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Patent # Description
2018/0133349 Radiolabeled GRPR-Antagonists For Diagnostic Imaging and Treatment of GRPR-Positive Cancer
The present invention relates to probes for use in the detection, imaging, diagnosis, targeting, treatment, etc. of cancers expressing the gastrin releasing...
2018/0133348 NUCLEAR IMAGING AND RADIOTHERAPEUTICS AGENTS TARGETING CARBONIC ANHYDRASE IX AND USES THEREOF
Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed....
2018/0133347 CONTRAST AGENTS FOR APPLICATIONS INCLUDING PERFUSION IMAGING
The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a...
2018/0133346 ULTRASMALL NANOPARTICLES AND METHODS OF MAKING AND USING SAME
An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow...
2018/0133345 Nano-Devices for Detection and Treatment of Cancer
Compositions and methods are described for detecting and treating conditions including cancer with target specific quantum dot nano-devices. In some aspects,...
2018/0133344 FULLERENE COMPOSITIONS
Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a...
2018/0133343 NANOPARTICLE CONJUGATES AND USES THEREOF
The targeted delivery of therapeutic agents to specific cells remains a challenge in drug delivery. Provided herein are nanoparticle-targeting agent conjugates...
2018/0133342 NANOPARTICLE IMMUNOCONJUGATES
Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no...
2018/0133341 BIOLOGICAL COMPLEXES AND METHODS FOR USING SAME
The disclosure provides complexes comprising targeting units, methods for their production, and methods for their use. In some embodiments, complexes comprise...
2018/0133340 ANTIBODY-DRUG CONJUGATES
An antibody-drug conjugate (ADC) has a structure represented by Formula (I): [D.sub.2-L.sub.2-Cn.sub.2 .sub.yG.sub.2-Ab-Sg.sub.1 ...
2018/0133339 A Novel Complex Comprising A Cell Penetrating Peptide, A Cargo And A TLR Peptide Agonist For Treatment Of...
The present invention provides a novel complex for use in the prevention and/or treatment of glioma, in particular glioblastoma, the complex comprising a) a...
2018/0133338 A Novel Complex Comprising A Cell Penetrating Peptide, A Cargo And A TLR Peptide Agonist For Treatment Of...
The present invention provides a novel complex for use in the prevention and/or treatment of colorectal cancer, the complex comprising a) a cell penetrating...
2018/0133337 CALICHEAMICIN CONSTRUCTS AND METHODS OF USE
Provided herein are antibody drug conjugates (ADCs) comprising calicheamicin and methods of using the same to treat proliferative disorders.
2018/0133336 TARGETING MACULA DENSA CELLS AS A NEW THERAPEUTIC APPROACH FOR KIDNEY DISEASE
There is no specific cure for chronic kidney disease (CKD), which affects one in every ten adults. The unmet medical need has created significant interest in...
2018/0133335 IRON CARBOHYDRATE COMPLEX FOR TREATMENT OF IRON DEFICIENCY OF A FETUS OR AN INFANT
Iron carbohydrate complex for treatment of fetal metal deficiency Disclosed herein is a pharmaceutical composition comprising an iron carbohydrate complex for...
2018/0133334 TARGETING AMINOACID LIPIDS
The present invention is directed to carrier systems comprising ether-lipids conjugated to one or more bioactive ligands and exposed on the surface of the...
2018/0133333 BIODEGRADABLE THERMO-RESPONSIVE POLYMERS AND USES THEREOF
The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble,...
2018/0133332 MUCOSAL DELIVERY OF THERAPEUTIC MOLECULES, PROTEINS, OR PARTICLES COUPLED TO CERAMIDE LIPIDS
Described herein are compositions and methods useful for allowing for the absorption (passage) of agents of interest, such as therapeutic agents, across...
2018/0133331 Site-Specific DNA-Doxorubicin Conjugates Display Enhanced Cytotoxicity to Breast Cancer Cells
Doxorubicin (Dox) is widely used for breast cancer treatment but causes serious side-effects including cardiotoxicity that may adversely impact patient...
2018/0133330 CONJUGATE INCLUDING PEPTIDE MOLECULE CAPABLE OF SELF-ASSEMBLY IN CELL ORGANELLE AND PHARMACEUTICAL COMPOSITION...
Disclosed are a conjugate including a mitochondria-targeting moiety and a peptide molecule capable of self-assembly; and a pharmaceutical composition for...
2018/0133329 COMPOSITIONS AND METHOD FOR STABILIZING A PHARMACEUTICAL FORMULATION, AND METHODS OF MAKING AND USING THE SAME
The disclosure pertains to compositions to stabilize nutrient, food, pharmaceutical, and biological formulations by preventing the crystallization or...
2018/0133328 INTERNALISATION OF HUMAN HTRA1 AND CARGO PROTEINS INTO MAMMALIAN CELLS
The invention is directed to methods for delivery of HTRA polypeptides and its variants into mammalian cells without using transfection reagents. The HTRA...
2018/0133327 Cell Penetrating Peptides and Complexes Comprising the Same
The present invention provides a cell penetrating peptide derived from ZEBRA, which is optionally linked to a cargo molecule, such as at least one antigen or...
2018/0133326 WOUND TREATMENT
Use of a moulding composition comprising a polymer and a setting agent for wound debridement, wherein said use comprises adding water to said moulding...
