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Patent # Description
2018/0127500 ANTIBODIES DIRECTED AGAINST T CELL IMMUNOGLOBULIN AND MUCIN PROTEIN 3 (TIM-3)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein...
2018/0127499 ANTI-LAG-3 ANTIBODIES AND METHODS OF USE THEREOF
The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical...
2018/0127498 ANTI-FCRN ANTIBODIES
The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and...
2018/0127497 USE OF KIT INHIBITORS TO CONDITION SUBJECTS FOR A HEMATOPOIETIC STEM CELL (HSC) TRANSPLANTATION
Provided herein are compositions and methods related to conditioning a subject for a hematopoietic stem cell (HSC) transplantation using an inhibitor of a stem...
2018/0127496 ANTIBODIES DIRECTED AGAINST LYMPHOCYTE ACTIVATION GENE 3 (LAG-3)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein...
2018/0127495 Human Antibody Specific for Interleukin-1alpha
Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1.alpha. and (ii) a constant region...
2018/0127494 IL-18 BINDING PROTEIN (IL-18BP) AND ANTIBODIES IN INFLAMMATORY DISEASES
The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders, in particular, the present invention...
2018/0127493 HUMANIZATION OF RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a...
2018/0127492 Agents, Uses and Methods for the Treatment of Synucleinopathy
The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's...
2018/0127491 Agents, Uses and Methods for the Treatment of Synucleinopathy
The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's...
2018/0127490 TREATING REFRACTORY MIGRAINE
Disclosed herein are methods of treating or reducing incidence of migraine and/or at least one secondary symptom associated with refractory migraine in a...
2018/0127489 MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including...
2018/0127488 Antibodies that Modulate Immunity to Drug Resistant and Latent MTB Infections
The invention is directed to compositions and methods for stimulating, enhancing or modulating the immune system of a patient before or after infection by a...
2018/0127487 ANTI-CHIKV ANTIBODIES AND USES THEREOF
The present invention concerns antibodies and antigen-binding fragments of antibodies which specifically bind to and neutralize Chikungunya virus (CHIKV) and...
2018/0127486 METHODS AND COMPOSITIONS FOR TREATMENT OF SYMPTOMS ASSOCIATED WITH INTRACRANIAL HEMORRHAGE
Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant...
2018/0127485 FIBRONECTIN-BASED BINDING MOLECULES AND USES THEREOF
The invention provides fibronectin type III (Fn3)-based binding molecules that bind to a specific target antigen. The invention further provides bispecific...
2018/0127484 PROCESS FOR A PREPARATION OF THE MODIFIED PORCINE PLASMA FIBRONECTIN FOR ENHANCE WOUND HEALING
This invention reveals the potential applications of modified porcine plasma fibronectin that could be applied as a safe material for clinical wound healing...
2018/0127483 VEGF-BINDING PROTEIN FOR BLOCKADE OF ANGIOGENESIS
Provided are chimeric VEGF-binding proteins and nucleic acids (e.g., a vector) encoding chimeric VEGF-binding proteins, methods and host cells for producing...
2018/0127482 Method for Selecting Odor-Controlling Substance
A method for searching for a substance suppressing a target odor through cross-adaptation is provided. A method for selecting a substance inducing ...
2018/0127481 RECOMBINANT pMHC CLASS II MOLECULES
Described herein are heterodimers containing at least one first polypeptide and at least one second polypeptide, wherein the first polypeptide and the second...
2018/0127480 HIGH AFFINITY CD47 ANALOGS
High affinity CD47 reagents are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased...
2018/0127479 T CELL RECEPTORS RECOGNIZING MHC CLASS II-RESTRICTED MAGE-A3
The invention provides an isolated or purified T-cell receptor (TCR) having antigenic specificity for MHC Class II-restricted MAGE-A3. The invention further...
2018/0127478 SINGLE CHAIN Fc-DIMER-HUMAN GROWTH HORMONE FUSION PROTEIN FOR IMPROVED DRUG DELIVERY
Disclosed herein is a recombinant polypeptide comprising two single chain Fc domains fused or covalently attached to each other by a peptide linker, with the...
2018/0127477 METHOD OF PRODUCTION OF GONADOTROPHIN
A host cell characterized in that it comprises integrated into its genome a sequence coding for the a chain of hCG, and use of the host cell to produce...
