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Patent # Description
2018/0125830 MICROBICIDAL COMPOSITION COMPRISING AN OCTOXYNOL AND A QUINOLIZIDINE ALKALOID COMPOUND OR A SOURCE THEREOF
The present invention provides microbicidal compositions comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof, and methods of...
2018/0125829 INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
2018/0125828 COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF PULMONARY HYPERTENSION
The present invention provides compositions and methods for the treatment or prevention of pulmonary hypertension comprising administering an ascomycin, or a...
2018/0125827 5-DEUTERO-THIAZOLIDINE-2,4-DIONE COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME
The invention provides deuterium-enriched thiazolidine-2,4-dione compounds (i.e., deuterium-enriched glitazone compounds), enantiopure forms of...
2018/0125826 SUBSTITUTED 1H-IMIDAZO[4,5-b]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical...
2018/0125825 BIOTIN FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
The invention relates to the use of biotin for treating Amyotrophic Lateral Sclerosis, as well as demyelinating peripheral neuropathies and Neuromyelitis...
2018/0125824 LIQUID FORMULATIONS OF BENDAMUSTINE
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
2018/0125823 IMIDAZOLE DERIVATIVES
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1' is CH.sub.3; R.sup.1 is methyl, ethyl, CF.sub.3, CH.sub.2OH, cyclopropyl or...
2018/0125822 TREATMENT USING DANTROLENE
Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for...
2018/0125821 TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE
The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to...
2018/0125820 SACUBITRIL-VALSARTAN DOSAGE REGIMEN FOR TREATING HEART FAILURE
The present invention relates to sacubitril-valsartan dosage regimens for the treatment of heart failure in a patient.
2018/0125819 AMORPHOUS TECOVIRIMAT PREPARATION
Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-et- ...
2018/0125818 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA
The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic...
2018/0125817 COMBINATIONS COMPRISING A PYRROLIDINE-2,5-DIONE IDO1 INHIBITOR AND AN ANTI-BODY
Combinations of an IDO1 inhibitor (e.g., a 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione compound), with an anti-PD1 antibody or anti-PD-L1 antibody, and an...
2018/0125816 SAROGLITAZAR MAGNESIUM FOR THE TREATMENT OF CHYLOMICRONEMIA SYNDROME
The present invention relates to the use of Saroglitazar Magnesium of formula (1), for the prevention, delay of progression, or treatment of a disease or...
2018/0125815 CDC7 KINASE INHIBITORS AND USES THEREOF
The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect,...
2018/0125814 CANCER TREATMENT METHOD USING AILANTHONE COMPOUNDS
A pharmaceutical composition comprising an ailanthone (AIL) compound or a derivative thereof, for the treatment of diseases or conditions caused by, dependent...
2018/0125813 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
The present invention relates to methods for treating or preventing chronic kidney disease and cardiovascular disease in patients with chronic kidney disease...
2018/0125812 Dehydroacetic Acid (DHAA) and Derivative for Uses in Treating Cancer
This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or...
2018/0125811 9,10-Alpha,Alpha-OH-Taxane Analogs and Methods for Production Thereof
Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds...
2018/0125810 NOVEL ANTITUMORAL USE OF CABAZITAXEL
The invention relates to a compound of formula: ##STR00001## which may be in base form or in the form of a hydrate or a solvate, in combination with prednisone...
2018/0125809 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g.,...
2018/0125808 BIOFILM INHIBITING COMPOSITIONS ENHANCING WEIGHT GAIN IN LIVESTOCK
A method of enhancing the growth of an animal, as well as treating or preventing antimicrobial infections is provided. The method includes causing the animal...
2018/0125807 3-METHANESULFONYLPROPIONITRILE FOR TREATING INFLAMMATION AND/OR PAIN
The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such...
2018/0125806 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES
Nitro oleic acid and related metabolites are agonists of PPAR-.gamma.. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-.gamma., relative to...
2018/0125805 PROPHYLACTIC/THERAPEUTIC AGENT FOR VIRUS INFECTIONS WHICH COMPRISES ALA COMPOUND
The present invention addresses the problem of providing a prophylactic/therapeutic agent which is inexpensive, has little adverse side effects and is...
2018/0125804 SYNERGISTIC FAMCICLOVIR AND CELECOXIB COMBINATION THERAPY FOR FUNCTIONAL SOMATIC SYNDROMES
The present invention relates to methods of treating fibromyalgia, by administering a therapeutically-effective combination of an antiviral component and a...
