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Patent # Description
2018/0125881 LINEAR POLYOL STABILIZED POLYFLUOROACRYLATE COMPOSITIONS
The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid...
2018/0125880 COMPOSITION FOR TREATING TISSUE LESIONS
Some embodiments are directed to a pharmaceutical composition including a biocompatible polymer in association with a eukaryotic cell, a platelet extract...
2018/0125879 Use of Polysaccharide for Treating ST-Elevation Myocardial Infarction and Diseases of the Digestion System
Provided herein are methods of treating ST-elevation myocardial infarction (STEMI) and diseases of the digestion system using .beta.-1,3/1,6-D-glucan derived...
2018/0125878 CONTINUOUSLY EXPRESSED THERAPEUTIC RNAS FOR TARGETED PROTEIN BINDING AND METHODS FOR THEIR USE
An RNA composition comprising an RNA aptamer and an shRNA molecule and/or an miRNA molecule are provided. The RNA composition may include an aptamer component...
2018/0125877 IMMUNE MODULATION WITH TLR9 AGONISTS FOR CANCER TREATMENT
The present invention relates to methods for treating a tumor, including a metastatic tumor, with TLR9 agonist in combination with an immune checkpoint...
2018/0125876 Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages
The present invention relates to methods and pharmaceutical composition for modulation polarization and activation of macrophages. In particular, the present...
2018/0125875 SYNERGISTIC ENHANCEMENT OF 5-FLUOROURACIL CYTOTOXICITY BY DEOXYURIDINE ANALOGS IN CANCER CELLS
In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant...
2018/0125874 Compositions and Methods to Accelerate Resolution of Acute Lung Inflammation
The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain...
2018/0125873 ANALOGUES OF ETOPOSIDE FOR THE TREATMENT OF TUMOURS
Compounds for treatment of a patient having a tumour that is metastatic and/or that reduces an organ function, wherein the compounds are of the general...
2018/0125872 FIXED-DOSE PHARMACEUTICAL COMPOSITION COMPRISING RIFABUTIN, CLARITHROMYCIN, AND CLOFAZIMINE
Oral administration of a solid dosage form of the present invention comprising an effective amount of rifabutin, an effective amount of clarithromycin, an...
2018/0125871 Targeting NAD+ to Treat Chemotherapy and Radiotherapy Induced Cognitive Impairment, Neuropathies and Inactivity
Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced...
2018/0125870 COMPOSITIONS, METHODS OF TREATMENT AND DIAGNOSTICS FOR TREATMENT OF HEPATIC STEATOSIS ALONE OR IN COMBINATION...
The present invention is directed to pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and/or prevention of an...
2018/0125869 BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE
The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically...
2018/0125868 CONNECTIVE TISSUE MONITORING, COMPOSITIONS FOR CONNECTIVE TISSUE TREATMENT AND METHODS FOR TREATING CONNECTIVE...
A method for treating a non-hemorrhoidal tendon injury in a performance animal in need thereof includes administering to the animal a composition comprising a...
2018/0125867 COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid .beta....
2018/0125866 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
2018/0125864 A METHOD FOR SCREENING REGULATOR OF MITOCHONDRIAL FISSION
The present invention is directed to a method for screening a regulator of mitochondrial fission using a cell treated to a protopanaxadiol (PPD)-type...
2018/0125863 ABIRATERONE ACETATE LIPID FORMULATIONS
Abiraterone acetate lipid formulations.
2018/0125862 TREATMENT FOR HEPATIC FIBROSIS
The invention relates to the treatment and reduction of fibrosis, specifically hepatic fibrosis. More specifically, embodiments of the invention provide...
2018/0125861 OCULAR THERAPY USING GLUCOCORTICOID DERIVATIVES SELECTIVELY PENETRATING POSTERIOR SEGMENT TISSUES
Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes...
2018/0125860 Contraceptive Compositions and Methods for Improved Efficacy and Modulation of Side Effects
Compositions and methods for the delivery of progestin hormones that have binding affinity to the Sex Hormone Binding Globulin (SHBG) are disclosed. The...
2018/0125859 Methods for Inhibiting the Development of Huntington's Disease
This invention relates to Huntington's disease and more specifically to methods for inhibiting the development of or treating Huntington's disease by...
2018/0125858 BIOAVAILABLE SOLID STATE (17- β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
Disclosed are bioavailable solid state (17-.beta.)-Hydroxy-4-Androsten-3-one esters suitable for pharmaceutical uses and administration to mammals in need of ...
2018/0125857 HIGH-STRENGTH TESTOSTERONE UNDECANOATE COMPOSITIONS
The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The...
2018/0125856 USE OF GLUCOCORTICOID RECEPTOR ANTAGONIST AND SOMATOSTATIN ANALOGUES TO TREAT ACTH-SECRETING TUMORS
Methods, compositions, and pharmaceutical formulations are provided for treatment of ACTH secreting tumors.
