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Patent # Description
2018/0117085 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST EPITHELIAL OVARIAN CANCER AND OTHER...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0117082 ANTIFUNGAL COMPOSITION/TREATMENT
An antifungal composition comprising an agent that affects the availability of functional amino acids and either i) another agent that affects the availability...
2018/0117081 PREPARATIONS FOR CONTROLLED-RELEASE OF HYPOCHLOROUS ACID
Provided are anti-microbial compositions that include an aqueous solution of hypochlorous acid encapsulated in a nanoparticle that allows for controlled...
2018/0117079 Methods And Compositions For Bowel Cleansing Before A Medical Procedure
Described are kits, food compositions and methods for cleaning the bowel, e.g., in preparation for a medical procedure, e.g., a diagnostic or treatment...
2018/0117075 THERAPY FOR MALIGNANT DISEASE
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a...
2018/0117074 METHOD FOR ASSESSING AND TREATING OR PREVENTING IMPAIRED PLASMA POLAR LIPID LEVELS
The invention pertains to the use of a preparation for the manufacture of a composition for preventing or treating impaired plasma levels of one or more polar...
2018/0117072 N-ACETYL MANNOSAMMINE AS A THERAPEUTIC AGENT
The invention relates to compositions and methods for treating kidney and muscle dysfunction that involves use of therapeutic amounts of N-acetyl mannosamine.
2018/0117068 Stabilized Modified Release Vitamin D Formulation and Method of Administering Same
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D.sub.2 and...
2018/0117066 System and Method for Diagnosis and Treatment
This invention relates the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the treating or preventing treatment resistant prostate...
2018/0117065 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY
The present application relates to a pharmaceutical composition comprising a combination of an FXR agonist and at least one additional therapeutic agent that...
2018/0117060 COMBINATION OF CATALYTIC MTORC 1/2 INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE
Disclosed are methods for the treatment of proliferative disorders. Disclosed in particular, are methods for treatment of proliferative disorders such as...
2018/0117059 METHODS FOR TREATING EGFR MUTANT CANCERS
Methods for the treatment of EGFR mutated cancer. For example, treatment of non-small cell lung cancer (NSCLC) with activating EGFR mutations (e.g., L858R and...
2018/0117058 SKIN-PENETRATING FORMULATION OF TAUROLIDINE
A composition comprising: hydrolysable taurolidine; and a hydrolysable lipophilic excipient; wherein the hydrolysable taurolidine is contained within the...
2018/0117056 CONTROL OF PARASITIC INFECTION IN ANIMALS
The invention relates to the use of alkaloid lolines to reduce parasitic infection in livestock and especially in ruminants, particularly sheep. The loline...
2018/0117052 COMBINATION THERAPIES FOR TREATING CANCERS
Provided herein are methods that relate to a therapeutic strategy for treatment of cancer, including hematological malignancies. In particular, the methods...
2018/0117049 METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION
Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering...
2018/0117048 6-AMINO-PURIN-8-ONE COMPOUNDS
Compounds of formula (I): ##STR00001## wherein R.sup.1 is C.sub.1-6alkylamino, C.sub.1-6alkoxy, or C.sub.3-7cycloalkyloxy; m is an integer having a value of 3 to...
2018/0117047 DRUG FOR PREVENTING AND/OR TREATING DEMENTIA
A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase...
2018/0117046 ANTI-ULCERATIVE COLITIS COMPOUND
Anti-ulcerative colitis compounds include quinazoline derivatives having the following structural formula: ##STR00001## wherein R is H, OH, or OCH.sub.3, R.sub.1...
2018/0117043 USE OF SRC PROTEIN INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS AND/OR TREATMENT OF...
The present invention provides use of a Src protein inhibitor N-(2-chloro-6-methylphenyl)-2-{6-[4-(3-hydroxyethyl)-1-piperazinyl]-2 ...
2018/0117041 LIVER X RECEPTOR MODULATORS
Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions...
2018/0117040 SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their...
2018/0117038 TREATMENT OF OPHTHALMIC CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM THE EYE
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2018/0117037 USE OF MASITINIB FOR TREATMENT OF AN AMYOTROPHIC LATERAL SCLEROSIS PATIENT SUBPOPULATION
Disclosed is a method for treating patients afflicted with non-aggressive or moderately aggressive amyotrophic lateral sclerosis (ALS) whose rate of change of...
2018/0117031 Crenolanib for Treating FLT3 Mutated Proliferative Disorders Associated Mutations
The present invention includes methods for treating a FLT3 mutated proliferative disorder comprising: measuring expression of a mutated FLT3 and one or more...
2018/0117029 Targeting Metabolic Vulnerability in Triple-Negative Breast Cancer
Methods for treating cancer in a subject by administering a therapeutically effective amount of a pyrimidine synthesis inhibitor and a genotoxic...
