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Patent # Description
2018/0135070 STRUCTURALLY MODIFIED COI1
Described herein are plants that are resistant to herbicides, such as herbicide compositions comprising coronatine, where the herbicide-resistant plants...
2018/0135069 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES FOR INCREASING PLANT YIELD AND/OR AGRICULTURAL CHARACTERISTICS
Provided are isolated polynucleotides which comprise a nucleic acid sequence at least 80% identical to SEQ ID NO: 321, 1-320, 322-480, 793-2945 or 2946;...
2018/0135068 SUPPRESSING MSH1 FUNCTION
The present invention provides methods of identifying and producing dominant negative MSH1 genes in plants and methods of using plants comprising dominant...
2018/0135067 PLANT BODY IDEAL FOR HIGH-DENSITY PLANTING AND USE THEREOF
In order to improve biomass productivity per unit area by extending the limit of high-density planting, the present invention produces plant biomass by...
2018/0135066 PRODUCTION OF DHA AND OTHER LC PUFAS IN PLANTS
The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory...
2018/0135065 REDUCING LEVELS OF NICOTINIC ALKALOIDS IN PLANTS
Two genes, A622 and NBB1, can be influenced to achieve a decrease of nicotinic alkaloid levels in plants. In particular, suppression of one or both of A622 and...
2018/0135064 REDUCING LEVELS OF NICOTINIC ALKALOIDS IN PLANTS
Two genes, A622 and NBB1, can be influenced to achieve a decrease of nicotinic alkaloid levels in plants. In particular, suppression of one or both of A622 and...
2018/0135063 PREPARATION AND USE OF PLANT EMBRYO EXPLANTS FOR TRANSFORMATION
The present invention relates to excision of explant material comprising meristematic tissue from seeds, and storage of such material prior to subsequent use...
2018/0135062 Recombinant Probiotic Bacteria
The invention is directed to recombinant probiotic bacteria, especially for use in the treatment of an inflammatory skin dysfunction, as well as a method for...
2018/0135061 METHODS OF MODULATING mRNA STABILITY AND PROTEIN EXPRESSION
A synthetic cDNA which encodes a protein wherein at least one optimal or non-optimal codon in a wild type DNA encoding the protein has been replaced...
2018/0135060 ESCHERICHIA COLI T7 EXPRESSION VECTOR, VECTORS FOR THE CO-EXPRESSION AND CO-PURIFICATION OF RECOMBINANT...
The present invention relates to a vector for the expression of recombinant proteins, antigens, pathogen-like particles and immunogenic complexes, said vector...
2018/0135059 SYNTHESIS OF OMEGA FUNCTIONALIZED PRODUCTS
The use of microorganisms to make omega- and/or omega-l-functionalized products through an iterative carbon chain elongation pathway that we call a reverse...
2018/0135058 CELL DEATH INDUCING AGENT FOR CELLS HAVING BRAF GENE MUTATION, GROWTH SUPPRESSING AGENT FOR SAME CELLS AND...
Cell death is induced and/or cell growth is suppressed for a cell having a mutation in the BRAF gene. A drug suppressing GST-.pi. is comprised as an active...
2018/0135057 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
The invention relates to antisense polynucleotide agents targeting the LECT2 gene, and methods of using such antisense polynucleotide agents to inhibit...
2018/0135056 DELIVERY OF THERAPEUTIC AGENT
A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method...
2018/0135055 COMPOSITION FOR CANCER CELL SENSITIZATION CONTAINING AS ACTIVE INGREDIENT SUBSTANCE INHIBITING EXPRESSION OF...
The present invention relates to a composition for cancer cell sensitization containing as an active ingredient a substance inhibiting the expression of an...
2018/0135054 MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE
Modified oligonucleotides comprising modifications at the 2' and/or 3' positions(s) along with methods of making and use, e.g., against HBV are disclosed.
2018/0135053 METHOD OF STIMULATING TLR9-ACTIVATED IMMUNE RESPONSE
A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen is disclosed herein. TLR9 is the cellular...
2018/0135052 APTAMERS AGAINST GLIOMA CELLS
Provided are aptamers able to bind to ligands associated with cancer cells. The ligands may particularly be associated with brain cancers, such as gliomas. The...
2018/0135051 THERAPEUTIC OLIGOMERS FOR TREATING AMYLOIDOSIS
This invention provides pharmaceutical compositions containing a UNA oligomer targeted to TTR and a pharmaceutically acceptable carrier. The compositions can...
2018/0135050 TREATMENT OF ALPHA-L-IDURONIDASE (IDUA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IDUA
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Alpha-L-Iduronidase (IDUA), in particular, by...
2018/0135049 RNAI INHIBITORS OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE FOR TREATING CARDIOVASCULAR AND PULMONARY CONDITIONS
The present disclosure provides for methods of treating or preventing a cardiovascular disorder and/or a related pulmonary disorder in a subject. In certain...
2018/0135048 COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
Methods and compositions are provided which employ a silencing element that, when ingested by a plant insect pest, such as a Coleopteran plant pest or a...
2018/0135047 OLIGODEOXY NUCLEOTIDE FOR PREPARING DRUGS FOR INHIBITING TUMOR GROWTH AND APPLICATION THEREOF
The present invention provides an oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and an application thereof. The core sequence of the...
