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Patent # Description
2018/0147258 RECOMBINANT FUSION PROTEIN FORMULATION
Provided is a liquid formulation that enables the stable storage of recombinant fusion proteins, comprising a recombinant fusion protein, a buffer salt, a...
2018/0147257 BTN3A ECTODOMAIN PROTEINS AND METHODS OF USE
BTN3A ectodomain polypeptides are provided, which comprise a BTN3A ectodomain (e.g., a BTN3A1, BTN3A2, or BTN3A3 ectodomain) and lack a BTN3A transmembrane...
2018/0147256 MEANS AND METHODS FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD).
The invention is related to facioscapulohumeral muscular dystrophy (FSHD) and in particular therapeutic means and methods for the treatment of the disease. In...
2018/0147255 INTRACELLULAR PH-RESPONSIVE FUSION PEPTIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF...
A pH-responsive fusion peptide according to the present disclosure, containing a cell-penetrating peptide exhibiting a positive charge, which contains 2-15...
2018/0147254 COMPOSITIONS COMPRISING CYCLOSPORIN
The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the...
2018/0147253 Treatment of Constipation-Predominant Irritable Bowel Syndrome
The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose...
2018/0147252 INHIBITORS OF MITOCHONDRIAL FISSION AND METHODS OF USE THEREOF
The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present...
2018/0147251 METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME
The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or...
2018/0147250 SYNTHETIC SUBSTRATES FOR ENZYMES THAT CATALYZE REACTIONS OF MODIFIED CYSTEINES AND RELATED METHODS
Synthetic probes for detecting the activity of enzymes that catalyze reactions of post-translationally modified cysteine residues are described. The probes...
2018/0147249 PHARMACEUTICAL COMPOSITION FOR TREATING ECZEMA AND METHOD FOR PREPARATION THEREOF
A pharmaceutical composition for treating eczema is disclosed. The pharmaceutical composition includes, by weight, 2 to 6 parts of Dried Rhizoma Zingiberis...
2018/0147248 METHOD FOR PREPARING BROCCOLI PROTEIN PEPTIDE, BROCCOLI PROTEIN PEPTIDE PREPARED THEREFROM AND USE THEREOF
Provided is a method for preparing a broccoli protein peptide. The method uses a broccoli protein as the raw material, and obtains a broccoli protein peptide...
2018/0147247 METHOD FOR PREPARATION OF A CANNABINOID EXTRACT FROM HEMP
The invention relates to a method for extraction and separation of cannabinoids from industrial hemp, designed for medicinal purposes, and also the preparation...
2018/0147246 Substantially Testosterone Free Compositions
1. A therapeutic composition, substantially free of testosterone, comprises (a) at least one Bulbine natalensis compound present in a therapeutically effective...
2018/0147245 SELECTIVE CELL TARGETING USING ADENOVIRUS AND CHEMICAL DIMERS
Compositions and methods for retargeting adenovirus to a cell using chemical dimers are described. In particular, a recombinant adenovirus comprising a nucleic...
2018/0147244 HONEY FRACTION
The present invention provides a honey fraction obtainable by a method comprising (a) obtaining an absorbed component by causing honey to be brought into...
2018/0147243 AMYLOID BETA FIBRIL DECOMPOSING AGENT, AND THERAPEUTIC OR PREVENTIVE AGENT AND THERAPEUTIC OR PREVENTIVE FOOD...
An object of the present invention is to provide: an amyloid .beta. fibril decomposing agent containing a natural product as an active ingredient; a...
2018/0147242 HEPATOCYTES AND HEPATIC NON-PARENCHYMAL CELLS, AND METHODS FOR PREPARATION THEREOF
The present invention pertains to hepatocytes, liver progenitor cells, cholangiocytes, liver sinusoidal endothelial progenitor cells, liver sinusoidal...
2018/0147241 Compositions and Methods for Treatment of Cardiovascular Disorders
Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a...
2018/0147240 NKP30 RECEPTOR TARGETED THERAPEUTICS
The invention is directed to T cells and other cells that express chimeric NK-p30 receptors ("chimeric NKp30 T cells"), methods of making and using chimeric...
2018/0147239 METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF
The present description relates to in vitro methods for culturing hematopoietic stem cells (HSCs) under mild hyperthermia conditions (e.g., between 38.degree....
2018/0147238 COMPOSITION OF IRON SUCROSE AND PROCESS FOR ITS PREPARATION
The present invention relates to composition of iron sucrose and process for its preparation. The present invention also related to a process for the...
2018/0147237 NANOPARTICLES FOR USE AS A THERAPEUTIC VACCINE
The present invention relates to the field of human health and more particularly concerns nanoparticles for use as a therapeutic vaccine in the context of...
2018/0147236 METHOD OF SUPPRESSING INFLAMMATION AND PROMOTING REPAIR OF INJURED NEURAL TISSUES WITH CARBOXYL-FUNCTIONALIZED...