2018/0117027 USE OF NON-PEPTIDIC NK1 RECEPTOR ANTAGONISTS FOR THE PRODUCTION OF APOPTOSIS IN TUMOUR CELLS
The invention relates to the use of substance P antagonists and, in particular, the use of non-peptidic NK1 receptor antagonists for the treatment of cancer...
2018/0117026 COMBINATION THERAPY USING ENANTIOPURE, OXY-SUBSTITUTED, DEUTERIUM-ENRICHED ...
The invention provides combination therapy using enantiopure deuterium-enriched pioglitazone, pharmaceutical compositions, and methods of treating nonalcoholic...
2018/0117023 ORAL SOLID DOSAGE FORM OF AMLODIPINE AND VETERINARY USES THEREOF
The invention relates to the field of animal health. In particular, the invention relates to an oral solid dosage form comprising, as pharmaceutically active...
2018/0117015 Targeting Metabolic Adaptive Responses to Chemotherapy
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that...
2018/0117014 METHODS OF INHIBITING LEUKOTRIENE A4 HYDROLASE
The present invention is directed to methods of inhibiting LTA.sub.4-h in a human patient and method of treating a condition ameliorated by the inhibition of...
2018/0117006 ANTI-FUGETACTIC AGENT AND IMMUNOTHERAPY AGENT COMBINATION THERAPY AND COMPOSITIONS FOR THE TREATMENT OF CANCER
The invention described herein relates to methods and compositions for treating cancer in a patient, or a tumor cell, by administering an effective amount of...
2018/0117003 METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING FATTY LIVER, PROTECTING LIVER FUNCTION OR AMELIORATING...
The present invention relates to methods and compositions for preventing or treating fatty liver, protecting liver function or ameliorating liver diseases...
2018/0117000 ENERGY METABOLIC ACTIVATING AGENT FOR MUSCLE CELLS
This invention provides a new energy-metabolic activating agent for muscle cells and provides compounds that are widely used in foods and drinks and in...
2018/0116992 Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same
The present disclosure provides, in part, modulators of prostate-specific G-protein receptor (OR51E2/PSGR) and methods of treating, preventing, and diagnosing...
2018/0116991 TOPICAL COMPOSITIONS COMPRISING POLYUNSATURATED FATTY ACIDS
The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), ##STR00001## or a pharmaceutically acceptable...
2018/0116989 Position-Specific Asymmetric Deuterium Enriched Catecholamine Derivatives And Medicaments Comprising Said Compounds
Herein described are deuterated catecholamine derivatives of the general Formula I ##STR00001## wherein, R.sub.1 is deuterium, R.sub.2, and R.sub.3 are...
2018/0116988 METHODS OF PREVENTING AND TREATING AUTOIMMUNITY
Methods of preventing, treating or ameliorating autoimmune diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of...
2018/0116985 AUTOIMMUNE DISORDER TREATMENT USING RXR AGONISTS
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat...
2018/0116978 FORMULATIONS OF TOCOTRIENOL QUINONES FOR THE TREATMENT OF OPHTHALMIC DISEASES
A formulation, comprising an ophthalmically effective amount of one or more tocotrienol quinones, particularly of alpha-tocotrienol quinone is disclosed. Use...
2018/0116977 NOVEL TREATMENT OF PROSTATE CARCINOMA
Disclosed herein are naphthoquinone analogs, such as plumbagin, pharmaceutical compositions that include naphthoquinone analogs, such as plumbagin, and methods...
2018/0116976 METHODS AND COMPOSITIONS FOR UNWANTED OR ABNORMAL MUSCLE CONTRACTIONS
The invention relates to methods and compositions for treating muscle cramps, muscle spasms, muscle spasticity, dystonias, and fasciculations.
2018/0116973 NANOFIBER SCAFFOLDS FOR BIOLOGICAL STRUCTURES
A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional...
2018/0116972 Lipid based nanocarrier compositions loaded with metal nanoparticles and therapeutic agent
The invention relates to non-polymeric lipid-based nanocarrier compositions loaded with metal nanoparticles and at least one therapeutic agent, useful agents...
2018/0116969 Multi-shell Capsule
The invention provides a multi-shell capsule for oral administration of a combination of pharmaceutical and/or nutrient ingredients (hereinafter referred to as...
2018/0116968 HYPROMELLOSE ACETATE SUCCINATE AND METHOD FOR PRODUCING THE SAME
There are provided HPMCAS (hypromellose acetate succinate) having such a property that a solution of the HPMCAS in a solvent has a controlled viscosity; and a...
2018/0116965 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluorom- ...
2018/0116964 SALT OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL- ]AMINO]BENZONITRILE
The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]- benzonitrile, pharmaceutical...
2018/0116961 STIMULANT ABUSE-DETERRENT COMPOSITIONS
The present invention provides an abuse deterrent oral fixed-dose composition, comprising a stimulant or opioid and an abuse deterrent active, wherein the...
2018/0116960 TREATING FUNGAL INFECTION OF THE NAIL UNIT
Described here are various compositions for the delivery active agents, e.g., antifungal agents. The compositions may be beneficial due to the particular...
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