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Patent # Description
2018/0125982 Etanercept Formulations Stabilized with Metal Ions
The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these...
2018/0125981 STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ANALOGUES AND/OR INSULIN DERIVATIVES
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.
2018/0125980 CANNABINOID COMPOSITION AND PRODUCTS INCLUDING ALPHA-TOCOPHEROL
A cannabinoid composition having an excipient including .alpha.-tocopherol and at least one isolated cannabinoid having a purity of greater than 80%. The...
2018/0125979 PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMINISTRATION OF HYDROPHOBIC DRUGS
Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions...
2018/0125978 Solid Carriers for Improved Delivery of Active Ingredients in Pharmaceutical Compositions
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein...
2018/0125977 ENHANCED DELIVERY EPINEPHRINE COMPOSITIONS
Pharmaceutical compositions having enhanced active component permeation properties are described.
2018/0125976 Conjugated Porphyrin Carbon Quantum Dots for Targeted Photodynamic Therapy
The present disclosure relates to porphyrin containing carbon quantum dots useful for bioimaging and/or phytodynamic therapy.
2018/0125975 EMISSIVE POLYMERIC MATRICES
The present disclosure relates to emissive polymeric matrices and methods of using them. The emissive polymeric matrices comprise a monomer such as, for...
2018/0125974 METHODS AND COMPOSITIONS FOR ENHANCED IMMUNOLOGICAL THERAPY AND TARGETING OF GRAM-POSITIVE BACTERIA
The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of,...
2018/0125973 THERAPEUTIC COMBINATIONS COMPRISING ANTI-CD73 ANTIBODIES AND USES THEREOF
The present invention provides therapeutic combinations featuring anti-CD73 antibodies (e.g., MED19447) and A2A receptor inhibitors and methods of using such...
2018/0125972 MULTIPLE ANTIGEN BINDING MOLECULAR FUSION, PHARMACEUTICAL COMPOSITION, METHOD FOR IDENTIFYING LINEAR EPITOPE,...
A multiple antigen-binding molecule fusion molecule containing a multiple antigen-binding molecule (.alpha.) having an immune cell antigen-binding region and a...
2018/0125971 Modulation of the Immune Response
Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription...
2018/0125970 METHODS FOR TREATING LUNG CANCER
Provided herein are methods for predicting a likelihood of responsiveness to treatment with a folate receptor alpha (FRA)-targeting agent in a patient having a...
2018/0125969 METHODS OF RATIONAL NICOTINE HAPTEN DESIGN AND USES THEREOF
Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing...
2018/0125968 POXVIRAL VACCINES
The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and...
2018/0125967 HIV Immune Stimulating Compositions Comprising Recombinantly Expressed Pili on Bacteria and Methods Related Thereto
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In...
2018/0125966 COMPOSITIONS CONTAINING AMBIENT-TEMPERATURE STABLE, INACTIVATED BUT THERAPEUTICALLY ACTIVE BIOPHARMACEUTICALS &...
The disclosure concerns compositions containing inactivated but therapeutically active biopharmaceuticals, and methods for formulation thereof....
2018/0125965 HAND, FOOT, AND MOUTH VACCINES AND METHODS OF MANUFACTURE AND USE THEREOF
The present disclosure relates to hand, foot, and mouth disease vaccines and immunogenic compositions having one or more antigens from at least one virus that...
2018/0125964 CHIMERIC DENGUE VIRUS E GLYCOPROTEINS COMPRISING MUTANT DOMAIN I AND DOMAIN II HINGE REGIONS
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein...
2018/0125963 NON-TYPEABLE HAEMOPHILUS INFLUENZAE VACCINES AND THEIR USES
Provided are non-typeable Haemophilus influenzae vaccines useful for the treatment of chronic obstructive pulmonary disease and asthma in a patient. In certain...
2018/0125962 Factor H Binding Proteins (FHBP) with Altered Properties and Methods of Use Thereof
Factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins, are...
2018/0125961 NEISSERIA MENINGITIDIS TRYPSIN-LIKE SERINE PROTEASE POLYPEPTIDES AND COMPOSITIONS THEREOF
The present invention relates to novel polypeptides derived from Neisseria meningitidis proteins, in particular auto-transporters of the trypsin-like serine...
2018/0125960 MENINGITIDIS VACCINES COMPRISING SUBTILINASES
The present invention relates to novel polypeptides derived from meningitis proteins, in particular auto-transporters of the subtilinase subclass, and their...