2018/0133325 STABILIZED PHARMACEUTICAL COMPOSITION
Provided is a pharmaceutical composition, which comprises 5-{[(3R)-1-acryloylpyrrolidin-3-yl]oxy}-6-ethyl-3-({4-[4-(4-methylpiperaz- ...
2018/0133324 WOUND HEALING USING TOPICAL SYSTEMS AND METHODS
The present invention generally relates to compositions and methods for topical or transdermal delivery and treatment of wounds and/or promoting wound healing....
2018/0133323 Optimized Fecal Microbiota Transplantation Carrier Medium
The present invention is a microbially inert, optimized carrier medium for fresh Fecal Microbiota Transplantation samples, intended for same-day ...
2018/0133322 RS7 Antibodies
This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these...
2018/0133321 CYTOMEGALOVIRUS VECTORS ELICITING T CELLS RESTRICTED BY MAJORHISTOCOMPATIBILITY COMPLEX E MOLECULES
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that...
2018/0133320 5-ALA DERIVATIVES AND USE THEREOF
The present invention is directed to new 5-ALA derivatives, particles and formulation thereof, related methods of preparation and methods of use thereof. In...
2018/0133318 ENHANCED PLASMONIC NANOPARTICLES FOR CANCER THERAPY AND DIAGNOSTICS
One or more techniques and/or products are disclosed using a process for preparing metallic nanoparticles. Resulting nanoparticles may comprise a ...
2018/0133317 COMPOSITION FOR TARGET-SPECIFIC PHOTOTHERMAL THERAPY
Provided are a composition for target-specific photothermal therapy and a method of photothermal therapy using the composition and more particularly, a method...
2018/0133316 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the...
2018/0133315 COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD79b ANTIBODY-DRUG CONJUGATE
The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD79b antibody-drug conjugate for the treatment of...
2018/0133314 DETECTION OF FGFR2
The present invention provides a pharmaceutical composition or a diagnostic composition targeting human fibroblast growth factor receptor 2 (hFGFR2).
2018/0133313 USE OF IMMUNE CHECKPOINT INHIBITORS IN CENTRAL NERVOUS SYSTEMS NEOPLASMS
This disclosure provides a method for treating glioma in a subject comprising administering to the subject an anti-Programmed Death-1 (PD-1) antibody. In some...
2018/0133312 COMBINATION OF ANTI-FGFR4-ANTIBODY AND BILE ACID SEQUESTRANT
The present invention relates to the amelioration of toxic effects that are caused by therapies aimed at FGFR4-inhibition. In particular, the invention relates...
2018/0133311 ENHANCING THE T-CELL STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS IN VITRO AND IN VIVO AND ITS USE IN...
We provide new methods of in vitro or in vivo enhancing the T-cell stimulatory capacity of human DCs and the use thereof in cancer vaccination. The method...
2018/0133310 METHODS AND COMPOSITIONS FOR TREATING HERPES
The present disclosure provides, inter alia, certain combinations of immunogenic compositions (e.g., vaccines) against HSV-2 and antiviral therapy. The...
2018/0133309 VACCINE AGAINST PORCINE PARVOVIRUS
The present invention relates to a porcine parvovirus (PPV) viral protein 2 (VP2) having at amino acid position 228 a glutamic acid residue or a glutamate...
2018/0133308 VACCINE COMPOSITIONS HAVING IMPROVED STABILITY AND IMMUNOGENICITY
Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a...
2018/0133307 Influenza Nucleic Acid Molecules and Vaccines Therefrom
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and...
2018/0133306 IMMUNIZATION OF AVIANS BY ADMINISTRATION OF NON-REPLICATING VECTORED VACCINES
The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to recombinant human...
2018/0133305 VERSATILE INFLUENZA VIRUS VACCINE COMPOSITION
The present invention relates to a versatile influenza virus vaccine composition using the HA2 helical domain of a hemagglutinin protein, which is an influenza...
2018/0133304 CANCER IMMUNOTHERAPY USING VIRUS PARTICLES
A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or...
2018/0133303 VIRUS-LIKE PARTICLES
Provided herein are membrane enveloped virus-like particles (VLPs), and methods of use and synthesis thereof. In particular, yeast-cell-derived VLPs are...
2018/0133302 VACCINE COMBINATION AGAINST MULTIPLE DENGUE VIRUS SEROTYPES AND PREPARATION AND APPLICATION THEREOF
Provided is a vaccine combination against multiple dengue virus serotypes and preparation thereof. The vaccine combination includes a first vaccine and a...
2018/0133301 IMMUNOGENIC AND VACCINE COMPOSITIONS FOR USE AGAINST BORDETELLA BRONCHISEPTICA INFECTION
The present invention in certain embodiments generally relates to an immunogenic composition comprising Bordetella sp. Adenylate cyclase toxin (CyaA) for use...
2018/0133300 Vaccine Composition for Treating or Preventing Shigellosis
The present invention relates to a Shigella strain, of which the surface exposure of a protective antigen existing on a cellular membrane is increased due to...
2018/0133299 COMPOSITIONS, METHODS AND THERAPIES FOR ADMINISTERING ANTIGEN PEPTIDE
The invention relates to compositions, methods and therapies for the treatment of inflammation caused by infection with Propionibacterium acnes. The...
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