2018/0127476 CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS
The present invention comprises compounds of Formula I. ##STR00001## wherein: Z.sub.4, Z.sub.7, Z.sub.9, Z.sub.11, Z.sub.22, Z.sub.23, Z.sub.26, Z.sub.30,...
2018/0127475 FGF-2 VARIANTS HAVING N-TERMINAL DELETIONS AND INCREASED RECEPTOR SELECTIVITY AND USES THEREOF
The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In...
2018/0127474 NOVEL ANTI-BAFF ANTIBODIES
The present invention relates to anti-BAFF antibody molecules, including novel humanized anti-BAFF antibodies, therapeutic and diagnostic methods and...
2018/0127473 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0127472 METHOD OF INHIBITING C5 CLEAVAGE
The invention relates to complement inhibitors that inhibit both the classical and alternative complement pathways. In particular, the invention relates to...
2018/0127471 MODIFIED AAV CAPSIDS AND USES THEREOF
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein that binds heparan sulfate proteoglycans, where the AAV...
2018/0127470 Cell Lines
The present invention relates to a process for producing a cell which constitutively expresses cytotoxic virus poly-peptides (e.g. VSV G or Gag-Pol). The...
2018/0127469 SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the...
2018/0127468 ANTI-HIV PEPTIDES
The present disclosure provides simple .beta.-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element...
2018/0127467 TEMPLATE-FIXED PEPTIDOMIMETICS
The template-fixed .beta.-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-.sup.DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-.sup.D-P- ro-Pro), disulfide bond between...
2018/0127466 NMDA RECEPTOR MODULATORS AND PRODRUGS, SALTS, AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0127465 MULTIFUNCTIONAL OPIOID RECEPTOR LIGANDS AND METHODS OF TREATING PAIN
Opioid receptor ligands (ORLs) that are multifunctional having agonist activity at mu opioid receptor (MOR), agonist activity at delta opioid receptor (DOR),...
2018/0127464 NOVEL EPHA4 INHIBITORS TARGETING ITS LIGAND BINDING DOMAIN
Provided herein are compounds and pharmaceutical compositions comprising EphA4 inhibitors. The EphA4 inhibitors and compositions thereof are useful for the...
2018/0127463 DESACETOXYTUBULYSIN H AND ANALOGS THEREOF
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X.sub.1, X.sub.2, X.sub.3, and...
2018/0127462 Method for extracting epsilon-polylysine and its hydrochloride salt from fermentation broth
The present invention provides a method for extracting .epsilon.-polylysine (.epsilon.-PL) and its hydrochloride salt from fermentation broth, which belongs to...
2018/0127461 Process Control System for Control and Regulation of a Modular Plant for the Production of Biopharmaceutical...
The invention relates to a modular production plant for continuous production and/or preparation of biopharmaceutical products, a computer-implemented method...
2018/0127460 Method for Chromatography
The present invention relates to the field of chromatography. More closely, the invention relates to a chromatographic method for purification of...
2018/0127458 Pulse combustion drying of proteins
Methods for pulse combustion spray drying of heat-sensitive protein compositions using high temperature pulsating jets to atomize and dry the feed...
2018/0127457 NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3BETA-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC...
5-cholesten, 3.beta.,25-diol, disulfate (25HCDS) has been found to be an authentic PPAR.gamma. agonist and LXR antagonist, and is used for the therapy of lipid...
2018/0127456 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents...
2018/0127455 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents...
2018/0127454 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING
The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the...
2018/0127453 2'-Arabino-Fluorooligonucleotide N3'.about.P5' Phosphoramidates: Their Synthesis and Use
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2'-arabino-fluoronucleoside and an internucleoside 3'-NH--P(--O)(OR)--O-5'...
2018/0127452 NOVEL POLYMORPH OF REGADENOSON AND PROCESS FOR PREPARATION THEREOF
Processes are provided for the preparation of a stable polymorphic form C of regadenoson, the process involving steps of a) obtaining a solution of regadenoson...
2018/0127451 SUBSTITUTED PURINE COMPOUNDS
The present invention relates to substituted purine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and...
2018/0127450 5-POSITION MODIFIED PYRIMIDINES AND THEIR USE
The present disclosure relates to the field of nucleic acid chemistry, specifically to 5-position modified uridines as well as phosphoramidite and triphosphate...
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