2018/0125959 COMPOSITIONS COMPRISING N. MENINGITIDIS PROTEINS
The invention relates to immunogenic compositions comprising at least two Neisseria meningitidis (Nm) protein antigens selected from the group consisting of a...
2018/0125958 Immunogenic Compositions and Uses Thereof
The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B...
2018/0125957 IMMUNOGENIC COMPOSITION COMPRISING MYCOPLASMA ANTIGENS
The present invention relates to an immunogenic composition comprising: a) one or more antigen of M. hyorhinis and one or more antigens of M. hyosynoviae; and...
2018/0125956 CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells...
2018/0125955 PLACENTAL VACCINATION THERAPY FOR CANCER
The present invention discloses methods of stimulating an immune response to cancer tissue and biological effectors used by tumors to defeat the host, through...
2018/0125953 HER2/NEU IMMUNOGENIC COMPOSITION
The invention provides for an immunogenic composition comprising a. a directed adjuvant comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a...
2018/0125952 PRIME-BOOST REGIMENS INVOLVING ADMINISTRATION OF AT LEAST ONE mRNA CONSTRUCT
The present invention relates to prime-boost regimens that involve the administration of at least one mRNA construct, such as the use of such constructs in...
2018/0125951 METHODS FOR ALLEVIATING HISTAMINE-INDEPENDENT PRURITUS USING NEUROTOXINS
Methods for treating, reducing the occurrence or preventing a histamine-independent pruritic itch using a clostridial toxin derivative are provided herein. In...
2018/0125950 LIVER CIRRHOSIS TREATMENT
A method of treating liver cirrhosis has `micro-cuts` being created within the parenchyma of a cirrhotic liver to create `micro-cavities`, so that hepatocytes...
2018/0125949 Lysosomal Targeting Peptides and Uses Thereof
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things,...
2018/0125948 TREATMENT OF OCULAR NEOVASCULARIZATION USING ANTI-VEGF PROTEINS
The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by...
2018/0125947 TREATMENT OF RETINAL DETACHMENT
The present invention relates to the Transferrin (Tf) or an active fragment thereof for use in the treatment of retinal detachment and/or for use in the...
2018/0125946 Treating Diabetes Melitus Using Insulin Injections Administered With Varying Injection Intervals
The present invention relates to methods for treatment of a condition or disease where administration of insulin will be of benefit, comprising administering,...
2018/0125945 STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ANALOGUES AND/OR INSULIN DERIVATIVES
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.
2018/0125944 STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ASPART
Stabilized pharmaceutical formulations of insulin aspart are disclosed.
2018/0125943 STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ANALOGUES AND/OR INSULIN DERIVATIVES
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.
2018/0125942 COMPOSITION FOR TREATMENT OF INFERTILITY
Preparations including FSH, for example recombinant FSH, for use in the treatment of infertility.
2018/0125941 IL-2 Variants for the Treatment of Autoimmune Diseases
This disclosure provides for a method for treating a condition by administering to a subject in need thereof a therapeutically-effective amount of a compound...
2018/0125940 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ENHANCING TARGETING OF THERAPEUTIC COMPOUNDS TO THE CENTRAL NERVOUS...
Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to, inter glia, the CNS applied via intranasal administration while...
2018/0125939 NOVEL THERAPY
A method for treating cystitis, in particular acute cystitis, comprising administering to a patient in need thereof, an effective amount of a reagent selected...
2018/0125938 MODIFIED CHEMOKINE PEPTIDE
The present invention provides a modified chemokine peptide, comprising (a) an "ELR" characteristic sequence which is situated at the N-terminus of the...
2018/0125937 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein...
2018/0125936 METHOD OF TREATING NEOPLASIAS
The present invention relates generally to a method of treating a neoplastic condition. More particularly, the present invention is directed to a method of...
2018/0125935 COMPOSITIONS AND METHODS FOR ADJOINING TYPE I AND TYPE II EXTRACELLULAR DOMAINS AS HETEROLOGOUS CHIMERIC PROTEINS
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as...
2018/0125934 Receptor-Based Antagonists of the Programmed Cell Death 1 (PD-1) Pathway
Provided herein are compositions and methods for alleviating cancer or infection in a subject by administering a therapeutically effective amount of a...
2018/0125933 INSULIN INDEPENDENCE AMONG PATIENTS WITH DIABETES UTILIZING AN OPTIMIZED HAMSTER REG3 GAMMA PEPTIDE
Embodiments of the present invention provide for novel therapies, pharmaceutical compositions and methods for insulin independence utilizing a new optimized...
2018/0125932 MODIFIED BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION
The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety...
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