2018/0125855 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
2018/0125854 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING THE SAME
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent ...
2018/0125853 OXAZINE DERIVATIVE FOR USE IN THE TREATMENT OR PREVENTION OF CEREBRAL AMYLOID ANGIOPATHY
The present invention relates to an oxazine derivative BACE-1 inhibitor and pharmaceutical compositions comprising such oxazine derivative for use in the...
2018/0125852 COMPOSITIONS AND METHODS FOR TREATMENT OF GLIOMA
In certain embodiments the present invention provides methods useful in the treatment of glioma, such as glioblastoma, such methods comprising administering to...
2018/0125851 METHODS FOR TREATING PULMONARY HYPERTENSION
The present invention provides a method of using arylpiperazine derivatives for treating pulmonary hypertension. The method comprises a step of administering...
2018/0125850 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer, for example an advanced solid tumor, such as a glioma, or angioimmunoblastic...
2018/0125849 PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS
The present invention concerns a compound of formula (I) ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, where R.sup.1-R.sup.3 and Y are...
2018/0125848 PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED...
The present disclosure relates to compounds of the Formula (I): ##STR00001## and pharmaceutically acceptable salts, as kinase modulators, compatible with the...
2018/0125847 METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSION MODULATION
Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a...
2018/0125846 Targeted Therapies for Cancer
Methods of treating, and for selecting a chemotherapy regimen for treatment of cancer in a patient (FIG. 9). For example, a patient genetic sample from a...
2018/0125845 Methods And Formulations For Modulating Lyn Kinase Activity And Treating Related Disorders
The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically...
2018/0125844 TREATMENT OF RELAPSED AND/OR REFRACTORY SOLID TUMORS AND NON-HODGKIN'S LYMPHOMAS
Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas...
2018/0125843 Method Of Treating Metabolic Disorders And Depression With Dopamine Receptor Agonists
This invention relates to methods and formulations for treating metabolic disorders and depression. In some embodiments, the methods comprise administering a...
2018/0125842 Ergoloid for Cancer
A drug developed to treat dementia which has been abandoned by its manufacturer, Novartis, is repurposed to enhance the treatment of cancer. The drug,...
2018/0125841 KETOCONAZOLE ENANTIOMER IN HUMANS
Treatment of patients with the 2S,4R ketoconazole enantiomer or its pharmaceutically acceptable salts, and solvates is useful for reducing systemic...
2018/0125840 TREATMENT OF PRURIGO NODULARIS
The present invention relates to methods for treating prurigo nodularis with anti-pruritic compositions, wherein the method provides a therapeutic effect in a...
2018/0125839 METHOD OF INHIBITING MUTANT C-KIT
The present invention includes a method of reducing or inhibiting the kinase activity of C-KIT mutant tyrosine kinase activity in a cell or a subject, and the...
2018/0125838 METHODS OF TREATMENT WITH DEUTERATED CFTR POTENTIATORS
Disclosed is a method of treating in a subject of treating diseases and conditions that are beneficially treated by administering a CFTR potentiator. The...
2018/0125837 COMPOSITIONS AND METHODS FOR TREATMENT RELATED TO FALL AND FALL FREQUENCY IN NEURODEGENERATIVE DISEASES
The present disclosure provides methods and compositions for treating fall-related symptoms in patients with neurodegenerative diseases such as Parkinson's...
2018/0125836 METHOD FOR INHIBITING PLATELET AGGREGATION
A method for inhibiting platelet aggregation in a patient in need thereof, comprising 1) administering to the patient a bolus injection of an active drug, in...
2018/0125835 Dosage and Use of an A2A Antagonist
The present invention relates to specific dosages of an A.sub.2A antagonist for use as a medicament and in particular useful for the treatment of Parkinson...
2018/0125834 METHODS OF TREATING BACTERIAL INFECTIONS AND FUNGAL INFECTIONS USING ENANTIOPURE DEUTERIUM-ENRICHED PIOGLITAZONE
The invention provides enantiopure deuterium-enriched pioglitazone, pharmaceutical compositions, and methods of treating bacterial infections and fungal...
2018/0125833 METHOD FOR PREVENTING LUNG DISEASES IN SMOKERS AND NON-SMOKERS USING ANTIHYPERTENSIVE DRUG
The present invention relates to a method for inhibiting lung diseases in smokers and non-smokers by blocking growth factor signaling using an antihypertensive...
2018/0125832 USE OF EP4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NASH-ASSOCIATED LIVER CANCER
This invention is directed to prostaglandin E2 receptor 4 (EP4) antagonists useful in the treatment of nonalcoholic steatohepatitis (NASH)-associated liver...
2018/0125831 COMBINATION THERAPIES FOR TREATING CANCER
Provided are methods for treating cancer in a patient by administering at least one antibiotic selected from the group consisting of clofazimine, rifabutin and...
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