2018/0135046 SMALL-INTERFERING RNA EXPRESSION SYSTEMS FOR PRODUCTION OF SMALL-INTERFERING RNAS AND THEIR USE
A method of preparing a library of small interfering RNA (siRNA) expression systems for producing siRNA for silencing of target genes by inducing degradation...
2018/0135045 High Throughput Discovery of New Genes From Complex Mixtures of Environmental Microbes
Compositions and methods for isolating new variants of known gene sequences are provided. The methods find use in identifying variants, particularly homologs,...
2018/0135044 NON-UNIQUE BARCODES IN A GENOTYPING ASSAY
The present disclosure involves ctDNA assays that interrogate many regions from a single sample with high precision and accuracy, while evaluating multiple...
2018/0135043 NUCLEIC ACID COMPLEXES FOR SCREENING BARCODED COMPOUNDS
The invention provides compositions comprising nucleic acid complexes for use in screening compounds based on their ability to modulate binding interactions,...
2018/0135042 METHODS AND COMPOSITIONS FOR LONG-RANGE HAPLOTYPE PHASING
Various approaches for generating read-sets from nucleic acid molecules and segments and phasing are disclosed. Nucleic acids are assembled into complexes...
2018/0135041 BACTERIAL ENGINEERING
Described is a process for producing a mutant bacterium which exhibits improved survival and/or growth under a selected growth condition, the process...
2018/0135040 METHODS FOR SEPARATING NUCLEIC ACIDS WITH GRAPHENE COATED MAGNETIC BEADS
Methods for separating and identifying nucleic acids utilize carbon coated magnetic beads. The method teaches that multivalent cations promote binding of...
2018/0135039 METHOD FOR PREPARING ELECTROCOMPETENT YEAST CELLS, AND METHOD FOR USING SAID CELLS
The present invention relates to improved yeast transformation of yeast cells and yeast cell libraries transformed thereby. More specifically, the present...
2018/0135038 IMMOBILIZED PLASMINOGENASE COMPOSITION, PREPARATION PROCESS, USE AND DEVICE COMPRISING SUCH A COMPOSITION
Disclosed is an enzymatic composition including:--at least one enzyme, termed plasminogenase, for converting, into plasmin, plasminogen from a blood plasma...
2018/0135037 THERMOPHILIC AND THERMOACIDOPHILIC METABOLISM GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
2018/0135036 Use of Polypeptides Having Protease Activity in Animal Feed and Detergents
The present invention relates to the use of isolated polypeptides having protease activity in animal feed and detergents. It also relates to the use of...
2018/0135035 Polypeptides Having Xylanase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to...
2018/0135034 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2018/0135033 DNA POLYMERASES WITH IMPROVED ACTIVITY
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful...
2018/0135032 Hyperactive Variants of the Transposase Protein of the Transposon System Sleeping Beauty
The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to...
2018/0135031 MICROORGANISM HAVING L-LYSINE PRODUCING ABILITY AND L-LYSINE PRODUCING METHOD USING SAME
The present invention relates to a microorganism having improved L-lysine-producing ability and an L-lysine-producing method using the same. More specifically,...
2018/0135030 COMPOSITIONS USEFUL IN TREATMENT OF ORNITHINE TRANSCARBAMYLASE (OTC) DEFICIENCY
Non-viral delivery systems comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for...
2018/0135029 METHOD FOR THE BIOTECHNOLOGICAL PRODUCTION OF FLAVONOIDS
A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section...
2018/0135028 NOVEL CAR ENZYMES AND IMPROVED PRODUCTION OF FATTY ALCOHOLS
The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
2018/0135027 MUTATED REP ENCODING SEQUENCES FOR USE IN AAV PRODUCTION
Nucleic acids encoding Parvoviral Rep proteins with a mutated nuclear localization signal (NLS) are provided. Also provided is a nucleic acid comprising a...
2018/0135026 DUCK EMBRYONIC DERIVED STEM CELL LINES FOR THE PRODUCTION OF VIRAL VACCINES
The present invention relates to the development and manufacturing of viral vaccines. In particular, the invention relates to the field of industrial...
2018/0135025 RETROVIRAL PARTICLE COMPRISING AT LEAST TWO ENCAPSIDATED NONVIRAL RNAS
The present invention relates to a retroviral system for the transfer of non-viral RNA into target cells and more particularly a retroviral particle capable of...
2018/0135024 METHOD FOR ISOLATING AND PURIFYING ADENO-ASSOCIATED VIRUS PARTICLES USING SALT
Methods for isolating and optionally purifying AAV particles grown in cell cultures using a combination of lyotropic salts, removal of insoluble producer cell...
2018/0135023 INDUCTION OF HEPATOCYTES BY STEM CELL DIFFERENTIATION WITH RNA
A novel method of inducing or producing hepatocytes from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The core of the...
2018/0135022 METHOD FOR PRODUCING ARTIFICIAL SYNCYTIOTROPHOBLAST AND PROGENITOR CELL THEREOF
According to the present invention, there is provided a method for producing artificial trophoblasts derived from human cells, that includes the steps of:...
2018/0135021 INDUCTION OF PANCREATIC BETA CELLS BY STEM CELL DIFFERENTIATION WITH RNA
A novel method of inducing or producing pancreatic beta cells from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The...
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