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Patent # Description
2018/0142001 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE
Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed....
2018/0142000 ANTI-CAMPYLOBACTER JEJUNI ANTIBODIES AND USES THEREFOR
Campylobacter jejuni is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated...
2018/0141999 ANTIBODY THERAPEUTICS AGAINST FILOVIRUS INFECTIONS AND USES THEREOF
Disclosed are bispecific antibodies and bispecific fusion constructs that bind to Niemann-Pick CI (NPC1) receptor for treating or preventing filovirus...
2018/0141998 CANCER NEOEPITOPES
Contemplated compositions and methods are directed to cancer neoepitopes and uses of such neoepitopes, especially to generate synthetic antibodies against...
2018/0141997 OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
2018/0141996 CELL-COLLAGEN-SILICA COMPOSITES AND METHODS OF MAKING AND USING THE SAME
Soluble, self-assembling collagens derived from tissues are extensively characterized such that one can predict and customize the final collagen-fibril matrix...
2018/0141995 Compositions and Methods for the Intracellular Disruption of VEGF and VEGFR-2 by Intraceptors
The present invention provides an intraceptor that interacts with and decreases activity of with VEGF and/or a VEGFR for the treatment of angiogenesis-related...
2018/0141994 TOLL-LIKE RECEPTOR 2 BINDING EPITOPE AND BINDING MEMBER THERETO
The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2...
2018/0141993 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0141992 CELLS LACKING B2M SURFACE EXPRESSION AND METHODS FOR ALLOGENEIC ADMINISTRATION OF SUCH CELLS
Disclosed herein are cells and populations of cells comprising a genome in which the B2M gene has been edited to eliminate surface expression of MHC Class I...
2018/0141991 METHODS AND POLYPEPTIDES FOR MODULATION OF IMMUNORESPONSE
A method for modulating an immunoresponse includes binding a TREM-like transcript 1 (TLT-1) polypeptide to an immune cell, wherein the binding of the TLT-1...
2018/0141990 ACYLATED GLUCAGON ANALOGUES
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular,...
2018/0141989 Variants of Adrenomedullin and Calcitonin Gene-Related Peptide and Methods of Use
Variant peptides of calcitonin gene-related peptide alpha (.alpha.CGRP), calcitonin gene-related peptide beta (.beta.CGRP), and adrenomedullin (AM) are...
2018/0141988 MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC3)
The present disclosure relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Glypican-3 (GPC3), which proteins preferably...
2018/0141987 Novel Synthetic Antimicrobial Peptides
The present invention provides anti-microbial compositions comprising synthetic peptides for therapeutic use. These compositions have found applications in...
2018/0141985 ANTI-TUMOR PEPTIDES AND USE THEREOF
The anti-tumor peptide provided by the present invention is a synthetic peptide having both amino acid sequences represented by the following (1) and (2): ...
2018/0141984 ANTIMICROBIAL PEPTIDE ANALOGUES DERIVED FROM ABALONE (HALIOTIS DISCUS) AND ANTIMICROBIAL PHARMACEUTICAL...
The present disclosure relates to an antimicrobial peptide analogue derived from abalone and an antimicrobial pharmaceutical composition containing the same....
2018/0141983 Anti-Cancer DNA Vaccine Employing Plasmids Encoding Signal Sequence, Mutant Oncoprotein Antigen, and Heat Shock...
Novel nucleic acid vectors comprising sequences encoding (a) an antigen, (b) a signal peptide, and (c) a heat shock protein, are disclosed, as are methods for...
2018/0141982 CATIONIC NEUROTOXINS
Engineered clostridial toxins comprising an amino acid modification that increases the isoelectric point of the engineered clostridial toxin to a value that is...
2018/0141981 IMMUNOGENIC COMPOSITION COMPRISING ENGINEERED ALPHA-HEMOLYSIN OLIGOPEPTIDES
The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present...
2018/0141980 TREPONEMA PALLIDUM TRIPLET ANTIGEN
A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino...
2018/0141979 MODULAR DNA-BINDING DOMAINS AND METHODS OF USE
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically...
2018/0141978 Truncated Rotavirus VP4 Protein And Application Thereof
The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and...
2018/0141977 ANTI-BACTERIAL AGENTS AND THEIR USE IN THERAPY
The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein...
2018/0141976 SPECIFIC MODIFICATION OF ANTIBODY WITH IGG-BINDING PEPTIDE
This invention relates to an IgG-binding peptide, an IgG-binding peptide modified with a cross-linking agent, a conjugate of the IgG-binding peptide modified...
