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Patent # Description
2018/0127753 POST-TRANSCRIPTIONALLY CHEMICALLY MODIFIED DOUBLE STRAND RNAs
Described are post transcriptionally chemically modified double strand RNAs (MdsRNAs) having more than 30 base pairs. The MdsRNAs inhibit gene expression in...
2018/0127752 THERAPEUTICS TARGETING IGFBP7 FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND METABOLIC DISEASES
Insulin-like growth factor-binding protein 7 (IGFBP7) has been identified herein as a therapeutic target for the treatment or prevention of heart diseases,...
2018/0127751 ANTISENSE COMPOUNDS TARGETING GENES ASSOCIATED WITH FIBRONECTIN
The present invention provides compounds comprising oligonucleotides complementary to a fibronectin transcript. Certain such compounds are useful for...
2018/0127750 MIR-155 INHIBITORS FOR TREATING CUTANEOUS T CELL LYMPHOMA (CTCL)
The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such...
2018/0127749 Compositions and Methods for Inhibiting Expression of Factor V
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of Factor V, comprising an antisense strand having a...
2018/0127748 METHODS RELATING TO THE PREVENTION AND TREATMENT OF DRUG RESISTANCE
Described herein are methods, assays, and compositions relating to the treatment and/or prevention of drug-resistance, e.g, by inhibiting the activity of...
2018/0127747 SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF
The present invention relates to a siRNA structure and the use thereof. More particularly, the invention relates to a double-stranded small interfering RNA...
2018/0127746 Production and Monitoring of Metabolites in Cells
Methods of making and monitoring metabolites in cells are provided.
2018/0127745 CELL SORTING
The invention provides for use of CRISPR-Cas systems to sort barcoded cells or molecules. Cells or nucleic acid molecules may be sorted from a heterogenous...
2018/0127744 METHODS FOR CELL LABEL CLASSIFICATION
Disclosed herein are methods and systems for classifying cell labels, for example identifying a signal cell label. In some embodiments, the method comprises:...
2018/0127743 SINGLE CELL BAR-CODING FOR ANTIBODY DISCOVERY
Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. In some aspects, such methods may comprise steps of:...
2018/0127742 PARTICULATE SOLID COMPOSITE MATERIAL FOR NUCLEIC ACID PURIFICATION, CONTAINING MAGNETIC NANOPARTICLES
Particulate solid composite material for purifying nucleic acids containing magnetic nanoparticles embedded in a carrier matrix based on at least one polymer...
2018/0127741 SYSTEM AND METHOD FOR SEQUESTERING SUBSTANCES IN BULK LIQUIDS
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid...
2018/0127740 BIOLOGIC SAMPLE COLLECTION DEVICES AND METHODS OF PRODUCTION AND USE THEREOF
Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a...
2018/0127739 DOSE AND LOCATION CONTROLLED DRUG/GENE/PARTICLE DELIVERY TO INDIVIDUAL CELLS BY NANOELECTROPORATION
A simple and low cost method of producing sealed arrays of laterally ordered nanochannels interconnected to microchannels of tunable size, over large surface...
2018/0127738 PRODUCTION AND THERAPEUTIC USES OF EPINUL PLURIPOTENT CELLS AND DIFFERENTIATED CELLS DERIVED THEREFROM
Compositions and methods are provided for the generation of highly potent conditioned stem (Epinul) cells from adult somatic cells or tissues. Such conditioned...
2018/0127737 NON-CONTACT SYSTEM FOR ACCELERATING WOUND HEALING USING AN ELECTROMAGNETIC COIL TO INDUCE AN ELECTRIC FIELD...
A system for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of...
2018/0127736 MICROPARTICLE SEPARATION APPARATUS ASSEMBLY COMPRISING MULTIPLE SEPARABLE PANELS
The present invention relates to a microparticle separation apparatus assembly comprising multiple separable panels, more specifically, to a microparticle...
2018/0127735 THROMBIN-THROMBOMODULIN FUSION PROTEINS AS PROTEIN C ACTIVATORS
Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to ...
2018/0127734 Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells
An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region...
2018/0127733 IDURONATE-2-SULFATASE AND USE THEREOF
Provided is a modified iduronate-2-sulfatase (IDS) gene constructed by inserting the nucleotide of SEQ ID NO: 2 into a wild-type IDS gene. In addition to being...
2018/0127732 FUSION POLYMERASES
Fusion polypeptides having a heterologous 5'-3' exonuclease domain linked to a polymerase that does not naturally have 5'-3' exonuclease activity, as well as...
2018/0127731 COMPOSITIONS AND METHODS FOR MODIFYING CELL SURFACE GLYCANS
Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.
2018/0127730 MODIFIED FATTY ACID BIOSYNTHESIS WITH ACP-DEPENDENT THIOLASES
Methods of using microorganisms to make chemicals and fuels, including carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and ...
2018/0127729 DLDH, DERIVATIVES THEREOF AND FORMULATIONS COMPRISING SAME FOR USE IN MEDICINE
The invention provides methods for treating a proliferative disease or disorder such as cancer by administering to patients suffering from the disease or...
2018/0127728 BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow...
