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Patent # Description
2018/0135121 PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as...
2018/0135120 COMPREHENSIVE METHODS FOR DETECTING GENOMIC VARIATIONS
The invention described herein provides methods and systems for comprehensive genomic analysis that enables the detection of a broad range of genomic...
2018/0135119 NUCLEIC ACID SEQUENCING SYSTEM
A nucleic acid sequencing system is provided, including a base provided with a clamping platform, a reagent storage unit, a fluid control unit, a mobile...
2018/0135118 Pinhole Zero-Mode Waveguides
Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The...
2018/0135117 SYSTEMS FOR HANDLING MICROFLUIDIC DROPLETS
The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while...
2018/0135116 METHOD AND DEVICE FOR THE DETECTION OF MOLECULAR INTERACTIONS
The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or...
2018/0135115 COMPOSITION AND METHOD FOR IMPROVING SIGNAL-TO-NOISE IN HYBRIDIZATION TO OLIGONUCLEOTIDE ARRAYS
Provided herein, among other things, are compositions for improving signal-to-noise in hybridization to oligonucleotide arrays. In some embodiments, the...
2018/0135114 METHOD FOR DETECTING MUTANT DNA
The present invention relates to a method for detecting of a mutant DNA using a probe, comprising: (1) contacting a sample containing a single-stranded DNA which...
2018/0135113 DETECTION OF DNA METHYLATION
In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive...
2018/0135112 LABELED CIRCULAR DNA MOLECULES FOR ANALYSIS OF DNA TOPOLOGY, AND TOPOISOMERASES AND FOR DRUG SCREENING
The present invention provides labeled circular plasmid DNA molecules for studying DNA topology and topoisomerases. The molecules of the present invention also...
2018/0135111 METHOD AND APPARATUS FOR ULTRASENSITIVE QUANTITATIVE ANALYSIS OF DNA BIOMARKER
The present invention relates to a method and an apparatus for ultrasensitive quantitative analysis of a DNA biomarker, and more particularly, provides a...
2018/0135110 DEVICES AND METHODS TO DETECT BIOMARKERS USING OLIGONUCLEOTIDES
Devices for detecting targets in a sample and methods for detecting such targets are discussed. The targets may be biomarkers associated with a disease or...
2018/0135109 EVALUATION OF CAS9 MOLECULE/GUIDE RNA MOLECULE COMPLEXES
Disclosed herein are methods for evaluation, selection, optimization, and design of Cas9 molecule/gRNA molecule complexes.
2018/0135108 METHOD FOR DETECTING BACTERIAL AND FUNGAL PATHOGENS
This disclosure provides a method for detecting bacterial and fungal pathogens at clinically relevant concentrations in a clinical fluid sample using a visual...
2018/0135107 Thermo-Controllable High-Density Chips for Multiplex Analyses
The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required....
2018/0135106 Thermo-Controllable High-Density Chips for Multiplex Analyses
The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required....
2018/0135105 ISOLATION OF NUCLEIC ACIDS
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from...
2018/0135104 MULTIPLEX AMPLIFICATION OF POLYNUCLEOTIDES
The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include...
2018/0135103 Methods for determining the amount of a nucleic acid of interest in an unprocessed sample
The present disclosure relates to methods for determining the amount or concentration of a nucleic acid of interest in an unprocessed sample by analyzing a...
2018/0135102 SCANNING REAL-TIME MICROFLUIDIC THERMOCYCLER AND METHODS FOR SYNCHRONIZED THERMOCYCLING AND SCANNING OPTICAL...
Systems and methods for performing simultaneous nucleic acid amplification and detection. The systems and methods comprise methods for managing a plurality of...
2018/0135101 Sample to Sequence
Method and sample vessels are provided for amplification and sequencing of nucleic acids in a sample.
2018/0135100 COMPOSITIONS, METHODS AND SYSTEMS FOR POLYMERASE CHAIN REACTION ASSAYS
Methods, devices, systems and compositions for detecting nucleic acids in polymerase chain reaction assays, such as droplet digital polymerase chain reaction...
2018/0135099 NANOREPORTERS AND METHODS OF MANUFACTURING AND USE THEREOF
The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In...
2018/0135098 SYSTEM FOR IMPROVING DIABETES TESTING AND REDUCING COUNTERFEITING
A diabetes test system for measuring blood glucose levels is provided, which includes a glucose meter, at least one diabetic test strip, and a container or...
2018/0135097 RAB ESCORT PROTEIN POTENCY ASSAY
Methods for measuring REP-1 and REP-2 activity are provided. In certain embodiments, a method includes: (a) contacting cells that do not express endogenous...
2018/0135096 METHOD FOR ISOLATING MICROORGANISMS ON A CULTURE MEDIUM, AND RELATED DEVICE
Method for isolating microorganism from a sample likely contaminated by microorganism, including: (a) device for isolating microorganisms including a bottom...