2018/0141975 COMPOSITIONS AND METHODS FOR INHIBITING CD279 INTERACTIONS
Methods and compositions for inhibiting and/or interfering with interactions between (1) programmed Death-1 protein (also known as CD279) and (2) programmed...
2018/0141974 PENTAPEPTIDE ASSOCIATED WITH INTEGRIN RECEPTOR ALPHA VBETA3
A pentapeptide associated with integrin receptor .alpha.v.beta.3, which has a sequence of arginine-tryptophan-arginine-asparagine-methionine. The pentapeptide...
2018/0141973 Derivatives of Dolastatin 10 and Uses Thereof
Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided. ##STR00001##
2018/0141972 NATIVE PROTEIN PURIFICATION TECHNOLOGY
The present invention relates to an isolated polypeptide comprising (a) a protein of interest; (b) a first member of a pair of binding partners; (c) an...
2018/0141971 19-NOR C3, 3-DISUBSTITUTED C21-C-BOUND HETEROARYL STEROIDS AND METHODS OF USE THEREOF
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof; wherein , R.sup.1, R.sup.2,...
2018/0141970 PROCESS USING DUAL SPECIFICITY OLIGONUCLEOTIDE AND DUAL SPECIFICITY OLIGONUCLEOTIDE
The present invention relates to various processes by a template-dependent extension reaction using a dual specificity oligonucleotide and a dual specificity...
2018/0141969 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING...
An organometallic compound represented by Formula 1: ##STR00001## wherein in Formula 1, groups and variables are the same as described in the specification.
2018/0141968 CRYSTALLINE LIGAND
A ligand crystal structure of 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bi- s(oxy)]bisdibenzo[d,f][1,3,2]-dioxaphosphepin. Formule...
2018/0141967 BIS(6-METHYL-3-SULPHOPHENYL)PHENYLPHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME
Provided are a water-soluble triarylphosphine for a palladium catalyst, which has high selectivity in a telomerization reaction and can be recovered with...
2018/0141966 CHIRAL SPIRO PHOSPHORUS-NIROGEN-SULPHUR TRIDENTATE LIGAND, PREPARATION METHOD AND APPLICATION THEREOF
The present invention relates to a chiral spiro phosphine-nitrogen-sulfur (P--N--S) tridentate ligand, preparation method and application thereof. The P--N--S...
2018/0141965 AUTOTAXIN INHIBITORS AND USES THEREOF
Novel inhibitors of the enzyme autotaxin are described. The inhibitors contain one or two zinc-binding groups at the appropriate distance, Also described are...
2018/0141964 FUNCTIONALIZED CYANOSILANE AND SYNTHESIS METHOD AND USE THEREOF
The present teachings relate to a functionalized silyl cyanide and synthetic methods thereof. As an example, the method may include adding a raw material...
2018/0141963 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2018/0141962 AZACARBAZOLE BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof,...
2018/0141961 Substituted Pyrazole Compounds Containing Pyrimidine and Preparation Method and Use Thereof
Disclosed are substituted pyrazole compounds containing pyrimidinyl as shown in Formula I: ##STR00001## The definitions of each of the substituents can be seen...
2018/0141960 PYRIDINE COMPOUNDS
The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory...
2018/0141959 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS
The present invention is directed to certain amides and heterocyclic compounds. The present invention also relates to uses of these compounds to treat several...
2018/0141958 COMPLEMENT C3D-BINDING COMPOUNDS
The disclosure provides for compounds that bind with a high affinity to the C3d component of complement. The disclosure further provides for the use of the...
2018/0141957 COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME AND ELECTRONIC DEVICE THEREOF
Provided are a compound represented by Formula 1, and an organic electric element comprising a first electrode, a second electrode, and an organic material...
2018/0141956 FUSED PYRIDINES AS KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2018/0141955 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpla]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
2018/0141954 PYRROLOPYRIMIDINES AS CFTR POTENTIATORS
The present invention relates to compounds of Formula I, ##STR00001## wherein R.sup.1a, R.sup.1b, R.sup.2, R.sup.3, R.sup.4, W, Y, and Z are as described herein,...
2018/0141953 Novel Breathing Control Modulating Compounds, and Methods of Making and Using Same
The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need...
2018/0141952 BICYCLIC HETEROCYCLIC COMPOUNDS AS PDE2 INHIBITORS
The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of...
2018/0141951 FUSED HETEROAROMATIC PYRROLIDINONES
Disclosed are compounds of Formula 1, ##STR00001## and pharmaceutically acceptable salts thereof, wherein G, L.sup.1, L.sup.2, R.sup.1, R.sup.2, R.sup.3, and...
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