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Patent # Description
2018/0142305 METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER...
In one embodiment, methods of theranostic classification of a breast cancer tumor are provided, wherein the classification is determined by detecting an...
2018/0142304 COMPOSITIONS AND METHODS FOR SCREENING SOLID TUMORS
The present technology relates to methods for determining whether a patient diagnosed with breast cancer, colorectal cancer, melanoma or lung cancer will...
2018/0142303 METHODS AND COMPOSITIONS FOR DIAGNOSING OR DETECTING LUNG CANCERS
A multi-analyte composition for the diagnosis of lung cancer or lung disease comprises a ligand selected from a nucleic acid sequence, polynucleotide or...
2018/0142302 METHODS OF PREDICTING THE NEED FOR SURGERY IN CROHN'S DISEASE
The present invention relates to methods of predicting susceptibility to a severe form of Crohn's disease in an individual by determining the presence or...
2018/0142301 PREDICTION OF THERAPEUTIC RESPONSE IN INFLAMMATORY CONDITIONS
Response to treatment of an inflammatory condition can be predicted based on characteristics of one or more markers from a subject. The markers can include...
2018/0142300 UNIVERSAL HAPLOTYPE-BASED NONINVASIVE PRENATAL TESTING FOR SINGLE GENE DISEASES
To detect a fetal mutation inherited from the mother without paternal genetic information, a property of each maternal haplotype can be measured in the...
2018/0142299 METHODS FOR PREPARING DNA REFERENCE MATERIALS AND CONTROLS
Disclosed are controls and reference materials for use in identifying any of a number of genotypes and/or for use in identifying or characterizing a disease or...
2018/0142298 SYSTEMS AND METHODS TO PREDICT AUTISM BEFORE ONSET OF BEHAVIORAL SYMPTOMS AND/OR TO DIAGNOSE AUTISM
Systems and methods to predict or diagnose autism are described. Using markers, the systems and methods can predict or diagnose autism based on significant...
2018/0142297 SYSTEMS AND METHODS FOR CHARACTERIZING GRANULOMATOUS DISEASES
The present disclosure relates to methods of characterizing disease. In particular, the present disclosure relates to genes associated with complicated...
2018/0142296 MULTIPLEXED OPTIMIZED MISMATCH AMPLIFICATION (MOMA)-REAL TIME PCR FOR ASSESSING CELL-FREE DNA
This invention relates to methods and compositions for assessing an amount of non-native nucleic acids in a sample, such as from a subject. The methods and...
2018/0142295 REGULATOR TARGETING FATTY ACID SYNTHASE AND METHOD OF USING THE SAME FOR IMPROVING MEAT QUALITY
A kit for real-time fluorescence quantitative PCR adapted to detect an expression level of a miRNA-4749-5 having a sequence of SEQ ID NO: 1 is disclosed. The...
2018/0142294 METHOD FOR AUTHENTICATING ACTIVE PHARMACEUTICAL INGREDIENTS
Provided is a method of authenticating an active pharmaceutical ingredient (API). The method includes providing an API or an API component and adding a nucleic...
2018/0142293 METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate...
2018/0142291 COMPOSITIONS AND PROCESSES FOR IMPROVED MASS SPECTROMETRY ANALYSIS
The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the...
2018/0142290 BLOCKING OLIGONUCLEOTIDES
A blocking oligonucleotide (10, 10A, 10A', 10A'', 10B, 10C, 10D, 10E) comprises a 3'-end complementary sequence (13) complementary to a 3'-end sequence (23) of...
2018/0142289 POLYNUCLEOTIDE LIBRARIES HAVING CONTROLLED STOICHIOMETRY AND SYNTHESIS THEREOF
Provided herein are compositions, methods and systems relating to libraries of polynucleotides having preselected stoichiometry with regard to species of...
2018/0142288 NUCLEIC ACID-POLYMER CONJUGATES FOR BRIGHT FLUORESCENT TAGS
A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is...
2018/0142287 Compositions, Methods and Kits for Detection of Genetic Variants for Alzheimer's Disease
Provided herein are methods, kits, and devices related to genetic variations of neurological disorders. For example, methods, kits, and devices for using such...
2018/0142286 CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
2018/0142285 METHOD TO DETECT ACTIVITY OF A POLYMERASE
The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase...
2018/0142284 MULTIPLEX ANALYSIS OF GENE EXPRESSION IN INDIVIDUAL LIVING CELLS
The technology as disclosed herein relates to methods, compositions and kits for multiplex measuring levels of expression of target RNA species (e.g., mRNA and...
2018/0142283 NUCLEIC ACID MODIFYING AGENTS AND USES THEREOF
In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups....
2018/0142282 GENERIC SAMPLE PREPARATION
The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for...
2018/0142281 ENHANCED UTILIZATION OF SURFACE PRIMERS IN CLUSTERS
Presented herein are methods and compositions for enhancing utilization of surface primers during the surface amplification process. The methods are useful for...