2018/0135095 ANTIBACTERIAL POLYPEPTIDE LIBRARIES AND METHODS FOR SCREENING THE SAME
Compositions and methods for isolating polypeptides having antibiotic activity are provided. In some aspects, bacterial cell populations are provided that...
2018/0135094 RAPID AND HIGH-SENSITIVE BACTERIA DETECTION
An improved method and related apparatus for detecting bacteria viability and drug effects using metabolic monitoring. A fluorescent material which is quenched...
2018/0135093 INSTRUMENT AND SYSTEM FOR RAPID MICROORGANISM IDENTIFICATION AND ANTIMICROBIAL AGENT SUSCEPTIBILITY TESTING
A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a...
2018/0135092 EXPRESSION SEQUENCES
An isolated nucleic acid encoding a leader, which has a specific sequence, an isolated leader peptide encoded by such nucleic acid, an expression cassette...
2018/0135091 SMALL SCALE CULTIVATION METHOD FOR SUSPENSION CELLS
The present invention pertains to the field of cell cultivation. Small scale cell culture systems are provided which simulate large scale perfusion cultures of...
2018/0135090 METHODS OF MANUFACTURING THERAPEUTIC PROTEINS
Disclosed herein are methods of manufacturing therapeutic proteins.
2018/0135089 Method for Do Novo Biosynthesis of Chondroitin Sulfate
The present invention relates to a method for chondroitin sulfate biosynthesis, belongs to the field of pharmaceuticals field. CS was biosynthesized by...
2018/0135088 METHOD FOR PRODUCING MODIFIED XYLOPOLYSACCHARIDE
Provided is a method for industrially mass-producing a modified xylopolysaccharide from biomass. The biomass used as a raw material includes xylan in plant...
2018/0135087 MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE
The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a...
2018/0135086 MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE, AND METHOD FOR PRODUCING O-ACETYL-HOMOSERINE BY USING SAME
The present disclosure relates to a protein having the activity of exporting O-acetylhomoserine and a novel modified protein thereof, a microorganism capable...
2018/0135084 Method of Producing Lipid
A method of producing a lipid, containing the steps of: culturing a transformant obtained by introducing a gene encoding the following protein (a) or (b)...
2018/0135083 METHOD OF FORMING DIHYDROFERULIC ACID
The present invention relates to a method of forming dihydroferulic acid comprising providing ferulic acid and incubating the ferulic acid with a bacterial...
2018/0135082 ENGINEERED MICROORGANSIMS & METHODS FOR IMPROVED CROTYL ALCOHOL PRODUCTION
Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic...
2018/0135081 METHODS FOR PRODUCTION OF OXYGENATED TERPENES
The present invention relates to methods for producing oxygenated terpenoids. Polynucleotides, derivative enzymes, and host cells for use in such methods are...
2018/0135080 METHOD FOR THE MONITORING OF MODIFIED NUCLEASES INDUCED-GENE EDITING EVENTS BY MOLECULAR COMBING
Methods for detecting and characterizing large genomic rearrangements induced by modified nucleases at high resolution and for quantifying the frequency of the...
2018/0135079 Polysaccharide Nanoparticles
Polysaccharide nanoparticles that are particularly useful in for example drug and agent delivery, tissue-specific targeting, for medical imaging and diagnosis,...
2018/0135078 AAV-VECTORS FOR USE IN GENE THERAPY OF CHOROIDEREMIA
The present invention relates to gene therapy for treatment or prevention of choroideremia.
2018/0135077 SERUM-FREE SUSPENSION SYSTEM FOR LENTIVIRAL PRODUCTION
A lentiviral vector production system comprises (a) a lentiviral culture supplement to control cell growth, (b) a transfection reagent comprising DHDMS, DOPE,...
2018/0135076 ADENO-ASSOCIATED VIRUS VECTOR
Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein...
2018/0135075 RECOMBINANT ADENOVIRUS EXPRESSING TWO TRANSGENES WITH A BIDIRECTIONAL PROMOTER
The invention provides recombinant adenovirus (rAd) and rAd vectors comprising a bidirectional mouse CMV (mCMV) promoter operably linked to a first transgene...
2018/0135074 RECOMBINANT AAV VECTORS FOR GENE THERAPY OF HUMAN HEMATOPOIETIC DISORDERS
Provided herein are recombinant AAV (rAAV) particles comprising a nucleic acid vector comprising a parvovirus B 19p6 promoter operatively linked to a...
2018/0135073 CRISPR-BASED GENOME MODIFICATION AND REGULATION
The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified...
2018/0135072 THREAD NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO HEMIPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of hemipteran pests through RNA interference-mediated inhibition of...
2018/0135071 Disease Resistant Potato Plants
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced...
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