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Patent # Description
2018/0134817 Catalyst Compositions and Use Thereof
This invention relates to novel transition metal catalyst compounds comprising four oxygen atoms bonded to a transition metal where two of the oxygen groups...
2018/0134816 Polymers Produced via Use of Quinolinyldiamido Transition Metal Complexes and Vinyl Transfer Agents
Catalyst systems with single site transition metal complexes (such as quinolinyldiamide transition metal complexes), an activator, and a metal hydrocarbenyl...
2018/0134815 Vinyl Modifier Composition And Processes For Utilizing Such Composition
An oxolanyl compound-containing composition comprising specified amounts of the meso-isomer of one or more of the oxolanyl compounds of specified structure is...
2018/0134814 ELIMINATION OF CONTAMINANTS IN WET NATURAL RUBBER
A method for preparation of decontaminated natural rubber is provided. The method is characterized in that it comprises a decontamination step in which wet...
2018/0134813 PROCESS FOR THE PREPARATION OF POLYSACCHARIDES
The present invention relates to a process for the preparation of a polysaccharide composed of D-xylose units of formula (III) linked together via beta 1,4...
2018/0134812 CELLULOSE ETHER POWDERS
Provided is a method of making methylcellulose-type ether in powder form, said method comprising (a) providing a solution of said methylcellulose-type ether...
2018/0134811 CELLULOSE ETHER POWDERS
Provided is a composition in powder form comprising methylcellulose, wherein said composition has a powder x-ray diffraction spectrum at source x-ray...
2018/0134810 URANIUM-CHELATING PEPTIDES AND USES THEREOF
The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated...
2018/0134809 ANTIBODY DUAL DISPLAY DUAL COMPOSITIONS AND METHODS OF USE THEREOF
Provided herein are display systems for simultaneously displaying two different ligand binding polypeptides at the surface of a phage. Also provided are kits,...
2018/0134808 ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS
An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
2018/0134807 COMPLEX-SPECIFIC ANTIBODIES AND ANTIBODY FRAGMENTS AND ITS USE
The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in...
2018/0134806 METHODS OF ADMINISTERING INHIBITORY ANTI-FACTOR XII/XIIA MONOCLONAL ANTIBODIES
The invention relates to inhibitory anti-factor XII/FXIla antibodies and methods of their use.
2018/0134805 MATERIAL AND METHODS FOR TREATING OR PREVENTING HER-3 ASSOCIATED DISEASES
Described herein are materials and methods for treating subjects having a HER-3 associated disease, by administering a first agent that binds to HER-3, in...
2018/0134804 MONOCLONAL ANTIGEN-BINDING PROTEINS TO INTRACELLULAR ONCOGENE PRODUCTS
Antigen binding proteins specific for an HLA-A2 restricted Ras peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms,...
2018/0134803 TREATMENT OF HER2-POSITIVE BREAST CANCER
Methods for the treatment of HER2-positive breast cancer are provided by neoadjuvant administration of pertuzumab and trastuzumab in combination with...
2018/0134802 COMPOSITIONS COMPRISING CHIMERIC ANTIGEN RECEPTORS, T CELLS COMPRISING THE SAME, AND METHODS OF USING THE SAME
Provided are isolated nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens. Also provided are isolated polypeptides...
2018/0134801 METHOD FOR TREATING A GD2 POSITIVE CANCER
The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a...
2018/0134800 HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR GLYPICAN-3 AND USE THEREOF
Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies...
2018/0134799 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
The present invention provides antibodies or the antigen-binding portion thereof, that bind to one or more carbohydrate antigens. Also disclosed herein are...
2018/0134798 DOSING FOR TREATMENT WITH ANTI-CD20/ANTI-CD3 BISPECIFIC ANTIBODIES
The invention provides methods of dosing for the treatment of cancers, such as B cell proliferative disorders, with anti-cluster of differentiation 20...
2018/0134797 ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
The present invention relates to anti-trans-ferrin receptor antibodies and methods of their use.
2018/0134796 IL13Ra2 Binding Agents and Use Thereof in Cancer Treatment
Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13R.alpha.2, a receptor polypeptide preferentially found on the...
2018/0134795 CD123 SPECIFIC MULTI-CHAIN CHIMERIC ANTIGEN RECEPTOR
The present invention relates to a new generation of chimeric antigen receptors (CAR) referred to as multi-chain CARs, which are made specific to the antigen...
2018/0134794 ANTI-MET ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND MET, AND METHODS OF USE THEREOF
Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof. The bispecific antigen-binding molecules...
2018/0134793 ANTIBODIES THAT BIND TO AXL PROTEINS
Antibodies that bind to AXL protein and variants thereof are described herein. AXL exhibits a distinct and limited expression pattern in normal adult...