2018/0127727 METHOD FOR PRODUCING MYOCARDIAL CELLS USING SYNTHETIC PEPTIDE
Provided is a method for producing myocardial cells from pluripotent stem cells. The myocardial cell production method provided by the present invention...
2018/0127726 STEM CELL REMOVING METHOD, DIFFERENTIATED CELL PROTECTIVE METHOD, AND CULTURE MEDIUM COMPOSITION
A stem cell removing method that certainly-removes an undifferentiated stem cell is provided. For this object, a cell group including a stem cell and a somatic...
2018/0127725 PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY AND USES THEREOF
A method of generating protein-induced pluripotent stem cells by delivering bacterial!y expressed reprogramming proteins into nuclei of starting somatic cells...
2018/0127724 ISOLATION OF BONA FIDE PANCREATIC PROGENITOR CELLS
The present invention relates to a method for isolating bona fide pancreatic progenitor cells and to cell populations enriched for bona fide pancreatic...
2018/0127723 TREATMENT OF PLURIPOTENT CELLS
The present invention provides a method for treating human pluripotent cells. In particular, the methods of the invention are directed to the treatment of...
2018/0127722 COMPOSITION FOR TREATING TENDONITIS AND MANUFACTURE THEREOF
A composition for treatment of tendonitis is provided. The composition comprises a pretreated adipose derived stem cell (ADSC), wherein the ADSC is pretreated...
2018/0127721 METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD, A MESENCHYMAL STEM...
The present invention relates to a method of isolating a mesenchymal stem cell population from the amniotic membrane of the umbilical cord, the method...
2018/0127720 MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS
Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an...
2018/0127719 COMPOSITIONS AND METHODS FOR IMPLANTATION OF PROCESSED ADIPOSE TISSUE AND PROCESSED ADIPOSE TISSUE PRODUCTS
The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed...
2018/0127718 METHOD FOR PRODUCING MEGAKARYOCYTES, PLATELETS AND/OR THROMBOPOIETIN USING MESENCHYMAL CELLS
Provided is a megakaryocyte and/or platelet production method, enabling to produce a megakaryocyte and/or platelet from mesenchymal cells such as preadipocytes...
2018/0127717 DENDRITIC CELL IMMUNOTHERAPY
Methods of providing a targeted immune response in a subject comprising administration of a dendritic cell population are provided. In some aspects, dendritic...
2018/0127716 ENRICHMENT OF CD16+ MONOCYTES TO IMPROVE DENDRITIC CELL VACCINE QUALITY
Compositions and methods are provided for converting the predominant circulating classical monocytes to a non-classical and/or intermediate monocyte phenotype...
2018/0127715 Engineered Artificial Antigen Presenting Cells for Tumor Infiltrating Lymphocyte Expansion
In some embodiments, compositions and methods relating to isolated artificial antigen presenting cells (aAPCs) are disclosed, including aAPCs comprising a...
2018/0127714 Method For Differentiating Pluripotent Stem Cells Into Desired Cell Type
Provided is a method of differentiating a pluripotent stem cell of mammalian origin into a desired cell type by predicting the direction of cell...
2018/0127713 Method of Producing Stem Cell-Derived Endothelial Cells and Uses Thereof
This disclosure relates to methods of generating endothelial cells derived from stem cells. In certain embodiments, the cells are useful for inducing...
2018/0127712 METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS
The present invention relates compounds for stabilizing cells and methods of their use.
2018/0127711 KITS AND MATERIALS FOR IMPLANTABLE COLLAGEN DEVICES
The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate...
2018/0127710 STEM CELL CARRIER AND METHOD FOR BONE REGENERATION WITH 3D CUSTOMIZED CAD/CAM USING THE CARRIER
A stem cell carrier includes a plurality of single units. The plurality of single units are formed three-dimensionally interconnected to each other to form a...
2018/0127708 METHODS FOR THE POSITIVE SELECTION OF ETHANOL OVERPRODUCING MUTANTS FROM SACCHAROMYCES CEREVISIAE
Described herein are new approaches for the selection of S. cerevisiae strains with increased ethanol production from hydrolyzed starch derived sugars. An...
2018/0127707 ASPERGILLUS NIGER F22 STRAIN HAVING NEMATICIDAL ACTIVITY AGAINST PLANT-PARASITIC NEMATODES, AND USE THEREOF
The present invention relates to an Aspergillus niger F22 strain having a nematicidal activity against plant-parasitic nematodes; a nematicidal microorganism...
2018/0127706 FILTER-BASED METHOD FOR EFFICIENT CAPTURE OF LYSIS OF SUSPENDED CELLS
A cell lysis workflow involving a cell suspension that is passed through a filter in a first flow direction from a first side of the filter toward a second...
2018/0127705 System and Method for Creating Tissue
A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with...
2018/0127704 CULTURING DEVICE
A culture device supplying an accurate amount of liquid into a culture bag has a culture bag having ports, a first bag holding portion having supporting...
2018/0127703 MEDICAL SAMPLE TRANSPORTATION CONTAINER
A portable apparatus for transport and incubation of a medical sample in a blood culture flask includes a sealable container having a thermally insulated...
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