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Patent # Description
2018/0134767 IDENTIFICATION OF ANTIBODIES SPECIFIC FOR LYSSAVIRUSES AND METHODS OF THEIR USE
Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for...
2018/0134766 IMMUNOMODULATORY FUSION PROTEINS
Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., a TGF.beta. trap, with a novel linker sequence to permit the fusion protein to...
2018/0134765 INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED ALPHA1-ALPHA2 DOMAINS OF NKG2D LIGANDS, AND...
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable...
2018/0134764 METHODS OF TREATMENT USING CTLA4 MUTANT MOLECULES
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or...
2018/0134763 BRAIN PENETRANT AMYLIN RECEPTOR BASED PEPTIDES FOR ALZHEIMER'S DISEASE
Amylin receptor antagonists capable of binding to the amylin receptor and inhibiting activity of amylin or amyloid-beta protein are provided. The amylin...
2018/0134762 OSTEOGENIC PROTEINS
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use...
2018/0134761 Compositions and Methods of Use for Treating Metabolic Disorders
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
2018/0134760 ANALOGUES OF VDAC1-DERlVED PEPTIDES
The present invention relates to peptides comprising analogues of VDAC1-derived peptides having improved pharmacokinetic characteristics compared to the native...
2018/0134759 METHODS FOR GENERATING ENDOGENOUSLY TAGGED PROTEINS
The present disclosure provides a method for endogenously tagging an endogenous protein in a cell, and a cell comprising an endogenously tagged protein. Also...
2018/0134758 Stabilized STAT3 Decoy Oligonucleotides and Uses Therefor
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to...
2018/0134757 POROUS PROTEIN PARTICLES AS CARRIERS FOR ACTIVES
Disclosed are high-porosity protein particles useful for carrying one or more agents of interest, methods for their manufacture and use, and products...
2018/0134756 MODIFIED LECTIN DERIVED FROM WISTERIA FLORIBUNDA
A Wisteria floribunda monomeric lectin polypeptide is provided. The Wisteria floribunda monomeric lectin polypeptide includes any one of the amino acid...
2018/0134755 MICROORGANISMS WITH INCREASED PHOTOSYNTHETIC CAPACITY
Microorganisms with increased photosynthetic capacity are described. Increased photosynthetic capacity is achieved by down-regulating activity of the RpaB...
2018/0134754 EXOSOMES AND METHODS OF MAKING AND USING THE SAME
Provided herein are isolated exosomes. An exome can include a nonstructural (NSs) protein of a virus, a glycoprotein (Gn protein) of a virus, or a combination...
2018/0134753 BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND...
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related...
2018/0134752 PAR1 AND PAR2 C-TAIL PEPTIDES AND PEPTIDE MIMETICS
The present invention concerns isolated PAR1 cytoplasmic tail (c-tail) peptides and isolated PAR2 cytoplasmic tail (c-tail) peptides, as well as compositions...
2018/0134751 Peptide And Its Derivatives Capable Of Inhibiting Replication Of Hepatitis C Virus In Human Adipose-Derived...
The present invention provides a peptide with sequence of DEAQETAVSSHEQD, a fragment of rabbit-.alpha.1 antiproteinase F, and its derivatives DEAQETAVSSHEQ and...
2018/0134750 INHIBITION OF GLIADIN PEPTIDES
Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers...
2018/0134749 NOVEL PEPTIDE AND COMPOSITION CONTAINING THE SAME
The present invention relates to a novel peptide and a composition including the same, and more particularly, to a novel peptide effective in...
2018/0134748 PROCESS FOR PREPARING COMPOUNDS HAVING TRIPLE ACTIVITIES OF THROMBOLYSIS, ANTITHROMBOTIC AND RADICAL SCAVENGING
The present invention relates to a compound simultaneously having triple activities of thrombolysis, antithrombosis and free radical scavenging, as well as the...
2018/0134747 SOLID PHASE SEQUENCE-INDEPENDENT NUCLEIC ACID ASSEMBLY
Disclosed herein are methods of assembling nucleic acid fragments, such as non overlapping nucleic acid fragments, in an orientation-specific, ...
2018/0134746 NUCLEIC ACID APTAMERS TO TREAT HISTONE-INDUCED DISEASE STATES
The present invention relates to optimized aptamers and methods of using these aptamers.
2018/0134745 METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS
The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)- ...