2018/0134792 ANTIBODIES THAT BIND TO AXL PROTEINS
Antibodies that bind to AXL protein and variants thereof are described herein. AXL exhibits a distinct and limited expression pattern in normal adult...
2018/0134791 COMPOSITIONS AND METHODS FOR INCREASING MUSCLE GROWTH
This disclosure is in the field of anti-Activin receptor IIB (ActRIIB) antibodies. In particular, it relates to the use of said antibodies for treating muscle...
2018/0134790 Antibodies Reactive with B7-H3 and Uses Thereof
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof,...
2018/0134789 INDUCIBLE BINDING PROTEINS AND METHODS OF USE
Provided herein are conditionally activated polypeptide constructs comprising a protease-activated domain binding to CD3, at least one half-life extension...
2018/0134788 Methods and Pharmaceutical Compositions (NTSR1 Inhibitors) for the Treatment of Hepatocellular Carcinomas
The present disclosure relates to methods and pharmaceutical compositions for the treatment of hepatocellular carcinomas (HCC in abbreviation, the term...
2018/0134787 ANTIBODY AGENTS SPECIFIC FOR HUMAN CD19 AND USES THEREOF
Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also...
2018/0134786 Cancer Cell Specific Anti-Podocalyxin Antibody and Method for Producing Same
The present invention provides a method for producing an antibody against podocalyxin expressed specifically in cancer cells. The method includes a step of...
2018/0134785 Mitigating Tissue Damage and Fibrosis Via Latent Transforming Growth Factor Beta Binding Protein (LTBP4)
The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta...
2018/0134784 Method of Treating Psoriasis with Anti-IL23 Specific Antibody
A method of treating psoriasis in a patient previously treated with and determined to be an inadequate responder to an IL-12/23p40 antibody by administering an...
2018/0134783 HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or...
2018/0134782 Use of Macrophage inflammatory protein-1Beta (MIP-1Beta) inhibitor to protect pancreas and prevent blood sugar...
The present invention relates to a use of a macrophage inflammatory protein-1.beta. (MIP-1.beta.) inhibitor to protect the pancreas and prevent blood sugar...
2018/0134781 Methods of Treating Obesity with Anti-ANGPTL8 Antibodies
The present invention provides antibodies that bind to ANGPTL8 and methods of using the same. According to certain embodiments, the invention includes methods...
2018/0134780 COMBINATION THERAPY WITH AN ANTI-ANG2 ANTIBODY AND A CD40 AGONIST
The present invention relates to the combination therapy of an antibodies that binds to human angiopoietin 2 (ANG-2) with a CD40 agonist.
2018/0134779 METHODS FOR TREATING DIABETES
Methods for treating diabetes by administering an inhibitor of GDF-8, or a related member of Transforming Growth Factor-beta (TGF-.beta.) superfamily of...
2018/0134778 METHODS AND COMPOSITIONS FOR TREATING AN ALPHAVIRUS INFECTION
Methods and pharmaceutical compositions for preventing, treating or suppressing symptoms of a disorder associated with an alphavirus infection. In particular,...
2018/0134777 Alpha-Synuclein Antibodies (11D12)
The invention relates to an antibody or fragment thereof and a method of treatment and/or diagnosis using the antibody. The antibody or fragment thereof binds...
2018/0134776 Alpha-Synuclein Antibodies (4H6)
The invention relates to an antibody or fragment thereof and to a method of treatment and/or diagnosis using the antibody or fragment thereof. The antibody or...
2018/0134775 Alpha-Synuclein Antibodies (7A11)
The invention relates to an antibody or fragment thereof and the use of the antibody in a method of treatment and/or diagnosis. The antibody or fragment...
2018/0134774 ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or...
2018/0134773 Method of Providing Disease-Specific Binding Molecules and Targets
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes...
2018/0134772 Anti-CGRP Antibody Formulation
Pharmaceutical formulations for anti-CGRP antibodies, and methods of using the same, are provided which are useful as treatment for migraines, episodic...
2018/0134771 NOVEL IMMUNOMODULATORY THERAPEUTIC STRATEGIES TARGETING TUMORS IN CANCER
The present invention discloses a method of treating, preventing or ameliorating tumor growth by immune response modulation via targeting ABCB5 and an immune...
2018/0134770 ANTIBODY PRODUCING NON-HUMAN ANIMALS
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human,...
2018/0134769 CLOSTRIDIUM DIFFICILE-SPECIFIC ANTIBODIES AND USES THEREOF
The present invention is directed to Clostridium difficile toxin-specific antibodies, compositions, and uses thereof. The anti-toxin antibodies may be specific...
2018/0134768 METHODS AND COMPOSITIONS FOR INHIBITING HIV TRANSMISSION
The present invention provides methods and compositions useful in the field of medicine, and particularly in the treatment of viral infections. More...
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