROXYMETHYL-2-METHYL-PENTANOIC ACID COMPOUND
The invention provides processes for preparing intermediates useful for preparing compounds of the formula: ##STR00001## or a tautomer or salt thereof, where...
2018/0118704 COMPOUNDS FOR TREATING PARASITIC INFECTIONS
Compounds and compositions comprising them are provided. The compounds and compositions are useful for inhibiting transport of heme across membranes in...
2018/0118700 NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC...
Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria...
2018/0118699 SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE
The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable...
2018/0118697 TRIAZOLE BENZAMIDE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME
The present disclosure is directed to triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for...
2018/0118696 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula I: ##STR00001## where R.sup.1-R.sup.6 are as defined in the specification, or a ...
2018/0118694 6-MEMBERED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
A compound represented by Formula (I): ##STR00001## wherein ##STR00002## or the like Y.sup.1 is O or the like; Z.sup.1 is C(R.sup.4) or N; Z.sup.2a is...
2018/0118693 COMPOUNDS FOR TREATMENT OF CANCER
The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating...
2018/0118691 HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES
The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation,...
2018/0118690 METHOD FOR PREPARING 5-FLUORO-1H-PYRAZOLE-4-CARBONYL FLUORIDES
The present invention relates to a novel method for preparing 5-fluoro-1H-pyrazole-4-carbonyl fluorides by halogen exchange reaction of ...
2018/0118689 CONTINUOUS FLOW CARBOXYLATION REACTION
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large...
2018/0118685 ANTHRACENE BASED COMPOUNDS AND THEIR USES
A compound of the general formula (A) ##STR00001## or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer,...
2018/0118681 CANNABINOID TYPE 1 RECEPTOR MODULATORS
The present disclosure relates to indole derivatives of the formula (I) which are cannabinoid type 1 receptor modulators and which are useful in the treatment...
2018/0118680 SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
The invention is concerned with the compounds of formula I or II: ##STR00001## and salts thereof. In addition, the present invention relates to methods of...
2018/0118676 NITRIC OXIDE DONATING DERIVATIVES OF LATANOPROST FREE ACID
The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of...
2018/0118675 PROCESSES FOR CONVERTING CARBOXAMIDES TO THIOCARBOXAMIDES
Process for converting a carboxamide to a thiocarboxamide includes reacting (a) a substrate that comprises a heteroatom-containing moiety and a carboxamide...
2018/0118674 HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF
The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the...
2018/0118671 BETA-NAPHTHOL ETHER SULFONATES, PROCESSES FOR PREPARING THEM AND USE THEREOF AS BRIGHTNESS IMPROVERS
The present invention relates to beta-naphthol ether sulfonic acids or salts thereof having the general formula (I) ...
2018/0118670 METHOD FOR PRODUCING ACYLSULFAMOYLBENZAMIDES
The invention relates to a method for producing compounds of formula (Ia), in particular to a method for producing ...
2018/0118668 NOVEL COMPOUND HAVING IMMUNE DISEASE TREATMENT EFFECT AND USE THEREOF
The present invention relates to a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the...
2018/0118667 SUBSTITUTED HYDROXYSTILBENES AND THEIR THERAPEUTIC APPLICATIONS
It discloses a compound of formula I that inhibits the activities of numerous of protein kinases involving the signaling of inflammatory cytokines, therefore,...
2018/0118666 PHTHALONITRILE COMPOUND
The present application relates to a novel phthalonitrile compound and a use thereof. The phthalonitrile compound has a novel structure and can exhibit...
2018/0118663 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in...
2018/0118661 COMPOUNDS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that may metabolize to ornithine. Also...
2018/0118659 PROCESS FOR CARRYING OUT A REACTION IN A REACTION COLUMN
A process for carrying out a reaction in a reaction column, said process comprising: providing a first reactant to the reaction column in the liquid phase;...
2018/0118657 METHODS FOR INHIBITING MUSCLE ATROPHY
In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an...
2018/0118650 DEHYDRATION OF ALPHA-SUBSTITUTED CARBOXYLIC ACIDS IN THE PRESENCE OF WATER AT HIGH PRESSURES
The present invention describes a process for dehydrating alpha-substituted carboxylic acids in the presence of water at high pressures while avoiding...
2018/0118649 METHOD FOR PRODUCING ACETIC ACID
Provided is a method for producing acetic acid, which suppresses catalyst precipitation and accumulation in an evaporator, can efficiently recycle catalysts to...
2018/0118643 PROCESS FOR THE PREPARATION OF VINYL CHLORIDE
A process for the production of vinyl chloride comprises the step of passing a feed stream comprising ethylene dichloride (EDC) over a catalyst system...
2018/0118642 METHOD FOR PRODUCING FLUORINATED ALKANE, METHOD FOR SEPARATING AND RECOVERING AMIDINE BASE, AND METHOD FOR...
The present invention provides: a method for producing a fluorinated alkane represented by the formula (2): R.sup.2--F, wherein an alcohol having 3 to 5 carbon...
2018/0118640 METHOD FOR PURIFYING METHANE-COMPRISING GAS
The invention is directed to the purification of gas streams comprising methane and hydrophobic pollutants. The invention provides a method for purifying a gas...
2018/0118639 SYSTEMS AND METHODS RELATED TO THE SYNGAS TO OLEFIN PROCESS
Disclosed herein is a system and method capable of producing butadiene from a product stream.
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