The present invention provides a method of suppressing inflammation and promoting repair of an injured neural tissue in a subject in need thereof, including...
2018/0147235 ALLERGY VACCINE COMPOSITION
The present invention provides an allergy vaccine composition that is useful as a prophylactic or therapeutic agent for an allergic disease and can safely and...
2018/0147234 COMPOSITIONS AND METHODS FOR TREATMENT OF FIBROMYALGIA
Provided herein are methods and compositions for the treatment of Fibromyalgia (FM) or Fibromyalgia syndrome (FMS). One aspect provides treating a subject...
2018/0147233 MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-,...
microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing...
2018/0147232 COMBINATION THERAPY USING PDK1 AND PI3K INHIBITORS
The present invention relates to methods and compositions for inhibiting growth and proliferation of cancer cells resistant to PI3K inhibition using a...
2018/0147231 METHOD FOR TREATMENT AND PROGNOSIS OF COLORECTAL CANCER
The invention relates to the treatment and prognosis of colorectal cancer, especially proximal colorectal cancer. It also relates to identifying patients with...
2018/0147229 MATERIALS AND METHODS FOR TREATING BACTERIAL INFECTIONS USING C-1 GENTAMICIN
Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a...
2018/0147228 USE OF AN AMINOGLYCOSIDE FOR NONSENSE MUTATION SUPPRESSION AND THE TREATMENT OF DISEASE
Methods of using and pharmaceutical compositions comprising (2R,3S,4R,5R,6S)-5-amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5- ...
2018/0147227 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES
The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing...
2018/0147226 METHODS AND ASSAYS FOR COMBINATION TREATMENT OF CANCER
The technology described herein is directed to the treatment of cancer, e.g. methods and assays relating to selecting and administering a chemotherapy with or...
2018/0147225 USE OF NAD PRECURSORS FOR BREAST ENHANCEMENT
Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an...
2018/0147224 METHODS FOR TREATING TUMORS IN SITU INCLUDING INTRATUMOR INJECTION OF CYTOTOXIC PARTICLES AND IMMUNE CHECKPOINT...
Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a...
2018/0147223 BOTULINUM NEUROTOXIN INHIBITORS
Present invention discloses a method of treating an individual suffering from botulism by inhibiting botulinum neurotoxins.
2018/0147222 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics,...
2018/0147221 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan...
2018/0147220 HONOKIOL AND MAGNOLOL FORMULATIONS WITH INCREASED STABILITY AND IMPROVED UPTAKE, AND METHODS OF USE THEREOF
Described herein are formulations and methods for treating, managing, or preventing sleeplessness or restlessness, for increasing focus or concentration, or...
2018/0147219 ENOLASE INHIBITORS AND METHODS OF TREATMENT THEREWITH
Provided herein are compounds of the formula (I) wherein the variables R.sub.1, R.sub.2, R.sub.3, R.sub.4, X.sub.1, X.sub.2, Y.sub.1, and A.sub.1 are as...
2018/0147218 Methods for Accelerated Return of Skin Integrity and for the Treatment of Impetigo
Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelorating the return of skin...
2018/0147217 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11BETA-17-21-TRIOL-3,20-DIONE DERIVATIVES
The present invention relates to pharmaceutical compositions comprising 4-pregenen-11.beta.-17-21-triol-3,20-dione derivatives, and their use as ...
2018/0147216 METHODS OF TREATING PANCREATIC CANCER
Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to...
2018/0147215 ORAL TESTOSTERONE UNDECANOATE THERAPY
The present disclosure provides methods and compositions for testosterone replacement therapy. The methods and compositions employ a fixed dose dosing regimen...
2018/0147214 D20 STABILIZED PHARMACEUTICAL FORMULATIONS
Provided herein is an ophthalmic composition formulated in deuterated water. Also disclosed herein are methods of treating, ameliorating, or reducing...
2018/0147213 METHODS OF COSMETICALLY TREATING SKIN CONDITIONS WITH A COSMETIC PERSONAL CLEANSING COMPOSITION
A method of treating a skin condition including applying a rinse-off multi-phase cleansing composition including a cleansing phase including an anionic...
2018/0147212 COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
A method of treating or preventing a bacterial infection of a subject may include combining levofloxacin and a diluent to form a treatment solution and...
2018/0147211 COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
A method of treating or preventing a bacterial infection of a subject may include combining linezolid and a diluent to form a treatment solution and topically...
2018/0147210 DOSING REGIMEN ASSOCIATED WITH LONG ACTING INJECTABLE PALIPERIDONE ESTERS
The present invention provides a method of treating patients in need of treatment with long acting injectable paliperidone palmitate formulations.
2018/0147209 PAR1 MODULATION TO ALTER MYELINATION
Materials and methods for modulating protease activated receptor 1 (PAR1) activity to alter myelination are provided.
2018/0147208 IMIDAZO-PYRAZINYL DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
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