2018/0134744 METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS
The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)- ...
2018/0134742 CRYSTALLINE FORMS OF NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, AND PHOSPHORYLATED ANALOGS THEREOF,...
The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): ##STR00001## wherein X.sup.-, Z.sup.1,...
2018/0134741 PREPARATION COMPRISING ARABINOXYLO-OLIGOSACCHARIDES
The present invention related to an arabinoxylo-oligosaccharide composition comprising at least one arabinose unit linked to one of the xylose units of the...
2018/0134740 NOVEL CROSSLINKED POLYMERIC SUBSTRATES METHODS OF PREPARATION AND END USE APPLICATIONS OF THE SUBSTRATES
A composition of matter wherein the composition comprises a siliceous substrate having silanols on the surface and a polymer selected from the group consisting...
2018/0134739 ALCOHOL COMPOUND
Disclosed is a metal alkoxide compound having physical properties suitable for a material for forming thin films by CVD, and particularly, a metal alkoxide...
2018/0134738 DISUBSTITUTED ALKYNE DICOBALT HEXACARBONYL COMPOUNDS, METHOD OF MAKING AND METHOD OF USE THEREOF
Described herein are cobalt compounds, processes for making cobalt compounds, cobalt compounds used as precursors for depositing cobalt-containing films (e.g.,...
2018/0134737 MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment...
2018/0134736 Luminescent Metal Halide Perovskites and Methods
Nanoscale metal halide perovskites are provided. The nanoscale metal halide perovskites may have a 2D structure, a quasi-2D structure, or a 3D structure....
2018/0134735 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
2018/0134734 PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE
A process for purifying an acryloyloxysilane comprising subjecting a mixture comprising an acryloyloxysilane, a haloorganoalkoxysilane, and an alkane-based...
2018/0134733 HIGHLY DISPERSIBLE ANTIMICROBIAL AND ADHESION AGENTS
Compositions of matter that have antimicrobial properties and adhesion properties and are highly dispersible in aqueous solutions. The presence of a large...
2018/0134732 HETEROCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
A heterocyclic compound and an organic electroluminescence device including the same, the heterocyclic compound being represented by Formula 1: ##STR00001##
2018/0134731 PROCESS TO PREPARE ALUMINOXANES
The present invention relates to a process to prepare alkylaluminoxanes by reaction of alkylaluminium with methacrylic acid or a conjugated unsaturated...
2018/0134730 IMPROVED PROCESS FOR PREPARING BORYL 7-AZAINDOLE COMPOUNDS
The present disclosure relates to an improved process for the preparation of 3-boryl substituted azaindole compounds in high yields and high selectivity. Such...
2018/0134729 METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS...
In one aspect, the invention relates to substituted 5H-[1,2,5]oxadiazolo [3',4':5,6]pyrazino[2,3-b]indole analogues, derivatives thereof, and related compound;...
2018/0134728 Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity
A series of substituted 3,4-di-hydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are...
2018/0134727 Inhibitors of RAD52 Recombination Protein and Methods Using Same
The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a...
2018/0134726 PLANT GROWTH REGULATING COMPOUNDS
The present invention relates to novel strigolactam derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions...
2018/0134725 CORTISTATIN ANALOGUES, SYNTHESES, AND USES THEREOF
New cortistatin compounds and pharmaceutically acceptable salts and pharmaceutically acceptable compositions thereof are provided. These compounds can be used...
2018/0134724 METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF
The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are...
2018/0134723 DRUG WITH ANTIVIRAL ACTIVITY (VARIANTS)
The invention relates to the field of organic chemistry and medicine, and more particularly to synthetic substances of the pyrimidine series, namely...
2018/0134722 AZA-PHENALENE-3-KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND ITS APPLICATION AS PARP INHIBITOR
Disclosed are an aza-phenalene-3-ketone derivative, a preparation method thereof and its application as a PARP inhibitor. The aza-phenalene-3-ketone derivative...
2018/0134721 ETHYNYL DERIVATIVES
The present invention relates to positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGluR4) that may be used for the treatment of...
2018/0134720 CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE
The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of...
2018/0134719 SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS
In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are...
2018/0134718 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention discloses novel indolocarbazole containing material which can be used for OLEDs. These materials may serve as hosts, charge transporting...
2018/0134717 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for...
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