2018/0142280 COMPOSITION FOR REDUCING INHIBITION OF NUCLEIC ACID AMPLIFICATION
A composition for reducing the inhibitory effects of contaminants on nucleic acid amplification is provided. The composition includes a plurality of zirconium...
2018/0142279 AUTOMATIC MICROFLUIDIC SYSTEM FOR ANTIBIOTIC SUSCEPTIBILITY TESTING AND METHOD OF OPERATING THEREOF
An automatic microfluidic system for antibiotic susceptibility testing of the present disclosure at least includes a microfluidic chip. The microfluidic chip...
2018/0142278 ENRICHMENT AND SELECTIVE CULTURE OF SALMONELLA AND SHIGELLA
What is disclosed relates to the detection and identification of bacteria of the genera Salmonella and Shigella. It relates more precisely to the methods of...
2018/0142277 ELECTROCHEMICAL SENSORS AND METHODS FOR USING ELECTROCHEMICAL SENSORS TO DETECT PLANT PATHOGEN INFECTION
Provided herein are plant/plant pathogen volatile compound electrochemical sensors, plant/plant pathogen volatile detection systems, and methods for detecting...
2018/0142276 MUTANT SUCROSE PHOSPHORYLASES WITH IMPROVED GLYCOSYLATION ACTIVITY TOWARDS POLYPHENOLS
The present invention relates to glycosylating polyphenols via biocatalysis. More specifically the present invention discloses particular mutants of the...
2018/0142275 IMMOBILIZED POLY(N)POLYMERASE
The present invention relates to an immobilized poly(N)polymerase (PNP), methods of producing said PNP and uses thereof. Further disclosed is an enzyme reactor...
2018/0142274 MICROORGANISM OF GENUS KOMAGATAEIBACTER HAVING ENHANCED CELLULOSE PRODUCTIVITY, METHOD OF PRODUCING CELLULOSE...
Provided are a microorganism of genus Komagataeibacter having enhanced cellulose productivity and yield, a method of producing cellulose by using the...
2018/0142273 ITERATIVE PLATFORM FOR THE SYNTHESIS OF ALPHA FUNCTIONALIZED PRODUCTS
The use of microorganisms to make alpha-functionalized chemicals and fuels, (e.g. alpha-functionalized carboxylic acids, alcohols, hydrocarbons, amines, and...
2018/0142272 ENZYMATIC MODIFICATION OF OIL
The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated...
2018/0142271 METHOD FOR PRODUCING 3-HYDROXYADIPIC ACID
A novel method of producing 3-hydroxyadipic acid using a metabolic pathway of a microorganism is disclosed. The method of producing 3-hydroxyadipic acid...
2018/0142270 STREPTOMYCES PSAMMOTICUS AND METHODS OF USING THE SAME FOR VANILLIN PRODUCTION
The present invention relates to a bacterial strain, Streptomyces psammoticus OMK-4, and a method for vanillin production by fermentation of the bacterial...
2018/0142269 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid...
2018/0142268 YEAST PROPAGATION SIMULTANEOUS WITH SACCHARIFICATION
The invention relates to a method for propagating yeast, for use in the production of a fermentation product from lignocellulosic biomass, including the steps...
2018/0142267 ELECTRON CONSUMING ETHANOL PRODUCTION PATHWAY TO DISPLACE GLYCEROL FORMATION IN S. CEREVISIAE
The present invention provides for a mechanism to completely replace the electron accepting function of glycerol formation with an alternative pathway to...
2018/0142266 A METHOD OF PRODUCING ALCOHOLS
There is provided a microbial cell which is capable of producing at least one higher alcohol, wherein the microbial cell is genetically modified to include an...
2018/0142265 MICROBIAL FERMENTATION FOR THE PRODUCTION OF TERPENES
The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a...
2018/0142264 NANOPARTICLE BIOHYBRID COMPLEXES
Disclosed herein are biohybrid protein complexes capable of using light energy to photocatalyze the reduction of N.sub.2 into NH.sub.3. Also provided are...
2018/0142263 CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE
The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of...
2018/0142262 METHOD FOR CORRECTING A GENETIC SEQUENCE
Methods of gene correction, methods of generating induced pluripotent stem cells (iPSCs), and methods of deriving multi-lineage cell types with therapeutic...
2018/0142261 TARGETED LIPID PARTICLES FOR SYSTEMIC DELIVERY OF NUCLEIC ACID MOLECULES TO LEUKOCYTES
Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further...
2018/0142260 PROMOTERS FOR EXPRESSION OF HETEROLOGOUS GENES
The present disclosure relates generally to promoters derived from the AAV anti-sense strand, their use in the expression of one or more heterologous coding...
2018/0142259 METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The...
2018/0142258 METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular,...
2018/0142257 METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular,...
2018/0142256 Replication-Deficient RNA Viruses as Vaccines
The present invention relates to a genome-replication-deficient and transcription-competent negative-strand RNA virus, which can be used for the expression of...
2018/0142255 OPTIMIZATION OF DETERMINANTS FOR SUCCESSFUL GENETIC CORRECTION OF DISEASES, MEDIATED BY HEMATOPOIETIC STEM CELLS
Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for...
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