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Patent # Description
2018/0147207 COMPOSITIONS AND METHODS FOR THERAPY OF PROSTATE CANCER USING DRUG COMBINATIONS TO TARGET POLYAMINE...
Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that...
2018/0147206 ACTIVATION OF NEURONAL STORE-OPERATED CALCIUM ENTRY PATHWAY FOR THE TREATMENT OF ALZHEIMER'S DISEASE
The present disclosure provides for new methods of treating Alzheimer's Disease. In particular, it concerns the activation of neuronal store-operated calcium...
2018/0147205 Therapeutic Compositions
The invention relates to a product containing the compound of formula (I) below (I) or a pharmaceutically acceptable salt of this compound, in combination with...
2018/0147204 STABLE AND SOLUBLE FORMULATIONS OF RECEPTOR TYROSINE KINASE INHIBITORS, AND METHODS OF PREPARATION THEREOF
The present disclosure relates to stable formulations of receptor tyrosine kinase inhibitors (TKI), e.g., pazopanib; methods of preparation thereof; and use of...
2018/0147203 CERDULATINIB FOR THE TREATMENT OF B-CELL MALIGNANCIES
Provided herein are compositions and methods for treating a relapsed or refractory hematologic cancer in a human patient in need thereof. The methods entail...
2018/0147202 TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE
The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK 1. In particular, the present invention is directed to...
2018/0147201 COMBINATIONS OF OPIOID/TLR4 ANTAGONISTS AND ACETAMINOPHEN FOR USE IN THE TREATMENT OF EMOTIONAL PAIN AND INSOMNIA
Disclosed are compositions for the treatment of emotional pain, physical pain, and insomnia comprising a compound comprising an opioid antagonist that treats...
2018/0147200 METHOD OF INDUCING AUTOPHAGY
The present invention provides a method of inducing autophagy, the method including administering to a subject an effective amount of a pyrroloquinoline...
2018/0147199 AQUEOUS LIQUID FORMULATION
A novel technique with which it is possible to suppress chemical degradation of a compound represented by general formula (1) or a salt thereof in an aqueous...
2018/0147198 COMBINATIONS OF PFKFB3 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS TO TREAT CANCER
Provided herein is a method of treating cancer and stimulating anti-tumor immunity in a subject in need thereof, the method including administering to the...
2018/0147197 Chloroquine Induction of Par-4 and Treatment of Cancer
Described herein are methods for treating cancer in a subject in need thereof by administering chloroquine, or a salt or prodrug thereof, optionally with...
2018/0147196 PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the...
2018/0147195 METHODS OF TREATING DEVELOPMENTAL DISORDERS USING PIPRADROL
Methods of treating developmental disorders by administering a pharmaceutical composition of pipradrol or a pharmaceutically acceptable salt thereof are...
2018/0147194 NOVEL COMPOUNDS AS REARRANGED DURING TRANSFECTION (RET) INHIBITORS
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing...
2018/0147193 Use of 4-Aminopyridine to Improve Neuro-Cognitive and/or Neuro-Psychiatric Impairment in Patients with...
Disclosed herein are methods and compositions related to use of aminopyridines, such as 4-aminopyridine, to improve the neuro-cognitive impairments and related...
2018/0147192 PHARMACEUTICAL COMPOSITION OF MEK INHIBITOR AND PREPARATION METHOD THEREOF
The present application provides a pharmaceutical composition comprising 6-(2-chloro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-methyl-4-oxo-4,5-dih- ...
2018/0147191 COMPOUND USEFUL FOR THE TREATMENT OF NONSENSE-MUTATION-MEDIATED DISEASES AND PHARMACEUTICAL COMPOSITION...
The present invention relates to the compound of formula (I) ##STR00001## for use in the treatment of a nonsense-mutation-mediated genetic disease.
2018/0147190 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide Compounds for the Management of CFTR Protein...
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic...
2018/0147189 ADMINISTRATION REGIMEN FOR THERAPEUTIC AGENTS FOR ATAXIA IN SPINOCEREBELLAR DEGENERATION
The present invention is directed to provide excellent pharmaceutical compositions for the treatment of ataxia in spinocerebellar degeneration with which the...
2018/0147188 DOSING REGIMEN FOR A SELECTIVE S1P1 RECEPTOR AGONIST
The present invention relates to a dosing regimen for (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylim- ino)-3-o-tolyl-thiazolidin-4-one.
2018/0147187 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
The present disclosure features compounds such as those having the Formulae (IIa), (IIb), (IIc), (IId), (IIIa), and (IIIb), which can increase cystic fibrosis...
2018/0147186 BENDAMUSTINE DERIVATIVES AND METHODS OF USING SAME
The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.
2018/0147185 AUTOTAXIN INHIBITORS AND USES THEREOF
Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and...
2018/0147184 BISAMIDE DERIVATIVE OF DICARBOXYLIC ACID AS AN AGENT FOR STIMULATING TISSUE REGENERATION AND RECOVERY OF...
The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ...
2018/0147183 USE OF R-OXIRACETAM IN PHARMACEUTICAL FIELD
Provided is a use of R-oxiracetam in the preparation of a drug for preventing or treating epilepsy. An experimental result shows that the R-oxiracetam has an...
