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Patent # Description
2018/0127449 METHODS FOR PURIFICATION OF MESSENGER RNA
The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure...
2018/0127448 Metal Complexes, Comprising Carbene Ligands Having an O-Substituted Non-Cyclometalated Aryl Group and Their Use...
Cyclometallated Ir complex comprising three N,N diaryl substituted carbene ligands, bearing substituents in the 2 position of the non-cyclometallated aryl...
2018/0127447 METATHESIS CATALYSTS AND METHODS THEREOF
The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides...
2018/0127446 CO-CRYSTALS, SALTS AND SOLID FORMS OF TENOFOVIR ALAFENAMIDE
The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such...
2018/0127445 TENOFOVIR MONOBENZYL ESTER PHOSPHAMIDE PRODRUG, PREPARATION METHOD AND USE THEREOF
The present invention relates to a tenofovir monobenzyl ester phosphamide prodrug, preparation method and pharmaceutical use thereof. Specifically, the present...
2018/0127444 BISPHOSPHITES HAVING 2,4-TERT-BUTYLPHENYL UNITS AND USE THEREOF AS LIGANDS IN HYDROFORMYLATION
The invention relates to bisphosphites having 2,4-tert-butylphenyl units and a method for the preparation thereof. Furthermore, the invention relates to the...
2018/0127443 Methods of Making Metal Halide Perovskites
Provided herein are methods of making metal halide perovskites, including methods of making bulk crystals or micro crystals. The metal halide perovskites may...
2018/0127442 METHOD FOR PRODUCING AQUEOUS HYDROLYSATES FROM AMINOALKYLTRIALKOXYSILANES
The present invention relates to a process for preparing aqueous hydrolysates of aminoalkyltrialkoxysilanes by (a) initially charging water, optionally...
2018/0127441 BORTEZOMIB-BASED DELIVERY SYSTEM
The invention relates to a class of molecules obtained for conjugating a species or substrate to Bortezomib by means of bonds of the boronic diester type which...
2018/0127440 PROCESS FOR SILANE OLIGOMER COMPOSTITION PREPARATION AND USE THEREOF
Epoxy silane oligomers are prepared from a glycidoxypropyl alkoxysilane in the presence of an alcohol and an esterification and/or transesterification...
2018/0127439 ANTIVIRAL AND ANTIBACTERIA AGENTS BASED ON QUATERNARY AMMONIUM COMPOUND COMPLEXED WITH BORIC ACID AND ITS...
The present document describes compounds resulting from the complexation of quaternary ammonium compounds with boric acid and/or its derivatives, and methods...
2018/0127438 LN(III) AND GA(III) METALLACROWN COMPLEXES
The present invention concerns heterometallic metallacrown compounds incorporating Ga(III) and Ln(III) cations, with a templating ligand such as...
2018/0127437 NOVEL FUSED IMIDAZOBENZOTHIAZOLE COMPOUNDS
The present invention relates to novel fused Imidazobenzothiazole derivatives, their pharmaceutically acceptable salts, and their isomers, steroisomers,...
2018/0127436 BMP POTENTIATORS
The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: ##STR00001## Also provided are methods of making the...
2018/0127435 NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE
Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes...
2018/0127434 TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHOD OF USE THEREOF
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity,...
2018/0127433 EPOXYAZULENE DERIVATIVES USEFUL FOR TREATING CANCER AND DIABETES
Disclosed is a compound of formula (I) in which R.sup.1-R.sup.5 and X.sup.1 are as described herein. Also provided are methods of using a compound of formula...
2018/0127432 Bicyclic-Fused Heteroaryl or Aryl Compounds
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, ...
2018/0127431 LACTAM KINASE INHIBITORS
Compounds useful as kinase inhibitors are provided herein, as well as salts, pharmaceutical compositions, methods of medical treatment and methods of synthesis...
2018/0127430 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0127429 ETHYNYL DERIVATIVES
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1 is hydrogen, F or Cl; L is a bond or lower alkylene; R.sup.2 is...