2018/0125803 METHODS OF INHIBITING PAIN
Provided are methods and compositions for preventing, reducing, mitigating and treating pain, particularly neuropathic pain by the combined administration of...
2018/0125802 SOLID-FORMING TOPICAL FORMULATIONS FOR PAIN CONTROL
Solid-forming topical formulations can include a local anesthetic, an emulsifying agent, polymer, and water. The formulation can include from 0.1 wt % to 5 wt...
2018/0125801 METHODS FOR SELECTING PHOSPHATASE SELECTIVE AND NON-SELECTIVE PHOSPHATASE INHIBITORS
The present invention discloses a method to discover selective inhibitors of phosphatases. Thus the invention provides a method for screening a test compound...
2018/0125800 Stable Formulation for Parenteral Administration of Tapentadol
The invention relates to an aqueous pharmaceutical composition for parenteral administration comprising Tapentadol or a physiologically acceptable salt...
2018/0125799 THERAPY FOR LEUKEMIA
A pharmaceutically acceptable composition and method for leukemia therapy in a patient in need of such therapy. The composition contains, as the only active...
2018/0125798 Compounds and Methods for Modulating Serotonin Receptors in the Periphery
This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to...
2018/0125797 METHODS FOR TREATING SKIN DISORDERS WITH A TOPICAL COMPOSITION OF BIS-(2-CHLOROETHYL)METHYLAMINE
Provided are methods for treating skin disorders comprising topically applying a highly stable pharmaceutical composition comprising ...
2018/0125796 TREATMENT OF MYCOBACTERIAL INFECTION
The invention provides a combination comprising a SERCA antagonist and an inhibitor of glycosphingolipid biosynthesis, for use in the treatment of an infection...
2018/0125795 CINNAMALDEHYDE COMPOSITIONS AND METHODS
Disclosed are solid cinnamaldehyde compositions and methods for producing solid cinnamaldehyde compositions that are virtually flavorless.
2018/0125794 Induced Expression of Brain Derived Neurotrophic Factor (BDNF) for Treatment of Neuromuscular,...
A method of treating a host of neuromuscular, neurodegenerative, developmental, autoimmune and metabolic diseases/disorders related to aging, such as traumatic...
2018/0125793 COMPOSITIONS AND METHODS FOR THE REMOVAL OF EAR WAX
The present invention includes compositions and methods for the treatment, softening and removal of ear wax by administering to the ear a solution of a...
2018/0125792 NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR COUGH
The use of a non-steroidal anti-inflammatory drug for the treatment of nonproductive cough caused by viruses or bacteria and a combination of at least one...
2018/0125791 POLYMER NANOCAPSULES FOR PROTEIN DELIVERY
A nanocapsule includes a shell including a polymer and a protein, a nucleic acid, or a combination thereof. The polymer has repeating units of Formula (I) (I)...
2018/0125790 Sustained Release Aminopyridine Composition
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2018/0125789 TABLETS COMPRISING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE
Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde ("Compound...
2018/0125788 Pharmaceutical Formulation Containing Gelling Agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together...
2018/0125787 TESTOSTERONE UNDECANOATE COMPOSITIONS
The present disclosure is drawn to pharmaceutical compositions and oral dosage forms containing testosterone undecanoate, as well as related methods of...
2018/0125786 STABILIZED PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING SAME
Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing...
2018/0125785 RIVASTIGMINE-CONTAINING SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION
The present invention relates to a rivastigmine-containing sustained-release pharmaceutical composition and, more specifically, to a rivastigmine-containing...
2018/0125784 DELAYED RELEASE PHARMACEUTICAL FORMULATION AND METHODS OF MAKING AND USING SAME
The present invention relates to a delayed release pharmaceutical formulation for delivering an active agent to the intestine, a method of preparing such...
2018/0125783 Nozzle Assembly and Methods for Use
The present disclosure provides an apparatus and methods of use for isolating particles. An example apparatus includes (a) a vessel defining a pressurizable...
2018/0125782 STABLE PHARMACEUTICAL COMPOSITION OF CLOPIDOGREL FREE BASE FOR ORAL AND PARENTERAL DELIVERY
The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, nm) of 100-500 nm, where the oil phase...
2018/0125781 MODULATION OF GEL TEMPERATURE OF POLOXAMER-CONTAINING FORMULATIONS
Disclosed herein are methods for modulation of gel temperature of poloxamer-containing formulations. Also described herein are sustained release pharmaceutical...
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