2018/0147182 Breast cancer therapeutic agent containing 5'-hydroxy-5-nitro-indirubin-3'-oxime as active ingredient
A breast cancer therapeutic agent containing 5'-hydroxy-5-nitro-indirubin-3'-oxime as active ingredient has been disclosed. Further, a breast cancer...
2018/0147181 Use of andrographolide derivatives in preparation of medicaments for preventing and treating inflammatory bowel...
The present invention provides uses of an andrographolide derivative in preparation of a medicament for preventing and treating inflammatory bowel disease. The...
2018/0147180 DEVICES AND METHODS FOR FACILITATING AND CONTROLLING USE OF A MEDICATION
A device includes a reservoir configured to store a drug formulation including at least one abuse-preventing additive. The device further includes means...
2018/0147179 CANNABINOID BLENDS AND FORMULATIONS, RELATED METHODS
The disclosure provides methods for making homogeneous powders that are enriched in cannabinoids, and for blending the mixtures with pigments, emulsifiers, or...
2018/0147178 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS...
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal...
2018/0147177 Antibacterial Compositions Comprising Copper Oxo-Hydroxide Nanoparticles and Their Uses as Biocidal Agents
Antibacterial compositions comprising nanoparticles formed from copper oxo-hydroxide are described that are capable of delivering biocidal concentrations of...
2018/0147176 COMPOSITION CONTAINING EICOSAPENTAENOIC ACID ALKYL ESTER, AND METHOD FOR PRODUCING SAME
Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7...
2018/0147175 COMPOSITIONS AND METHODS FOR TREATMENT OF MOVEMENT DISORDERS
The present invention relates to the treatment and prevention of movement disorders with the administration of one or more propionyl-CoA precursors.
2018/0147174 VITAMIN A FOR PARENTERAL ADMINSTRATION
The present disclosure relates to emulsions for parenteral administration comprising 1000 to 5000, preferably 1500 to 3000 IU, vitamin A per ml, wherein the...
2018/0147173 COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING CANCER AND NEUROLOGIC DISEASE
The present disclosure provides compositions comprising 15-HEPE and methods of using same for treating and/or preventing cancer and neurological diseases in a...
2018/0147172 Compositions for Mitigating Head Trauma
A method for mitigating the effects of traumatic brain injury in an individual comprising is disclosed. The method includes administering an amount of a...
2018/0147171 TRANS10:CIS12 ISOMER OF CONJUGATED LINOLEIC ACID AS A THERAPEUTIC AND PREVENTATIVE AGENT FOR HYPERTENSION...
Described herein are compositions and methods for the use of t10:c12 conjugated linoleic acid to reduce hypertension in pregnant women. Advantageously, by...
2018/0147170 ANTIHYPERTENSIVE AGENT
Provided is an antihypertensive agent that is safe and has a mild effect. An antihypertensive agent comprising S-1-propenylcysteine or a salt thereof as an active...
2018/0147169 PHARMACEUTICAL COMPOSITIONS AND THE TREATMENT OF OVERACTIVE BLADDER
The present invention relates to methods of treating overactive bladder and the symptoms associated therewith, for example, urinary urgency, frequency of...
2018/0147168 ANTIMICROBIALS AND METHODS OF USE THEREOF
This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof....
2018/0147167 METHODS AND COMPOSITIONS TO MODULATE THE GUT MICROBIOTA AND TO MANAGE WEIGHT
Methods of weight management for a subject are provided. Generally the methods comprising: administering an effective amount to the small intestine and/or...
2018/0147166 BENZENE-1,3,5-TRICARBOXAMIDE DERIVATIVES AND USES THEREOF
The present invention relates to compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents...
2018/0147165 METHODS FOR THE TREATMENT OF ROSACEA
The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and...
2018/0147164 2-amino-N'-benzylideneacetohydrazides and Derivatives for the Management of CFTR Protein Mediated Diseases
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic...
2018/0147163 COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS
The present invention relates to compositions comprising at least two different active compounds and the use of such combination compositions in medicine, in...
2018/0147162 OPHTHALMIC COMPOSITIONS
Provided herein is an ophthalmic composition including a therapeutic active agent and an anti-inflammatory agent, in which the active agent is at least about...
2018/0147161 MULTIDRUG BRITTLE MATRIX COMPOSITIONS
Dual and triple therapy combinations of drugs formulated as brittle matrix particles with a high surface area are provided herein. These particle formulations...
2018/0147160 Compositions for Use in Treating Parkinson's Disease and Related Disorders
The present invention relates to methods of treating and managing Parkinson's disease and related disorders. The methods especially find use in managing motor...
2018/0147159 Astaxanthin Anti-Inflammatory Synergistic Combinations
Compositions having synergistic combinations of astaxanthin with a tomato extract lycopene, and optionally with carnosic acid and/or lutein. Compositions...
2018/0147158 DETOXIFYING ANTIMICROBIAL MOLECULAR COMPLEX
The invention relates to a food additive which includes at least one clay interspersed with volatile antimicrobial agents. Such an additive can be added to the...
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