2018/0127428 NOVEL SALT OF FUSED PYRIMIDINE COMPOUND AND CRYSTAL THEREOF
Provided is a salt having a high selectivity to BTK and is useful as a drug ingredient for a pharmaceutical product. It has been found that fumarate of Compound A...
2018/0127427 METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
2018/0127426 TGF-Beta Inhibitors
Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the...
2018/0127425 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention discloses compounds according to Formula I: ##STR00001## Wherein R.sup.1a, R.sup.1b, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
2018/0127424 INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
The present invention is directed to compounds encompassed by the Formula (I): ##STR00001## pharmaceutical compositions thereof, methods for inhibiting LTA-4 ...
2018/0127423 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, ...
2018/0127422 COMPOUNDS
A first aspect of the-invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R.sub.1 is...
2018/0127421 BRASSINOSTEROID MIMETICS
The disclosure provides brassinosteroid mimetics and method of using such mimetics.
2018/0127420 CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL...
Disclosed area condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications...
2018/0127419 PREPARATION AND USE OF KINASE INHIBITOR
Disclosed are a preparation method for a kinase inhibitor and a use thereof. The kinase inhibitor is a compound represented by formula (I) wherein the groups...
2018/0127418 HETEROCYCLES USEFUL AS IDO AND TDO INHIBITORS
Provided are compounds of Formula (I) shown below using for treatment of diseases or disorders mediated by IDO and/or TDO, pharmaceutical compositions and...
2018/0127417 INTERMEDIATES FOR PREPARING CGRP RECEPTOR ANTAGONISTS
The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for...
2018/0127416 NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B...
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1 to R.sup.6, V, W, X and Y are as described herein, compositions...
2018/0127415 DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2018/0127414 PYRIDOPYRIMIDINONES AND METHODS OF USE THEREOF
The invention relates to pyridopyrimidinone compounds of formula I ##STR00001## or pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2,...
2018/0127413 TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using...
2018/0127412 MALEATE SALTS OF A B-RAF KINASE INHIBITOR, CRYSTALLINE FORMS, METHODS OF PREPARATION, AND USES THEREFORE
The invention relates to 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo [d] imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa [b] benzofuran-5-yl) ...
2018/0127411 INDAZOLE AND AZAINDAZOLE BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof,...
2018/0127410 KINASE INHIBITORS
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
2018/0127409 AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS
The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or...
2018/0127408 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2018/0127407 Benzothiazole Or Benzoxazole Compounds As Sumo Activators
Provided are SUMO activators, which can enhance SUMOylation of SERCA2a, which are useful in the treatment of heart failure, cardiovascular diseases, cancer,...
2018/0127406 ARYLCYCLOPROPYLAMINE BASED DEMETHYLASE INHIBITORS OF LSD1 AND THEIR MEDICAL USE
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and...
2018/0127405 COMPOUNDS
Compounds of formula (I) ##STR00001## wherein: R.sup.1 is heteroaryl optionally substituted by methyl, ethyl, halo or =0; and R.sup.2 is H, methyl or ethyl....
2018/0127404 BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I...
2018/0127403 N-ARYL-HYDROACRIDINES AS LIGHT EMITTING ELEMENTS FOR ELECTROLUMINESCENT DEVICES
A compound having a tricyclic nucleus and having formula (I) ##STR00001## wherein Ar is C.sub.3-C.sub.25 aryl in which at least one aromatic ring atom is...
2018/0127402 ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES
A compound which is a benzimidazolyl isoxazole of formula (I): wherein: R.sup.0 and R, which are the same or different, are each H or C.sub.1-6 alkyl; R.sup.9,...
2018/0127401 SUBSTITUTED OXOPYRIDINE DERIVATIVES
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of...
2018/0127400 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
The disclosure encompasses compounds having e.g., Formula (Ia) or (Ib), compositions thereof, and methods of modulating CFTR activity. The disclosure also...
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